Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6218
Gene name Gene Name - the full gene name approved by the HGNC.	Ribosomal protein S17
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RPS17
Synonyms (NCBI Gene) Gene synonyms aliases	DBA4, RPS17L, RPS17L1, RPS17L2, S17, eS17
Disease Acronyms (UniProt) Disease acronyms from UniProt database	DBA4
Chromosome Chromosome number	15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	15q25.2
Summary Summary of gene provided in NCBI Entrez Gene.	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal

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SNP ID	Visualize variation	Clinical significance	Consequence
rs6991	A>C,G	Pathogenic, uncertain-significance	Stop gained, non coding transcript variant, coding sequence variant, synonymous variant
rs116840811	A>C	Pathogenic	Initiator codon variant, non coding transcript variant, missense variant
rs116840812	CT>-	Pathogenic	Non coding transcript variant, coding sequence variant, frameshift variant

Show/Hide all(73)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051166	hsa-miR-16-5p	CLASH	23622248
MIRT049945	hsa-miR-30a-5p	CLASH	23622248
MIRT048036	hsa-miR-148a-3p	CLASH	23622248
MIRT047810	hsa-miR-30d-5p	CLASH	23622248
MIRT046624	hsa-miR-222-3p	CLASH	23622248
MIRT044696	hsa-miR-320a	CLASH	23622248
MIRT039783	hsa-miR-615-3p	CLASH	23622248
MIRT560742	hsa-miR-5692a	PAR-CLIP	20371350
MIRT560741	hsa-miR-369-3p	PAR-CLIP	20371350
MIRT560740	hsa-miR-4687-3p	PAR-CLIP	20371350
MIRT560739	hsa-miR-4433a-5p	PAR-CLIP	20371350
MIRT560738	hsa-miR-6755-3p	PAR-CLIP	20371350
MIRT560737	hsa-miR-374c-5p	PAR-CLIP	20371350
MIRT560736	hsa-miR-655-3p	PAR-CLIP	20371350
MIRT560735	hsa-miR-4433b-5p	PAR-CLIP	20371350
MIRT560734	hsa-miR-4646-3p	PAR-CLIP	20371350
MIRT560742	hsa-miR-5692a	PAR-CLIP	20371350
MIRT560741	hsa-miR-369-3p	PAR-CLIP	20371350
MIRT560740	hsa-miR-4687-3p	PAR-CLIP	20371350
MIRT560739	hsa-miR-4433a-5p	PAR-CLIP	20371350
MIRT560738	hsa-miR-6755-3p	PAR-CLIP	20371350
MIRT560737	hsa-miR-374c-5p	PAR-CLIP	20371350
MIRT560736	hsa-miR-655-3p	PAR-CLIP	20371350
MIRT560735	hsa-miR-4433b-5p	PAR-CLIP	20371350
MIRT560734	hsa-miR-4646-3p	PAR-CLIP	20371350
MIRT560742	hsa-miR-5692a	PAR-CLIP	20371350
MIRT560741	hsa-miR-369-3p	PAR-CLIP	20371350
MIRT560740	hsa-miR-4687-3p	PAR-CLIP	20371350
MIRT560739	hsa-miR-4433a-5p	PAR-CLIP	20371350
MIRT560738	hsa-miR-6755-3p	PAR-CLIP	20371350
MIRT560737	hsa-miR-374c-5p	PAR-CLIP	20371350
MIRT560736	hsa-miR-655-3p	PAR-CLIP	20371350
MIRT560735	hsa-miR-4433b-5p	PAR-CLIP	20371350
MIRT560734	hsa-miR-4646-3p	PAR-CLIP	20371350
MIRT560742	hsa-miR-5692a	PAR-CLIP	20371350
MIRT560741	hsa-miR-369-3p	PAR-CLIP	20371350
MIRT560740	hsa-miR-4687-3p	PAR-CLIP	20371350
MIRT560739	hsa-miR-4433a-5p	PAR-CLIP	20371350
MIRT560738	hsa-miR-6755-3p	PAR-CLIP	20371350
MIRT560737	hsa-miR-374c-5p	PAR-CLIP	20371350
MIRT560736	hsa-miR-655-3p	PAR-CLIP	20371350
MIRT560735	hsa-miR-4433b-5p	PAR-CLIP	20371350
MIRT560734	hsa-miR-4646-3p	PAR-CLIP	20371350
MIRT560742	hsa-miR-5692a	PAR-CLIP	20371350
MIRT560741	hsa-miR-369-3p	PAR-CLIP	20371350
MIRT560740	hsa-miR-4687-3p	PAR-CLIP	20371350
MIRT560739	hsa-miR-4433a-5p	PAR-CLIP	20371350
MIRT560738	hsa-miR-6755-3p	PAR-CLIP	20371350
MIRT560737	hsa-miR-374c-5p	PAR-CLIP	20371350
MIRT560736	hsa-miR-655-3p	PAR-CLIP	20371350
MIRT560735	hsa-miR-4433b-5p	PAR-CLIP	20371350
MIRT560734	hsa-miR-4646-3p	PAR-CLIP	20371350
MIRT560742	hsa-miR-5692a	PAR-CLIP	20371350
MIRT560741	hsa-miR-369-3p	PAR-CLIP	20371350
MIRT560740	hsa-miR-4687-3p	PAR-CLIP	20371350
MIRT560739	hsa-miR-4433a-5p	PAR-CLIP	20371350
MIRT560738	hsa-miR-6755-3p	PAR-CLIP	20371350
MIRT560737	hsa-miR-374c-5p	PAR-CLIP	20371350
MIRT560736	hsa-miR-655-3p	PAR-CLIP	20371350
MIRT560735	hsa-miR-4433b-5p	PAR-CLIP	20371350
MIRT560734	hsa-miR-4646-3p	PAR-CLIP	20371350
MIRT1317732	hsa-miR-3120-3p	CLIP-seq
MIRT1317733	hsa-miR-3647-3p	CLIP-seq
MIRT1317734	hsa-miR-374c	CLIP-seq
MIRT1317735	hsa-miR-655	CLIP-seq
MIRT1317732	hsa-miR-3120-3p	CLIP-seq
MIRT1317733	hsa-miR-3647-3p	CLIP-seq
MIRT1317734	hsa-miR-374c	CLIP-seq
MIRT1317735	hsa-miR-655	CLIP-seq
MIRT1317732	hsa-miR-3120-3p	CLIP-seq
MIRT1317733	hsa-miR-3647-3p	CLIP-seq
MIRT1317734	hsa-miR-374c	CLIP-seq
MIRT1317735	hsa-miR-655	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003735	Function	Structural constituent of ribosome	HDA	15883184
GO:0003735	Function	Structural constituent of ribosome	IMP	18697920
GO:0003735	Function	Structural constituent of ribosome	NAS	17647292, 18412286
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	NAS	3240863
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006364	Process	RRNA processing	IMP	18697920
GO:0006412	Process	Translation	IC	8706699
GO:0006413	Process	Translational initiation	NAS	17647292
GO:0006413	Process	Translational initiation	TAS
GO:0006614	Process	SRP-dependent cotranslational protein targeting to membrane	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0019083	Process	Viral transcription	TAS
GO:0022627	Component	Cytosolic small ribosomal subunit	HDA	15883184
GO:0022627	Component	Cytosolic small ribosomal subunit	IDA	8706699
GO:0034101	Process	Erythrocyte homeostasis	IMP	17647292
GO:0042274	Process	Ribosomal small subunit biogenesis	IMP	18697920

MIM	HGNC	e!Ensembl
180472	10397	ENSG00000182774

Protein

UniProt ID

P08708

Protein name

Small ribosomal subunit protein eS17 (40S ribosomal protein S17)

Protein function

Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of

PDB

4UG0 , 4V6X , 5A2Q , 5AJ0 , 5FLX , 5LKS , 5OA3 , 5T2C , 5VYC , 6FEC , 6G18 , 6G4S , 6G4W , 6G51 , 6G53 , 6G5H , 6G5I , 6IP5 , 6IP6 , 6IP8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6YBD , 6YBS , 6YBW , 6Z6L , 6Z6M , 6Z6N , 6ZLW , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZMT , 6ZMW , 6ZN5 , 6ZOJ , 6ZOK , 6ZOL , 6ZON , 6ZP4

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00833	Ribosomal_S17e	1 → 122	Ribosomal S17	Family

Sequence

MGRVRTKTVKKAARVIIEKYYTRLGNDFHTNKRVCEEIAIIPSKKLRNKIAGYVTHLMKR
IQRGPVRGISIKLQEEERERRDNYVPEVSALDQEIIEVDPDTKEMLKLLDFGSLSNLQVT
QPTVGMNFKTPRGPV

Sequence length

135

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Show/Hide Causal Diseases (6)

Disease term	Disease name	dbSNP ID	References
Causal
Anemia	Anemia, Macrocytic, Anemia, Diamond-Blackfan	rs118204044, rs118204045, rs118204046, rs121918330, rs869320719, rs869312029, rs121918332, rs869320724, rs767094129, rs786205058, rs786205059, rs137853119, rs137853120, rs137853121, rs1384933966 View all (89 more)	17647292, 28297620
Atrial septal defect	Atrial Septal Defects	rs137852951, rs137852953, rs137852955, rs267607106, rs104893900, rs104893901, rs104893903, rs606231358, rs606231359, rs137852683, rs606231360, rs104893907, rs104894073, rs1585703301, rs104894074 View all (25 more)
Diamond-blackfan anemia	Diamond-Blackfan Anemia 4	rs121434389, rs1570566590, rs151155897, rs143951267, rs267607023, rs786200892, rs148622862, rs397507554, rs121434405, rs1571026775, rs142156224, rs267607021, rs1581931541, rs267607022, rs61762293 View all (76 more)	22045982, 23812780, 19061985
Leukemia	Acute leukemia	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297
Migraine	Migraine Disorders	rs794727411
Neutropenia	Neutropenia	rs879253882

Show/Hide Text Mining Associations (18)

Disease Name	Relationship Type	References
Associations from Text Mining
Alzheimer Disease	Associate	34225819
Amyotrophic Lateral Sclerosis	Associate	28328930
Anemia	Associate	25853866
Anemia Diamond Blackfan	Associate	18535205, 19061985, 19765279, 19773262, 20116044, 20378560, 20921022, 22045982, 22262766, 22689679, 23812780, 24675553, 25853866, 25946618
Bone Marrow Diseases	Associate	25853866
Colonic Neoplasms	Associate	35712285
Congenital Hereditary and Neonatal Diseases and Abnormalities	Associate	19773262
COVID 19	Associate	35558576
Growth Disorders	Associate	22262766
Hematologic Neoplasms	Associate	8387429
Hepatitis E	Associate	25853866
Infections	Associate	25853866
Lupus Erythematosus Systemic	Associate	35558576
Microsatellite Instability	Associate	30664178
Mouth Neoplasms	Associate	27411053
Myotonic Dystrophy	Associate	19605641
Neoplasms	Associate	27411053
Polycystic Ovary Syndrome	Associate	32729067

RPS17 (ribosomal protein S17)