Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6293
Gene name Gene Name - the full gene name approved by the HGNC.	VPS52 subunit of GARP complex
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	VPS52
Synonyms (NCBI Gene) Gene synonyms aliases	ARE1, SAC2, SACM2L, dJ1033B10.5
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6p21.32
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein that is similar to the yeast suppressor of actin mutations 2 gene. The yeast protein forms a subunit of the tetrameric Golgi-associated retrograde protein complex that is involved in vesicle trafficking from from both early and

Show/Hide all(174)

miRTarBase ID	miRNA	Experiments	Reference
MIRT651672	hsa-miR-7109-3p	HITS-CLIP	23824327
MIRT651671	hsa-miR-330-3p	HITS-CLIP	23824327
MIRT651670	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT651669	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT651668	hsa-miR-4719	HITS-CLIP	23824327
MIRT651667	hsa-miR-205-5p	HITS-CLIP	23824327
MIRT651666	hsa-miR-4252	HITS-CLIP	23824327
MIRT651665	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT651664	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT651663	hsa-miR-513b-5p	HITS-CLIP	23824327
MIRT651673	hsa-miR-6771-3p	HITS-CLIP	23824327
MIRT651672	hsa-miR-7109-3p	HITS-CLIP	23824327
MIRT651671	hsa-miR-330-3p	HITS-CLIP	23824327
MIRT651670	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT651669	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT651668	hsa-miR-4719	HITS-CLIP	23824327
MIRT651667	hsa-miR-205-5p	HITS-CLIP	23824327
MIRT651666	hsa-miR-4252	HITS-CLIP	23824327
MIRT651665	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT651664	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT651663	hsa-miR-513b-5p	HITS-CLIP	23824327
MIRT491962	hsa-miR-142-3p	PAR-CLIP	23592263
MIRT491961	hsa-miR-302f	PAR-CLIP	23592263
MIRT491960	hsa-miR-7161-3p	PAR-CLIP	23592263
MIRT491958	hsa-miR-4779	PAR-CLIP	23592263
MIRT491959	hsa-miR-4255	PAR-CLIP	23592263
MIRT491957	hsa-miR-4459	PAR-CLIP	23592263
MIRT491956	hsa-miR-665	PAR-CLIP	23592263
MIRT491954	hsa-miR-655-5p	PAR-CLIP	23592263
MIRT491955	hsa-miR-4663	PAR-CLIP	23592263
MIRT491953	hsa-miR-7160-5p	PAR-CLIP	23592263
MIRT491952	hsa-miR-8077	PAR-CLIP	23592263
MIRT491950	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT491951	hsa-miR-8085	PAR-CLIP	23592263
MIRT491949	hsa-miR-3175	PAR-CLIP	23592263
MIRT491948	hsa-miR-124-5p	PAR-CLIP	23592263
MIRT491946	hsa-miR-3671	PAR-CLIP	23592263
MIRT491947	hsa-miR-6807-5p	PAR-CLIP	23592263
MIRT491945	hsa-miR-628-5p	PAR-CLIP	23592263
MIRT491944	hsa-miR-3591-5p	PAR-CLIP	23592263
MIRT491943	hsa-miR-607	PAR-CLIP	23592263
MIRT491942	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT651672	hsa-miR-7109-3p	HITS-CLIP	23824327
MIRT651671	hsa-miR-330-3p	HITS-CLIP	23824327
MIRT651670	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT651669	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT651668	hsa-miR-4719	HITS-CLIP	23824327
MIRT651667	hsa-miR-205-5p	HITS-CLIP	23824327
MIRT651666	hsa-miR-4252	HITS-CLIP	23824327
MIRT651665	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT651664	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT651663	hsa-miR-513b-5p	HITS-CLIP	23824327
MIRT651673	hsa-miR-6771-3p	HITS-CLIP	23824327
MIRT651672	hsa-miR-7109-3p	HITS-CLIP	23824327
MIRT651671	hsa-miR-330-3p	HITS-CLIP	23824327
MIRT651670	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT651669	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT651668	hsa-miR-4719	HITS-CLIP	23824327
MIRT651667	hsa-miR-205-5p	HITS-CLIP	23824327
MIRT651666	hsa-miR-4252	HITS-CLIP	23824327
MIRT651665	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT651664	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT651663	hsa-miR-513b-5p	HITS-CLIP	23824327
MIRT491962	hsa-miR-142-3p	PAR-CLIP	23592263
MIRT491961	hsa-miR-302f	PAR-CLIP	23592263
MIRT491960	hsa-miR-7161-3p	PAR-CLIP	23592263
