CCL4 (C-C motif chemokine ligand 4)

Gene

• Entrez ID: 6351
• Gene name: C-C motif chemokine ligand 4
• Gene symbol: CCL4
• Synonyms (NCBI Gene): ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4
• Chromosome: 17
• Chromosome location: 17q12
• Summary: The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004669	hsa-miR-195-5p	ELISA, Immunoprecipitaion, qRT-PCR, Western blot	20952681

Transcription factors

Transcription factor	Regulation	Reference
CREM	Repression	16443828
NFKB1	Unknown	11342414
RELA	Unknown	11342414

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005125	Function	Cytokine activity	IEA
GO:0005125	Function	Cytokine activity	TAS	2462251
GO:0005515	Function	Protein binding	IPI	23597562, 25416956, 31515488, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IEA
GO:0005615	Component	Extracellular space	TAS	2521882
GO:0006935	Process	Chemotaxis	IEA
GO:0006954	Process	Inflammatory response	IBA
GO:0006954	Process	Inflammatory response	IEA
GO:0006954	Process	Inflammatory response	TAS	2521882
GO:0006955	Process	Immune response	IEA
GO:0006955	Process	Immune response	TAS	10929056
GO:0007155	Process	Cell adhesion	TAS	10929056
GO:0007163	Process	Establishment or maintenance of cell polarity	TAS	9759849
GO:0007165	Process	Signal transduction	TAS	9558100, 10929056
GO:0007267	Process	Cell-cell signaling	TAS	2521882
GO:0008009	Function	Chemokine activity	IBA
GO:0008009	Function	Chemokine activity	IEA
GO:0008009	Function	Chemokine activity	TAS	10929056
GO:0009615	Process	Response to virus	TAS	9743377
GO:0009636	Process	Response to toxic substance	IDA	10841574
GO:0030335	Process	Positive regulation of cell migration	IBA
GO:0031726	Function	CCR1 chemokine receptor binding	IPI	7545673
GO:0031730	Function	CCR5 chemokine receptor binding	IPI	10383387, 10679098
GO:0042802	Function	Identical protein binding	IPI	20959807
GO:0043922	Process	Host-mediated suppression of viral transcription	IDA	10841574
GO:0048020	Function	CCR chemokine receptor binding	IBA
GO:0048245	Process	Eosinophil chemotaxis	IBA
GO:0050850	Process	Positive regulation of calcium-mediated signaling	IMP	10679098
GO:0051928	Process	Positive regulation of calcium ion transport	IDA	8699119
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IBA
GO:0070098	Process	Chemokine-mediated signaling pathway	IBA
GO:2000503	Process	Positive regulation of natural killer cell chemotaxis	IDA	7545673

Other IDs

• MIM: 182284
• HGNC: 10630
• e!Ensembl: ENSG00000275302

Interactions View interactions

Pathways

KEGG:

Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
NF-kappa B signaling pathway
Toll-like receptor signaling pathway
Cytosolic DNA-sensing pathway
Human cytomegalovirus infection

Reactome:

Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling