CCL20 (C-C motif chemokine ligand 20)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6364
Gene name Gene Name - the full gene name approved by the HGNC.
C-C motif chemokine ligand 20
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CCL20
Synonyms (NCBI Gene) Gene synonyms aliases
CKb4, Exodus, LARC, MIP-3-alpha, MIP-3a, MIP3A, SCYA20, ST38
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q36.3
Summary Summary of gene provided in NCBI Entrez Gene.
This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The pr
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(22)
miRTarBase ID miRNA Experiments Reference
MIRT006199 hsa-miR-21-5p ELISA, Immunofluorescence, Luciferase reporter assay 22001440
MIRT006199 hsa-miR-21-5p ELISA, Immunofluorescence, Luciferase reporter assay 22001440
MIRT006199 hsa-miR-21-5p ELISA, Immunofluorescence, Luciferase reporter assay 22001440
MIRT006199 hsa-miR-21-5p ELISA, Immunofluorescence, Luciferase reporter assay 22001440
MIRT006199 hsa-miR-21-5p ELISA, Immunofluorescence, Luciferase reporter assay 22001440
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(4)
Transcription factor Regulation Reference
CEBPD Activation 23028973
NFKB1 Unknown 19939449;22240809
RELA Activation 11749970
RELA Unknown 22240809
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0005125 Function Cytokine activity IEA
GO:0005515 Function Protein binding IPI 17703191, 18239685, 28381538
GO:0005576 Component Extracellular region IEA
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
601960 10619 ENSG00000115009
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P78556
Protein name C-C motif chemokine 20 (Beta-chemokine exodus-1) (CC chemokine LARC) (Liver and activation-regulated chemokine) (Macrophage inflammatory protein 3 alpha) (MIP-3-alpha) (Small-inducible cytokine A20) [Cleaved into: CCL20(1-67); CCL20(1-64); CCL20(2-70)]
Protein function Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:11035086, PubMed:11352563, PubMed:20068036). The li
PDB 1M8A , 2HCI , 2JYO , 5UR7 , 6WWZ , 7T1E
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00048 IL8 30 → 89 Small cytokines (intecrine/chemokine), interleukin-8 like Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level). Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels seen in thymus, prostate,
Sequence
Sequence length 96
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
IL-17 signaling pathway
TNF signaling pathway
Rheumatoid arthritis 		  Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (6)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Asthma Age of onset of childhood onset asthma, Asthma (childhood onset), Asthma, Asthma onset (childhood vs adult), Asthma (age of onset) N/A N/A GWAS
Biliary Cholangitis Primary biliary cholangitis N/A N/A GWAS
Crohn Disease Crohn's disease N/A N/A GWAS
Eczema Eczema N/A N/A GWAS
Show/Hide Text Mining Associations (189)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Abnormalities Drug Induced Associate 17146629
Abortion Habitual Inhibit 26345847
Adenocarcinoma Stimulate 35164838
Adenocarcinoma of Lung Associate 32019546, 34580602, 35437508, 35733175, 35864953, 37335089, 37938151, 39838222
Adenoma Associate 21249124, 30753331
Adenoma Stimulate 23790181
Anemia Associate 16413387
Aortic Aneurysm Abdominal Associate 29229985
Aortic Aneurysm Familial Abdominal 1 Stimulate 25548922
Arthritis Associate 29880013