Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6210
Gene name	Ribosomal protein S15a
Gene symbol	RPS15A
Synonyms (NCBI Gene)	DBA20S15auS8
Chromosome	16
Chromosome location	16p12.3
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1567287990	C>T	Pathogenic	Synonymous variant, coding sequence variant

143

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miRTarBase ID	miRNA	Experiments	Reference
MIRT052449	hsa-let-7a-5p	CLASH	23622248
MIRT050832	hsa-miR-17-5p	CLASH	23622248
MIRT049566	hsa-miR-92a-3p	CLASH	23622248
MIRT048568	hsa-miR-100-5p	CLASH	23622248
MIRT046168	hsa-miR-27b-3p	CLASH	23622248
MIRT038026	hsa-miR-423-5p	CLASH	23622248
MIRT037867	hsa-miR-455-3p	CLASH	23622248
MIRT632485	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT632484	hsa-miR-5197-5p	HITS-CLIP	23824327
MIRT632483	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT632482	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT632481	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT632480	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT632479	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT632478	hsa-miR-3666	HITS-CLIP	23824327
MIRT632477	hsa-miR-4295	HITS-CLIP	23824327
MIRT632476	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT632475	hsa-miR-183-5p	HITS-CLIP	23824327
MIRT632474	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT632473	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT632472	hsa-miR-3135b	HITS-CLIP	23824327
MIRT632471	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT632470	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT632469	hsa-miR-3652	HITS-CLIP	23824327
MIRT632468	hsa-miR-4430	HITS-CLIP	23824327
MIRT632467	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT574500	hsa-miR-496	PAR-CLIP	20371350
MIRT574499	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT574497	hsa-miR-6504-3p	PAR-CLIP	20371350
MIRT574498	hsa-miR-1827	PAR-CLIP	20371350
MIRT574495	hsa-miR-3924	PAR-CLIP	20371350
MIRT542716	hsa-miR-3609	PAR-CLIP	21572407
MIRT542717	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT542715	hsa-miR-6732-3p	PAR-CLIP	21572407
MIRT542714	hsa-miR-10a-5p	PAR-CLIP	21572407
MIRT542713	hsa-miR-10b-5p	PAR-CLIP	21572407
MIRT542712	hsa-miR-520g-3p	PAR-CLIP	21572407
MIRT542711	hsa-miR-520h	PAR-CLIP	21572407
MIRT542710	hsa-miR-3065-5p	PAR-CLIP	21572407
MIRT542709	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT542708	hsa-miR-339-5p	PAR-CLIP	21572407
MIRT542707	hsa-miR-939-3p	PAR-CLIP	21572407
MIRT542706	hsa-miR-4421	PAR-CLIP	21572407
MIRT542705	hsa-miR-5699-3p	PAR-CLIP	21572407
MIRT542704	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT542703	hsa-miR-7110-3p	PAR-CLIP	21572407
MIRT542702	hsa-miR-6817-3p	PAR-CLIP	21572407
MIRT542701	hsa-miR-1285-3p	PAR-CLIP	21572407
MIRT542700	hsa-miR-3187-5p	PAR-CLIP	21572407
MIRT542699	hsa-miR-5189-5p	PAR-CLIP	21572407
MIRT542698	hsa-miR-612	PAR-CLIP	21572407
MIRT542697	hsa-miR-6860	PAR-CLIP	21572407
MIRT542696	hsa-miR-661	PAR-CLIP	21572407
MIRT542695	hsa-miR-196a-3p	PAR-CLIP	21572407
MIRT542694	hsa-miR-6895-3p	PAR-CLIP	21572407
MIRT542693	hsa-miR-593-3p	PAR-CLIP	21572407
MIRT542692	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT542691	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT542690	hsa-miR-6873-3p	PAR-CLIP	21572407
MIRT542689	hsa-miR-6818-3p	PAR-CLIP	21572407
MIRT496153	hsa-miR-4330	PAR-CLIP	22291592
MIRT496152	hsa-miR-4680-5p	PAR-CLIP	22291592
MIRT496151	hsa-miR-3119	PAR-CLIP	22291592
MIRT496150	hsa-miR-7158-3p	PAR-CLIP	22291592
MIRT496149	hsa-miR-203b-3p	PAR-CLIP	22291592
MIRT449079	hsa-miR-548l	PAR-CLIP	22100165
MIRT449078	hsa-miR-4428	PAR-CLIP	22100165
MIRT449077	hsa-miR-3173-3p	PAR-CLIP	22100165
MIRT449076	hsa-miR-6891-5p	PAR-CLIP	22100165
MIRT449075	hsa-miR-3664-3p	PAR-CLIP	22100165
MIRT449074	hsa-miR-1266-5p	PAR-CLIP	22100165
MIRT449073	hsa-miR-4518	PAR-CLIP	22100165
MIRT449072	hsa-miR-488-3p	PAR-CLIP	22100165
MIRT632485	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT632484	hsa-miR-5197-5p	HITS-CLIP	23824327
MIRT632483	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT632482	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT632481	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT632480	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT632479	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT632478	hsa-miR-3666	HITS-CLIP	23824327
MIRT632477	hsa-miR-4295	HITS-CLIP	23824327
MIRT632476	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT632475	hsa-miR-183-5p	HITS-CLIP	23824327
MIRT632474	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT632473	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT632472	hsa-miR-3135b	HITS-CLIP	23824327
MIRT632471	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT632470	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT632469	hsa-miR-3652	HITS-CLIP	23824327
MIRT632468	hsa-miR-4430	HITS-CLIP	23824327
MIRT632467	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT574500	hsa-miR-496	PAR-CLIP	20371350
MIRT574499	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT574497	hsa-miR-6504-3p	PAR-CLIP	20371350
MIRT574498	hsa-miR-1827	PAR-CLIP	20371350
MIRT574495	hsa-miR-3924	PAR-CLIP	20371350
MIRT542716	hsa-miR-3609	PAR-CLIP	21572407
MIRT542717	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT542715	hsa-miR-6732-3p	PAR-CLIP	21572407
MIRT542714	hsa-miR-10a-5p	PAR-CLIP	21572407
MIRT542713	hsa-miR-10b-5p	PAR-CLIP	21572407
MIRT542712	hsa-miR-520g-3p	PAR-CLIP	21572407
MIRT542711	hsa-miR-520h	PAR-CLIP	21572407
MIRT542710	hsa-miR-3065-5p	PAR-CLIP	21572407
MIRT542709	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT542708	hsa-miR-339-5p	PAR-CLIP	21572407
MIRT542707	hsa-miR-939-3p	PAR-CLIP	21572407
MIRT542706	hsa-miR-4421	PAR-CLIP	21572407
MIRT542705	hsa-miR-5699-3p	PAR-CLIP	21572407
MIRT542704	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT542703	hsa-miR-7110-3p	PAR-CLIP	21572407
MIRT542702	hsa-miR-6817-3p	PAR-CLIP	21572407
MIRT542701	hsa-miR-1285-3p	PAR-CLIP	21572407
MIRT542700	hsa-miR-3187-5p	PAR-CLIP	21572407
MIRT542699	hsa-miR-5189-5p	PAR-CLIP	21572407
MIRT542698	hsa-miR-612	PAR-CLIP	21572407
MIRT542697	hsa-miR-6860	PAR-CLIP	21572407
MIRT542696	hsa-miR-661	PAR-CLIP	21572407
MIRT542695	hsa-miR-196a-3p	PAR-CLIP	21572407
MIRT542694	hsa-miR-6895-3p	PAR-CLIP	21572407
MIRT542693	hsa-miR-593-3p	PAR-CLIP	21572407
MIRT542692	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT542691	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT542690	hsa-miR-6873-3p	PAR-CLIP	21572407
MIRT542689	hsa-miR-6818-3p	PAR-CLIP	21572407
MIRT496153	hsa-miR-4330	PAR-CLIP	22291592
MIRT496152	hsa-miR-4680-5p	PAR-CLIP	22291592
MIRT496151	hsa-miR-3119	PAR-CLIP	22291592
MIRT496150	hsa-miR-7158-3p	PAR-CLIP	22291592
MIRT496149	hsa-miR-203b-3p	PAR-CLIP	22291592
MIRT449079	hsa-miR-548l	PAR-CLIP	22100165
MIRT449078	hsa-miR-4428	PAR-CLIP	22100165
MIRT449077	hsa-miR-3173-3p	PAR-CLIP	22100165
MIRT449076	hsa-miR-6891-5p	PAR-CLIP	22100165
MIRT449075	hsa-miR-3664-3p	PAR-CLIP	22100165
MIRT449074	hsa-miR-1266-5p	PAR-CLIP	22100165
MIRT449073	hsa-miR-4518	PAR-CLIP	22100165
MIRT449072	hsa-miR-488-3p	PAR-CLIP	22100165
MIRT1317715	hsa-miR-29a	CLIP-seq
MIRT1317716	hsa-miR-29b	CLIP-seq
MIRT1317717	hsa-miR-29c	CLIP-seq
MIRT1317718	hsa-miR-671-5p	CLIP-seq

