Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6259
Gene name	Receptor like tyrosine kinase
Gene symbol	RYK
Synonyms (NCBI Gene)	D3S3195JTK5JTK5ARYK1
Chromosome	3
Chromosome location	3q22.2
Summary	The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product bel

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miRTarBase ID	miRNA	Experiments	Reference
MIRT002602	hsa-miR-124-3p	Microarray	15685193
MIRT002602	hsa-miR-124-3p	Microarray;Other	15685193
MIRT025856	hsa-miR-7-5p	Microarray	17612493
MIRT654069	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT654068	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT654067	hsa-miR-1251-5p	HITS-CLIP	23824327
MIRT654066	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT654065	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT654064	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT654063	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT513230	hsa-miR-4453	PAR-CLIP	23446348
MIRT513229	hsa-miR-4538	PAR-CLIP	23446348
MIRT513228	hsa-miR-7705	PAR-CLIP	23446348
MIRT513227	hsa-miR-16-1-3p	PAR-CLIP	23446348
MIRT513226	hsa-miR-4797-3p	PAR-CLIP	23446348
MIRT513224	hsa-miR-4264	PAR-CLIP	23446348
MIRT513225	hsa-miR-4529-5p	PAR-CLIP	23446348
MIRT513223	hsa-miR-548s	PAR-CLIP	23446348
MIRT513222	hsa-miR-4701-5p	PAR-CLIP	23446348
MIRT513221	hsa-miR-588	PAR-CLIP	23446348
MIRT513220	hsa-miR-4435	PAR-CLIP	23446348
MIRT513219	hsa-miR-3187-3p	PAR-CLIP	23446348
MIRT654069	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT654068	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT654067	hsa-miR-1251-5p	HITS-CLIP	23824327
MIRT654066	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT654065	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT654064	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT654063	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT513230	hsa-miR-4453	PAR-CLIP	23446348
MIRT513229	hsa-miR-4538	PAR-CLIP	23446348
MIRT513228	hsa-miR-7705	PAR-CLIP	23446348
MIRT513227	hsa-miR-16-1-3p	PAR-CLIP	23446348
MIRT513226	hsa-miR-4797-3p	PAR-CLIP	23446348
MIRT513224	hsa-miR-4264	PAR-CLIP	23446348
MIRT513225	hsa-miR-4529-5p	PAR-CLIP	23446348
MIRT513223	hsa-miR-548s	PAR-CLIP	23446348
MIRT513222	hsa-miR-4701-5p	PAR-CLIP	23446348
MIRT513221	hsa-miR-588	PAR-CLIP	23446348
MIRT513220	hsa-miR-4435	PAR-CLIP	23446348
MIRT513219	hsa-miR-3187-3p	PAR-CLIP	23446348
MIRT1323723	hsa-miR-1238	CLIP-seq
MIRT1323724	hsa-miR-124	CLIP-seq
MIRT1323725	hsa-miR-1251	CLIP-seq
MIRT1323726	hsa-miR-27a	CLIP-seq
MIRT1323727	hsa-miR-27b	CLIP-seq
MIRT1323728	hsa-miR-3622a-5p	CLIP-seq
MIRT1323729	hsa-miR-3714	CLIP-seq
MIRT1323730	hsa-miR-380	CLIP-seq
MIRT1323731	hsa-miR-3910	CLIP-seq
MIRT1323732	hsa-miR-3973	CLIP-seq
MIRT1323733	hsa-miR-4263	CLIP-seq
MIRT1323734	hsa-miR-4282	CLIP-seq
MIRT1323735	hsa-miR-4307	CLIP-seq
MIRT1323736	hsa-miR-4422	CLIP-seq
MIRT1323737	hsa-miR-4521	CLIP-seq
MIRT1323738	hsa-miR-4680-5p	CLIP-seq
MIRT1323739	hsa-miR-4727-5p	CLIP-seq
MIRT1323740	hsa-miR-4735-5p	CLIP-seq
MIRT1323741	hsa-miR-4769-3p	CLIP-seq
MIRT1323742	hsa-miR-506	CLIP-seq
MIRT1323743	hsa-miR-513a-5p	CLIP-seq
MIRT1323744	hsa-miR-544	CLIP-seq
MIRT1323745	hsa-miR-548a-5p	CLIP-seq
MIRT1323746	hsa-miR-548ab	CLIP-seq
MIRT1323747	hsa-miR-548ak	CLIP-seq
MIRT1323748	hsa-miR-548b-5p	CLIP-seq
MIRT1323749	hsa-miR-548c-5p	CLIP-seq
MIRT1323750	hsa-miR-548d-5p	CLIP-seq
MIRT1323751	hsa-miR-548h	CLIP-seq
MIRT1323752	hsa-miR-548i	CLIP-seq
MIRT1323753	hsa-miR-548j	CLIP-seq
