RPS9 (ribosomal protein S9)

Gene

• Entrez ID: 6203
• Gene name: Ribosomal protein S9
• Gene symbol: RPS9
• Synonyms (NCBI Gene): S9, uS4
• Chromosome: 19
• Chromosome location: 19q13.42
• Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT047594	hsa-miR-10a-5p	CLASH	23622248
MIRT047453	hsa-miR-10b-5p	CLASH	23622248
MIRT045647	hsa-miR-149-5p	CLASH	23622248
MIRT043770	hsa-miR-328-3p	CLASH	23622248
MIRT043674	hsa-miR-342-3p	CLASH	23622248
MIRT043338	hsa-miR-331-3p	CLASH	23622248
MIRT042287	hsa-miR-484	CLASH	23622248
MIRT039014	hsa-miR-766-3p	CLASH	23622248
MIRT038095	hsa-miR-423-5p	CLASH	23622248
MIRT036686	hsa-miR-935	CLASH	23622248
MIRT036124	hsa-miR-1296-5p	CLASH	23622248
MIRT716365	hsa-miR-5088-3p	HITS-CLIP	19536157
MIRT716364	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT716363	hsa-miR-1248	HITS-CLIP	19536157
MIRT716362	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT721078	hsa-miR-412-3p	HITS-CLIP	19536157
MIRT721077	hsa-miR-6754-3p	HITS-CLIP	19536157
MIRT721076	hsa-miR-6837-3p	HITS-CLIP	19536157
MIRT716360	hsa-miR-1256	HITS-CLIP	19536157
MIRT716358	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT716357	hsa-miR-6780a-3p	HITS-CLIP	19536157
MIRT716356	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT716355	hsa-miR-4642	HITS-CLIP	19536157
MIRT716354	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT716365	hsa-miR-5088-3p	HITS-CLIP	19536157
MIRT716364	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT716363	hsa-miR-1248	HITS-CLIP	19536157
MIRT716362	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT716361	hsa-miR-6886-3p	HITS-CLIP	19536157
MIRT716360	hsa-miR-1256	HITS-CLIP	19536157
MIRT716359	hsa-miR-6851-3p	HITS-CLIP	19536157
MIRT716358	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT716357	hsa-miR-6780a-3p	HITS-CLIP	19536157
MIRT716356	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT716355	hsa-miR-4642	HITS-CLIP	19536157
MIRT716354	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT526722	hsa-miR-6888-5p	PAR-CLIP	22012620
MIRT526721	hsa-miR-153-3p	PAR-CLIP	22012620
MIRT716365	hsa-miR-5088-3p	HITS-CLIP	19536157
MIRT716364	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT716363	hsa-miR-1248	HITS-CLIP	19536157
MIRT716362	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT721078	hsa-miR-412-3p	HITS-CLIP	19536157
MIRT721077	hsa-miR-6754-3p	HITS-CLIP	19536157
MIRT721076	hsa-miR-6837-3p	HITS-CLIP	19536157
MIRT716360	hsa-miR-1256	HITS-CLIP	19536157
MIRT716358	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT716357	hsa-miR-6780a-3p	HITS-CLIP	19536157
MIRT716356	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT716355	hsa-miR-4642	HITS-CLIP	19536157
MIRT716354	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT716365	hsa-miR-5088-3p	HITS-CLIP	19536157
MIRT716364	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT716363	hsa-miR-1248	HITS-CLIP	19536157
MIRT716362	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT716361	hsa-miR-6886-3p	HITS-CLIP	19536157
MIRT716360	hsa-miR-1256	HITS-CLIP	19536157
MIRT716359	hsa-miR-6851-3p	HITS-CLIP	19536157
MIRT716358	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT716357	hsa-miR-6780a-3p	HITS-CLIP	19536157
MIRT716356	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT716355	hsa-miR-4642	HITS-CLIP	19536157
MIRT716354	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT526722	hsa-miR-6888-5p	PAR-CLIP	22012620
MIRT526721	hsa-miR-153-3p	PAR-CLIP	22012620
MIRT1319033	hsa-miR-1207-5p	CLIP-seq
