CCL7 (C-C motif chemokine ligand 7)

Gene

• Entrez ID: 6354
• Gene name: C-C motif chemokine ligand 7
• Gene symbol: CCL7
• Synonyms (NCBI Gene): FIC, MARC, MCP-3, MCP3, NC28, SCYA6, SCYA7
• Chromosome: 17
• Chromosome location: 17q12
• Summary: This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The p

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029409	hsa-miR-26b-5p	Microarray	19088304
MIRT054392	hsa-let-7f-5p	Luciferase reporter assay	22894925
MIRT1958657	hsa-miR-300	CLIP-seq
MIRT1958658	hsa-miR-381	CLIP-seq
MIRT1958659	hsa-miR-4666-3p	CLIP-seq
MIRT1958660	hsa-miR-4789-5p	CLIP-seq
MIRT2436134	hsa-miR-188-3p	CLIP-seq
MIRT2436135	hsa-miR-324-5p	CLIP-seq
MIRT2436136	hsa-miR-4328	CLIP-seq
MIRT2436137	hsa-miR-765	CLIP-seq
MIRT2436134	hsa-miR-188-3p	CLIP-seq
MIRT2436135	hsa-miR-324-5p	CLIP-seq
MIRT2436136	hsa-miR-4328	CLIP-seq
MIRT2436137	hsa-miR-765	CLIP-seq
MIRT2446479	hsa-let-7a	CLIP-seq
MIRT2446480	hsa-let-7b	CLIP-seq
MIRT2446481	hsa-let-7c	CLIP-seq
MIRT2446482	hsa-let-7d	CLIP-seq
MIRT2446483	hsa-let-7e	CLIP-seq
MIRT2446484	hsa-let-7f	CLIP-seq
MIRT2446485	hsa-let-7g	CLIP-seq
MIRT2446486	hsa-let-7i	CLIP-seq
MIRT2446487	hsa-miR-1321	CLIP-seq
MIRT2446488	hsa-miR-202	CLIP-seq
MIRT2446489	hsa-miR-3123	CLIP-seq
MIRT2446490	hsa-miR-3154	CLIP-seq
MIRT2446491	hsa-miR-3925-5p	CLIP-seq
MIRT2446492	hsa-miR-3927	CLIP-seq
MIRT2446493	hsa-miR-4451	CLIP-seq
MIRT2446494	hsa-miR-4458	CLIP-seq
MIRT2446495	hsa-miR-4500	CLIP-seq
MIRT2446496	hsa-miR-4739	CLIP-seq
MIRT2446497	hsa-miR-4756-5p	CLIP-seq
MIRT2436137	hsa-miR-765	CLIP-seq
MIRT2446498	hsa-miR-98	CLIP-seq
MIRT2446479	hsa-let-7a	CLIP-seq
MIRT2446480	hsa-let-7b	CLIP-seq
MIRT2446481	hsa-let-7c	CLIP-seq
MIRT2446482	hsa-let-7d	CLIP-seq
MIRT2446483	hsa-let-7e	CLIP-seq
MIRT2446484	hsa-let-7f	CLIP-seq
MIRT2446485	hsa-let-7g	CLIP-seq
MIRT2446486	hsa-let-7i	CLIP-seq
MIRT2498670	hsa-miR-1273f	CLIP-seq
MIRT2446487	hsa-miR-1321	CLIP-seq
MIRT2498671	hsa-miR-1323	CLIP-seq
MIRT2498672	hsa-miR-143	CLIP-seq
MIRT2436134	hsa-miR-188-3p	CLIP-seq
MIRT2446488	hsa-miR-202	CLIP-seq
MIRT1958657	hsa-miR-300	CLIP-seq
MIRT2498673	hsa-miR-3120-3p	CLIP-seq
MIRT2446489	hsa-miR-3123	CLIP-seq
MIRT2446490	hsa-miR-3154	CLIP-seq
MIRT2436135	hsa-miR-324-5p	CLIP-seq
MIRT2498674	hsa-miR-338-5p	CLIP-seq
