RPS27 (ribosomal protein S27)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 6232
Gene name Ribosomal protein S27
Gene symbol RPS27
Synonyms (NCBI Gene)
DBA17MPS-1MPS1S27eS27
Chromosome 1
Chromosome location 1q21.3
Summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of
miRNA miRNA information provided by mirtarbase database.
128
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (128)
miRTarBase ID miRNA Experiments Reference
MIRT031378 hsa-miR-16-5p Proteomics 18668040
MIRT051425 hsa-let-7e-5p CLASH 23622248
MIRT050605 hsa-miR-20a-5p CLASH 23622248
MIRT048465 hsa-miR-100-5p CLASH 23622248
MIRT044612 hsa-miR-320a CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
37
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (37)
GO ID Ontology Definition Evidence Reference
GO:0000028 Process Ribosomal small subunit assembly IBA
GO:0002181 Process Cytoplasmic translation IC 23636399
GO:0003677 Function DNA binding NAS 8908372
GO:0003723 Function RNA binding HDA 22681889
GO:0003723 Function RNA binding IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
603702 10416 ENSG00000177954
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P42677
Protein name Small ribosomal subunit protein eS27 (40S ribosomal protein S27) (Metallopan-stimulin 1) (MPS-1)
Protein function Component of the small ribosomal subunit (PubMed:23636399, PubMed:8706699). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for proper rRNA processing and matura
PDB 4UG0 , 4V6X , 5A2Q , 5AJ0 , 5FLX , 5LKS , 5OA3 , 5T2C , 5VYC , 6FEC , 6G18 , 6G4S , 6G4W , 6G51 , 6G53 , 6G5H , 6G5I , 6IP5 , 6IP6 , 6IP8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6YBD , 6YBW , 6Z6L , 6Z6M , 6Z6N , 6ZLW , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZMT , 6ZMW , 6ZN5 , 6ZOJ , 6ZOK , 6ZON , 6ZP4 , 6ZUO , 6ZV6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01667 Ribosomal_S27e 28 → 82 Ribosomal protein S27 Family
Tissue specificity TISSUE SPECIFICITY: Expressed in a wide variety of actively proliferating cells and tumor tissues. {ECO:0000269|PubMed:8407955}.
Sequence
Sequence length 84
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Ribosome
Coronavirus disease - COVID-19 		  Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
L13a-mediated translational silencing of Ceruloplasmin expression
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Major pathway of rRNA processing in the nucleolus and cytosol
Mitotic Prometaphase
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
EML4 and NUDC in mitotic spindle formation
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
34
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Diamond-Blackfan anemia 17 Pathogenic rs1085307115 RCV000477728
Show/Hide Unknown Diseases (15)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Benign; Likely benign rs138950537 RCV005922674
Cervical cancer Benign; Likely benign rs138950537 RCV005922677
Clear cell carcinoma of kidney Benign; Likely benign rs138950537 RCV005922678
Colon adenocarcinoma Benign; Likely benign rs138950537 RCV005922673
Show/Hide Text Mining Associations (15)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Atypical Hemolytic Uremic Syndrome Associate 37373158
Breast Neoplasms Associate 32444848, 33305312
Carcinoma Hepatocellular Associate 32627011
Colorectal Neoplasms Associate 31506433
Endometriosis Associate 34266426
Epilepsy Partial with Variable Foci Associate 34266426
Inflammation Associate 35546566
Melanoma Associate 24913145, 8407955
Neoplasm Metastasis Associate 32444848
Neoplasms Associate 31506433, 32444848, 35546566, 8407955