MIRT1319034	hsa-miR-1271	CLIP-seq
MIRT1319035	hsa-miR-182	CLIP-seq
MIRT1319036	hsa-miR-3126-5p	CLIP-seq
MIRT1319037	hsa-miR-338-3p	CLIP-seq
MIRT1319038	hsa-miR-4459	CLIP-seq
MIRT1319039	hsa-miR-4530	CLIP-seq
MIRT1319040	hsa-miR-4690-3p	CLIP-seq
MIRT1319041	hsa-miR-4736	CLIP-seq
MIRT1319042	hsa-miR-4763-3p	CLIP-seq
MIRT1319043	hsa-miR-4779	CLIP-seq
MIRT1319044	hsa-miR-518a-3p	CLIP-seq
MIRT1319045	hsa-miR-518b	CLIP-seq
MIRT1319046	hsa-miR-518c	CLIP-seq
MIRT1319047	hsa-miR-518d-3p	CLIP-seq
MIRT1319048	hsa-miR-518e	CLIP-seq
MIRT1319049	hsa-miR-518f	CLIP-seq
MIRT1319050	hsa-miR-548ad	CLIP-seq
MIRT1319051	hsa-miR-552	CLIP-seq
MIRT1319052	hsa-miR-665	CLIP-seq
MIRT1319053	hsa-miR-96	CLIP-seq
MIRT1319033	hsa-miR-1207-5p	CLIP-seq
MIRT1319034	hsa-miR-1271	CLIP-seq
MIRT1319035	hsa-miR-182	CLIP-seq
MIRT1319041	hsa-miR-4736	CLIP-seq
MIRT1319042	hsa-miR-4763-3p	CLIP-seq
MIRT1319044	hsa-miR-518a-3p	CLIP-seq
MIRT1319045	hsa-miR-518b	CLIP-seq
MIRT1319046	hsa-miR-518c	CLIP-seq
MIRT1319047	hsa-miR-518d-3p	CLIP-seq
MIRT1319048	hsa-miR-518e	CLIP-seq
MIRT1319049	hsa-miR-518f	CLIP-seq
MIRT1319050	hsa-miR-548ad	CLIP-seq
MIRT1319053	hsa-miR-96	CLIP-seq
MIRT1319033	hsa-miR-1207-5p	CLIP-seq
MIRT1319034	hsa-miR-1271	CLIP-seq
MIRT1319035	hsa-miR-182	CLIP-seq
MIRT1319036	hsa-miR-3126-5p	CLIP-seq
MIRT1319037	hsa-miR-338-3p	CLIP-seq
MIRT1319038	hsa-miR-4459	CLIP-seq
MIRT1319039	hsa-miR-4530	CLIP-seq
MIRT1319040	hsa-miR-4690-3p	CLIP-seq
MIRT1319041	hsa-miR-4736	CLIP-seq
MIRT1319042	hsa-miR-4763-3p	CLIP-seq
MIRT1319043	hsa-miR-4779	CLIP-seq
MIRT1319050	hsa-miR-548ad	CLIP-seq
MIRT1319051	hsa-miR-552	CLIP-seq
MIRT1319052	hsa-miR-665	CLIP-seq
MIRT1319053	hsa-miR-96	CLIP-seq
MIRT1319033	hsa-miR-1207-5p	CLIP-seq
MIRT1319034	hsa-miR-1271	CLIP-seq
MIRT1319035	hsa-miR-182	CLIP-seq
MIRT1319037	hsa-miR-338-3p	CLIP-seq
MIRT1319039	hsa-miR-4530	CLIP-seq
MIRT1319041	hsa-miR-4736	CLIP-seq
MIRT1319042	hsa-miR-4763-3p	CLIP-seq
MIRT1319050	hsa-miR-548ad	CLIP-seq
MIRT1319053	hsa-miR-96	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003735	Function	Structural constituent of ribosome	HDA	15883184
GO:0003735	Function	Structural constituent of ribosome	IBA	21873635
GO:0005515	Function	Protein binding	IPI	18420587, 21988832
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA	18420587
GO:0005737	Component	Cytoplasm	IDA	18420587
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	NAS	7772601
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006364	Process	RRNA processing	TAS
GO:0006412	Process	Translation	IC	8706699, 15883184
GO:0006412	Process	Translation	IMP	18420587
GO:0006413	Process	Translational initiation	TAS
GO:0006614	Process	SRP-dependent cotranslational protein targeting to membrane	TAS
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	18420587
GO:0015935	Component	Small ribosomal subunit	IBA	21873635
GO:0016020	Component	Membrane	HDA	19946888
GO:0019083	Process	Viral transcription	TAS
GO:0019843	Function	RRNA binding	IBA	21873635
GO:0022627	Component	Cytosolic small ribosomal subunit	HDA	15883184
GO:0022627	Component	Cytosolic small ribosomal subunit	IBA	21873635
GO:0022627	Component	Cytosolic small ribosomal subunit	IDA	8706699
GO:0045182	Function	Translation regulator activity	IMP	18420587
GO:0045202	Component	Synapse	IEA
GO:0045903	Process	Positive regulation of translational fidelity	IBA	21873635
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:1990904	Component	Ribonucleoprotein complex	IDA	17289661

Other IDs

• MIM: 603631
• HGNC: 10442
• e!Ensembl: ENSG00000170889

Protein

• UniProt ID: P46781
• Protein name: Small ribosomal subunit protein uS4 (40S ribosomal protein S9)
• Protein function: Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of
• PDB: 4UG0, 4V6X, 5A2Q, 5AJ0, 5FLX, 5LKS, 5OA3, 5T2C, 5VYC, 6FEC, 6G18, 6G4S, 6G4W, 6G51, 6G53, 6G5H, 6G5I, 6IP5, 6IP6, 6IP8, 6OLE, 6OLF, 6OLG, 6OLI, 6OLZ, 6OM0, 6OM7, 6QZP, 6XA1, 6Y0G, 6Y2L, 6Y57, 6YBW, 6Z6L, 6Z6M, 6Z6N, 6ZLW, 6ZM7, 6ZME, 6ZMI, 6ZMO, 6ZMT, 6ZMW, 6ZN5, 6ZOJ, 6ZOK, 6ZON, 6ZP4, 6ZUO, 6ZV6, 6ZVH
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00163	Ribosomal_S4	9 → 107	Ribosomal protein S4/S9 N-terminal domain	Family
  PF01479	S4	108 → 154	S4 domain	Domain

• Sequence:

  MPVARSWVCRKTYVTPRRPFEKSRLDQELKLIGEYGLRNKREVWRVKFTLAKIRKAAREL
  LTLDEKDPRRLFEGNALLRRLVRIGVLDEGKMKLDYILGLKIEDFLERRLQTQVFKLGLA
  KSIHHARVLIRQRHIRVRKQVVNIPSFIVRLDSQKHIDFSLRSPYGGGRPGRVKRKNAKK
  GQGGAGAGDDEEED

• Sequence length: 194

Pathways

KEGG:

Ribosome
Coronavirus disease - COVID-19

Reactome:

L13a-mediated translational silencing of Ceruloplasmin expression
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Major pathway of rRNA processing in the nucleolus and cytosol
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243

Unknown
Disease term	Disease name	Evidence	References	Source
Takayasu Arteritis	Takayasu Arteritis			GWAS
Crohn Disease	Crohn Disease			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Breast Neoplasms	Associate	29081411, 33305312
Carcinoma Squamous Cell	Associate	24457517
Colorectal Neoplasms	Associate	24009741
Glioma	Associate	20221446
Head and Neck Neoplasms	Associate	31159745
Leukemia Myeloid Acute	Associate	35035819
Light Fixation Seizure Syndrome	Associate	24009741
Microsatellite Instability	Associate	30664178
Neoplasms	Associate	20221446
Retinitis Pigmentosa 11	Associate	9802568
Takayasu Arteritis	Associate	25604533, 27769046, 28756073
Triple Negative Breast Neoplasms	Associate	33305312