Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6258
Gene name	Retinoid X receptor gamma
Gene symbol	RXRG
Synonyms (NCBI Gene)	NR2B3RXR-gammaRXRCRXRgamma
Chromosome	1
Chromosome location	1q23.3
Summary	This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D

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miRTarBase ID	miRNA	Experiments
MIRT1323494	hsa-miR-106a	CLIP-seq
MIRT1323495	hsa-miR-106b	CLIP-seq
MIRT1323496	hsa-miR-17	CLIP-seq
MIRT1323497	hsa-miR-20a	CLIP-seq
MIRT1323498	hsa-miR-20b	CLIP-seq
MIRT1323499	hsa-miR-3160-5p	CLIP-seq
MIRT1323500	hsa-miR-3180-5p	CLIP-seq
MIRT1323501	hsa-miR-3689a-3p	CLIP-seq
MIRT1323502	hsa-miR-3689c	CLIP-seq
MIRT1323503	hsa-miR-3689d	CLIP-seq
MIRT1323504	hsa-miR-4685-5p	CLIP-seq
MIRT1323505	hsa-miR-4728-5p	CLIP-seq
MIRT1323506	hsa-miR-519d	CLIP-seq
MIRT1323507	hsa-miR-579	CLIP-seq
MIRT1323508	hsa-miR-765	CLIP-seq
MIRT1323509	hsa-miR-93	CLIP-seq
MIRT2320354	hsa-miR-1293	CLIP-seq
MIRT2320355	hsa-miR-1343	CLIP-seq
MIRT2320356	hsa-miR-2110	CLIP-seq
MIRT2320357	hsa-miR-23a	CLIP-seq
MIRT2320358	hsa-miR-23b	CLIP-seq
MIRT2320359	hsa-miR-23c	CLIP-seq
MIRT2320360	hsa-miR-3144-5p	CLIP-seq
MIRT2320361	hsa-miR-3150a-3p	CLIP-seq
MIRT2320362	hsa-miR-3175	CLIP-seq
MIRT1323500	hsa-miR-3180-5p	CLIP-seq
MIRT2320363	hsa-miR-3191	CLIP-seq
MIRT2320364	hsa-miR-4260	CLIP-seq
MIRT2320365	hsa-miR-4474-3p	CLIP-seq
MIRT2320366	hsa-miR-4476	CLIP-seq
MIRT2320367	hsa-miR-4483	CLIP-seq
MIRT2320368	hsa-miR-4511	CLIP-seq
MIRT2320369	hsa-miR-4652-5p	CLIP-seq
MIRT2320370	hsa-miR-4793-5p	CLIP-seq
MIRT2320371	hsa-miR-485-5p	CLIP-seq
MIRT2320372	hsa-miR-491-5p	CLIP-seq
MIRT2320373	hsa-miR-520a-5p	CLIP-seq
MIRT2320374	hsa-miR-525-5p	CLIP-seq
MIRT2320375	hsa-miR-939	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0003707	Function	Nuclear steroid receptor activity	IEA
GO:0004879	Function	Nuclear receptor activity	IBA
GO:0004879	Function	Nuclear receptor activity	IEA
GO:0004879	Function	Nuclear receptor activity	TAS	8034312
GO:0005515	Function	Protein binding	IPI	16189514, 20133701, 20211142, 21516116, 21900206, 21988832, 25303530, 25416956, 25910212, 28514442, 29892012, 31515488, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0007399	Process	Nervous system development	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0030154	Process	Cell differentiation	IBA
GO:0030518	Process	Nuclear receptor-mediated steroid hormone signaling pathway	IEA
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0044323	Function	Retinoic acid-responsive element binding	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048384	Process	Retinoic acid receptor signaling pathway	IBA
GO:0048384	Process	Retinoic acid receptor signaling pathway	IEA
GO:0090575	Component	RNA polymerase II transcription regulator complex	IBA
GO:0140693	Function	Molecular condensate scaffold activity	IDA	31881311
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
180247	10479	ENSG00000143171

P48443

Protein name

Retinoic acid receptor RXR-gamma (Nuclear receptor subfamily 2 group B member 3) (Retinoid X receptor gamma)

Protein function

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR

PDB

2GL8 , 7A79

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF11825	Nuc_recep-AF1	25 → 134	Nuclear/hormone receptor activator site AF-1	Family
PF00105	zf-C4	137 → 206	Zinc finger, C4 type (two domains)	Domain
PF00104	Hormone_recep	255 → 443	Ligand-binding domain of nuclear hormone receptor	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in aortic endothelial cells (at protein level). {ECO:0000269|PubMed:28167758}.

Sequence

MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVG
TPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPG
IGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKD
CLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERIL
EAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVI
LLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKD
MQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLL
LRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT

Sequence length

463

Interactions

View interactions

	KEGG		Reactome
	PPAR signaling pathway Th17 cell differentiation Thyroid hormone signaling pathway Adipocytokine signaling pathway Parathyroid hormone synthesis, secretion and action Pathways in cancer Transcriptional misregulation in cancer Chemical carcinogenesis - receptor activation Thyroid cancer Small cell lung cancer Non-small cell lung cancer Gastric cancer Lipid and atherosclerosis		Nuclear Receptor transcription pathway Signaling by Retinoic Acid

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL ISCHEMIA	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (16)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Aphasia	Associate	27251476	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Associate	29073238, 31558802	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Associate	40155870	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Inhibit	40155870	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	31525256	★★★★★ ★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Associate	27251476	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Gestational	Associate	27636996, 34633445	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Retinopathy	Associate	22180072	★★★★★ ★☆☆☆☆ Found in Text Mining only
Eye Diseases	Associate	36490268	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Associate	31526458	★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome	Inhibit	25867398	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	31558802	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	31525256	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	31558802, 40155870	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcopenia	Associate	36147639	★★★★★ ★☆☆☆☆ Found in Text Mining only
Scotoma	Associate	27251476	★★★★★ ★☆☆☆☆ Found in Text Mining only

RXRG (retinoid X receptor gamma)