SCNN1G (sodium channel epithelial 1 subunit gamma)

Gene

• Entrez ID: 6340
• Gene name: Sodium channel epithelial 1 subunit gamma
• Gene symbol: SCNN1G
• Synonyms (NCBI Gene): BESC3, ENaCg, ENaCgamma, LDLS2, PHA1, PHA1B3, SCNEG
• Chromosome: 16
• Chromosome location: 16p12.2
• Summary: Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit,

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs5736	G>A	Benign-likely-benign, benign, likely-benign, pathogenic	Missense variant, coding sequence variant
rs5738	G>A	Benign-likely-benign, benign, likely-benign, pathogenic	Missense variant, coding sequence variant
rs72647541	G>A	Conflicting-interpretations-of-pathogenicity, likely-benign	Synonymous variant, coding sequence variant
rs137853342	G>A	Pathogenic	Coding sequence variant, stop gained
rs886041786	->GCCG	Pathogenic	Frameshift variant, coding sequence variant
rs1567262640	G>A	Pathogenic	Splice acceptor variant
rs1567270184	AGCTC>-	Pathogenic	Frameshift variant, coding sequence variant
rs1596760831	->C	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1596777509	GCAGCACCCCA>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1596779402	G>A	Pathogenic	Splice acceptor variant
rs1596779433	G>-	Pathogenic	Coding sequence variant, frameshift variant
rs1596779485	G>A	Likely-pathogenic	Coding sequence variant, stop gained

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT648317	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT648316	hsa-miR-5702	HITS-CLIP	23824327
MIRT648315	hsa-miR-7154-5p	HITS-CLIP	23824327
MIRT648314	hsa-miR-433-3p	HITS-CLIP	23824327
MIRT648313	hsa-miR-937-5p	HITS-CLIP	23824327
MIRT648312	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT648311	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT648310	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT530818	hsa-miR-186-3p	PAR-CLIP	22012620
MIRT530816	hsa-miR-4286	PAR-CLIP	22012620
MIRT530815	hsa-miR-6887-3p	PAR-CLIP	22012620
MIRT530814	hsa-miR-7106-3p	PAR-CLIP	22012620
MIRT648317	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT648316	hsa-miR-5702	HITS-CLIP	23824327
MIRT648315	hsa-miR-7154-5p	HITS-CLIP	23824327
MIRT648314	hsa-miR-433-3p	HITS-CLIP	23824327
MIRT648313	hsa-miR-937-5p	HITS-CLIP	23824327
MIRT648312	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT648311	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT648310	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT530818	hsa-miR-186-3p	PAR-CLIP	22012620
MIRT530816	hsa-miR-4286	PAR-CLIP	22012620
MIRT530815	hsa-miR-6887-3p	PAR-CLIP	22012620
MIRT530814	hsa-miR-7106-3p	PAR-CLIP	22012620
MIRT1330424	hsa-miR-10a	CLIP-seq
MIRT1330425	hsa-miR-10b	CLIP-seq
MIRT1330426	hsa-miR-1285	CLIP-seq
MIRT1330427	hsa-miR-1304	CLIP-seq
MIRT1330428	hsa-miR-2116	CLIP-seq
MIRT1330429	hsa-miR-3119	CLIP-seq
MIRT1330430	hsa-miR-3122	CLIP-seq
MIRT1330431	hsa-miR-3174	CLIP-seq
MIRT1330432	hsa-miR-3187-5p	CLIP-seq
MIRT1330433	hsa-miR-3189-5p	CLIP-seq
MIRT1330434	hsa-miR-3591-3p	CLIP-seq
MIRT1330435	hsa-miR-3616-5p	CLIP-seq
MIRT1330436	hsa-miR-3620	CLIP-seq
MIRT1330437	hsa-miR-3647-5p	CLIP-seq
MIRT1330438	hsa-miR-3689a-3p	CLIP-seq
MIRT1330439	hsa-miR-3689c	CLIP-seq
MIRT1330440	hsa-miR-3913-5p	CLIP-seq
MIRT1330441	hsa-miR-3929	CLIP-seq
MIRT1330442	hsa-miR-3940-5p	CLIP-seq
MIRT1330443	hsa-miR-4325	CLIP-seq
MIRT1330444	hsa-miR-4419b	CLIP-seq
MIRT1330445	hsa-miR-4433	CLIP-seq
MIRT1330446	hsa-miR-4478	CLIP-seq
MIRT1330447	hsa-miR-4507	CLIP-seq
MIRT1330448	hsa-miR-4677-5p	CLIP-seq
MIRT1330449	hsa-miR-4728-5p	CLIP-seq
MIRT1330450	hsa-miR-4747-5p	CLIP-seq
MIRT1330451	hsa-miR-4773	CLIP-seq
MIRT1330452	hsa-miR-4793-3p	CLIP-seq
MIRT1330453	hsa-miR-4795-5p	CLIP-seq
MIRT1330454	hsa-miR-485-5p	CLIP-seq
MIRT1330455	hsa-miR-550a	CLIP-seq
MIRT1330456	hsa-miR-573	CLIP-seq
MIRT1330457	hsa-miR-579	CLIP-seq
MIRT1330458	hsa-miR-612	CLIP-seq
MIRT1330459	hsa-miR-635	CLIP-seq
MIRT1330460	hsa-miR-661	CLIP-seq
MIRT1330461	hsa-miR-665	CLIP-seq
MIRT1330462	hsa-miR-921	CLIP-seq
MIRT1330426	hsa-miR-1285	CLIP-seq
MIRT1330430	hsa-miR-3122	CLIP-seq
MIRT2097850	hsa-miR-3136-3p	CLIP-seq
MIRT1330431	hsa-miR-3174	CLIP-seq
MIRT1330432	hsa-miR-3187-5p	CLIP-seq
MIRT1330435	hsa-miR-3616-5p	CLIP-seq
MIRT1330437	hsa-miR-3647-5p	CLIP-seq
MIRT1330438	hsa-miR-3689a-3p	CLIP-seq
MIRT1330439	hsa-miR-3689c	CLIP-seq
MIRT1330440	hsa-miR-3913-5p	CLIP-seq
MIRT1330441	hsa-miR-3929	CLIP-seq
MIRT1330443	hsa-miR-4325	CLIP-seq
MIRT2097851	hsa-miR-433	CLIP-seq
MIRT1330444	hsa-miR-4419b	CLIP-seq
MIRT1330446	hsa-miR-4478	CLIP-seq
MIRT1330449	hsa-miR-4728-5p	CLIP-seq
MIRT1330450	hsa-miR-4747-5p	CLIP-seq
MIRT1330451	hsa-miR-4773	CLIP-seq
MIRT1330452	hsa-miR-4793-3p	CLIP-seq
MIRT1330453	hsa-miR-4795-5p	CLIP-seq
MIRT1330454	hsa-miR-485-5p	CLIP-seq
MIRT1330455	hsa-miR-550a	CLIP-seq
MIRT1330456	hsa-miR-573	CLIP-seq
MIRT1330458	hsa-miR-612	CLIP-seq
MIRT1330460	hsa-miR-661	CLIP-seq
MIRT1330462	hsa-miR-921	CLIP-seq
MIRT1330430	hsa-miR-3122	CLIP-seq
MIRT1330435	hsa-miR-3616-5p	CLIP-seq
MIRT1330436	hsa-miR-3620	CLIP-seq
MIRT1330437	hsa-miR-3647-5p	CLIP-seq
MIRT1330438	hsa-miR-3689a-3p	CLIP-seq
MIRT1330439	hsa-miR-3689c	CLIP-seq
MIRT1330440	hsa-miR-3913-5p	CLIP-seq
MIRT1330441	hsa-miR-3929	CLIP-seq
MIRT1330443	hsa-miR-4325	CLIP-seq
MIRT1330444	hsa-miR-4419b	CLIP-seq
MIRT1330446	hsa-miR-4478	CLIP-seq
MIRT1330449	hsa-miR-4728-5p	CLIP-seq
MIRT1330450	hsa-miR-4747-5p	CLIP-seq
MIRT1330452	hsa-miR-4793-3p	CLIP-seq
MIRT1330453	hsa-miR-4795-5p	CLIP-seq
MIRT1330454	hsa-miR-485-5p	CLIP-seq
MIRT1330455	hsa-miR-550a	CLIP-seq
MIRT2322190	hsa-miR-564	CLIP-seq
MIRT1330456	hsa-miR-573	CLIP-seq
MIRT1330459	hsa-miR-635	CLIP-seq
MIRT1330426	hsa-miR-1285	CLIP-seq
MIRT1330430	hsa-miR-3122	CLIP-seq
MIRT1330432	hsa-miR-3187-5p	CLIP-seq
