Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6209
Gene name	Ribosomal protein S15
Gene symbol	RPS15
Synonyms (NCBI Gene)	RIGS15uS19
Chromosome	19
Chromosome location	19p13.3
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

Show/Hide all (19)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022282	hsa-miR-124-3p	Proteomics	18668037
MIRT049096	hsa-miR-92a-3p	CLASH	23622248
MIRT048661	hsa-miR-99a-5p	CLASH	23622248
MIRT048590	hsa-miR-100-5p	CLASH	23622248
MIRT041653	hsa-miR-484	CLASH	23622248
MIRT041056	hsa-miR-505-3p	CLASH	23622248
MIRT040870	hsa-miR-18a-3p	CLASH	23622248
MIRT039745	hsa-miR-615-3p	CLASH	23622248
MIRT036366	hsa-miR-1229-3p	CLASH	23622248
MIRT052682	hsa-miR-1260b	CLASH	23622248
MIRT1317712	hsa-miR-3607-5p	CLIP-seq
MIRT1317713	hsa-miR-4663	CLIP-seq
MIRT1317714	hsa-miR-933	CLIP-seq
MIRT1317712	hsa-miR-3607-5p	CLIP-seq
MIRT1317713	hsa-miR-4663	CLIP-seq
MIRT1317714	hsa-miR-933	CLIP-seq
MIRT1317712	hsa-miR-3607-5p	CLIP-seq
MIRT1317713	hsa-miR-4663	CLIP-seq
MIRT1317714	hsa-miR-933	CLIP-seq

Show/Hide all (41)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000028	Process	Ribosomal small subunit assembly	IEA
GO:0000056	Process	Ribosomal small subunit export from nucleus	IMP	16037817
GO:0001649	Process	Osteoblast differentiation	HDA	16210410
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003677	Function	DNA binding	NAS	2159154, 2821540
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003735	Function	Structural constituent of ribosome	HDA	15883184
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	IMP	18697920
GO:0005515	Function	Protein binding	IPI	24725412, 24947832, 25416956, 26824392, 32814053
GO:0005634	Component	Nucleus	NAS	2159154, 2821540
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	NAS	16037817
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006364	Process	RRNA processing	IMP	18697920
GO:0006412	Process	Translation	IC	8706699, 15883184
GO:0006412	Process	Translation	IEA
GO:0015935	Component	Small ribosomal subunit	IEA
GO:0016020	Component	Membrane	HDA	16210410, 19946888
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0022627	Component	Cytosolic small ribosomal subunit	HDA	15883184
GO:0022627	Component	Cytosolic small ribosomal subunit	IBA
GO:0022627	Component	Cytosolic small ribosomal subunit	IDA	8706699
GO:0022627	Component	Cytosolic small ribosomal subunit	IEA
GO:0022627	Component	Cytosolic small ribosomal subunit	NAS	25901680
GO:0042274	Process	Ribosomal small subunit biogenesis	IMP	18697920
GO:0045202	Component	Synapse	IEA
GO:0097371	Function	MDM2/MDM4 family protein binding	IPI	23874713
GO:0097421	Process	Liver regeneration	IEA
GO:1901798	Process	Positive regulation of signal transduction by p53 class mediator	IDA	23874713
GO:1990904	Component	Ribonucleoprotein complex	IEA
GO:1990948	Function	Ubiquitin ligase inhibitor activity	IDA	23874713

MIM	HGNC	e!Ensembl
180535	10388	ENSG00000115268

P62841

Protein name

Small ribosomal subunit protein uS19 (40S ribosomal protein S15) (RIG protein)

Protein function

Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399).

PDB

4UG0 , 4V6X , 5A2Q , 5AJ0 , 5FLX , 5LKS , 5OA3 , 5T2C , 5VYC , 6FEC , 6G18 , 6G4S , 6G4W , 6G51 , 6G53 , 6G5H , 6G5I , 6IP5 , 6IP6 , 6IP8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6YBS , 6Z6L , 6Z6M , 6Z6N , 6ZLW , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZMT , 6ZMW , 6ZN5 , 6ZOJ , 6ZOL , 6ZON , 6ZP4 , 6ZUO , 6ZV6 , 6ZVH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00203	Ribosomal_S19	43 → 128	Ribosomal protein S19	Domain

Sequence

MAEVEQKKKRTFRKFTYRGVDLDQLLDMSYEQLMQLYSARQRRRLNRGLRRKQHSLLKRL
RKAKKEAPPMEKPEVVKTHLRDMIILPEMVGSMVGVYNGKTFNQVEIKPEMIGHYLGEFS
ITYKPVKHGRPGIGATHSSRFIPLK

Sequence length

145

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
RPS15-related disorder	Likely benign; Benign	rs367617949, rs778995103, rs201657403	RCV003922006 RCV003944321 RCV003900061

Show/Hide Text Mining Associations (17)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Cerebral Infarction	Associate	37322932, 37603533
COVID 19	Associate	36509426
Disease	Associate	30181176
Esophageal Squamous Cell Carcinoma	Associate	37264021
Hepatomegaly	Associate	37603533
Infertility Male	Associate	36369953
Inflammation	Associate	32330594
Kidney Diseases	Associate	37603533
Klinefelter Syndrome	Associate	35622500
Leukemia Lymphocytic Chronic B Cell	Associate	26675346, 30181176, 33054084, 34251413, 37955424
Leukemia Prolymphocytic T Cell	Associate	26466571, 35438042
Liver Failure	Associate	37603533
Necrosis	Associate	37603533
Neoplasm Metastasis	Associate	37264021
Neoplasms	Associate	26466571, 32330594, 37603533
Polycystic Ovary Syndrome	Associate	33622336
Virus Diseases	Associate	36509426

RPS15 (ribosomal protein S15)