Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6367
Gene name Gene Name - the full gene name approved by the HGNC.
C-C motif chemokine ligand 22
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CCL22
Synonyms (NCBI Gene) Gene synonyms aliases
A-152E5.1, ABCD-1, DC/B-CK, MDC, SCYA22, STCP-1
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16q21
Summary Summary of gene provided in NCBI Entrez Gene.
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006869 hsa-miR-34a-5p Luciferase reporter assay 22975373
MIRT006869 hsa-miR-34a-5p Luciferase reporter assay 22975373
MIRT006869 hsa-miR-34a-5p Luciferase reporter assay 22975373
MIRT675850 hsa-miR-4798-3p HITS-CLIP 23824327
MIRT632179 hsa-miR-3929 HITS-CLIP 23824327
Transcription factors
Transcription factor Regulation Reference
NFKB1 Activation 17018379
RELA Activation 17018379
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002548 Process Monocyte chemotaxis IBA 21873635
GO:0005515 Function Protein binding IPI 32296183
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IBA 21873635
GO:0006935 Process Chemotaxis TAS 10861057
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602957 10621 ENSG00000102962
Protein
UniProt ID O00626
Protein name C-C motif chemokine 22 (CC chemokine STCP-1) (MDC(1-69)) (Macrophage-derived chemokine) (Small-inducible cytokine A22) (Stimulated T-cell chemotactic protein 1) [Cleaved into: MDC(3-69); MDC(5-69); MDC(7-69)]
Protein function May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for pr
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00048 IL8 34 91 Small cytokines (intecrine/chemokine), interleukin-8 like Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found in lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and spleen. Very weak expression i
Sequence
Sequence length 93
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
C-type lectin receptor signaling pathway
  Chemokine receptors bind chemokines
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Dermatitis Dermatitis, Atopic rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 22125604, 18249437
Unknown
Disease term Disease name Evidence References Source
Endometriosis Endometriosis 30579999 ClinVar
Multiple Sclerosis Multiple Sclerosis GWAS
Systemic lupus erythematosus Systemic lupus erythematosus GWAS
Asthma Asthma GWAS
Associations from Text Mining
Disease Name Relationship Type References
Abortion Spontaneous Associate 36096448
Allergic Fungal Sinusitis Associate 26047816
Aortic Aneurysm Abdominal Stimulate 20348247
Appendicitis Associate 31845023
Arthritis Psoriatic Associate 11310827
Arthritis Rheumatoid Associate 24286358, 28148302
Asthma Stimulate 18684970
Asthma Associate 19594754, 35000593, 38253462
Autoimmune Diseases Associate 25970596
Bacteremia Associate 39966757