CCL3 (C-C motif chemokine ligand 3)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6348
Gene name Gene Name - the full gene name approved by the HGNC.
C-C motif chemokine ligand 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CCL3
Synonyms (NCBI Gene) Gene synonyms aliases
G0S19-1, LD78, LD78ALPHA, MIP-1-alpha, MIP1A, SCI, SCYA3
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q12
Summary Summary of gene provided in NCBI Entrez Gene.
This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be a
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(4)
miRTarBase ID miRNA Experiments Reference
MIRT438283 hsa-miR-223-3p Luciferase reporter assay 24084739
MIRT438283 hsa-miR-223-3p Luciferase reporter assay 24084739
MIRT736396 hsa-miR-369-3p qRT-PCR, Flow cytometry 33679688
MIRT756279 hsa-miR-877-3p qRT-PCR, ELISA 34768991
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(7)
Transcription factor Regulation Reference
E2F1 Unknown 17707233
NFKB1 Activation 16982926
NFKB1 Unknown 11342414;17707233
RELA Activation 16982926
RELA Unknown 11342414;17707233
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(85)
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade IEP 12032188
GO:0000165 Process MAPK cascade IMP 21147091
GO:0001649 Process Osteoblast differentiation IEP 21403648
GO:0001775 Process Cell activation IDA 10706735
GO:0002548 Process Monocyte chemotaxis IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
182283 10627 ENSG00000277632
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P10147
Protein name C-C motif chemokine 3 (G0/G1 switch regulatory protein 19-1) (Macrophage inflammatory protein 1-alpha) (MIP-1-alpha) (PAT 464.1) (SIS-beta) (Small-inducible cytokine A3) (Tonsillar lymphocyte LD78 alpha protein) [Cleaved into: MIP-1-alpha(4-69) (LD78-alph
Protein function Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, H
PDB 1B50 , 1B53 , 2X69 , 2X6G , 3FPU , 3H44 , 3KBX , 4RA8 , 4ZKB , 5COR , 5D65 , 7F1Q , 7F1T
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00048 IL8 31 → 88 Small cytokines (intecrine/chemokine), interleukin-8 like Domain
Sequence
Sequence length 92
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
Toll-like receptor signaling pathway
Chagas disease
Human cytomegalovirus infection
Rheumatoid arthritis
Lipid and atherosclerosis 		  Chemokine receptors bind chemokines
Interleukin-10 signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (2)
Causal
Disease term Disease name dbSNP ID References
Glomerulonephritis Glomerulonephritis rs778043831 10385480
Pulmonary fibrosis Pulmonary Fibrosis rs121918666, rs199422300, rs121917834, rs199422294, rs201159197, rs199422297, rs199422305, rs751381953, rs876661305, rs878853260, rs1555811762, rs1060502990, rs1555903332, rs1554038539, rs1554042899
View all (1 more)		 17720292, 16324872
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Atherosclerosis Atherosclerosis 24370436 ClinVar
Show/Hide Text Mining Associations (256)
Associations from Text Mining
Disease Name Relationship Type References
Acne Vulgaris Associate 38115273
Acquired Immunodeficiency Syndrome Associate 16773571, 8986820
Adenocarcinoma of Lung Associate 38204755
AIDS Dementia Complex Stimulate 8570619
AIDS Dementia Complex Associate 8784788
Air crescent sign Associate 10469367
Allergic Fungal Sinusitis Associate 33629532
Alzheimer Disease Associate 30336198, 9665462
Anemia Associate 21859849
Anemia Aplastic Associate 1586705