RPS26 (ribosomal protein S26)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 6231
Gene name Ribosomal protein S26
Gene symbol RPS26
Synonyms (NCBI Gene)
DBA10S26eS26
Chromosome 12
Chromosome location 12q13.2
Summary This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S26E family of ribosomal proteins. Mutations in this gene are found in Diamond-Blackfan anemia 10. There are multiple processed pseudogenes of this ge
miRNA miRNA information provided by mirtarbase database.
47
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT050095 hsa-miR-26a-5p CLASH 23622248
MIRT048619 hsa-miR-99a-5p CLASH 23622248
MIRT047775 hsa-miR-139-5p CLASH 23622248
MIRT045055 hsa-miR-186-5p CLASH 23622248
MIRT038666 hsa-miR-196a-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
36
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0002181 Process Cytoplasmic translation IC 23636399
GO:0002181 Process Cytoplasmic translation IDA 25957688
GO:0002181 Process Cytoplasmic translation NAS 25901680
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003729 Function MRNA binding IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
603701 10414 ENSG00000197728
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P62854
Protein name Small ribosomal subunit protein eS26 (40S ribosomal protein S26)
Protein function Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957
PDB 4UG0 , 4V6X , 5A2Q , 5AJ0 , 5FLX , 5LKS , 5OA3 , 5T2C , 5VYC , 6G5H , 6IP5 , 6IP6 , 6IP8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6YBD , 6YBW , 6Z6L , 6Z6M , 6Z6N , 6ZLW , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZMW , 6ZN5 , 6ZOJ , 6ZOK , 6ZON , 6ZP4 , 6ZV6 , 6ZVH , 6ZVJ , 6ZXG , 6ZXH , 7A09 , 7K5I , 7QP6 , 7QP7 , 7R4X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01283 Ribosomal_S26e 1 → 107 Ribosomal protein S26e Family
Sequence
Sequence length 115
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Ribosome
Coronavirus disease - COVID-19 		  L13a-mediated translational silencing of Ceruloplasmin expression
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Major pathway of rRNA processing in the nucleolus and cytosol
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
165
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (6)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Anemia Likely pathogenic rs1593023809 RCV001003805
Diamond-Blackfan anemia Pathogenic; Likely pathogenic rs2136753785, rs2136753850, rs2540723664, rs2540724145, rs2540722839, rs2540723571, rs1895894261, rs148622862, rs148942765, rs797045919, rs143951267, rs2540722766 RCV002377582
RCV002386606
RCV002320488
RCV002320613
RCV002376054
RCV002428064
RCV002435649
RCV002435658
RCV002433720
RCV005470386
RCV002415402
RCV004521051
Diamond-Blackfan anemia 10 Pathogenic; Likely pathogenic rs2136753785, rs2136753495, rs2136753850, rs1895894261, rs148622862, rs148942765, rs786203998, rs797045919, rs140419130, rs143951267, rs267607023, rs786200892, rs2540722911, rs2540722756, rs1555208596
View all (2 more)		 RCV001390815
RCV001783693
RCV001870068
RCV005098379
RCV003225993
RCV000167574
RCV000167575
RCV000195166
RCV002866640
RCV000006496
RCV000006497
RCV000006498
RCV000006499
RCV000006500
RCV003133807
RCV003486337
RCV003507629
RCV000559583
RCV001194602
RCV001202198
RCV001202461
Diamond-Blackfan anemia 15 with mandibulofacial dysostosis Pathogenic rs148942765, rs786203998 RCV000191914
RCV000191913
Show/Hide Unknown Diseases (10)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Benign rs77499413 RCV005920186
Cholangiocarcinoma Benign rs77499413 RCV005920194
Gastric cancer Benign rs77499413 RCV005920190
Lung cancer Benign rs77499413 RCV005920195
Show/Hide Text Mining Associations (13)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenomyosis Associate 40527793
Anemia Diamond Blackfan Associate 20116044, 22045982, 22262766, 22689679, 23812780, 24675553, 25946618, 31277601
Autoimmune Diseases Associate 28248954
Chondrosarcoma Associate 32469486
Diabetes Mellitus Associate 38041572
Diabetes Mellitus Type 1 Associate 22144904, 23900168, 38041572
Diabetic Retinopathy Associate 39719581
Diamond Blackfan Anemia 10 Associate 31277601
Glomerulonephritis IGA Associate 33754492
Latent Autoimmune Diabetes in Adults Associate 38041572