Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	634
Gene name Gene Name - the full gene name approved by the HGNC.	CEA cell adhesion molecule 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CEACAM1
Synonyms (NCBI Gene) Gene synonyms aliases	BGP, BGP1, BGPI
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19q13.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a

Show/Hide all(7)

miRTarBase ID	miRNA	Experiments
MIRT882915	hsa-miR-1343	CLIP-seq
MIRT882916	hsa-miR-3074-5p	CLIP-seq
MIRT882917	hsa-miR-520d-5p	CLIP-seq
MIRT882918	hsa-miR-524-5p	CLIP-seq
MIRT882919	hsa-miR-935	CLIP-seq
MIRT2198338	hsa-miR-1270	CLIP-seq
MIRT2198339	hsa-miR-620	CLIP-seq

Transcription factors

Show/Hide all(8)

Transcription factor	Regulation	Reference
HNF4A	Activation	8055923
IRF1	Activation	21050451
NFKB1	Activation	11306560
RELA	Activation	11306560
SOX9	Unknown	22209504
SP2	Repression	15126343
USF1	Activation	21050451;8055923
USF2	Activation	8055923

Show/Hide all(86)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	NAS	15687237
GO:0001558	Process	Regulation of cell growth	ISS
GO:0001568	Process	Blood vessel development	ISS
GO:0001915	Process	Negative regulation of T cell mediated cytotoxicity	IDA	18424730
GO:0002682	Process	Regulation of immune system process	IBA
GO:0002859	Process	Negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IMP	23696226
GO:0003779	Function	Actin binding	IPI	17192268
GO:0005515	Function	Protein binding	IPI	11035932, 11994468, 14522961, 16246332, 16282604, 18424730, 18497748, 21982860, 23696226, 25363763, 27442026
GO:0005516	Function	Calmodulin binding	ISS
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	17192268
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	NAS	15687237
GO:0005886	Component	Plasma membrane	TAS
GO:0005911	Component	Cell-cell junction	IDA	16291724
GO:0005912	Component	Adherens junction	IEA
GO:0005912	Component	Adherens junction	ISS
GO:0006469	Process	Negative regulation of protein kinase activity	ISS
GO:0007155	Process	Cell adhesion	ISS
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	ISS
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	NAS	15687237
GO:0007165	Process	Signal transduction	IBA
GO:0007229	Process	Integrin-mediated signaling pathway	NAS	15687237
GO:0009925	Component	Basal plasma membrane	IEA
GO:0009925	Component	Basal plasma membrane	ISS
GO:0009986	Component	Cell surface	IBA
GO:0009986	Component	Cell surface	IDA	25363763
GO:0009986	Component	Cell surface	ISS
GO:0010594	Process	Regulation of endothelial cell migration	ISS
GO:0015125	Function	Bile acid transmembrane transporter activity	ISS
GO:0015721	Process	Bile acid and bile salt transport	ISS
GO:0016020	Component	Membrane	IDA	11994468
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	2457922
GO:0016324	Component	Apical plasma membrane	IDA	10436421
GO:0016324	Component	Apical plasma membrane	IEA
GO:0016324	Component	Apical plasma membrane	ISS
GO:0016328	Component	Lateral plasma membrane	IEA
GO:0016328	Component	Lateral plasma membrane	ISS
GO:0016477	Process	Cell migration	NAS	15687237
GO:0019900	Function	Kinase binding	IPI	7478590
GO:0019903	Function	Protein phosphatase binding	IPI	18424730
GO:0030054	Component	Cell junction	IDA	8018919
GO:0030054	Component	Cell junction	ISS
GO:0030334	Process	Regulation of cell migration	IDA	16291724
GO:0030658	Component	Transport vesicle membrane	IEA
GO:0030853	Process	Negative regulation of granulocyte differentiation	ISS
GO:0031005	Function	Filamin binding	IPI	16291724
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031528	Component	Microvillus membrane	IEA
GO:0032692	Process	Negative regulation of interleukin-1 production	ISS
GO:0032869	Process	Cellular response to insulin stimulus	ISS
GO:0035579	Component	Specific granule membrane	TAS
GO:0035726	Process	Common myeloid progenitor cell proliferation	ISS
GO:0038016	Process	Insulin receptor internalization	ISS
GO:0038158	Process	Granulocyte colony-stimulating factor signaling pathway	ISS
GO:0042058	Process	Regulation of epidermal growth factor receptor signaling pathway	ISS
GO:0042101	Component	T cell receptor complex	IDA	18424730
GO:0042802	Function	Identical protein binding	IDA	26483485
GO:0042802	Function	Identical protein binding	IPI	19948502, 21982860, 26483485, 27442026
GO:0042803	Function	Protein homodimerization activity	ISS
GO:0042995	Component	Cell projection	IEA
GO:0043116	Process	Negative regulation of vascular permeability	ISS
GO:0043318	Process	Negative regulation of cytotoxic T cell degranulation	IDA	18424730
GO:0044319	Process	Wound healing, spreading of cells	IDA	16291724
GO:0045601	Process	Regulation of endothelial cell differentiation	ISS
GO:0045717	Process	Negative regulation of fatty acid biosynthetic process	ISS
GO:0046983	Function	Protein dimerization activity	ISS
GO:0050860	Process	Negative regulation of T cell receptor signaling pathway	IDA	18424730
GO:0051055	Process	Negative regulation of lipid biosynthetic process	ISS
GO:0051896	Process	Regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS
GO:0060312	Process	Regulation of blood vessel remodeling	ISS
GO:0070062	Component	Extracellular exosome	HDA	19199708, 23533145
GO:0070161	Component	Anchoring junction	IEA
GO:0070372	Process	Regulation of ERK1 and ERK2 cascade	ISS
GO:0070821	Component	Tertiary granule membrane	TAS
GO:0090331	Process	Negative regulation of platelet aggregation	ISS
GO:0098742	Process	Cell-cell adhesion via plasma-membrane adhesion molecules	ISS
GO:1901143	Process	Insulin catabolic process	ISS
GO:1903385	Process	Regulation of homophilic cell adhesion	ISS
GO:1903670	Process	Regulation of sprouting angiogenesis	ISS
GO:1990782	Function	Protein tyrosine kinase binding	IBA
GO:1990782	Function	Protein tyrosine kinase binding	IPI	18424730
GO:2000346	Process	Negative regulation of hepatocyte proliferation	ISS
GO:2001214	Process	Positive regulation of vasculogenesis	ISS