MIRT1323754	hsa-miR-548w	CLIP-seq
MIRT1323755	hsa-miR-548y	CLIP-seq
MIRT1323756	hsa-miR-554	CLIP-seq
MIRT1323757	hsa-miR-559	CLIP-seq
MIRT1323758	hsa-miR-564	CLIP-seq
MIRT1323759	hsa-miR-567	CLIP-seq
MIRT1323760	hsa-miR-576-5p	CLIP-seq
MIRT1323724	hsa-miR-124	CLIP-seq
MIRT1323761	hsa-miR-1297	CLIP-seq
MIRT1323762	hsa-miR-1299	CLIP-seq
MIRT1323763	hsa-miR-1305	CLIP-seq
MIRT1323764	hsa-miR-26a	CLIP-seq
MIRT1323765	hsa-miR-26b	CLIP-seq
MIRT1323766	hsa-miR-3194-5p	CLIP-seq
MIRT1323728	hsa-miR-3622a-5p	CLIP-seq
MIRT1323729	hsa-miR-3714	CLIP-seq
MIRT1323731	hsa-miR-3910	CLIP-seq
MIRT1323767	hsa-miR-3942-3p	CLIP-seq
MIRT1323733	hsa-miR-4263	CLIP-seq
MIRT1323736	hsa-miR-4422	CLIP-seq
MIRT1323768	hsa-miR-4465	CLIP-seq
MIRT1323769	hsa-miR-4509	CLIP-seq
MIRT1323737	hsa-miR-4521	CLIP-seq
MIRT1323770	hsa-miR-4744	CLIP-seq
MIRT1323771	hsa-miR-4782-5p	CLIP-seq
MIRT1323772	hsa-miR-4799-5p	CLIP-seq
MIRT1323773	hsa-miR-498	CLIP-seq
MIRT1323742	hsa-miR-506	CLIP-seq
MIRT1323774	hsa-miR-516b	CLIP-seq
MIRT1323758	hsa-miR-564	CLIP-seq
MIRT1323760	hsa-miR-576-5p	CLIP-seq
MIRT1323775	hsa-miR-590-3p	CLIP-seq
MIRT1323776	hsa-miR-7	CLIP-seq
MIRT1323777	hsa-miR-875-3p	CLIP-seq
MIRT1323736	hsa-miR-4422	CLIP-seq
MIRT2096109	hsa-miR-548ae	CLIP-seq
MIRT2096110	hsa-miR-548aj	CLIP-seq
MIRT2096111	hsa-miR-548am	CLIP-seq
MIRT2096112	hsa-miR-548x	CLIP-seq
MIRT2096113	hsa-miR-1267	CLIP-seq
MIRT1323761	hsa-miR-1297	CLIP-seq
MIRT1323762	hsa-miR-1299	CLIP-seq
MIRT1323763	hsa-miR-1305	CLIP-seq
MIRT2096114	hsa-miR-218	CLIP-seq
MIRT1323764	hsa-miR-26a	CLIP-seq
MIRT1323765	hsa-miR-26b	CLIP-seq
MIRT2096115	hsa-miR-3152-3p	CLIP-seq
MIRT2096116	hsa-miR-3182	CLIP-seq
MIRT2096117	hsa-miR-324-5p	CLIP-seq
MIRT2096118	hsa-miR-330-3p	CLIP-seq
MIRT1323728	hsa-miR-3622a-5p	CLIP-seq
MIRT1323736	hsa-miR-4422	CLIP-seq
MIRT1323768	hsa-miR-4465	CLIP-seq
MIRT2096119	hsa-miR-4652-3p	CLIP-seq
MIRT1323771	hsa-miR-4782-5p	CLIP-seq
MIRT1323773	hsa-miR-498	CLIP-seq
MIRT1323774	hsa-miR-516b	CLIP-seq
MIRT2096120	hsa-miR-520d-5p	CLIP-seq
MIRT2096121	hsa-miR-524-5p	CLIP-seq
MIRT1323758	hsa-miR-564	CLIP-seq
MIRT2096122	hsa-miR-636	CLIP-seq
MIRT1323776	hsa-miR-7	CLIP-seq
MIRT1323777	hsa-miR-875-3p	CLIP-seq
MIRT1323724	hsa-miR-124	CLIP-seq
MIRT2096113	hsa-miR-1267	CLIP-seq
MIRT1323762	hsa-miR-1299	CLIP-seq
MIRT2096114	hsa-miR-218	CLIP-seq
MIRT2096115	hsa-miR-3152-3p	CLIP-seq
MIRT2096116	hsa-miR-3182	CLIP-seq
MIRT1323728	hsa-miR-3622a-5p	CLIP-seq
MIRT1323729	hsa-miR-3714	CLIP-seq
MIRT1323731	hsa-miR-3910	CLIP-seq
MIRT1323734	hsa-miR-4282	CLIP-seq
MIRT2320409	hsa-miR-4635	CLIP-seq
MIRT2096119	hsa-miR-4652-3p	CLIP-seq
MIRT2320410	hsa-miR-4709-3p	CLIP-seq
MIRT1323771	hsa-miR-4782-5p	CLIP-seq
MIRT1323742	hsa-miR-506	CLIP-seq
MIRT1323774	hsa-miR-516b	CLIP-seq
MIRT1323758	hsa-miR-564	CLIP-seq
MIRT2096122	hsa-miR-636	CLIP-seq
MIRT1323776	hsa-miR-7	CLIP-seq
MIRT1323777	hsa-miR-875-3p	CLIP-seq
MIRT2432887	hsa-miR-1913	CLIP-seq
MIRT1323726	hsa-miR-27a	CLIP-seq
MIRT1323727	hsa-miR-27b	CLIP-seq
MIRT2432888	hsa-miR-3189-5p	CLIP-seq
MIRT2432889	hsa-miR-324-3p	CLIP-seq
MIRT1323739	hsa-miR-4727-5p	CLIP-seq
MIRT1323740	hsa-miR-4735-5p	CLIP-seq
MIRT2432890	hsa-miR-4758-3p	CLIP-seq
MIRT1323741	hsa-miR-4769-3p	CLIP-seq
MIRT1323743	hsa-miR-513a-5p	CLIP-seq
MIRT1323744	hsa-miR-544	CLIP-seq
MIRT2690081	hsa-miR-3977	CLIP-seq
MIRT2690082	hsa-miR-4328	CLIP-seq
MIRT2690083	hsa-miR-4436b-3p	CLIP-seq
MIRT2690084	hsa-miR-4708-3p	CLIP-seq
MIRT1323760	hsa-miR-576-5p	CLIP-seq
MIRT2690085	hsa-miR-587	CLIP-seq

