Gene Gene information from NCBI Gene database.
Entrez ID 6302
Gene name Tetraspanin 31
Gene symbol TSPAN31
Synonyms (NCBI Gene)
SAS
Chromosome 12
Chromosome location 12q14.1
Summary The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate
miRNA miRNA information provided by mirtarbase database.
333
miRTarBase ID miRNA Experiments Reference
MIRT1459716 hsa-miR-1228 CLIP-seq
MIRT1459717 hsa-miR-125a-5p CLIP-seq
MIRT1459718 hsa-miR-125b CLIP-seq
MIRT1459719 hsa-miR-1291 CLIP-seq
MIRT1459720 hsa-miR-1303 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
5
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183
GO:0005886 Component Plasma membrane TAS 8134123
GO:0008284 Process Positive regulation of cell population proliferation TAS 8134123
GO:0016020 Component Membrane IEA
GO:0016020 Component Membrane TAS 8134123
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
181035 10539 ENSG00000135452
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q12999
Protein name Tetraspanin-31 (Tspan-31) (Sarcoma-amplified sequence)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00335 Tetraspanin 9 199 Tetraspanin family Family
Sequence
Sequence length 210
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
MULTIPLE SCLEROSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Breast Neoplasms Associate 33378415
★☆☆☆☆
Found in Text Mining only
Burkitt Lymphoma Associate 9737661
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 28670683
★☆☆☆☆
Found in Text Mining only
Carnevale syndrome Associate 7592643
★☆☆☆☆
Found in Text Mining only
Glioblastoma Associate 15494095
★☆☆☆☆
Found in Text Mining only
Liposarcoma Associate 7592643
★☆☆☆☆
Found in Text Mining only
Multiple Sclerosis Associate 23160276
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Neoplasms Associate 24085196, 28670683, 35307915
★☆☆☆☆
Found in Text Mining only
Oligodendroglioma Associate 18544654
★☆☆☆☆
Found in Text Mining only
Ovarian Neoplasms Associate 35120576
★☆☆☆☆
Found in Text Mining only