MIRT1330435	hsa-miR-3616-5p	CLIP-seq
MIRT1330437	hsa-miR-3647-5p	CLIP-seq
MIRT2394095	hsa-miR-3652	CLIP-seq
MIRT1330438	hsa-miR-3689a-3p	CLIP-seq
MIRT1330439	hsa-miR-3689c	CLIP-seq
MIRT1330440	hsa-miR-3913-5p	CLIP-seq
MIRT1330441	hsa-miR-3929	CLIP-seq
MIRT1330443	hsa-miR-4325	CLIP-seq
MIRT1330444	hsa-miR-4419b	CLIP-seq
MIRT2394096	hsa-miR-4430	CLIP-seq
MIRT1330446	hsa-miR-4478	CLIP-seq
MIRT2394097	hsa-miR-4505	CLIP-seq
MIRT1330449	hsa-miR-4728-5p	CLIP-seq
MIRT1330452	hsa-miR-4793-3p	CLIP-seq
MIRT1330453	hsa-miR-4795-5p	CLIP-seq
MIRT1330454	hsa-miR-485-5p	CLIP-seq
MIRT1330455	hsa-miR-550a	CLIP-seq
MIRT2322190	hsa-miR-564	CLIP-seq
MIRT1330456	hsa-miR-573	CLIP-seq
MIRT1330458	hsa-miR-612	CLIP-seq
MIRT1330459	hsa-miR-635	CLIP-seq
MIRT2394098	hsa-miR-647	CLIP-seq
MIRT1330426	hsa-miR-1285	CLIP-seq
MIRT1330430	hsa-miR-3122	CLIP-seq
MIRT1330431	hsa-miR-3174	CLIP-seq
MIRT1330432	hsa-miR-3187-5p	CLIP-seq
MIRT1330438	hsa-miR-3689a-3p	CLIP-seq
MIRT1330439	hsa-miR-3689c	CLIP-seq
MIRT1330440	hsa-miR-3913-5p	CLIP-seq
MIRT1330441	hsa-miR-3929	CLIP-seq
MIRT1330443	hsa-miR-4325	CLIP-seq
MIRT1330444	hsa-miR-4419b	CLIP-seq
MIRT1330446	hsa-miR-4478	CLIP-seq
MIRT1330449	hsa-miR-4728-5p	CLIP-seq
MIRT1330451	hsa-miR-4773	CLIP-seq
MIRT1330452	hsa-miR-4793-3p	CLIP-seq
MIRT1330454	hsa-miR-485-5p	CLIP-seq
MIRT1330455	hsa-miR-550a	CLIP-seq
MIRT1330458	hsa-miR-612	CLIP-seq
MIRT1330460	hsa-miR-661	CLIP-seq
MIRT1330462	hsa-miR-921	CLIP-seq
MIRT2690248	hsa-miR-1283	CLIP-seq
MIRT1330430	hsa-miR-3122	CLIP-seq
MIRT1330431	hsa-miR-3174	CLIP-seq
MIRT1330438	hsa-miR-3689a-3p	CLIP-seq
MIRT1330439	hsa-miR-3689c	CLIP-seq
MIRT1330440	hsa-miR-3913-5p	CLIP-seq
MIRT1330441	hsa-miR-3929	CLIP-seq
MIRT1330443	hsa-miR-4325	CLIP-seq
MIRT1330444	hsa-miR-4419b	CLIP-seq
MIRT1330446	hsa-miR-4478	CLIP-seq
MIRT1330449	hsa-miR-4728-5p	CLIP-seq
MIRT1330452	hsa-miR-4793-3p	CLIP-seq
MIRT1330454	hsa-miR-485-5p	CLIP-seq
MIRT1330455	hsa-miR-550a	CLIP-seq
MIRT1330462	hsa-miR-921	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005216	Function	Monoatomic ion channel activity	IMP	22864553
GO:0005272	Function	Sodium channel activity	IDA	24124190, 32729833
GO:0005272	Function	Sodium channel activity	IEA
GO:0005515	Function	Protein binding	IPI	11244092, 16423824, 21775436, 22493497
GO:0005654	Component	Nucleoplasm	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	24124190
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	NAS	24419567
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006814	Process	Sodium ion transport	IEA
GO:0006814	Process	Sodium ion transport	IEA
GO:0006883	Process	Intracellular sodium ion homeostasis	IDA	16423824
GO:0006883	Process	Intracellular sodium ion homeostasis	IEA
GO:0008217	Process	Regulation of blood pressure	NAS	24419567
GO:0009897	Component	External side of plasma membrane	IEA
GO:0015280	Function	Ligand-gated sodium channel activity	IBA
GO:0015280	Function	Ligand-gated sodium channel activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0016324	Component	Apical plasma membrane	IDA	18174164
GO:0016324	Component	Apical plasma membrane	IEA
GO:0016324	Component	Apical plasma membrane	ISS
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034706	Component	Sodium channel complex	IBA
GO:0034706	Component	Sodium channel complex	IDA	16423824, 17502380, 24124190, 32729833
GO:0034706	Component	Sodium channel complex	IEA
GO:0034706	Component	Sodium channel complex	IPI	21775436
GO:0035725	Process	Sodium ion transmembrane transport	IBA
GO:0035725	Process	Sodium ion transmembrane transport	IDA	24124190
GO:0050699	Function	WW domain binding	IEA
GO:0050699	Function	WW domain binding	IPI	10642508
GO:0050891	Process	Multicellular organismal-level water homeostasis	IDA	24124190
GO:0050914	Process	Sensory perception of salty taste	NAS	22983350
GO:0050915	Process	Sensory perception of sour taste	NAS	22983350
GO:0055078	Process	Sodium ion homeostasis	IDA	24124190
GO:0070062	Component	Extracellular exosome	IDA	15326289
GO:0071468	Process	Cellular response to acidic pH	IDA	16423824
GO:0098719	Process	Sodium ion import across plasma membrane	IDA	16423824
GO:0098719	Process	Sodium ion import across plasma membrane	IEA
GO:1904045	Process	Cellular response to aldosterone	IEA
GO:1904045	Process	Cellular response to aldosterone	NAS	24419567
GO:1904117	Process	Cellular response to vasopressin	NAS	24419567