Show/Hide all (72)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	IDA	10454588
GO:0004714	Function	Transmembrane receptor protein tyrosine kinase activity	IBA
GO:0004888	Function	Transmembrane signaling receptor activity	IDA	10454588
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0005109	Function	Frizzled binding	IEA
GO:0005109	Function	Frizzled binding	ISS
GO:0005109	Function	Frizzled binding	NAS	20004982
GO:0005515	Function	Protein binding	IPI	15454084
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005634	Component	Nucleus	NAS	20004982
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS	8386829
GO:0006468	Process	Protein phosphorylation	IDA	10454588
GO:0007165	Process	Signal transduction	TAS	8386829
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IBA
GO:0007409	Process	Axonogenesis	IBA
GO:0007409	Process	Axonogenesis	IEA
GO:0007409	Process	Axonogenesis	ISS
GO:0007409	Process	Axonogenesis	TAS	24431302
GO:0007411	Process	Axon guidance	IEA
GO:0007411	Process	Axon guidance	ISS
GO:0007411	Process	Axon guidance	NAS	20004982
GO:0007416	Process	Synapse assembly	NAS	20004982
GO:0010976	Process	Positive regulation of neuron projection development	IBA
GO:0015026	Function	Coreceptor activity	TAS	24431302
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	ISS
GO:0016020	Component	Membrane	NAS	8726462
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0017147	Function	Wnt-protein binding	IEA
GO:0017147	Function	Wnt-protein binding	ISS
GO:0017147	Function	Wnt-protein binding	NAS	20004982
GO:0022008	Process	Neurogenesis	NAS	20004982
GO:0022038	Process	Corpus callosum development	IEA
GO:0022038	Process	Corpus callosum development	ISS
GO:0030182	Process	Neuron differentiation	IEA
GO:0030182	Process	Neuron differentiation	ISS
GO:0031175	Process	Neuron projection development	IEA
GO:0031175	Process	Neuron projection development	ISS
GO:0035567	Process	Non-canonical Wnt signaling pathway	NAS	20004982
GO:0036518	Process	Chemorepulsion of dopaminergic neuron axon	IEA
GO:0036518	Process	Chemorepulsion of dopaminergic neuron axon	ISS
GO:0042813	Function	Wnt receptor activity	IEA
GO:0042813	Function	Wnt receptor activity	ISS
GO:0043235	Component	Receptor complex	IBA
GO:0043410	Process	Positive regulation of MAPK cascade	IDA	10454588
GO:0048705	Process	Skeletal system morphogenesis	IEA
GO:0048787	Component	Presynaptic active zone membrane	IEA
GO:0048843	Process	Negative regulation of axon extension involved in axon guidance	IEA
GO:0048846	Process	Axon extension involved in axon guidance	IEA
GO:0050919	Process	Negative chemotaxis	IEA
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA
GO:0060070	Process	Canonical Wnt signaling pathway	NAS	20004982
GO:0060071	Process	Wnt signaling pathway, planar cell polarity pathway	IEA
GO:0060071	Process	Wnt signaling pathway, planar cell polarity pathway	TAS	23517308
GO:0071679	Process	Commissural neuron axon guidance	IEA
GO:0071679	Process	Commissural neuron axon guidance	ISS
GO:0098839	Component	Postsynaptic density membrane	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:1904935	Process	Positive regulation of cell proliferation in midbrain	ISS
GO:1904948	Process	Midbrain dopaminergic neuron differentiation	IEA
GO:1904948	Process	Midbrain dopaminergic neuron differentiation	ISS

