BDKRB1 (bradykinin receptor B1)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
623
Gene name Gene Name - the full gene name approved by the HGNC.
Bradykinin receptor B1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
BDKRB1
Synonyms (NCBI Gene) Gene synonyms aliases
B1BKR, B1R, BKB1R, BKR1, BRADYB1
Chromosome Chromosome number
14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
14q32.2
Summary Summary of gene provided in NCBI Entrez Gene.
Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. The protein encoded by this gene belongs to the G-protein coupled receptor 1 family. Two types of G-protein coupled receptors
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
miRTarBase ID miRNA Experiments Reference
MIRT023170 hsa-miR-124-3p Microarray 18668037
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(11)
Transcription factor Regulation Reference
CREB1 Unknown 10842322
ETV4 Unknown 10842322
GATA1 Unknown 10842322
GTF2B Unknown 15705059
NFKB1 Unknown 15705059
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(23)
GO ID Ontology Definition Evidence Reference
GO:0001933 Process Negative regulation of protein phosphorylation IEA
GO:0002687 Process Positive regulation of leukocyte migration IEA
GO:0004930 Function G protein-coupled receptor activity IBA 21873635
GO:0004947 Function Bradykinin receptor activity IBA 21873635
GO:0005515 Function Protein binding IPI 23597562
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
600337 1029 ENSG00000100739
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P46663
Protein name B1 bradykinin receptor (B1R) (BK-1 receptor)
Protein function This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.
PDB 7EIB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 54 → 312 7 transmembrane receptor (rhodopsin family) Family
Sequence
Sequence length 353
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Calcium signaling pathway
Neuroactive ligand-receptor interaction
Complement and coagulation cascades
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Pathways in cancer 		  Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Epilepsy Epilepsy, Temporal Lobe, Uncinate Epilepsy, Epilepsy, Benign Psychomotor, Childhood, Epilepsy, Lateral Temporal rs113994140, rs28937874, rs1589762127, rs104894166, rs28939075, rs2134001459, rs104894167, rs119488099, rs119488100, rs387906420, rs121917752, rs121918622, rs281865564, rs387907313, rs397514670
View all (165 more)		 15196965
Show/Hide Text Mining Associations (39)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 24475248, 27484806
Adenoma Associate 22468084
Asthma Associate 24475248
Atrial Fibrillation Associate 36042613
Carcinogenesis Associate 22468084
Carcinoma Hepatocellular Associate 34206871
Carcinoma in Situ Associate 22468084
Cardiomyopathies Associate 24466231
Cardiomyopathy Dilated Inhibit 9410910
Chromosome Deletion Associate 32917334