Other IDs

• MIM: 600761
• HGNC: 10602
• e!Ensembl: ENSG00000166828

Protein

• UniProt ID: P51170
• Protein name: Epithelial sodium channel subunit gamma (ENaC subunit gamma) (ENaCG) (Epithelial Na(+) channel subunit gamma) (Gamma-ENaC) (Amiloride-sensitive sodium channel subunit gamma) (Gamma-NaCH) (Nonvoltage-gated sodium channel 1 subunit gamma) (SCNEG) (Sodium ch
• Protein function: This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:30251954, PubMed:32729833, PubMed:7550319, PubMed:7762608, PubMed:9792722
• PDB: 6BQN, 6WTH, 9BLR, 9BTG, 9BTU
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00858	ASC	32 → 552	Amiloride-sensitive sodium channel	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in kidney (at protein level). {ECO:0000269|PubMed:22207244}.
• Sequence:

  MAPGEKIKAKIKKNLPVTGPQAPTIKELMRWYCLNTNTHGCRRIVVSRGRLRRLLWIGFT
  LTAVALILWQCALLVFSFYTVSVSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQE
  TREALKSLYGFPESRKRREAESWNSVSEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKR
  KVGGSIIHKASNVMHIESKQVVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQ
  VPLEKKINMSYSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNNRENETILSTSMG
  GSEYGLQVILYINEEEYNPFLVSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLT
  ESFKLSEPYSQCTEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAA
  NYCNYQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWL
  LPVLTWDQGRQVNKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMS
  CSVVCVIEIIEVFFIDFFSIIARRQWQKAKEWWAWKQAPPCPEAPRSPQGQDNPALDIDD
  DLPTFNSALHLPPALGTQVPGTPPPKYNTLRLERAFSNQLTDTQMLDEL

