CCL11 (C-C motif chemokine ligand 11)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 6356
Gene name C-C motif chemokine ligand 11
Gene symbol CCL11
Synonyms (NCBI Gene)
SCYA11
Chromosome 17
Chromosome location 17q12
Summary This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies
miRNA miRNA information provided by mirtarbase database.
49
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (49)
miRTarBase ID miRNA Experiments Reference
MIRT019315 hsa-miR-148b-3p Microarray 17612493
MIRT564003 hsa-miR-1277-5p PAR-CLIP 20371350
MIRT564002 hsa-miR-5011-5p PAR-CLIP 20371350
MIRT564001 hsa-miR-190a-3p PAR-CLIP 20371350
MIRT459497 hsa-miR-6758-5p PAR-CLIP 23592263
Transcription factors Transcription factors information provided by TRRUST V2 database.
9
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (9)
Transcription factor Regulation Reference
NFKB1 Activation 16604092
NFKB1 Unknown 10586089;11076795;14660485
RELA Activation 16604092
RELA Unknown 10586089;11076795;14660485
STAT3 Activation 19265112
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
53
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (53)
GO ID Ontology Definition Evidence Reference
GO:0001938 Process Positive regulation of endothelial cell proliferation IDA 19525930
GO:0002544 Process Chronic inflammatory response IEA
GO:0002551 Process Mast cell chemotaxis IEA
GO:0005125 Function Cytokine activity IEA
GO:0005515 Function Protein binding IPI 18275857, 21314817, 23597562, 28381538
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
601156 10610 ENSG00000172156
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P51671
Protein name Eotaxin (C-C motif chemokine 11) (Eosinophil chemotactic protein) (Small-inducible cytokine A11)
Protein function In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions (PubMed:8597956). Binds to CCR3 (PubMed:8631813). {ECO:0000269|PubMed:8597956, ECO:0
PDB 1EOT , 2EOT , 2MPM , 7SCS
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00048 IL8 30 → 88 Small cytokines (intecrine/chemokine), interleukin-8 like Domain
Sequence
Sequence length 97
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
IL-17 signaling pathway
Asthma 		  Chemokine receptors bind chemokines
Interleukin-4 and Interleukin-13 signaling
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
4
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (3)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
CCL11-related disorder Benign; Likely benign rs1129844, rs375131716 RCV003974708
RCV003907367
Inherited susceptibility to asthma risk factor rs1396407521 RCV000008873
Susceptibility to HIV infection protective rs4795895 RCV000008872
Show/Hide Text Mining Associations (156)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acquired Immunodeficiency Syndrome Associate 11501668
Acute Febrile Encephalopathy Associate 22012040
adult multisystem inflammatory disease COVID 19 related Associate 36102684
Allergic Fungal Sinusitis Associate 25624129, 26047816
Alzheimer Disease Associate 26324103
Anastomotic Leak Stimulate 35652588
Aneurysm Associate 23887838
Aortic Aneurysm Abdominal Associate 27126477
Aphasia Primary Progressive Associate 34602080
Arthritis Psoriatic Associate 40149440