Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
624
Gene name Gene Name - the full gene name approved by the HGNC.
Bradykinin receptor B2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
BDKRB2
Synonyms (NCBI Gene) Gene synonyms aliases
B2R, BK-2, BK2, BKR2, BRB2
Chromosome Chromosome number
14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
14q32.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Bradykinin is released upon activation by pathophysiologic conditions such as tr
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT054128 hsa-miR-129-5p Luciferase reporter assay, qRT-PCR 25008064
MIRT054128 hsa-miR-129-5p Luciferase reporter assay, qRT-PCR 25008064
MIRT723809 hsa-miR-6892-3p HITS-CLIP 19536157
MIRT723808 hsa-miR-2276-5p HITS-CLIP 19536157
MIRT723807 hsa-miR-1237-3p HITS-CLIP 19536157
Transcription factors
Transcription factor Regulation Reference
CREB1 Unknown 15632413
KLF4 Activation 15632413
TP53 Activation 15632413
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002020 Function Protease binding IPI 17077303
GO:0004435 Function Phosphatidylinositol phospholipase C activity TAS 8302267
GO:0004930 Function G protein-coupled receptor activity IBA 21873635
GO:0004947 Function Bradykinin receptor activity IBA 21873635
GO:0004947 Function Bradykinin receptor activity IDA 17077303
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
113503 1030 ENSG00000168398
Protein
UniProt ID P30411
Protein name B2 bradykinin receptor (B2R) (BK-2 receptor)
Protein function Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
PDB 7F2O , 7F6H , 7F6I
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 74 332 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Widespread in normal smooth muscle tissue and neurons. {ECO:0000269|PubMed:7835885}.
Sequence
Sequence length 391
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Calcium signaling pathway
cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Complement and coagulation cascades
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Endocrine and other factor-regulated calcium reabsorption
Chagas disease
Pathways in cancer
  Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Cardiomyopathy Cardiomyopathies, Primary, Cardiomyopathies rs267607003, rs267607002, rs267607004, rs63750743, rs121908333, rs121908334, rs104894655, rs121434420, rs121434421, rs193922674, rs111517471, rs121908987, rs193922384, rs121909374, rs121909377
View all (900 more)
10614985
Dermatitis Dermatitis, Occupational rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 30685357
Epilepsy Epilepsy, Temporal Lobe, Uncinate Epilepsy, Epilepsy, Benign Psychomotor, Childhood, Epilepsy, Lateral Temporal rs113994140, rs28937874, rs1589762127, rs104894166, rs28939075, rs2134001459, rs104894167, rs119488099, rs119488100, rs387906420, rs121917752, rs121918622, rs281865564, rs387907313, rs397514670
View all (165 more)
15196965
Hypertension Hypertensive disease rs13306026 10614985
Unknown
Disease term Disease name Evidence References Source
Mental depression Unipolar Depression, Major Depressive Disorder 19086053 ClinVar
Gout Gout GWAS
Associations from Text Mining
Disease Name Relationship Type References
Altitude Sickness Associate 20511677
Angioedema Associate 23730990
Asthma Associate 26880163
Astrocytoma Associate 36348016
Cardiovascular Diseases Associate 10553917, 15894833
Chromosome Deletion Associate 32917334
Colitis Ulcerative Associate 15805101
Cough Associate 35352885
Diabetes Gestational Inhibit 34557552
Diabetes Mellitus Associate 23243416