Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6204
Gene name	Ribosomal protein S10
Gene symbol	RPS10
Synonyms (NCBI Gene)	DBA9S10eS10
Chromosome	6
Chromosome location	6p21.31
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

Show/Hide all (20)

miRTarBase ID	miRNA	Experiments	Reference
MIRT052450	hsa-let-7a-5p	CLASH	23622248
MIRT050485	hsa-miR-20a-5p	CLASH	23622248
MIRT049763	hsa-miR-92a-3p	CLASH	23622248
MIRT044184	hsa-miR-99b-5p	CLASH	23622248
MIRT041658	hsa-miR-484	CLASH	23622248
MIRT041658	hsa-miR-484	CLASH	23622248
MIRT041482	hsa-miR-193b-3p	CLASH	23622248
MIRT039432	hsa-miR-421	CLASH	23622248
MIRT038039	hsa-miR-423-5p	CLASH	23622248
MIRT036090	hsa-miR-1296-5p	CLASH	23622248
MIRT052799	hsa-miR-3176	CLASH	23622248
MIRT1317623	hsa-miR-129-5p	CLIP-seq
MIRT1317624	hsa-miR-186	CLIP-seq
MIRT1317625	hsa-miR-3183	CLIP-seq
MIRT1317626	hsa-miR-4272	CLIP-seq
MIRT1317627	hsa-miR-4687-3p	CLIP-seq
MIRT1317628	hsa-miR-4723-3p	CLIP-seq
MIRT1317629	hsa-miR-515-5p	CLIP-seq
MIRT1317630	hsa-miR-647	CLIP-seq
MIRT1317626	hsa-miR-4272	CLIP-seq

Show/Hide all (31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003735	Function	Structural constituent of ribosome	HDA	15883184
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0005515	Function	Protein binding	IPI	20159986, 28065601, 28132843, 30021884, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA	20159986
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005840	Component	Ribosome	NAS	7772601
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	IC	8706699, 15883184
GO:0016020	Component	Membrane	HDA	19946888
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0022626	Component	Cytosolic ribosome	IEA
GO:0022627	Component	Cytosolic small ribosomal subunit	HDA	15883184
GO:0022627	Component	Cytosolic small ribosomal subunit	IBA
GO:0022627	Component	Cytosolic small ribosomal subunit	IDA	8706699
GO:0022627	Component	Cytosolic small ribosomal subunit	IEA
GO:0022627	Component	Cytosolic small ribosomal subunit	NAS	25901680
GO:0045202	Component	Synapse	IEA
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
603632	10383	ENSG00000124614

P46783

Protein name

Small ribosomal subunit protein eS10 (40S ribosomal protein S10)

Protein function

Component of the 40S ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399).

PDB

4UG0 , 4V6X , 5A2Q , 5AJ0 , 5FLX , 5LKS , 5OA3 , 5T2C , 5VYC , 6FEC , 6G51 , 6G53 , 6G5H , 6G5I , 6IP5 , 6IP6 , 6IP8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6YBS , 6Z6L , 6Z6M , 6Z6N , 6ZLW , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZMT , 6ZMW , 6ZN5 , 6ZOJ , 6ZOL , 6ZON , 6ZP4 , 6ZUO , 6ZV6 , 6ZVH , 6ZVJ , 6ZXD , 6ZXE

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03501	S10_plectin	3 → 98	Plectin/S10 domain	Domain

Sequence

MLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQSLKSRGYVKE
QFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRRSRPETGRPRPKGLEGERPARLTRG
EADRDTYRRSAVPPGADKKAEAGAGSATEFQFRGGFGRGRGQPPQ

Sequence length

165

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

150

Show/Hide Causal Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Diamond-Blackfan anemia	Pathogenic; Likely pathogenic	rs2113806114, rs2533030608, rs267607022, rs1581931439, rs1765648528	RCV001381292 RCV002428903 RCV001851701 RCV000809206 RCV001035752
Diamond-Blackfan anemia 9	Pathogenic	rs2533030608, rs267607021, rs1581931541, rs267607022	RCV005252150 RCV000006562 RCV000006563 RCV000006564
RPS10-related disorder	Likely pathogenic	rs2533019856	RCV003400021

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Alzheimer Disease	Associate	30040709
Anemia Diamond Blackfan	Associate	20116044, 22262766, 24675553, 25946618
Hereditary Breast and Ovarian Cancer Syndrome	Associate	30206415
Lymphoma Large Cell Anaplastic	Associate	30206415
Neoplasms	Associate	30607635
Neurodegenerative Diseases	Associate	30040709
Obesity	Associate	26449484
Sarcopenia	Associate	35241739

RPS10 (ribosomal protein S10)