MIRT1958658	hsa-miR-381	CLIP-seq
MIRT2446491	hsa-miR-3925-5p	CLIP-seq
MIRT2446492	hsa-miR-3927	CLIP-seq
MIRT2436136	hsa-miR-4328	CLIP-seq
MIRT2446493	hsa-miR-4451	CLIP-seq
MIRT2446494	hsa-miR-4458	CLIP-seq
MIRT2446495	hsa-miR-4500	CLIP-seq
MIRT2498675	hsa-miR-4640-3p	CLIP-seq
MIRT1958659	hsa-miR-4666-3p	CLIP-seq
MIRT2498676	hsa-miR-4668-3p	CLIP-seq
MIRT2498677	hsa-miR-4699-5p	CLIP-seq
MIRT2498678	hsa-miR-4708-5p	CLIP-seq
MIRT2446496	hsa-miR-4739	CLIP-seq
MIRT2446497	hsa-miR-4756-5p	CLIP-seq
MIRT2498679	hsa-miR-4770	CLIP-seq
MIRT1958660	hsa-miR-4789-5p	CLIP-seq
MIRT2498680	hsa-miR-548aa	CLIP-seq
MIRT2498681	hsa-miR-548ac	CLIP-seq
MIRT2498682	hsa-miR-548d-3p	CLIP-seq
MIRT2498683	hsa-miR-548o	CLIP-seq
MIRT2498684	hsa-miR-548z	CLIP-seq
MIRT2498685	hsa-miR-7	CLIP-seq
MIRT2436137	hsa-miR-765	CLIP-seq
MIRT2446498	hsa-miR-98	CLIP-seq
MIRT2446479	hsa-let-7a	CLIP-seq
MIRT2446480	hsa-let-7b	CLIP-seq
MIRT2446481	hsa-let-7c	CLIP-seq
MIRT2446482	hsa-let-7d	CLIP-seq
MIRT2446483	hsa-let-7e	CLIP-seq
MIRT2446484	hsa-let-7f	CLIP-seq
MIRT2446485	hsa-let-7g	CLIP-seq
MIRT2446486	hsa-let-7i	CLIP-seq
MIRT2498670	hsa-miR-1273f	CLIP-seq
MIRT2446487	hsa-miR-1321	CLIP-seq
MIRT2498671	hsa-miR-1323	CLIP-seq
MIRT2498672	hsa-miR-143	CLIP-seq
MIRT2436134	hsa-miR-188-3p	CLIP-seq
MIRT2446488	hsa-miR-202	CLIP-seq
MIRT1958657	hsa-miR-300	CLIP-seq
MIRT2498673	hsa-miR-3120-3p	CLIP-seq
MIRT2446489	hsa-miR-3123	CLIP-seq
MIRT2446490	hsa-miR-3154	CLIP-seq
MIRT2436135	hsa-miR-324-5p	CLIP-seq
MIRT2498674	hsa-miR-338-5p	CLIP-seq
MIRT1958658	hsa-miR-381	CLIP-seq
MIRT2446491	hsa-miR-3925-5p	CLIP-seq
MIRT2446492	hsa-miR-3927	CLIP-seq
MIRT2436136	hsa-miR-4328	CLIP-seq
MIRT2446493	hsa-miR-4451	CLIP-seq
MIRT2446494	hsa-miR-4458	CLIP-seq
MIRT2446495	hsa-miR-4500	CLIP-seq
MIRT2498675	hsa-miR-4640-3p	CLIP-seq
MIRT1958659	hsa-miR-4666-3p	CLIP-seq
MIRT2498676	hsa-miR-4668-3p	CLIP-seq
MIRT2498677	hsa-miR-4699-5p	CLIP-seq
MIRT2498678	hsa-miR-4708-5p	CLIP-seq
MIRT2446496	hsa-miR-4739	CLIP-seq
MIRT2446497	hsa-miR-4756-5p	CLIP-seq
MIRT2498679	hsa-miR-4770	CLIP-seq
MIRT1958660	hsa-miR-4789-5p	CLIP-seq
MIRT2498683	hsa-miR-548o	CLIP-seq
MIRT2498685	hsa-miR-7	CLIP-seq
MIRT2436137	hsa-miR-765	CLIP-seq
MIRT2446498	hsa-miR-98	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
LEF1	Unknown	11118053

