RPS26 (ribosomal protein S26)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6231
Gene name Gene Name - the full gene name approved by the HGNC.
Ribosomal protein S26
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RPS26
Synonyms (NCBI Gene) Gene synonyms aliases
DBA10, S26, eS26
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q13.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S26E family of ribosomal proteins. Mutations in this gene are found in Diamond-Blackfan anemia 10. There are multiple processed pseudogenes of this ge
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(47)
miRTarBase ID miRNA Experiments Reference
MIRT050095 hsa-miR-26a-5p CLASH 23622248
MIRT048619 hsa-miR-99a-5p CLASH 23622248
MIRT047775 hsa-miR-139-5p CLASH 23622248
MIRT045055 hsa-miR-186-5p CLASH 23622248
MIRT038666 hsa-miR-196a-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(36)
GO ID Ontology Definition Evidence Reference
GO:0002181 Process Cytoplasmic translation IC 23636399
GO:0002181 Process Cytoplasmic translation IDA 25957688
GO:0002181 Process Cytoplasmic translation NAS 25901680
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003729 Function MRNA binding IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
603701 10414 ENSG00000197728
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P62854
Protein name Small ribosomal subunit protein eS26 (40S ribosomal protein S26)
Protein function Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957
PDB 4UG0 , 4V6X , 5A2Q , 5AJ0 , 5FLX , 5LKS , 5OA3 , 5T2C , 5VYC , 6G5H , 6IP5 , 6IP6 , 6IP8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6YBD , 6YBW , 6Z6L , 6Z6M , 6Z6N , 6ZLW , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZMW , 6ZN5 , 6ZOJ , 6ZOK , 6ZON , 6ZP4 , 6ZV6 , 6ZVH , 6ZVJ , 6ZXG , 6ZXH , 7A09 , 7K5I , 7QP6 , 7QP7 , 7R4X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01283 Ribosomal_S26e 1 → 107 Ribosomal protein S26e Family
Sequence
Sequence length 115
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Ribosome
Coronavirus disease - COVID-19 		  L13a-mediated translational silencing of Ceruloplasmin expression
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Major pathway of rRNA processing in the nucleolus and cytosol
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (3)
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Disease merge term Disease name dbSNP ID References
Diamond-Blackfan anemia diamond-blackfan anemia 10 rs797045919, rs143951267, rs1555208596, rs267607023, rs786200892, rs148622862, rs148942765, rs786203998 N/A
diamond-blackfan anemia Diamond-Blackfan anemia rs143951267, rs148942765 N/A
Diamond-Blackfan Anemia With Mandibulofacial Dysostosis diamond-blackfan anemia 15 with mandibulofacial dysostosis rs148942765, rs786203998 N/A
Show/Hide Unknown Diseases (14)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Anorexia Anorexia nervosa N/A N/A GWAS
Asthma Age of onset of adult onset asthma, Asthma, Asthma (adult onset), Asthma (moderate or severe) N/A N/A GWAS
Crohn Disease Crohn's disease N/A N/A GWAS
Dermatitis Atopic dermatitis N/A N/A GWAS
Show/Hide Text Mining Associations (13)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenomyosis Associate 40527793
Anemia Diamond Blackfan Associate 20116044, 22045982, 22262766, 22689679, 23812780, 24675553, 25946618, 31277601
Autoimmune Diseases Associate 28248954
Chondrosarcoma Associate 32469486
Diabetes Mellitus Associate 38041572
Diabetes Mellitus Type 1 Associate 22144904, 23900168, 38041572
Diabetic Retinopathy Associate 39719581
Diamond Blackfan Anemia 10 Associate 31277601
Glomerulonephritis IGA Associate 33754492
Latent Autoimmune Diabetes in Adults Associate 38041572