RRM1 (ribonucleotide reductase catalytic subunit M1)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6240
Gene name Gene Name - the full gene name approved by the HGNC.
Ribonucleotide reductase catalytic subunit M1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RRM1
Synonyms (NCBI Gene) Gene synonyms aliases
PEOB6, R1, RIR1, RR1
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11p15.4
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(94)
miRTarBase ID miRNA Experiments Reference
MIRT004159 hsa-miR-192-5p Microarray 16822819
MIRT023637 hsa-miR-1-3p Proteomics 18668040
MIRT049472 hsa-miR-92a-3p CLASH 23622248
MIRT046549 hsa-let-7i-5p CLASH 23622248
MIRT037088 hsa-miR-877-3p CLASH 23622248
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
Transcription factor Regulation Reference
E2F1 Activation 14618416
TFDP1 Activation 14618416
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(48)
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000731 Process DNA synthesis involved in DNA repair NAS 10716435
GO:0003824 Function Catalytic activity IEA
GO:0004748 Function Ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IBA
GO:0004748 Function Ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
180410 10451 ENSG00000167325
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P23921
Protein name Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit)
Protein function Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
PDB 2WGH , 3HNC , 3HND , 3HNE , 3HNF , 4X3V , 5D1Y , 5TUS , 6AUI , 6L3R , 6L7L , 6LKM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03477 ATP-cone 1 → 89 ATP cone domain Domain
PF00317 Ribonuc_red_lgN 141 → 213 Ribonucleotide reductase, all-alpha domain Domain
PF02867 Ribonuc_red_lgC 216 → 738 Ribonucleotide reductase, barrel domain Family
Sequence
Sequence length 792
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Purine metabolism
Pyrimidine metabolism
Glutathione metabolism
Drug metabolism - other enzymes
Metabolic pathways
Nucleotide metabolism 		  Interconversion of nucleotide di- and triphosphates
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (3)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
External Ophthalmoplegia progressive external ophthalmoplegia with mitochondrial DNA deletions N/A N/A GenCC
Glioblastoma Glioblastoma N/A N/A GWAS
Progressive External Ophthalmoplegia with Mitochondrial DNA Deletions progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 6 N/A N/A GenCC
Show/Hide Text Mining Associations (69)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 22569992, 23038758, 23470290, 26374242, 30458017
Adenocarcinoma of Lung Associate 18414411, 40191558
Adrenal Cortex Neoplasms Associate 25497672
Adrenal Gland Neoplasms Associate 25497672
Adrenocortical Carcinoma Associate 22547773
Amyotrophic Lateral Sclerosis Associate 23558684, 24464995, 26883171
Autoimmune enteropathy Associate 1361864
Biliary Tract Diseases Associate 22760605
Brain Neoplasms Associate 29923182
Breast Neoplasms Associate 12938148, 19968494, 21394302, 24215511, 24578158, 33832110