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002548	Process	Monocyte chemotaxis	IC	10660125
GO:0005125	Function	Cytokine activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 26095031, 27044744, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IEA
GO:0005615	Component	Extracellular space	TAS	7916328
GO:0006874	Process	Intracellular calcium ion homeostasis	TAS	10770925
GO:0006935	Process	Chemotaxis	IEA
GO:0006935	Process	Chemotaxis	TAS	9780207
GO:0006954	Process	Inflammatory response	IBA
GO:0006954	Process	Inflammatory response	IDA	10748004
GO:0006954	Process	Inflammatory response	IEA
GO:0006955	Process	Immune response	IEA
GO:0007010	Process	Cytoskeleton organization	IDA	10072545
GO:0007165	Process	Signal transduction	TAS	10201901, 10770925
GO:0007249	Process	Canonical NF-kappaB signal transduction	IDA	1406630, 9346484, 10882101, 25038658, 34721373
GO:0007267	Process	Cell-cell signaling	TAS	7916328
GO:0008009	Function	Chemokine activity	IBA
GO:0008009	Function	Chemokine activity	IDA	10072545
GO:0008009	Function	Chemokine activity	IEA
GO:0008009	Function	Chemokine activity	TAS	10770925
GO:0008201	Function	Heparin binding	IEA
GO:0008360	Process	Regulation of cell shape	IDA	10072545
GO:0010332	Process	Response to gamma radiation	IEA
GO:0023019	Process	Signal transduction involved in regulation of gene expression	IDA	1406630, 9346484, 25038658, 34721373
GO:0030335	Process	Positive regulation of cell migration	IBA
GO:0030335	Process	Positive regulation of cell migration	IDA	7545673
GO:0031726	Function	CCR1 chemokine receptor binding	IPI	7545673, 10660125
GO:0031727	Function	CCR2 chemokine receptor binding	IEA
GO:0048020	Function	CCR chemokine receptor binding	IBA
GO:0048245	Process	Eosinophil chemotaxis	IBA
GO:0048245	Process	Eosinophil chemotaxis	IDA	10072545
GO:0050729	Process	Positive regulation of inflammatory response	IDA	38417634
GO:0050729	Process	Positive regulation of inflammatory response	IDA	38417634
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IBA
GO:0070098	Process	Chemokine-mediated signaling pathway	IBA
GO:0071361	Process	Cellular response to ethanol	IEA
GO:1900016	Process	Negative regulation of cytokine production involved in inflammatory response	IDA	16968406
GO:2000503	Process	Positive regulation of natural killer cell chemotaxis	IDA	7545673

Other IDs

• MIM: 158106
• HGNC: 10634
• e!Ensembl: ENSG00000108688

Protein

• UniProt ID: P80098
• Protein name: C-C motif chemokine 7 (Monocyte chemoattractant protein 3) (Monocyte chemotactic protein 3) (MCP-3) (NC28) (Small-inducible cytokine A7)
• Protein function: Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.
• PDB: 1BO0, 1NCV, 4ZKC, 7S58, 7S59, 7SCU, 8FJ3, 8FK6, 8FK8, 8JPS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00048	IL8	32 → 90	Small cytokines (intecrine/chemokine), interleukin-8 like	Domain

• Sequence:

  MKASAALLCLLLTAAAFSPQGLAQPVGINTSTTCCYRFINKKIPKQRLESYRRTTSSHCP
  REAVIFKTKLDKEICADPTQKWVQDFMKHLDKKTQTPKL

• Sequence length: 99

Pathways

KEGG:

Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
IL-17 signaling pathway

Reactome:

Chemokine receptors bind chemokines