SCD (stearoyl-CoA desaturase)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID 6319
Gene name Stearoyl-CoA desaturase
Gene symbol SCD
Synonyms (NCBI Gene)
FADS5MSTP008SCD1SCDOShSCD1
Chromosome 10
Chromosome location 10q24.31
Summary This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. The protein belongs to the fatty acid desaturase family and is an integral membrane protein located in the endoplasmic reticulum. Transcripts of approx
miRNA miRNA information provided by mirtarbase database.
2907
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Show/Hide all (2907)
miRTarBase ID miRNA Experiments Reference
MIRT017330 hsa-miR-335-5p Microarray 18185580
MIRT020585 hsa-miR-155-5p Proteomics 18668040
MIRT024946 hsa-miR-215-5p Microarray 19074876
MIRT025105 hsa-miR-181a-5p Sequencing 20371350
MIRT026303 hsa-miR-192-5p Microarray 19074876
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Show/Hide all (2)
Transcription factor Regulation Reference
RARA Activation 11397803
SREBF1 Unknown 11414710
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
31
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Show/Hide all (31)
GO ID Ontology Definition Evidence Reference
GO:0004768 Function Stearoyl-CoA 9-desaturase activity IBA
GO:0004768 Function Stearoyl-CoA 9-desaturase activity IDA 15907797, 18765284
GO:0004768 Function Stearoyl-CoA 9-desaturase activity IEA
GO:0004768 Function Stearoyl-CoA 9-desaturase activity TAS 10229681
GO:0005506 Function Iron ion binding IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
MIM HGNC e!Ensembl
604031 10571 ENSG00000099194
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O00767
Protein name Stearoyl-CoA desaturase (hSCD1) (EC 1.14.19.1) (Acyl-CoA desaturase) (Delta(9)-desaturase) (Delta-9 desaturase) (Fatty acid desaturase)
Protein function Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at t
PDB 4ZYO
Family and domains
Tissue specificity TISSUE SPECIFICITY: Detected in fetal liver, lung and brain. Highly expressed in adult adipose tissue, and at lower levels in adult brain and lung. {ECO:0000269|PubMed:15907797}.
Sequence 
MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYK
DKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAH
RLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFS
HVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGE
TFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNY
HHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
Sequence length 359
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
  KEGG  Reactome
  Biosynthesis of unsaturated fatty acids
Metabolic pathways
Fatty acid metabolism
PPAR signaling pathway
AMPK signaling pathway
Alcoholic liver disease 		  Activation of gene expression by SREBF (SREBP)
Fatty acyl-CoA biosynthesis
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis