Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6224
Gene name Gene Name - the full gene name approved by the HGNC.	Ribosomal protein S20
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RPS20
Synonyms (NCBI Gene) Gene synonyms aliases	S20, uS10
Chromosome Chromosome number	8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	8q12.1
Summary Summary of gene provided in NCBI Entrez Gene.	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

Show/Hide all(132)

miRTarBase ID	miRNA	Experiments	Reference
MIRT439734	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT439734	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT1317754	hsa-miR-4670-3p	CLIP-seq
MIRT1317755	hsa-miR-548aa	CLIP-seq
MIRT1317756	hsa-miR-548ac	CLIP-seq
MIRT1317757	hsa-miR-548ae	CLIP-seq
MIRT1317758	hsa-miR-548aj	CLIP-seq
MIRT1317759	hsa-miR-548am	CLIP-seq
MIRT1317760	hsa-miR-548d-3p	CLIP-seq
MIRT1317761	hsa-miR-548x	CLIP-seq
MIRT1317762	hsa-miR-548z	CLIP-seq
MIRT1317763	hsa-miR-1207-3p	CLIP-seq
MIRT1317764	hsa-miR-1262	CLIP-seq
MIRT1317765	hsa-miR-1292	CLIP-seq
MIRT1317766	hsa-miR-141	CLIP-seq
MIRT1317767	hsa-miR-1827	CLIP-seq
MIRT1317768	hsa-miR-200a	CLIP-seq
MIRT1317769	hsa-miR-2467-3p	CLIP-seq
MIRT1317770	hsa-miR-25	CLIP-seq
MIRT1317771	hsa-miR-3160-3p	CLIP-seq
MIRT1317772	hsa-miR-3163	CLIP-seq
MIRT1317773	hsa-miR-32	CLIP-seq
MIRT1317774	hsa-miR-34b	CLIP-seq
MIRT1317775	hsa-miR-3612	CLIP-seq
MIRT1317776	hsa-miR-3614-5p	CLIP-seq
MIRT1317777	hsa-miR-363	CLIP-seq
MIRT1317778	hsa-miR-367	CLIP-seq
MIRT1317779	hsa-miR-4257	CLIP-seq
MIRT1317780	hsa-miR-4325	CLIP-seq
MIRT1317781	hsa-miR-4459	CLIP-seq
MIRT1317782	hsa-miR-4471	CLIP-seq
MIRT1317783	hsa-miR-4487	CLIP-seq
MIRT1317784	hsa-miR-4646-5p	CLIP-seq
MIRT1317785	hsa-miR-4695-5p	CLIP-seq
MIRT1317786	hsa-miR-4701-3p	CLIP-seq
MIRT1317787	hsa-miR-508-5p	CLIP-seq
MIRT1317788	hsa-miR-542-3p	CLIP-seq
MIRT1317789	hsa-miR-548c-3p	CLIP-seq
MIRT1317790	hsa-miR-558	CLIP-seq
MIRT1317791	hsa-miR-650	CLIP-seq
MIRT1317792	hsa-miR-661	CLIP-seq
MIRT1317793	hsa-miR-665	CLIP-seq
MIRT1317794	hsa-miR-766	CLIP-seq
MIRT1317795	hsa-miR-92a	CLIP-seq
MIRT1317796	hsa-miR-92b	CLIP-seq
MIRT2094430	hsa-miR-1228	CLIP-seq
MIRT1317764	hsa-miR-1262	CLIP-seq
MIRT1317767	hsa-miR-1827	CLIP-seq
MIRT1317769	hsa-miR-2467-3p	CLIP-seq
MIRT1317770	hsa-miR-25	CLIP-seq
MIRT1317771	hsa-miR-3160-3p	CLIP-seq
MIRT1317773	hsa-miR-32	CLIP-seq
MIRT1317775	hsa-miR-3612	CLIP-seq
MIRT1317777	hsa-miR-363	CLIP-seq
MIRT2094431	hsa-miR-3664-3p	CLIP-seq
MIRT1317778	hsa-miR-367	CLIP-seq
MIRT1317779	hsa-miR-4257	CLIP-seq
MIRT1317780	hsa-miR-4325	CLIP-seq
