UniProt ID |
P19793
|
Protein name |
Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha) |
Protein function |
Receptor for retinoic acid that acts as a transcription factor (PubMed:10874028, PubMed:11162439, PubMed:11915042, PubMed:37478846). Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in respons |
PDB |
1BY4
,
1DSZ
,
1FBY
,
1FM6
,
1FM9
,
1G1U
,
1G5Y
,
1K74
,
1MV9
,
1MVC
,
1MZN
,
1R0N
,
1RDT
,
1RXR
,
1XLS
,
1XV9
,
1XVP
,
1YNW
,
2ACL
,
2NLL
,
2P1T
,
2P1U
,
2P1V
,
2ZXZ
,
2ZY0
,
3DZU
,
3DZY
,
3E00
,
3E94
,
3FAL
,
3FC6
,
3FUG
,
3H0A
,
3KWY
,
3NSP
,
3NSQ
,
3OAP
,
3OZJ
,
3PCU
,
3R29
,
3R2A
,
3R5M
,
3UVV
,
4CN2
,
4CN3
,
4CN5
,
4CN7
,
4J5W
,
4J5X
,
4K4J
,
4K6I
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF11825
|
Nuc_recep-AF1 |
17 → 127 |
Nuclear/hormone receptor activator site AF-1 |
Family |
PF00105
|
zf-C4 |
133 → 202 |
Zinc finger, C4 type (two domains) |
Domain |
PF00104
|
Hormone_recep |
257 → 442 |
Ligand-binding domain of nuclear hormone receptor |
Domain |
|
Tissue specificity |
TISSUE SPECIFICITY: Expressed in lung fibroblasts (at protein level) (PubMed:30216632). Expressed in monocytes (PubMed:26463675). Highly expressed in liver, also found in kidney and brain (PubMed:14702039, PubMed:2159111, PubMed:24275569). {ECO:0000269|Pu |
Sequence |
|
Sequence length |
462 |
Interactions |
View interactions
|
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Amyotrophic lateral sclerosis |
Amyotrophic Lateral Sclerosis, Familial |
rs267607084, rs312262720, rs312262752, rs121908287, rs121908288, rs29001584, rs28941475, rs121434378, rs386134173, rs386134174, rs80356730, rs80356727, rs4884357, rs80356717, rs80356733, rs80356731, rs80356726, rs267606928, rs267606929, rs121434591, rs121912431, rs121912432, rs121912433, rs121912434, rs121912435, rs121912440, rs121912436, rs121912437, rs121912438, rs121912439, rs74315452, rs121912442, rs121912443, rs121912444, rs121912446, rs121912447, rs1197141604, rs121912448, rs121912449, rs121912450, rs121912451, rs121912452, rs121912453, rs121912454, rs369600566, rs121912455, rs121912456, rs121912457, rs121912458, rs1555836889, rs121909667, rs121909668, rs121909669, rs121909671, rs121909535, rs121909537, rs121909538, rs121909539, rs121909540, rs121909542, rs121909544, rs80356734, rs367543041, rs80356740, rs80356719, rs80356721, rs80356723, rs80356725, rs387906627, rs387906628, rs387906709, rs387906710, rs387906711, rs387906829, rs387907264, rs387907265, rs387907266, rs312262739, rs312262709, rs312262749, rs200793464, rs147713329, rs312262788, rs397514262, rs63751180, rs587777132, rs730880025, rs730880026, rs730880027, rs368743618, rs730880029, rs730882255, rs730882256, rs786205611, rs121912441, rs199947197, rs780136067, rs772731615, rs879253926, rs879254294, rs764717219, rs886041390, rs750159428, rs753207473, rs267607087, rs767350733, rs778305085, rs1554707680, rs1554707622, rs1393363759, rs750959420, rs1555509569, rs1554716504, rs11556620, rs1247392012, rs142083484, rs140385286, rs371575563, rs1402429085, rs1555179091, rs1555179087, rs746971952