MIRT491958	hsa-miR-4779	PAR-CLIP	23592263
MIRT491959	hsa-miR-4255	PAR-CLIP	23592263
MIRT491957	hsa-miR-4459	PAR-CLIP	23592263
MIRT491956	hsa-miR-665	PAR-CLIP	23592263
MIRT491954	hsa-miR-655-5p	PAR-CLIP	23592263
MIRT491955	hsa-miR-4663	PAR-CLIP	23592263
MIRT491953	hsa-miR-7160-5p	PAR-CLIP	23592263
MIRT491952	hsa-miR-8077	PAR-CLIP	23592263
MIRT491950	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT491951	hsa-miR-8085	PAR-CLIP	23592263
MIRT491949	hsa-miR-3175	PAR-CLIP	23592263
MIRT491948	hsa-miR-124-5p	PAR-CLIP	23592263
MIRT491946	hsa-miR-3671	PAR-CLIP	23592263
MIRT491947	hsa-miR-6807-5p	PAR-CLIP	23592263
MIRT491945	hsa-miR-628-5p	PAR-CLIP	23592263
MIRT491944	hsa-miR-3591-5p	PAR-CLIP	23592263
MIRT491943	hsa-miR-607	PAR-CLIP	23592263
MIRT491942	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT1487124	hsa-miR-1202	CLIP-seq
MIRT1487125	hsa-miR-1304	CLIP-seq
MIRT1487126	hsa-miR-140-5p	CLIP-seq
MIRT1487127	hsa-miR-1827	CLIP-seq
MIRT1487128	hsa-miR-2682	CLIP-seq
MIRT1487129	hsa-miR-3194-5p	CLIP-seq
MIRT1487130	hsa-miR-34a	CLIP-seq
MIRT1487131	hsa-miR-34c-5p	CLIP-seq
MIRT1487132	hsa-miR-3613-3p	CLIP-seq
MIRT1487133	hsa-miR-3664-3p	CLIP-seq
MIRT1487134	hsa-miR-3972	CLIP-seq
MIRT1487135	hsa-miR-4257	CLIP-seq
MIRT1487136	hsa-miR-4271	CLIP-seq
MIRT1487137	hsa-miR-4436a	CLIP-seq
MIRT1487138	hsa-miR-4499	CLIP-seq
MIRT1487139	hsa-miR-449a	CLIP-seq
MIRT1487140	hsa-miR-449b	CLIP-seq
MIRT1487141	hsa-miR-449c	CLIP-seq
MIRT1487142	hsa-miR-4513	CLIP-seq
MIRT1487143	hsa-miR-4658	CLIP-seq
MIRT1487144	hsa-miR-4704-3p	CLIP-seq
MIRT1487145	hsa-miR-4725-3p	CLIP-seq
MIRT1487146	hsa-miR-4756-3p	CLIP-seq
MIRT1487147	hsa-miR-4758-5p	CLIP-seq
MIRT1487148	hsa-miR-4765	CLIP-seq
MIRT1487149	hsa-miR-5095	CLIP-seq
MIRT1487150	hsa-miR-526b	CLIP-seq
MIRT1487151	hsa-miR-548v	CLIP-seq
MIRT1487152	hsa-miR-617	CLIP-seq
MIRT2146641	hsa-miR-3153	CLIP-seq
MIRT2146642	hsa-miR-3173-3p	CLIP-seq
MIRT2146643	hsa-miR-3545-5p	CLIP-seq
MIRT2146644	hsa-miR-4463	CLIP-seq
MIRT2146645	hsa-miR-4494	CLIP-seq
MIRT2146646	hsa-miR-4668-5p	CLIP-seq
MIRT2146647	hsa-miR-4795-5p	CLIP-seq
MIRT2146648	hsa-miR-542-3p	CLIP-seq
MIRT2146649	hsa-miR-635	CLIP-seq
MIRT2146650	hsa-miR-671-5p	CLIP-seq
MIRT2367238	hsa-miR-1184	CLIP-seq
MIRT2367239	hsa-miR-1205	CLIP-seq
MIRT2367240	hsa-miR-1262	CLIP-seq
MIRT1487125	hsa-miR-1304	CLIP-seq
MIRT1487127	hsa-miR-1827	CLIP-seq
MIRT2367241	hsa-miR-18a	CLIP-seq
MIRT2367242	hsa-miR-18b	CLIP-seq
MIRT2367243	hsa-miR-21	CLIP-seq
MIRT1487128	hsa-miR-2682	CLIP-seq
MIRT2367244	hsa-miR-3147	CLIP-seq
MIRT2367245	hsa-miR-3158-5p	CLIP-seq
MIRT2367246	hsa-miR-3166	CLIP-seq
MIRT2146642	hsa-miR-3173-3p	CLIP-seq
MIRT2367247	hsa-miR-3189-3p	CLIP-seq
MIRT2367248	hsa-miR-3192	CLIP-seq
MIRT1487133	hsa-miR-3664-3p	CLIP-seq
MIRT2367249	hsa-miR-4267	CLIP-seq
MIRT1487136	hsa-miR-4271	CLIP-seq
MIRT2367250	hsa-miR-4300	CLIP-seq
MIRT2367251	hsa-miR-4425	CLIP-seq
MIRT1487137	hsa-miR-4436a	CLIP-seq
MIRT2367252	hsa-miR-4455	CLIP-seq
MIRT2146644	hsa-miR-4463	CLIP-seq
MIRT2367253	hsa-miR-4493	CLIP-seq
MIRT2146645	hsa-miR-4494	CLIP-seq
MIRT1487138	hsa-miR-4499	CLIP-seq
MIRT1487141	hsa-miR-449c	CLIP-seq
MIRT1487142	hsa-miR-4513	CLIP-seq
MIRT2367254	hsa-miR-4701-3p	CLIP-seq
MIRT2367255	hsa-miR-4713-3p	CLIP-seq
MIRT1487145	hsa-miR-4725-3p	CLIP-seq
MIRT2367256	hsa-miR-4731-5p	CLIP-seq
MIRT2367257	hsa-miR-4735-3p	CLIP-seq
MIRT1487146	hsa-miR-4756-3p	CLIP-seq
MIRT2367258	hsa-miR-4761-5p	CLIP-seq
MIRT2367259	hsa-miR-4771	CLIP-seq
MIRT2146648	hsa-miR-542-3p	CLIP-seq
MIRT2367260	hsa-miR-544	CLIP-seq
MIRT2367261	hsa-miR-590-5p	CLIP-seq
MIRT2367262	hsa-miR-609	CLIP-seq
MIRT1487152	hsa-miR-617	CLIP-seq
MIRT2146650	hsa-miR-671-5p	CLIP-seq
MIRT2367263	hsa-miR-920	CLIP-seq
MIRT1487132	hsa-miR-3613-3p	CLIP-seq
MIRT1487150	hsa-miR-526b	CLIP-seq
MIRT1487151	hsa-miR-548v	CLIP-seq
MIRT1487152	hsa-miR-617	CLIP-seq
MIRT1487132	hsa-miR-3613-3p	CLIP-seq
MIRT1487150	hsa-miR-526b	CLIP-seq
MIRT1487151	hsa-miR-548v	CLIP-seq
MIRT1487152	hsa-miR-617	CLIP-seq

