SERPINB4 (serpin family B member 4)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6318
Gene name Gene Name - the full gene name approved by the HGNC.
Serpin family B member 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SERPINB4
Synonyms (NCBI Gene) Gene synonyms aliases
LEUPIN, PI11, SCCA-2, SCCA1, SCCA2
Chromosome Chromosome number
18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
18q21.33
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with serpin B
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(18)
miRTarBase ID miRNA Experiments Reference
MIRT443446 hsa-miR-4517 PAR-CLIP 22100165
MIRT443445 hsa-miR-3123 PAR-CLIP 22100165
MIRT443444 hsa-miR-556-5p PAR-CLIP 22100165
MIRT443443 hsa-miR-6807-5p PAR-CLIP 22100165
MIRT443446 hsa-miR-4517 PAR-CLIP 22100165
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(11)
GO ID Ontology Definition Evidence Reference
GO:0002020 Function Protease binding IPI 21857942
GO:0004867 Function Serine-type endopeptidase inhibitor activity IBA 21873635
GO:0004867 Function Serine-type endopeptidase inhibitor activity IDA 21857942
GO:0004867 Function Serine-type endopeptidase inhibitor activity NAS 7589435
GO:0005615 Component Extracellular space IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
600518 10570 ENSG00000206073
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P48594
Protein name Serpin B4 (Leupin) (Peptidase inhibitor 11) (PI-11) (Squamous cell carcinoma antigen 2) (SCCA-2)
Protein function May act as a protease inhibitor to modulate the host immune response against tumor cells.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00079 Serpin 6 → 390 Serpin (serine protease inhibitor) Domain
Tissue specificity TISSUE SPECIFICITY: Squamous cells.
Sequence
Sequence length 390
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  
  Amoebiasis  
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Dermatitis Contact Dermatitis rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 25724174
Show/Hide Text Mining Associations (19)
Associations from Text Mining
Disease Name Relationship Type References
Allergic Fungal Sinusitis Associate 19153309, 22508623
Bowen's Disease Associate 36085041
Carcinogenesis Stimulate 17291250, 17638865
Carcinoma Non Small Cell Lung Associate 36791109
Carcinoma Squamous Cell Associate 10867615, 21857942, 36085041
Cholesteatoma Associate 23285167
Crohn Disease Associate 39838210
Dermatitis Atopic Associate 28734739
Idiopathic Pulmonary Fibrosis Associate 37858084
Infections Associate 10683336