Gene Gene information from NCBI Gene database.
Entrez ID 624
Gene name Bradykinin receptor B2
Gene symbol BDKRB2
Synonyms (NCBI Gene)
B2RBK-2BK2BKR2BRB2
Chromosome 14
Chromosome location 14q32.2
Summary This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Bradykinin is released upon activation by pathophysiologic conditions such as tr
miRNA miRNA information provided by mirtarbase database.
931
miRTarBase ID miRNA Experiments Reference
MIRT054128 hsa-miR-129-5p Luciferase reporter assayqRT-PCR 25008064
MIRT054128 hsa-miR-129-5p Luciferase reporter assayqRT-PCR 25008064
MIRT723809 hsa-miR-6892-3p HITS-CLIP 19536157
MIRT723808 hsa-miR-2276-5p HITS-CLIP 19536157
MIRT723807 hsa-miR-1237-3p HITS-CLIP 19536157
Transcription factors Transcription factors information provided by TRRUST V2 database.
3
Transcription factor Regulation Reference
CREB1 Unknown 15632413
KLF4 Activation 15632413
TP53 Activation 15632413
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
38
GO ID Ontology Definition Evidence Reference
GO:0002020 Function Protease binding IPI 17077303
GO:0003008 Process System process IEA
GO:0004435 Function Phosphatidylinositol-4,5-bisphosphate phospholipase C activity TAS 8302267
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0004947 Function Bradykinin receptor activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
113503 1030 ENSG00000168398
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P30411
Protein name B2 bradykinin receptor (B2R) (BK-2 receptor)
Protein function Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
PDB 7F2O , 7F6H , 7F6I
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 74 332 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Widespread in normal smooth muscle tissue and neurons. {ECO:0000269|PubMed:7835885}.
Sequence
Sequence length 391
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Calcium signaling pathway
cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Complement and coagulation cascades
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Endocrine and other factor-regulated calcium reabsorption
Chagas disease
Pathways in cancer
  Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Hereditary angioedema with normal C1Inh not provided rs1595266840 RCV001027409
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Altitude Sickness Associate 20511677
Angioedema Associate 23730990
Asthma Associate 26880163
Astrocytoma Associate 36348016
Cardiovascular Diseases Associate 10553917, 15894833
Chromosome Deletion Associate 32917334
Colitis Ulcerative Associate 15805101
Cough Associate 35352885
Diabetes Gestational Inhibit 34557552
Diabetes Mellitus Associate 23243416