, rs1555836950, rs368276916, rs140376902, rs747220413, rs76731700, rs770684782, rs1200906022, rs1804449, rs1482760341, rs769898852, rs140599944, rs757972700, rs1555451521, rs1592362719, rs1555836803, rs763455928, rs1378590183, rs1583695322, rs1362178149, rs1197928094, rs368751524, rs1555509609, rs1574787779, rs1601157750, rs1301635320, rs1341055534, rs1402092579, rs1568809172, rs1555836170, rs1315541036, rs1339283341, rs1643659556, rs1644506661, rs1435710212, rs1553122918, rs1689580631, rs374047961, rs775935265, rs2076486420, rs1820836522, rs757260058, rs1844420892, rs1833371664, rs1833438306, rs1833451208, rs2083790483, rs1303294230, rs1226110412, rs2053207945, rs2053208751, rs2053501632, rs2053539304, rs1567479067, rs544088874, rs1228194239, rs1568807400, rs1169198442, rs2049594204, rs2049594311, rs1568810641, rs1568811372, rs2049618449, rs1476760624, rs2079347087 View all (171 more) |
11796754 |
Lateral sclerosis |
AMYOTROPHIC LATERAL SCLEROSIS 1, Amyotrophic Lateral Sclerosis, Sporadic |
rs386134181, rs386134176, rs386134174, rs386134184, rs386134178, rs1693780539, rs1574698048 |
11796754 |
Prostate cancer |
Malignant neoplasm of prostate |
rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 |
15318950 |
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Pancreatic adenocarcinoma |
Adenocarcinoma of pancreas |
PDAC patients with high expression of PSMA6 having a significantly shorter overall survival rate. |
26619011 |
ClinVar, CBGDA |
Crohn Disease |
Crohn Disease |
|
|
GWAS |
Keratoconus |
Keratoconus |
|
|
GWAS |
|
Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Abortion Habitual |
Stimulate
|
28076928 |
Abortion Spontaneous |
Stimulate
|
28076928 |
Acute Kidney Injury |
Associate
|
36443310 |
Adenomatous Polyposis Coli |
Associate
|
12771132 |
Adenomyosis |
Associate
|
17296180 |
Alzheimer Disease |
Associate
|
19374686 |
Amaurosis Fugax |
Associate
|
21709632 |
Aniridia |
Associate
|
34827649 |
Arthritis Rheumatoid |
Associate
|
28335003, 29848990 |
Atherosclerosis |
Associate
|
14534304, 36613720 |
Atherosclerosis |
Inhibit
|
24391011 |
Autoimmune Diseases |
Associate
|
28335003 |
Breast Neoplasms |
Associate
|
12841681, 15082790, 15318936, 18565212, 19644018, 23180655, 25013807, 25328014, 25778982, 25833198, 26310932, 27530324, 30857277, 33478016, 34239022, 35406808, 36930833, 9343423 View all (3 more) |
Breast Neoplasms |
Stimulate
|
28427429 |
Carcinogenesis |
Associate
|
22205725, 22948024, 24103747, 26156677 |
Carcinoma Adenoid Cystic |
Associate
|
37040084 |
Carcinoma Ductal Breast |
Associate
|
18565212 |
Carcinoma Hepatocellular |
Associate
|
17604322, 17900311, 23317196, 23690070, 24103747, 34861383, 35712812 |
Carcinoma Intraductal Noninfiltrating |
Associate
|
11092983 |
Carcinoma Renal Cell |
Associate
|
19753122 |
Carcinoma Squamous Cell |
Associate
|
11077050 |
Cardiomyopathies |
Associate
|
37542511 |
Cardiomyopathy Hypertrophic |
Associate
|
33757590 |
Cardiovascular Diseases |
Associate
|
33055159 |
Carotid Artery Diseases |
Associate
|
21709632 |
Carotid Stenosis |
