CCL3 (C-C motif chemokine ligand 3)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 6348
Gene name C-C motif chemokine ligand 3
Gene symbol CCL3
Synonyms (NCBI Gene)
G0S19-1LD78LD78ALPHAMIP-1-alphaMIP1ASCISCYA3
Chromosome 17
Chromosome location 17q12
Summary This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be a
miRNA miRNA information provided by mirtarbase database.
4
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (4)
miRTarBase ID miRNA Experiments Reference
MIRT438283 hsa-miR-223-3p Luciferase reporter assay 24084739
MIRT438283 hsa-miR-223-3p Luciferase reporter assay 24084739
MIRT736396 hsa-miR-369-3p qRT-PCRFlow cytometry 33679688
MIRT756279 hsa-miR-877-3p qRT-PCRELISA 34768991
Transcription factors Transcription factors information provided by TRRUST V2 database.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
E2F1 Unknown 17707233
NFKB1 Activation 16982926
NFKB1 Unknown 11342414;17707233
RELA Activation 16982926
RELA Unknown 11342414;17707233
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
79
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade IEP 12032188
GO:0001649 Process Osteoblast differentiation IEP 21403648
GO:0001775 Process Cell activation IDA 10706735
GO:0002548 Process Monocyte chemotaxis IC 10660125
GO:0002548 Process Monocyte chemotaxis IDA 10706735
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
182283 10627 ENSG00000277632
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P10147
Protein name C-C motif chemokine 3 (G0/G1 switch regulatory protein 19-1) (Macrophage inflammatory protein 1-alpha) (MIP-1-alpha) (PAT 464.1) (SIS-beta) (Small-inducible cytokine A3) (Tonsillar lymphocyte LD78 alpha protein) [Cleaved into: MIP-1-alpha(4-69) (LD78-alph
Protein function Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, H
PDB 1B50 , 1B53 , 2X69 , 2X6G , 3FPU , 3H44 , 3KBX , 4RA8 , 4ZKB , 5COR , 5D65 , 7F1Q , 7F1T
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00048 IL8 31 → 88 Small cytokines (intecrine/chemokine), interleukin-8 like Domain
Sequence
Sequence length 92
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
Toll-like receptor signaling pathway
Chagas disease
Human cytomegalovirus infection
Rheumatoid arthritis
Lipid and atherosclerosis 		  Chemokine receptors bind chemokines
Interleukin-10 signaling
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (12)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ATHEROSCLEROSIS — CTD, Disgenet
CTD, Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BRAIN ISCHEMIA — CTD, Disgenet
CTD, Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLONIC NEOPLASMS — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (256)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Acne Vulgaris Associate 38115273
★★★★★
★☆☆☆☆
Found in Text Mining only
Acquired Immunodeficiency Syndrome Associate 16773571, 8986820
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of Lung Associate 38204755
★★★★★
★☆☆☆☆
Found in Text Mining only
AIDS Dementia Complex Stimulate 8570619
★★★★★
★☆☆☆☆
Found in Text Mining only
AIDS Dementia Complex Associate 8784788
★★★★★
★☆☆☆☆
Found in Text Mining only
Air crescent sign Associate 10469367
★★★★★
★☆☆☆☆
Found in Text Mining only
Allergic Fungal Sinusitis Associate 33629532
★★★★★
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Associate 30336198, 9665462
★★★★★
★☆☆☆☆
Found in Text Mining only
Anemia Associate 21859849
★★★★★
★☆☆☆☆
Found in Text Mining only
Anemia Aplastic Associate 1586705
★★★★★
★☆☆☆☆
Found in Text Mining only