Show/Hide all(35)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000938	Component	GARP complex	IBA
GO:0000938	Component	GARP complex	IDA	25799061
GO:0000938	Component	GARP complex	NAS	25799061
GO:0005515	Function	Protein binding	IPI	15878329, 18985028, 20163565, 20685960, 21516116, 23932592, 25416956, 25799061, 26496610, 26871637, 28514442, 29892012, 31515488, 32296183, 33961781, 36217029
GO:0005768	Component	Endosome	IEA
GO:0005794	Component	Golgi apparatus	IDA	15878329
GO:0005794	Component	Golgi apparatus	IEA
GO:0005829	Component	Cytosol	IEA
GO:0006605	Process	Protein targeting	IEA
GO:0006896	Process	Golgi to vacuole transport	IBA
GO:0007041	Process	Lysosomal transport	IBA
GO:0007041	Process	Lysosomal transport	IDA	25799061
GO:0010008	Component	Endosome membrane	IEA
GO:0010668	Process	Ectodermal cell differentiation	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IDA	25799061
GO:0016020	Component	Membrane	IEA
GO:0019905	Function	Syntaxin binding	IBA
GO:0019905	Function	Syntaxin binding	IPI	15878329
GO:0032456	Process	Endocytic recycling	IBA
GO:0032456	Process	Endocytic recycling	IMP	25799061
GO:0032456	Process	Endocytic recycling	NAS	25799061
GO:0032588	Component	Trans-Golgi network membrane	TAS
GO:0042147	Process	Retrograde transport, endosome to Golgi	IBA
GO:0042147	Process	Retrograde transport, endosome to Golgi	NAS	25799061
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	15878329
GO:0048611	Process	Embryonic ectodermal digestive tract development	IEA
GO:0055037	Component	Recycling endosome	IDA	25799061
GO:0055037	Component	Recycling endosome	IEA
GO:0055037	Component	Recycling endosome	NAS	25799061
GO:0090119	Process	Vesicle-mediated cholesterol transport	IEA
GO:0098793	Component	Presynapse	IEA
GO:0098794	Component	Postsynapse	IEA
GO:1990745	Component	EARP complex	IDA	25799061
GO:1990745	Component	EARP complex	IPI	25799061