Show/Hide all (34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	NAS	9582194
GO:0003735	Function	Structural constituent of ribosome	HDA	15883184
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	9582194
GO:0005515	Function	Protein binding	IPI	24965446, 32814053
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IDA	15108328
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0006412	Process	Translation	IC	8706699, 15883184
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	9582194
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	15108328
GO:0009615	Process	Response to virus	IDA	15108328
GO:0016020	Component	Membrane	HDA	19946888
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0022627	Component	Cytosolic small ribosomal subunit	HDA	15883184
GO:0022627	Component	Cytosolic small ribosomal subunit	IBA
GO:0022627	Component	Cytosolic small ribosomal subunit	IDA	8706699
GO:0022627	Component	Cytosolic small ribosomal subunit	NAS	25901680
GO:0032040	Component	Small-subunit processome	IDA	34516797
GO:0042274	Process	Ribosomal small subunit biogenesis	IDA	34516797
GO:0045787	Process	Positive regulation of cell cycle	IDA	15108328
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
603674	10389	ENSG00000134419

P62244

Protein name

Small ribosomal subunit protein uS8 (40S ribosomal protein S15a)

Protein function

Component of the small ribosomal subunit (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenes

PDB

4UG0 , 4V6X , 5A2Q , 5AJ0 , 5FLX , 5LKS , 5OA3 , 5T2C , 5VYC , 6FEC , 6G18 , 6G4S , 6G4W , 6G51 , 6G53 , 6G5H , 6G5I , 6IP5 , 6IP6 , 6IP8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6YBW , 6Z6L , 6Z6M , 6Z6N , 6ZLW , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZMT , 6ZMW , 6ZN5 , 6ZOJ , 6ZOK , 6ZON , 6ZP4 , 6ZUO , 6ZV6 , 6ZVH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00410	Ribosomal_S8	5 → 130	Ribosomal protein S8	Domain

Sequence

MVRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVRFLTVMMKHGYIGEFEIIDDHRAGK
IVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLLPSRQFGFIVLTTSAGIMDHEEARRKH
TGGKILGFFF

Sequence length

130

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Diamond-Blackfan anemia 20	Pathogenic	rs1567287990	RCV000754827

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	25833696
Anemia Diamond Blackfan	Associate	20116044
Carcinogenesis	Associate	25833696
Glioblastoma	Associate	27130037
Lung Neoplasms	Stimulate	25833696
Neoplasm Metastasis	Associate	38063205
Neoplasms	Associate	27130037
Osteosarcoma	Associate	25409460
Polycystic Ovary Syndrome	Associate	33622336
Squamous Cell Carcinoma of Head and Neck	Associate	38063205

RPS15A (ribosomal protein S15a)