Associate
|
21709632 |
Cell Transformation Neoplastic |
Associate
|
26156677 |
Chediak Higashi Syndrome |
Associate
|
31139831 |
Cholangiocarcinoma |
Associate
|
26310932 |
Cholestasis |
Associate
|
25798860 |
Colonic Diseases |
Associate
|
20145122 |
Colonic Neoplasms |
Associate
|
25171473 |
Colonic Neoplasms |
Inhibit
|
27167203 |
Colorectal Neoplasms |
Associate
|
12771132, 17604322, 18196974, 20558521, 22108803, 25171473, 26450852, 27167203, 29740162, 33472949, 37246895, 7883226 |
Colorectal Neoplasms |
Stimulate
|
20558521 |
Coronary Disease |
Associate
|
20855565 |
COVID 19 |
Associate
|
36918693 |
Crohn Disease |
Associate
|
28335003 |
Cystic Fibrosis |
Associate
|
33050003 |
Diabetes Complications |
Associate
|
22180072 |
Diabetes Gestational |
Associate
|
27636996, 34633445 |
Diabetes Mellitus |
Associate
|
9065481 |
Diabetes Mellitus Type 2 |
Associate
|
14534304, 22023374, 29057944 |
Diabetic Retinopathy |
Associate
|
22180072 |
DiGeorge Syndrome |
Associate
|
35940635 |
Drug Related Side Effects and Adverse Reactions |
Associate
|
28669525, 37040084 |
Dyslipidemias |
Associate
|
22896670 |
Endometrial Neoplasms |
Associate
|
22205725 |
Esophageal Squamous Cell Carcinoma |
Associate
|
32194853 |
Esophagitis |
Associate
|
11315258 |
Fatty Liver |
Associate
|
25948673 |
Foramen Ovale Patent |
Associate
|
23147404 |
Gallbladder Neoplasms |
Associate
|
27167107 |
Glomerulonephritis |
Associate
|
26610845 |
Granulomatosis with Polyangiitis |
Associate
|
25939343 |
Head and Neck Neoplasms |
Associate
|
36902107 |
Heart Failure |
Associate
|
32154187 |
Hematologic Neoplasms |
Associate
|
12149223 |
Hemolytic Uremic Syndrome |
Inhibit
|
40108621 |
Hepatolenticular Degeneration |
Associate
|
30709419 |
Hereditary Breast and Ovarian Cancer Syndrome |
Associate
|
11092983 |
Herpes Zoster |
Associate
|
27777363 |
HIV Infections |
Inhibit
|
23106848 |
Hyperaldosteronism |
Associate
|
27777363 |
Hyperlipoproteinemias |
Associate
|
22023374 |
Hypertension |
Inhibit
|
21709632 |
Hypertension |
Associate
|
22023374 |
Hypertensive Retinopathy |
Associate
|
22180072 |
Hypertriglyceridemia |
Associate
|
12519787 |
Hypothyroidism |
Associate
|
10194237, 37563580 |
Hypoxia |
Inhibit
|
32978975 |
Inflammation |
Inhibit
|
23690070, 24391011 |
Inflammation |
Associate
|
27106679, 31173497, 31638178, 37542511 |
Inflammatory Bowel Diseases |
Associate
|
28335003, 35275975 |
Intellectual Disability |
Associate
|
29769320 |
Iron Overload |
Stimulate
|
21114893 |
Keratoconus |
Associate
|
26040312 |
Kidney Diseases |
Associate
|
36443310 |
Kidney Neoplasms |
Associate
|
29991691 |
Leukemia |
Associate
|
10601023, 8634447 |
Leukemia Lymphoma Adult T Cell |
Associate
|
18559673 |
Leukemia Myeloid |
Associate
|
10068679, 11756188, 15026318, 16946489, 30225259, 8530518, 8634447 |
Leukemia Myeloid Acute |
Associate
|
23823656, 32434928 |
Leukemia Plasma Cell |
Associate
|
22508408 |
Leukemia Promyelocytic Acute |
Associate
|
10601023, 10979971, 20159609, 8634447 |
Leukemia T Cell |
Associate
|
11035054 |
