Gene Gene information from NCBI Gene database.
Entrez ID 6374
Gene name C-X-C motif chemokine ligand 5
Gene symbol CXCL5
Synonyms (NCBI Gene)
ENA-78SCYB5
Chromosome 4
Chromosome location 4q13.3
Summary This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein co
miRNA miRNA information provided by mirtarbase database.
228
miRTarBase ID miRNA Experiments Reference
MIRT019453 hsa-miR-148b-3p Microarray 17612493
MIRT025829 hsa-miR-7-5p Microarray 19073608
MIRT707535 hsa-miR-1277-5p HITS-CLIP 21572407
MIRT707534 hsa-miR-369-3p HITS-CLIP 21572407
MIRT707532 hsa-miR-5692b HITS-CLIP 21572407
Transcription factors Transcription factors information provided by TRRUST V2 database.
4
Transcription factor Regulation Reference
NFKB1 Unknown 11559712
RELA Unknown 11559712
SP1 Activation 11559712
ZNF148 Unknown 11559712
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
22
GO ID Ontology Definition Evidence Reference
GO:0005125 Function Cytokine activity IEA
GO:0005515 Function Protein binding IPI 32296183
GO:0005576 Component Extracellular region IEA
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600324 10642 ENSG00000163735
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P42830
Protein name C-X-C motif chemokine 5 (ENA-78(1-78)) (Epithelial-derived neutrophil-activating protein 78) (Neutrophil-activating peptide ENA-78) (Small-inducible cytokine B5) [Cleaved into: ENA-78(8-78); ENA-78(9-78)]
Protein function Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.
PDB 2MGS , 8XWS , 8XX7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00048 IL8 47 106 Small cytokines (intecrine/chemokine), interleukin-8 like Domain
Sequence
MSLLSSRAARVPGPSSSLCALLVLLLLLTQPGPIASAGPAAAVLRELRCVCLQTTQGVHP
KMISNLQVFAIGPQCSKVEVVASLKNGKEICLDPEAPFLKKVIQKI
LDGGNKEN
Sequence length 114
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
IL-17 signaling pathway
TNF signaling pathway
Pertussis
Rheumatoid arthritis
  Chemokine receptors bind chemokines
G alpha (i) signalling events
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CROHN'S DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HYPERSENSITIVITY CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
IDIOPATHIC PULMONARY FIBROSIS Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Acute Coronary Syndrome Associate 18769620
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Associate 34133324
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of Lung Inhibit 20562917
★☆☆☆☆
Found in Text Mining only
Adenomatous Polyposis Coli Stimulate 35537038
★☆☆☆☆
Found in Text Mining only
Adrenocortical Carcinoma Associate 34220331
★☆☆☆☆
Found in Text Mining only
Allergic Fungal Sinusitis Stimulate 19153309, 22508623
★☆☆☆☆
Found in Text Mining only
Allergic Fungal Sinusitis Associate 26047816
★☆☆☆☆
Found in Text Mining only
Alveolitis Extrinsic Allergic Associate 19535235
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Stimulate 34440700
★☆☆☆☆
Found in Text Mining only
Anastomotic Leak Associate 32307587
★☆☆☆☆
Found in Text Mining only