Gene Gene information from NCBI Gene database.
Entrez ID 6383
Gene name Syndecan 2
Gene symbol SDC2
Synonyms (NCBI Gene)
CD362HSPGHSPG1SYND2
Chromosome 8
Chromosome location 8q22.1
Summary The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are req
miRNA miRNA information provided by mirtarbase database.
205
miRTarBase ID miRNA Experiments Reference
MIRT468760 hsa-miR-495-3p PAR-CLIP 23592263
MIRT468759 hsa-miR-5688 PAR-CLIP 23592263
MIRT468758 hsa-miR-7-1-3p PAR-CLIP 23592263
MIRT468757 hsa-miR-7-2-3p PAR-CLIP 23592263
MIRT468756 hsa-miR-3125 PAR-CLIP 23592263
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 9660868, 11356864, 18093920, 22660413, 32296183, 32814053, 33961781
GO:0005788 Component Endoplasmic reticulum lumen TAS
GO:0005796 Component Golgi lumen TAS
GO:0005886 Component Plasma membrane IDA
GO:0005886 Component Plasma membrane TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
142460 10659 ENSG00000169439
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P34741
Protein name Syndecan-2 (SYND2) (Fibroglycan) (Heparan sulfate proteoglycan core protein) (HSPG) (CD antigen CD362)
Protein function Cell surface proteoglycan which regulates dendritic arbor morphogenesis.
PDB 6ITH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01034 Syndecan 138 199 Syndecan domain Family
Sequence
MRRAWILLTLGLVACVSAESRAELTSDKDMYLDNSSIEEASGVYPIDDDDYASASGSGAD
EDVESPELTTSRPLPKILLTSAAPKVETTTLNIQNKIPAQTKSPEETDKEKVHLSDSERK
MDPAEEDTNVYTEKHSDSLFKRTEVLAAVIAGGVIGFLFAIFLILLLVYRMRKKDEGSYD
LGERKPSSAAYQKAPTKEF
YA
Sequence length 201
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Cell adhesion molecules
Cytoskeleton in muscle cells
Malaria
Proteoglycans in cancer
Fluid shear stress and atherosclerosis
  A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG biosynthesis
HS-GAG degradation
Cell surface interactions at the vascular wall
Syndecan interactions
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective EXT2 causes exostoses 2
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
EPHB-mediated forward signaling
Defective B3GALT6 causes EDSP2 and SEMDJL1
Post-translational protein phosphorylation
Retinoid metabolism and transport
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
9
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CHRONIC OBSTRUCTIVE PULMONARY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CLEFT PALATE Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CLEFT UPPER LIP Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COMPLETE UNILATERAL CLEFT LIP Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adenocarcinoma Associate 23327652, 34397867
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of Lung Associate 30106131
★☆☆☆☆
Found in Text Mining only
Adenoma Associate 28058013, 28753106, 36203138
★☆☆☆☆
Found in Text Mining only
Adenoma Stimulate 29730903
★☆☆☆☆
Found in Text Mining only
Adenoma Villous Associate 29730903
★☆☆☆☆
Found in Text Mining only
Adenomatous Polyps Associate 29225717
★☆☆☆☆
Found in Text Mining only
Arrest of spermatogenesis Associate 39285301
★☆☆☆☆
Found in Text Mining only
Arthritis Associate 17545191
★☆☆☆☆
Found in Text Mining only
Azoospermia Associate 39285301
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 19383343, 23327652, 24357546, 25623282
★☆☆☆☆
Found in Text Mining only