CCL18 (C-C motif chemokine ligand 18)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6362
Gene name Gene Name - the full gene name approved by the HGNC.
C-C motif chemokine ligand 18
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CCL18
Synonyms (NCBI Gene) Gene synonyms aliases
AMAC-1, AMAC1, CKb7, DC-CK1, DCCK1, MIP-4, PARC, SCYA18
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q12
Summary Summary of gene provided in NCBI Entrez Gene.
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(7)
miRTarBase ID miRNA Experiments Reference
MIRT870937 hsa-miR-346 CLIP-seq
MIRT870938 hsa-miR-4251 CLIP-seq
MIRT870939 hsa-miR-4288 CLIP-seq
MIRT870940 hsa-miR-4663 CLIP-seq
MIRT870941 hsa-miR-539 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(20)
GO ID Ontology Definition Evidence Reference
GO:0002548 Process Monocyte chemotaxis IBA 21873635
GO:0005515 Function Protein binding IPI 21481794
GO:0005615 Component Extracellular space IBA 21873635
GO:0006935 Process Chemotaxis TAS 9192897
GO:0006954 Process Inflammatory response IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
603757 10616 ENSG00000275385
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P55774
Protein name C-C motif chemokine 18 (Alternative macrophage activation-associated CC chemokine 1) (AMAC-1) (CC chemokine PARC) (Dendritic cell chemokine 1) (DC-CK1) (Macrophage inflammatory protein 4) (MIP-4) (Pulmonary and activation-regulated chemokine) (Small-induc
Protein function Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph node
PDB 4MHE
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00048 IL8 28 → 85 Small cytokines (intecrine/chemokine), interleukin-8 like Domain
Tissue specificity TISSUE SPECIFICITY: Expressed at high levels in lung, lymph nodes, placenta, bone marrow, dendritic cells present in germinal centers and T-cell areas of secondary lymphoid organs and macrophages derived from peripheral blood monocytes. Not expressed by p
Sequence
Sequence length 89
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway 		 
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Lung cancer Malignant neoplasm of lung rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135 23349697
Show/Hide Text Mining Associations (121)
Associations from Text Mining
Disease Name Relationship Type References
Acquired Immunodeficiency Syndrome Associate 16773571
Adenocarcinoma of Lung Associate 23349697
Airway Obstruction Associate 22246175
Anemia Aplastic Associate 35571618
Anodontia Associate 21943944
Aortic Aneurysm Abdominal Associate 25517227
Arthritis Rheumatoid Stimulate 15331393, 16984635, 34404786
Arthritis Rheumatoid Associate 17875202, 32404914
Ascites Associate 27613122
Asthma Stimulate 19017877