Gene Gene information from NCBI Gene database.
Entrez ID 6241
Gene name Ribonucleotide reductase regulatory subunit M2
Gene symbol RRM2
Synonyms (NCBI Gene)
C2orf48R2RR2RR2M
Chromosome 2
Chromosome location 2p25.1
Summary This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Tr
miRNA miRNA information provided by mirtarbase database.
812
miRTarBase ID miRNA Experiments Reference
MIRT005050 hsa-let-7b-5p Microarray 17699775
MIRT016281 hsa-miR-193b-3p Microarray 20304954
MIRT020622 hsa-miR-155-5p Proteomics 18668040
MIRT025270 hsa-miR-34a-5p Proteomics 21566225
MIRT025270 hsa-miR-34a-5p Proteomics 21566225
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
E2F1 Activation 19416980
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
31
GO ID Ontology Definition Evidence Reference
GO:0001824 Process Blastocyst development IEA
GO:0004748 Function Ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IBA
GO:0004748 Function Ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IEA
GO:0004748 Function Ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IEA
GO:0004748 Function Ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
180390 10452 ENSG00000171848
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P31350
Protein name Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit)
Protein function Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
PDB 2UW2 , 3OLJ , 3VPM , 3VPN , 3VPO
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00268 Ribonuc_red_sm 79 346 Ribonucleotide reductase, small chain Domain
Sequence
Sequence length 389
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Purine metabolism
Pyrimidine metabolism
Glutathione metabolism
Drug metabolism - other enzymes
Metabolic pathways
Nucleotide metabolism
p53 signaling pathway
  Interconversion of nucleotide di- and triphosphates
G1/S-Specific Transcription
Transcriptional Regulation by E2F6
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Gastric cancer Uncertain significance rs2527831152 RCV005932592
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acute Kidney Injury Associate 37789254
Adenocarcinoma Associate 22569992, 32416156
Adenocarcinoma of Lung Associate 18414411, 32149133, 32578582, 33126397, 33411689, 34304612, 35898471, 36311801, 37863324, 39311766, 40191558
Adenomyosis Associate 38195505
Adrenocortical Carcinoma Associate 35500219
Amyotrophic Lateral Sclerosis Associate 24497641, 28793209
Arthritis Rheumatoid Associate 30106091, 36717858
Arthritis Rheumatoid Stimulate 35200126
Asthma Associate 34088958
Biliary Tract Diseases Associate 22760605