Liposarcoma |
Associate
|
8990192 |
Liver Cirrhosis Biliary |
Associate
|
30528300 |
Liver Diseases |
Associate
|
35246921 |
Liver Failure |
Associate
|
17272513 |
Lymphohistiocytosis Hemophagocytic |
Associate
|
21325597 |
Lymphoma T Cell |
Associate
|
18559673 |
Lymphoma T Cell Cutaneous |
Associate
|
10194237, 12149223, 19791803, 21649908, 25826424, 28370539, 29599065, 35778597 |
Lymphoma T Cell Cutaneous |
Inhibit
|
37947652 |
Macrophage Activation Syndrome |
Associate
|
22002519 |
Macular Degeneration |
Associate
|
26883505 |
Marijuana Abuse |
Associate
|
34500744 |
Melanoma |
Associate
|
30200275, 9228081 |
Melanoma Cutaneous Malignant |
Associate
|
26575331 |
Metabolic Diseases |
Associate
|
22140563 |
Metabolic Syndrome |
Inhibit
|
24060638 |
Metabolic Syndrome |
Associate
|
29057944 |
Multiple Myeloma |
Associate
|
25669983 |
Mycosis Fungoides |
Associate
|
33299887 |
Myocardial Infarction |
Associate
|
30413149 |
Neoplasm Metastasis |
Inhibit
|
12006550 |
Neoplasms |
Inhibit
|
10389997, 20145122, 20799942, 23605322, 25141867 |
Neoplasms |
Associate
|
15140235, 17900311, 19644018, 20145122, 20558521, 22205725, 26156677, 26310932, 26898458, 30176882, 30651555, 30893778, 33187070, 33352140, 33390794, 34870752, 35406808, 38143770, 39210506, 7883226, 8794365 View all (6 more) |
Neoplasms Adipose Tissue |
Associate
|
21471513, 23907847 |
Neoplasms Second Primary |
Associate
|
21292633 |
Neoplastic Syndromes Hereditary |
Associate
|
16936639 |
Nephrotic Syndrome |
Associate
|
26610845 |
Neurodegenerative Diseases |
Associate
|
26883505, 33187070 |
Non Muscle Invasive Bladder Neoplasms |
Associate
|
33024200 |
Obesity |
Associate
|
22023374, 22205725, 29454501 |
Obesity Metabolically Benign |
Associate
|
27106679 |
Oligodendroglioma |
Associate
|
8798469 |
Osteoarthritis |
Associate
|
24286485 |
Osteosarcoma |
Associate
|
12006550 |
Ovarian Neoplasms |
Associate
|
31865146, 38143770 |
Overweight |
Associate
|
22023374 |
Pancreatic Neoplasms |
Associate
|
23826131, 28573829, 31210298 |
Pneumonia Aspiration |
Associate
|
30225259 |
Polycystic Ovary Syndrome |
Associate
|
31173497 |
Prostatitis |
Associate
|
12514092, 26310932 |
Rectal Neoplasms |
Associate
|
20558521 |
Retinoblastoma |
Associate
|
9260893 |
Rhabdomyosarcoma |
Associate
|
25915942 |
Sezary Syndrome |
Associate
|
15245439 |
Sjogren's Syndrome |
Associate
|
19404300 |
Sleep Wake Disorders |
Associate
|
31139831 |
Sleepiness |
Associate
|
31139831 |
Squamous Cell Carcinoma of Head and Neck |
Associate
|
10738115 |
Stomach Neoplasms |
Associate
|
11044367, 12970875, 22901127, 23605322 |
Stomach Neoplasms |
Stimulate
|
26898458 |
Thyroid cancer follicular |
Associate
|
33009242 |
Thyroid Neoplasms |
Associate
|
26310932 |
Thyroid Neoplasms |
Inhibit
|
33009242 |
Urinary Bladder Neoplasms |
Associate
|
26901314, 30651555 |
Uterine Cervical Neoplasms |
Associate
|
21736279 |
Vasospasm Intracranial |
Associate
|
31595394 |
Vitamin D Deficiency |
Associate
|
25171473 |
Zinc Deficiency Neonatal due to Low Breast Milk Zinc |
Inhibit
|
24029070 |
|