MIM	HGNC	e!Ensembl
603443	10518	ENSG00000223501

Protein

UniProt ID

Q8N1B4

Protein name

Vacuolar protein sorting-associated protein 52 homolog (SAC2 suppressor of actin mutations 2-like protein)

Protein function

Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors bet

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04129	Vps52	94 → 601	Vps52 / Sac2 family	Family

Sequence

MAAAATMAAAARELVLRAGTSDMEEEEGPLAGGPGLQEPLQLGELDITSDEFILDEVDVH
IQANLEDELVKEALKTGVDLRHYSKQVELELQQIEQKSIRDYIQESENIASLHNQITACD
AVLERMEQMLGAFQSDLSSISSEIRTLQEQSGAMNIRLRNRQAVRGKLGELVDGLVVPSA
LVTAILEAPVTEPRFLEQLQELDAKAAAVREQEARGTAACADVRGVLDRLRVKAVTKIRE
FILQKIYSFRKPMTNYQIPQTALLKYRFFYQFLLGNERATAKEIRDEYVETLSKIYLSYY
RSYLGRLMKVQYEEVAEKDDLMGVEDTAKKGFFSKPSLRSRNTIFTLGTRGSVISPTELE
APILVPHTAQRGEQRYPFEALFRSQHYALLDNSCREYLFICEFFVVSGPAAHDLFHAVMG
RTLSMTLKHLDSYLADCYDAIAVFLCIHIVLRFRNIAAKRDVPALDRYWEQVLALLWPRF
ELILEMNVQSVRSTDPQRLGGLDTRPHYITRRYAEFSSALVSINQTIPNERTMQLLGQLQ
VEVENFVLRVAAEFSSRKEQLVFLINNYDMMLGVLMERAADDSKEVESFQQLLNARTQEF
IEELLSPPFGGLVAFVKEAEALIERGQAERLRGEEARVTQLIRGFGSSWKSSVESLSQDV
MRSFTNFRNGTSIIQGALTQLIQLYHRFHRVLSQPQLRALPARAELINIHHLMVELKKHK
PNF

Sequence length

723

Interactions

View interactions

	Reactome
			Retrograde transport at the Trans-Golgi-Network

VPS52 (VPS52 subunit of GARP complex)