Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6241
Gene name Gene Name - the full gene name approved by the HGNC.
Ribonucleotide reductase regulatory subunit M2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RRM2
Synonyms (NCBI Gene) Gene synonyms aliases
C2orf48, R2, RR2, RR2M
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p25.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Tr
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005050 hsa-let-7b-5p Microarray 17699775
MIRT016281 hsa-miR-193b-3p Microarray 20304954
MIRT020622 hsa-miR-155-5p Proteomics 18668040
MIRT025270 hsa-miR-34a-5p Proteomics 21566225
MIRT025270 hsa-miR-34a-5p Proteomics 21566225
Transcription factors
Transcription factor Regulation Reference
E2F1 Activation 19416980
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000083 Process Regulation of transcription involved in G1/S transition of mitotic cell cycle TAS
GO:0004748 Function Ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IBA 21873635
GO:0004748 Function Ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor ISS
GO:0004748 Function Ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor NAS 1627826
GO:0005515 Function Protein binding IPI 17726094, 21336276, 22632967, 28514442, 32296183
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
180390 10452 ENSG00000171848
Protein
UniProt ID P31350
Protein name Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit)
Protein function Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
PDB 2UW2 , 3OLJ , 3VPM , 3VPN , 3VPO
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00268 Ribonuc_red_sm 79 346 Ribonucleotide reductase, small chain Domain
Sequence
Sequence length 389
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Purine metabolism
Pyrimidine metabolism
Glutathione metabolism
Drug metabolism - other enzymes
Metabolic pathways
Nucleotide metabolism
p53 signaling pathway
  Interconversion of nucleotide di- and triphosphates
G1/S-Specific Transcription
Transcriptional Regulation by E2F6
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
15814641
Colorectal neoplasms Colorectal Neoplasms rs28929483, rs63751108, rs28929484, rs63749831, rs63750047, rs63751207, rs63749811, rs1553350126, rs63750875, rs63750955, rs587776706, rs63750871, rs587776715, rs63751466, rs63750049
View all (1682 more)
15814641
Lung adenocarcinoma Adenocarcinoma of lung (disorder) rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370
View all (5 more)
27602772
Associations from Text Mining
Disease Name Relationship Type References
Acute Kidney Injury Associate 37789254
Adenocarcinoma Associate 22569992, 32416156
Adenocarcinoma of Lung Associate 18414411, 32149133, 32578582, 33126397, 33411689, 34304612, 35898471, 36311801, 37863324, 39311766, 40191558
Adenomyosis Associate 38195505
Adrenocortical Carcinoma Associate 35500219
Amyotrophic Lateral Sclerosis Associate 24497641, 28793209
Arthritis Rheumatoid Associate 30106091, 36717858
Arthritis Rheumatoid Stimulate 35200126
Asthma Associate 34088958
Biliary Tract Diseases Associate 22760605