Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6256
Gene name Gene Name - the full gene name approved by the HGNC.
Retinoid X receptor alpha
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RXRA
Synonyms (NCBI Gene) Gene synonyms aliases
NR2B1, RXR-alpha, RXRalpha
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9q34.2
Summary Summary of gene provided in NCBI Entrez Gene.
Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by bind
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs1057519958 C>A,T Likely-pathogenic Coding sequence variant, missense variant
rs1588299621 G>A Likely-pathogenic Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT042547 hsa-miR-423-3p CLASH 23622248
MIRT054229 hsa-miR-128-3p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 23990020
MIRT054351 hsa-miR-574-3p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 23626837
MIRT617638 hsa-miR-6782-3p HITS-CLIP 23824327
MIRT617637 hsa-miR-488-5p HITS-CLIP 23824327
Transcription factors
Transcription factor Regulation Reference
NR1I2 Unknown 21295138
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 17426122
GO:0000785 Component Chromatin IDA 18511497, 25592151
GO:0000785 Component Chromatin ISA
GO:0000976 Function Transcription regulatory region sequence-specific DNA binding IDA 18511497
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
180245 10477 ENSG00000186350
Protein
UniProt ID P19793
Protein name Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha)
Protein function Receptor for retinoic acid that acts as a transcription factor (PubMed:10874028, PubMed:11162439, PubMed:11915042, PubMed:37478846). Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in respons
PDB 1BY4 , 1DSZ , 1FBY , 1FM6 , 1FM9 , 1G1U , 1G5Y , 1K74 , 1MV9 , 1MVC , 1MZN , 1R0N , 1RDT , 1RXR , 1XLS , 1XV9 , 1XVP , 1YNW , 2ACL , 2NLL , 2P1T , 2P1U , 2P1V , 2ZXZ , 2ZY0 , 3DZU , 3DZY , 3E00 , 3E94 , 3FAL , 3FC6 , 3FUG , 3H0A , 3KWY , 3NSP , 3NSQ , 3OAP , 3OZJ , 3PCU , 3R29 , 3R2A , 3R5M , 3UVV , 4CN2 , 4CN3 , 4CN5 , 4CN7 , 4J5W , 4J5X , 4K4J , 4K6I
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF11825 Nuc_recep-AF1 17 127 Nuclear/hormone receptor activator site AF-1 Family
PF00105 zf-C4 133 202 Zinc finger, C4 type (two domains) Domain
PF00104 Hormone_recep 257 442 Ligand-binding domain of nuclear hormone receptor Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in lung fibroblasts (at protein level) (PubMed:30216632). Expressed in monocytes (PubMed:26463675). Highly expressed in liver, also found in kidney and brain (PubMed:14702039, PubMed:2159111, PubMed:24275569). {ECO:0000269|Pu
Sequence
Sequence length 462
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  PPAR signaling pathway
Efferocytosis
PI3K-Akt signaling pathway
Th17 cell differentiation
Thyroid hormone signaling pathway
Adipocytokine signaling pathway
Parathyroid hormone synthesis, secretion and action
Non-alcoholic fatty liver disease
Bile secretion
Hepatitis C
Pathways in cancer
Transcriptional misregulation in cancer
Chemical carcinogenesis - receptor activation
Thyroid cancer
Small cell lung cancer
Non-small cell lung cancer
Gastric cancer
Lipid and atherosclerosis
  RORA activates gene expression
Recycling of bile acids and salts
Synthesis of bile acids and bile salts
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
PPARA activates gene expression
Carnitine metabolism
Regulation of pyruvate dehydrogenase (PDH) complex
Endogenous sterols
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by PPARalpha
Circadian Clock
SUMOylation of intracellular receptors
Signaling by Retinoic Acid
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
Transcriptional regulation of granulopoiesis
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis, Familial rs267607084, rs312262720, rs312262752, rs121908287, rs121908288, rs29001584, rs28941475, rs121434378, rs386134173, rs386134174, rs80356730, rs80356727, rs4884357, rs80356717, rs80356733
View all (171 more)
11796754
Lateral sclerosis AMYOTROPHIC LATERAL SCLEROSIS 1, Amyotrophic Lateral Sclerosis, Sporadic rs386134181, rs386134176, rs386134174, rs386134184, rs386134178, rs1693780539, rs1574698048 11796754
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 15318950
Unknown
Disease term Disease name Evidence References Source
Pancreatic adenocarcinoma Adenocarcinoma of pancreas PDAC patients with high expression of PSMA6 having a significantly shorter overall survival rate. 26619011 ClinVar, CBGDA
Crohn Disease Crohn Disease GWAS
Keratoconus Keratoconus GWAS
Associations from Text Mining
Disease Name Relationship Type References
Abortion Habitual Stimulate 28076928
Abortion Spontaneous Stimulate 28076928
Acute Kidney Injury Associate 36443310
Adenomatous Polyposis Coli Associate 12771132
Adenomyosis Associate 17296180
Alzheimer Disease Associate 19374686
Amaurosis Fugax Associate 21709632
Aniridia Associate 34827649
Arthritis Rheumatoid Associate 28335003, 29848990
Atherosclerosis Associate 14534304, 36613720