MIM	HGNC	e!Ensembl
600524	10481	ENSG00000163785

P34925

Protein name

Tyrosine-protein kinase RYK (EC 2.7.10.1)

Protein function

May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-termina

PDB

6TUA

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02019	WIF	66 → 194	WIF domain	Family
PF07714	PK_Tyr_Ser-Thr	330 → 596	Protein tyrosine and serine/threonine kinase	Domain

Tissue specificity

TISSUE SPECIFICITY: Observed in all the tissues examined.

Sequence

MRGAARLGRPGRSCLPGARGLRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASA
GPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVPSETNFLHFTWHAKSKVE
YKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSS
KNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVI
FLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSYPT
LRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQ
AFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLK
LFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVK
ITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQ
TPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFH
AALGAYV

Sequence length

607

Interactions

View interactions

	KEGG		Reactome
	Wnt signaling pathway Axon guidance		TCF dependent signaling in response to WNT

Show/Hide Unknown Diseases (13)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign	rs55965934, rs116266774	RCV005929766 RCV005913496
Cervical cancer	Benign	rs55965934	RCV005929769
Gastric cancer	Benign	rs55965934	RCV005929771
Lung cancer	Benign	rs55965934	RCV005929775
Lymphoma	Benign	rs55965934	RCV005929772
Malignant tumor of esophagus	Benign	rs55965934	RCV005929767
Nonpapillary renal cell carcinoma	Benign	rs55965934	RCV005929768
Orofacial cleft 1	Uncertain significance	rs2472778738	RCV003335995
Ovarian serous cystadenocarcinoma	Benign	rs55965934	RCV005929773
RYK-related disorder	Benign; Conflicting classifications of pathogenicity; Uncertain significance; Likely benign	rs587744425, rs1425051712, rs753323111, rs2015586744, rs61732795, rs139860270, rs2472769572, rs1284777873	RCV003907756 RCV003963769 RCV003406190 RCV003907059 RCV003969856 RCV003937296 RCV003937299 RCV003970833
Sarcoma	Benign	rs55965934	RCV005929770
Thymoma	Benign	rs55965934	RCV005929774
Uterine corpus endometrial carcinoma	Benign	rs116266774	RCV005913497

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Arthritis Rheumatoid	Associate	33178184
Breast Neoplasms	Associate	36210461
Cleft Lip	Associate	34684112
Glioblastoma	Stimulate	28086236
Glioma	Associate	28086236
IgA Vasculitis	Associate	33178184
Melanoma	Associate	24865425
Mesothelioma	Associate	36471440
Neointima	Associate	34684112
Neoplasms	Associate	35715770
Orofacial Cleft 1	Associate	34684112
Prostatitis	Associate	10660600
Squamous Cell Carcinoma of Head and Neck	Associate	35715770

RYK (receptor like tyrosine kinase)