RPS27 (ribosomal protein S27)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6232
Gene name Gene Name - the full gene name approved by the HGNC.
Ribosomal protein S27
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RPS27
Synonyms (NCBI Gene) Gene synonyms aliases
DBA17, MPS-1, MPS1, S27, eS27
Disease Acronyms (UniProt) Disease acronyms from UniProt database
DBA17
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q21.3
Summary Summary of gene provided in NCBI Entrez Gene.
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(128)
miRTarBase ID miRNA Experiments Reference
MIRT031378 hsa-miR-16-5p Proteomics 18668040
MIRT051425 hsa-let-7e-5p CLASH 23622248
MIRT050605 hsa-miR-20a-5p CLASH 23622248
MIRT048465 hsa-miR-100-5p CLASH 23622248
MIRT044612 hsa-miR-320a CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(26)
GO ID Ontology Definition Evidence Reference
GO:0000028 Process Ribosomal small subunit assembly IBA 21873635
GO:0000184 Process Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
GO:0003677 Function DNA binding NAS 8908372
GO:0003723 Function RNA binding HDA 22681889
GO:0003723 Function RNA binding IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
603702 10416 ENSG00000177954
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P42677
Protein name Small ribosomal subunit protein eS27 (40S ribosomal protein S27) (Metallopan-stimulin 1) (MPS-1)
Protein function Component of the small ribosomal subunit (PubMed:23636399, PubMed:8706699). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for proper rRNA processing and matura
PDB 4UG0 , 4V6X , 5A2Q , 5AJ0 , 5FLX , 5LKS , 5OA3 , 5T2C , 5VYC , 6FEC , 6G18 , 6G4S , 6G4W , 6G51 , 6G53 , 6G5H , 6G5I , 6IP5 , 6IP6 , 6IP8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6YBD , 6YBW , 6Z6L , 6Z6M , 6Z6N , 6ZLW , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZMT , 6ZMW , 6ZN5 , 6ZOJ , 6ZOK , 6ZON , 6ZP4 , 6ZUO , 6ZV6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01667 Ribosomal_S27e 28 → 82 Ribosomal protein S27 Family
Tissue specificity TISSUE SPECIFICITY: Expressed in a wide variety of actively proliferating cells and tumor tissues. {ECO:0000269|PubMed:8407955}.
Sequence
Sequence length 84
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Ribosome
Coronavirus disease - COVID-19 		  Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
L13a-mediated translational silencing of Ceruloplasmin expression
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Major pathway of rRNA processing in the nucleolus and cytosol
Mitotic Prometaphase
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
EML4 and NUDC in mitotic spindle formation
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (4)
Causal
Disease term Disease name dbSNP ID References
Anemia Anemia, Anemia, Macrocytic, Anemia, Diamond-Blackfan rs118204044, rs118204045, rs118204046, rs121918330, rs869320719, rs869312029, rs121918332, rs869320724, rs767094129, rs786205058, rs786205059, rs137853119, rs137853120, rs137853121, rs1384933966
View all (89 more)		 25424902, 28297620
Diamond-blackfan anemia DIAMOND-BLACKFAN ANEMIA 17 rs121434389, rs1570566590, rs151155897, rs143951267, rs267607023, rs786200892, rs148622862, rs397507554, rs121434405, rs1571026775, rs142156224, rs267607021, rs1581931541, rs267607022, rs61762293
View all (76 more)		 25424902
Leukemia Acute leukemia rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297
Migraine Migraine Disorders rs794727411
Show/Hide Text Mining Associations (15)
Associations from Text Mining
Disease Name Relationship Type References
Atypical Hemolytic Uremic Syndrome Associate 37373158
Breast Neoplasms Associate 32444848, 33305312
Carcinoma Hepatocellular Associate 32627011
Colorectal Neoplasms Associate 31506433
Endometriosis Associate 34266426
Epilepsy Partial with Variable Foci Associate 34266426
Inflammation Associate 35546566
Melanoma Associate 24913145, 8407955
Neoplasm Metastasis Associate 32444848
Neoplasms Associate 31506433, 32444848, 35546566, 8407955