• Sequence length: 649

Pathways

KEGG:

Taste transduction
Aldosterone-regulated sodium reabsorption

Reactome:

Stimuli-sensing channels

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Bronchiectasis with or without elevated sweat chloride 3	Pathogenic; Likely pathogenic	rs866495683, rs1596760831	RCV004798928 RCV000991457	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Liddle syndrome 2	Pathogenic; Likely pathogenic	rs137853342, rs2141946607, rs1567270184, rs1596760831	RCV000009372 RCV000680189 RCV000684754 RCV000991457	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Pseudohypoaldosteronism, type IB1, autosomal recessive	Likely pathogenic	rs764425655, rs1596760831	RCV001449732 RCV000991457	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Pseudohypoaldosteronism, type IB3, autosomal recessive	Pathogenic	rs1596779402, rs1567262640, rs1596779433	RCV002310624 RCV002310625 RCV002310626	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
SCNN1G-related disorder	Likely pathogenic	rs1960103151	RCV003416929	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AUTISM SPECTRUM DISORDER	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CYSTIC FIBROSIS	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
FOCAL SEGMENTAL GLOMERULOSCLEROSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSIVE DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPOTENSION	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IDIOPATHIC BRONCHIECTASIS	—	Disgenet, Orphanet Disgenet, Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIDDLE SYNDROME	—	ClinGen, Disgenet, GWAS catalog, Orphanet ClinGen, Disgenet, GWAS catalog, Orphanet ClinGen, Disgenet, GWAS catalog, Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Liddle syndrome 1	Uncertain significance; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Monosomy 7 myelodysplasia and leukemia syndrome 1	Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myoepithelial tumor	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSEUDOHYPOALDOSTERONISM	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSEUDOHYPOALDOSTERONISM, TYPE I, AUTOSOMAL RECESSIVE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Achard Thiers syndrome	Stimulate	37417251	★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of Lung	Associate	34111567	★☆☆☆☆ Found in Text Mining only
Bartter syndrome type 3	Associate	18443236	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Associate	26723502	★☆☆☆☆ Found in Text Mining only
Bronchiectasis	Associate	18507830	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Associate	34111567	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	35865652	★☆☆☆☆ Found in Text Mining only
Cardiomyopathy Dilated	Associate	26437894	★☆☆☆☆ Found in Text Mining only
Cystic Fibrosis	Associate	19017867, 25900089	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Dwarfism Pituitary	Associate	25157616	★☆☆☆☆ Found in Text Mining only
Essential Hypertension	Associate	15661075	★☆☆☆☆ Found in Text Mining only
Fibroma	Associate	26121316	★☆☆☆☆ Found in Text Mining only
Glioma	Associate	26108662	★☆☆☆☆ Found in Text Mining only
Hypertension	Associate	24735600, 29792170	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hypotension	Associate	18443236, 21562341	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hypoxia Brain	Stimulate	37285404	★☆☆☆☆ Found in Text Mining only
Inflammation	Associate	26723502	★☆☆☆☆ Found in Text Mining only
Liddle Syndrome	Associate	15198480, 29792170, 30977777, 31655555, 34223773, 35723567	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malaria	Inhibit	26437894	★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Inhibit	25450293	★☆☆☆☆ Found in Text Mining only
Potassium aggravated myotonia	Associate	26723502	★☆☆☆☆ Found in Text Mining only
Precancerous Conditions	Associate	26723502	★☆☆☆☆ Found in Text Mining only
Pseudohypoaldosteronism	Stimulate	21750640	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pseudohypoaldosteronism	Associate	23762408, 27485500	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pulmonary Arterial Hypertension	Associate	31655555, 34223773	★☆☆☆☆ Found in Text Mining only
Pulmonary Edema	Inhibit	26437894	★☆☆☆☆ Found in Text Mining only
Sarcoma	Associate	26121316	★☆☆☆☆ Found in Text Mining only
Sarcoma Ewing	Associate	26121316	★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Inhibit	36389709	★☆☆☆☆ Found in Text Mining only