Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
6385
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Syndecan 4 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
SDC4 |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
SYND4 |
Chromosome
Chromosome number
|
20 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
20q13.12 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene i |
UniProt ID |
P31431
|
Protein name |
Syndecan-4 (SYND4) (Amphiglycan) (Ryudocan core protein) |
Protein function |
Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). |
PDB |
1EJP
,
1EJQ
,
1OBY
,
1YBO
,
8BLV
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF01034
|
Syndecan |
139 → 196 |
Syndecan domain |
Family |
|
Tissue specificity |
TISSUE SPECIFICITY: Detected in fibroblasts (at protein level) (PubMed:1500433, PubMed:36213313). Also expressed in epithelial cells (PubMed:1500433). {ECO:0000269|PubMed:1500433, ECO:0000269|PubMed:36213313}. |
Sequence |
|
Sequence length |
198 |
Interactions |
View interactions
|
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Lung carcinoma |
Non-Small Cell Lung Carcinoma |
rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193 View all (44 more) |
22919003 |
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Psoriasis |
Psoriasis |
|
|
GWAS |
|
Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Adenocarcinoma of Lung |
Associate
|
28971587 |
Alzheimer Disease |
Stimulate
|
30718543 |
Ascites |
Associate
|
33721368 |
Asthma |
Associate
|
22268118 |
Atrial Fibrillation |
Associate
|
36341343 |
Breast Neoplasms |
Associate
|
11786412, 21430259, 22513363, 25361632, 36152082, 36335555, 39938698 |
Carcinoma Hepatocellular |
Associate
|
17259344, 24751902, 28993096 |
Carcinoma Non Small Cell Lung |
Associate
|
32503508 |
Cartilage Diseases |
Associate
|
31455087 |
Colorectal Neoplasms |
Associate
|
12055189 |
Communication Disorders |
Inhibit
|
29368632 |
Coronary Artery Disease |
Associate
|
25410619 |
Diabetic Foot |
Associate
|
39557273 |
Endometriosis |
Associate
|
27041028 |
Esophageal Squamous Cell Carcinoma |
Associate
|
31345182 |
Essential Hypertension |
Associate
|
25410619 |
Fibrocartilaginous embolism |
Associate
|
30370584 |
Hemolytic Uremic Syndrome |
Associate
|
32635212 |
Hypertension |
Associate
|
25410619 |
Immunoglobulin G4 Related Disease |
Associate
|
40076757 |
Infections |
Stimulate
|
19519784 |
Leukemia Myeloid Acute |
Associate
|
11313277 |
Lung Neoplasms |
Associate
|
28950338, 32852072 |
Lymphatic Metastasis |
Associate
|
36199068 |
Melanoma |
Associate
|
19696445, 20803552, 25216363 |
Neoplasm Metastasis |
Associate
|
19696445, 37935976 |
Neoplasm Metastasis |
Inhibit
|
23844358 |
Neoplasms |
Associate
|
15141079, 21072196, 21430259, 23844358, 30179249, 32489258, 35833571, 39938698, 40076757 |
Neoplasms Germ Cell and Embryonal |
Associate
|
23844358 |
Neurofibromatosis Familial Spinal |
Associate
|
37217626 |
Osteoarthritis |
Inhibit
|
30553836 |
Osteoarthritis |
Associate
|
31455087 |
Osteosarcoma |
Associate
|
37935976 |
Ovarian Neoplasms |
Associate
|
33721368 |
Overweight |
Associate
|
25410619 |
Pancreatic Neoplasms |
Associate
|
36199068 |
Pituitary Neoplasms |
Associate
|
36686480 |
Prostatic Neoplasms |
Associate
|
34445387 |
Pulmonary Disease Chronic Obstructive |
Associate
|
31695352, 37257701 |
Seminoma |
Associate
|
23844358 |
Stomach Neoplasms |
Associate
|
37155874 |
Stroke |
Associate
|
38067435 |
Thyroid Cancer Papillary |
Associate
|
30165731, 30614796, 30872410 |
Thyroid Neoplasms |
Associate
|
32489258 |
Triple Negative Breast Neoplasms |
Associate
|
39938698 |
Urinary Bladder Neoplasms |
Associate
|
35246056 |
Uterine Cervical Neoplasms |
Associate
|
35937409 |
|