SCN2B (sodium voltage-gated channel beta subunit 2)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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6327 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Sodium voltage-gated channel beta subunit 2 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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SCN2B |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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ATFB14 |
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Chromosome
Chromosome number
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11 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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11q23.3 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or |
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SNPs
SNP information provided by dbSNP.
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||
| UniProt ID | O60939 | ||||||||||
| Protein name | Sodium channel regulatory subunit beta-2 | ||||||||||
| Protein function | Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes (PubMed:19808477, PubMed:23559163, PubMed:26894959, PubMed:30765605, PubMed:30765606, PubMed:35277491, PubMed:3682320 | ||||||||||
| PDB | 5FDY , 5FEB , 6J8E , 6J8G , 6J8H , 6J8I , 6J8J , 6VRR , 7W77 , 7W7F , 7W9K , 7W9L , 7W9M , 7W9P , 7W9T , 7XM9 , 7XMF , 7XMG , 7XVE , 7XVF , 8G1A , 8GZ1 , 8GZ2 , 8I5B , 8I5G , 8I5X , 8I5Y , 8S9B , 8S9C , 8THG , 8THH , 8XMN , 8XMO | ||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 215 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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