MIRT2094432	hsa-miR-4433	CLIP-seq
MIRT1317781	hsa-miR-4459	CLIP-seq
MIRT2094433	hsa-miR-4474-5p	CLIP-seq
MIRT1317783	hsa-miR-4487	CLIP-seq
MIRT1317785	hsa-miR-4695-5p	CLIP-seq
MIRT1317786	hsa-miR-4701-3p	CLIP-seq
MIRT2094434	hsa-miR-4768-3p	CLIP-seq
MIRT1317787	hsa-miR-508-5p	CLIP-seq
MIRT2094435	hsa-miR-510	CLIP-seq
MIRT2094436	hsa-miR-512-5p	CLIP-seq
MIRT1317790	hsa-miR-558	CLIP-seq
MIRT1317791	hsa-miR-650	CLIP-seq
MIRT1317792	hsa-miR-661	CLIP-seq
MIRT1317793	hsa-miR-665	CLIP-seq
MIRT1317794	hsa-miR-766	CLIP-seq
MIRT1317795	hsa-miR-92a	CLIP-seq
MIRT1317796	hsa-miR-92b	CLIP-seq
MIRT2094430	hsa-miR-1228	CLIP-seq
MIRT1317764	hsa-miR-1262	CLIP-seq
MIRT1317767	hsa-miR-1827	CLIP-seq
MIRT1317769	hsa-miR-2467-3p	CLIP-seq
MIRT1317770	hsa-miR-25	CLIP-seq
MIRT1317771	hsa-miR-3160-3p	CLIP-seq
MIRT1317773	hsa-miR-32	CLIP-seq
MIRT1317774	hsa-miR-34b	CLIP-seq
MIRT1317775	hsa-miR-3612	CLIP-seq
MIRT1317776	hsa-miR-3614-5p	CLIP-seq
MIRT1317777	hsa-miR-363	CLIP-seq
MIRT2094431	hsa-miR-3664-3p	CLIP-seq
MIRT1317778	hsa-miR-367	CLIP-seq
MIRT2318933	hsa-miR-3919	CLIP-seq
MIRT2318934	hsa-miR-3929	CLIP-seq
MIRT1317779	hsa-miR-4257	CLIP-seq
MIRT1317780	hsa-miR-4325	CLIP-seq
MIRT2318935	hsa-miR-4329	CLIP-seq
MIRT2318936	hsa-miR-4419b	CLIP-seq
MIRT2094432	hsa-miR-4433	CLIP-seq
MIRT1317781	hsa-miR-4459	CLIP-seq
MIRT2094433	hsa-miR-4474-5p	CLIP-seq
MIRT2318937	hsa-miR-4478	CLIP-seq
MIRT1317783	hsa-miR-4487	CLIP-seq
MIRT1317785	hsa-miR-4695-5p	CLIP-seq
MIRT1317786	hsa-miR-4701-3p	CLIP-seq
MIRT2094434	hsa-miR-4768-3p	CLIP-seq
MIRT2318938	hsa-miR-485-5p	CLIP-seq
MIRT1317787	hsa-miR-508-5p	CLIP-seq
MIRT2094435	hsa-miR-510	CLIP-seq
MIRT2094436	hsa-miR-512-5p	CLIP-seq
MIRT1317788	hsa-miR-542-3p	CLIP-seq
MIRT2318939	hsa-miR-548u	CLIP-seq
MIRT1317790	hsa-miR-558	CLIP-seq
MIRT2318940	hsa-miR-587	CLIP-seq
MIRT1317791	hsa-miR-650	CLIP-seq
MIRT1317792	hsa-miR-661	CLIP-seq
MIRT1317793	hsa-miR-665	CLIP-seq
MIRT1317794	hsa-miR-766	CLIP-seq
MIRT1317795	hsa-miR-92a	CLIP-seq
MIRT1317796	hsa-miR-92b	CLIP-seq
MIRT2094430	hsa-miR-1228	CLIP-seq
MIRT1317767	hsa-miR-1827	CLIP-seq
MIRT1317769	hsa-miR-2467-3p	CLIP-seq
MIRT1317771	hsa-miR-3160-3p	CLIP-seq
MIRT1317774	hsa-miR-34b	CLIP-seq
MIRT1317775	hsa-miR-3612	CLIP-seq
MIRT1317776	hsa-miR-3614-5p	CLIP-seq
MIRT1317779	hsa-miR-4257	CLIP-seq
MIRT1317781	hsa-miR-4459	CLIP-seq
MIRT2094433	hsa-miR-4474-5p	CLIP-seq
MIRT1317783	hsa-miR-4487	CLIP-seq
MIRT1317785	hsa-miR-4695-5p	CLIP-seq
MIRT1317790	hsa-miR-558	CLIP-seq
MIRT1317791	hsa-miR-650	CLIP-seq
MIRT1317793	hsa-miR-665	CLIP-seq
MIRT2690000	hsa-miR-4668-3p	CLIP-seq

Show/Hide all(33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003735	Function	Structural constituent of ribosome	HDA	15883184
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	8479924
GO:0005515	Function	Protein binding	IPI	18274552, 21145461, 22046132, 24725412, 24947832, 25866880, 28065601, 28132843, 31046837, 35271311
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0006412	Process	Translation	IC	8706699, 15883184
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	8479924
GO:0015935	Component	Small ribosomal subunit	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0022626	Component	Cytosolic ribosome	IEA
GO:0022627	Component	Cytosolic small ribosomal subunit	HDA	15883184
GO:0022627	Component	Cytosolic small ribosomal subunit	IBA
GO:0022627	Component	Cytosolic small ribosomal subunit	IDA	8706699
GO:0022627	Component	Cytosolic small ribosomal subunit	IEA
GO:0022627	Component	Cytosolic small ribosomal subunit	NAS	25901680
GO:0045202	Component	Synapse	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0097371	Function	MDM2/MDM4 family protein binding	IPI	23874713
GO:1901798	Process	Positive regulation of signal transduction by p53 class mediator	IDA	23874713
GO:1990904	Component	Ribonucleoprotein complex	IEA
GO:1990948	Function	Ubiquitin ligase inhibitor activity	IDA	23874713

MIM	HGNC	e!Ensembl
603682	10405	ENSG00000008988

Protein

UniProt ID

P60866

Protein name

Small ribosomal subunit protein uS10 (40S ribosomal protein S20)

Protein function

Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399).

PDB

4UG0 , 4V6X , 5A2Q , 5AJ0 , 5FLX , 5LKS , 5OA3 , 5T2C , 5VYC , 6FEC , 6G51 , 6G53 , 6G5H , 6G5I , 6IP5 , 6IP6 , 6IP8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6YBS , 6Z6L , 6Z6M , 6Z6N , 6ZLW , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZMT , 6ZMW , 6ZN5 , 6ZOJ , 6ZOL , 6ZON , 6ZP4 , 6ZUO , 6ZV6 , 6ZVH , 6ZVJ , 6ZXD , 6ZXE

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00338	Ribosomal_S10	21 → 115	Ribosomal protein S10p/S20e	Family

Sequence

MAFKDTGKTPVEPEVAIHRIRITLTSRNVKSLEKVCADLIRGAKEKNLKVKGPVRMPTKT
LRITTRKTPCGEGSKTWDRFQMRIHKRLIDLHSPSEIVKQITSISIEPGVEVEVTIADA

Sequence length

119

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Show/Hide Unknown Diseases (4)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Anemia	Diamond-Blackfan anemia	N/A	N/A	GenCC
Colorectal Cancer	familial colorectal cancer, familial colorectal cancer type X	N/A	N/A	GenCC
Lynch Syndrome	Lynch syndrome	N/A	N/A	GenCC
Systemic lupus erythematosus	Systemic lupus erythematosus	N/A	N/A	GWAS

Show/Hide Text Mining Associations (18)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Alzheimer Disease	Associate	35766008
Alzheimer Disease	Inhibit	36195955
Anemia Diamond Blackfan	Associate	32790018
Breast Neoplasms	Associate	32444848
Carcinoma Hepatocellular	Associate	36378050
Carcinoma Renal Cell	Associate	36484407
Colorectal Neoplasms	Associate	24941021, 32790018, 35682850
Colorectal Neoplasms Hereditary Nonpolyposis	Associate	24941021, 35682850
COVID 19	Associate	36509426
Glioblastoma	Associate	21649900, 26506620
Infections	Associate	36509426
Kidney Neoplasms	Associate	36484407
Lymphatic Metastasis	Associate	36484407
Medulloblastoma	Associate	16968546
Neoplasms	Associate	32444848, 35682850, 36484407
Stomach Neoplasms	Associate	30061673
Venous Thromboembolism	Associate	29620629
Virus Diseases	Associate	36509426

RPS20 (ribosomal protein S20)