Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6386
Gene name Gene Name - the full gene name approved by the HGNC.
Syndecan binding protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SDCBP
Synonyms (NCBI Gene) Gene synonyms aliases
MDA-9, MDA9, SDCBP1, ST1, SYCL, TACIP18
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q12.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of tran
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001503 hsa-miR-155-5p pSILAC 18668040
MIRT001503 hsa-miR-155-5p Reporter assay;Other 20584899
MIRT001503 hsa-miR-155-5p Proteomics 18668040
MIRT027019 hsa-miR-103a-3p Sequencing 20371350
MIRT028447 hsa-miR-30a-5p Proteomics 18668040
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002091 Process Negative regulation of receptor internalization IMP 25893292
GO:0005109 Function Frizzled binding IPI 18256285
GO:0005137 Function Interleukin-5 receptor binding ISS 11498591
GO:0005515 Function Protein binding IPI 12842047, 18256285, 18832467, 22660413, 24722188, 25122212, 25416956, 25893292, 25910212, 26787460, 27107012, 27386966, 29892012, 31515488, 32296183, 32814053
GO:0005546 Function Phosphatidylinositol-4,5-bisphosphate binding IDA 27386966
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602217 10662 ENSG00000137575
Protein
UniProt ID O00560
Protein name Syntenin-1 (Melanoma differentiation-associated protein 9) (MDA-9) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18) (Scaffold protein Pbp1) (Syndecan-binding protein 1)
Protein function Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD
PDB 1N99 , 1NTE , 1OBX , 1OBY , 1OBZ , 1R6J , 1V1T , 1W9E , 1W9O , 1W9Q , 1YBO , 4Z33 , 6R9H , 6RLC , 7FSG , 7FSH , 7FSI , 7FSJ , 7FSK , 7FSL , 7FSM , 7FSN , 7FSO , 7FSP , 7FSQ , 7FSR , 7FSS , 7FST , 7FSU , 7FSV , 7FSW , 7FSX , 7FSY , 7FSZ , 7FT0 , 7FT1 , 7FT2 , 7FT3 , 7FT4 , 7FT5 , 7FT6 , 7FT7 , 7FT8 , 7FT9 , 7FTA , 7FTB , 7FTC , 7FTD , 8AAI , 8AAK , 8AAO
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00595 PDZ 114 191 PDZ domain Domain
PF00595 PDZ 198 270 PDZ domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in lung cancers, including adenocarcinoma, squamous cell carcinoma and small-cell carcinoma (at protein level) (PubMed:25893292). Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression
Sequence
MSLYPSLEDLKVDKVIQAQTAFSANPANPAILSEASAPIPHDGNLYPRLYPELSQYMGLS
LNEEEIRANVAVVSGAPLQGQLVARPSSINYMVAPVTGNDVGIRRAEIKQGIREVILCKD
QDGKIGLRLKSIDNGIFVQLVQANSPASLVGLRFGDQVLQINGENCAGWSSDKAHKVLKQ
AFGEKITMTIR
DRPFERTITMHKDSTGHVGFIFKNGKITSIVKDSSAARNGLLTEHNICE
INGQNVIGLKDSQIADILSTSGTVVTITIM
PAFIFEHIIKRMAPSIMKSLMDHTIPEV
Sequence length 298
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Ephrin signaling
Neurofascin interactions
Neutrophil degranulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Arthritis Degenerative polyarthritis rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470 18784066
Associations from Text Mining
Disease Name Relationship Type References
Arthritis Rheumatoid Associate 37415981
Asthma Stimulate 40634444
Breast Neoplasms Stimulate 32595209
Breast Neoplasms Associate 36834839
Carcinoma Associate 36870688
Carcinoma Basal Cell Associate 23873690
Carcinoma Non Small Cell Lung Associate 32901857
Carcinoma Pancreatic Ductal Stimulate 35241737
Carcinoma Small Cell Associate 24722482
Carcinoma Squamous Cell Associate 37562257