MIM	HGNC	e!Ensembl
109770	1814	ENSG00000079385

Protein

UniProt ID

P13688

Protein name

Cell adhesion molecule CEACAM1 (Biliary glycoprotein 1) (BGP-1) (Carcinoembryonic antigen-related cell adhesion molecule 1) (CEA cell adhesion molecule 1) (CD antigen CD66a)

Protein function

[Isoform 1]: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin action and also functions as an activator during angioge

PDB

2GK2 , 4QXW , 4WHD , 5DZL , 6AW2 , 6GBG , 6GBH , 6V3P , 6XNO , 6XNT , 6XNW , 6XO1 , 7MU8 , 7RPP , 8CXJ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07686	V-set	38 → 141	Immunoglobulin V-set domain	Domain
PF13927	Ig_3	146 → 219		Domain
PF13895	Ig_2	239 → 318	Immunoglobulin domain	Domain
PF00047	ig	331 → 411	Immunoglobulin domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in columnar epithelial cells of the colon (at protein level) (PubMed:10436421). The predominant forms expressed by T cells are those containing a long cytoplasmic domain (PubMed:18424730). Expressed in granulocytes and lympho

Sequence

MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFNVAEGKEVLLLVHNLPQ
QLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIYPNASLLIQNVTQNDTGFY
TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWI
NNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTP
TISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELFIPNITVNNSGSYTCH
ANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGISIRWF
FKNQSLPSSERMKLSQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVNYNALP
QENGLSPGAIAGIVIGVVALVALIAVALACFLHFGKTGRASDQRDLTEHKPSVSNHTQDH
SNDPPNKMNEVTYSTLNFEAQQPTQPTSASPSLTATEIIYSEVKKQ

Sequence length

526

Interactions

View interactions

	Reactome
			Fibronectin matrix formation Cell surface interactions at the vascular wall Neutrophil degranulation

CEACAM1 (CEA cell adhesion molecule 1)