S100B (S100 calcium binding protein B)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6285
Gene name Gene Name - the full gene name approved by the HGNC.
S100 calcium binding protein B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
S100B
Synonyms (NCBI Gene) Gene synonyms aliases
NEF, S100, S100-B, S100beta
Chromosome Chromosome number
21
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
21q22.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of ce
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(16)
miRTarBase ID miRNA Experiments Reference
MIRT003735 hsa-miR-29a-3p Luciferase reporter assay, qRT-PCR, Northern blot 19102781
MIRT003736 hsa-miR-29b-3p Luciferase reporter assay, qRT-PCR, Northern blot 19102781
MIRT731708 hsa-miR-296-5p Luciferase reporter assay 27186401
MIRT731708 hsa-miR-296-5p Luciferase reporter assay, qRT-PCR, Western blot 27186401
MIRT1324165 hsa-miR-1182 CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
Transcription factor Regulation Reference
HOXC11 Unknown 20145129
TP53 Activation 15178678
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(33)
GO ID Ontology Definition Evidence Reference
GO:0001726 Component Ruffle IDA 10913138
GO:0005509 Function Calcium ion binding IBA 21873635
GO:0005509 Function Calcium ion binding NAS 9519411
GO:0005515 Function Protein binding IPI 3111527, 10913138, 16189514, 17660747, 17726019, 20591429, 21516116, 25416956, 26496610, 26871637, 27107012, 29997244, 31515488, 31837246, 32296183, 32814053
GO:0005576 Component Extracellular region TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
176990 10500 ENSG00000160307
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P04271
Protein name Protein S100-B (S-100 protein beta chain) (S-100 protein subunit beta) (S100 calcium-binding protein B)
Protein function Small zinc- and- and calcium-binding protein that is highly expressed in astrocytes and constitutes one of the most abundant soluble proteins in brain (PubMed:20950652, PubMed:6487634). Weakly binds calcium but binds zinc very tightly-distinct b
PDB 1MQ1 , 1UWO , 2H61 , 2M49 , 2PRU , 3CZT , 3D0Y , 3D10 , 3HCM , 4XYN , 5CSF , 5CSI , 5CSJ , 5CSN , 5D7F
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01023 S_100 4 → 46 S-100/ICaBP type calcium binding domain Domain
PF00036 EF-hand_1 53 → 81 EF hand Domain
Tissue specificity TISSUE SPECIFICITY: Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues. {ECO:0000269|PubMed:2394738}.
Sequence
Sequence length 92
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Nuclear signaling by ERBB4
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Advanced glycosylation endproduct receptor signaling
TRAF6 mediated NF-kB activation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)		 20398908, 22146151, 21070816
Show/Hide Unknown Diseases (3)
Unknown
Disease term Disease name Evidence References Source
Brain neoplasms Brain Neoplasms, Malignant neoplasm of brain, Benign neoplasm of brain, unspecified, Brain Tumor, Primary, Recurrent Brain Neoplasm, Primary malignant neoplasm of brain 27935819 ClinVar
Mental depression Mental Depression, Depressive disorder, Unipolar Depression, Recurrent depression, Major Depressive Disorder 19497163, 8804639, 20962330, 16797859, 8840925, 18939940, 20398908 ClinVar
Myocardial infarction Myocardial Infarction 9788975 ClinVar
Show/Hide Text Mining Associations (125)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 29607329
Adenoma Oxyphilic Associate 28986304
Adenoma Pleomorphic Associate 1659204
Aging Premature Associate 35069971
Agnosia Stimulate 21070816
Alzheimer Disease Stimulate 15781852
Alzheimer Disease Associate 18494933, 24586351, 2529544, 30045751, 33982673, 38178159, 8786385
Amyotrophic Lateral Sclerosis Associate 30572951
Anemia Sickle Cell Associate 32379790
Aspergillosis Associate 22114731