RPS7 (ribosomal protein S7)

Gene Gene information from NCBI Gene database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 6201
Gene name Ribosomal protein S7
Gene symbol RPS7
Synonyms (NCBI Gene)
DBA8S7eS7
Chromosome 2
Chromosome location 2p25.3
Summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro
SNPs SNP information provided by dbSNP.
3
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (3)
SNP ID Visualize variation Clinical significance Consequence
rs397507554 G>A Pathogenic Splice donor variant
rs1057519624 G>T Pathogenic Splice acceptor variant
rs1572360944 T>G Likely-pathogenic Intron variant
miRNA miRNA information provided by mirtarbase database.
48
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (48)
miRTarBase ID miRNA Experiments Reference
MIRT000168 hsa-miR-21-5p qRT-PCRQuantitative proteomic approach 19253296
MIRT000168 hsa-miR-21-5p Microarray 20371350
MIRT000168 hsa-miR-21-5p Microarray 17968323
MIRT000168 hsa-miR-21-5p Microarray 17991735
MIRT000168 hsa-miR-21-5p Microarray 19682430
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
59
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (59)
GO ID Ontology Definition Evidence Reference
GO:0001843 Process Neural tube closure IEA
GO:0002181 Process Cytoplasmic translation IC 23636399
GO:0002181 Process Cytoplasmic translation NAS 25901680
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003723 Function RNA binding NAS 8522193
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
603658 10440 ENSG00000171863
Protein Protein information from UniProt database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P62081
Protein name Small ribosomal subunit protein eS7 (40S ribosomal protein S7)
Protein function Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for rRNA maturation (PubMed:19061985). Part of the sm
PDB 4UG0 , 4V6X , 5A2Q , 5AJ0 , 5FLX , 5LKS , 5OA3 , 5T2C , 5VYC , 6FEC , 6G18 , 6G4S , 6G4W , 6G51 , 6G53 , 6G5H , 6G5I , 6IP5 , 6IP6 , 6IP8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6YBD , 6YBW , 6Z6L , 6Z6M , 6Z6N , 6ZLW , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZMT , 6ZMW , 6ZN5 , 6ZOJ , 6ZOK , 6ZON , 6ZP4 , 6ZUO , 6ZV6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01251 Ribosomal_S7e 7 → 191 Ribosomal protein S7e Family
Sequence
Sequence length 194
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Ribosome
Coronavirus disease - COVID-19 		  L13a-mediated translational silencing of Ceruloplasmin expression
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Major pathway of rRNA processing in the nucleolus and cytosol
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
189
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (2)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Diamond-Blackfan anemia Pathogenic rs2528177029 RCV002364144
Diamond-Blackfan anemia 8 Pathogenic; Likely pathogenic rs1661257691, rs397507554, rs2528177027, rs1064796859, rs2528176273, rs1057519624, rs1572360944 RCV001333634
RCV000006525
RCV003226070
RCV003507623
RCV003507711
RCV003615991
RCV000412538
RCV000853497
RCV001252962
Show/Hide Unknown Diseases (10)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Chronic lymphocytic leukemia/small lymphocytic lymphoma Benign rs2071639 RCV005896179
Clear cell carcinoma of kidney Benign rs539208774 RCV005926679
Familial cancer of breast Likely benign; Benign rs373405472, rs1238368020, rs2071639 RCV005930392
RCV005869876
RCV005896174
Malignant lymphoma, large B-cell, diffuse Benign rs2071639 RCV005896177
Show/Hide Text Mining Associations (8)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acute Kidney Injury Associate 36277893
Alzheimer Disease Associate 35766008
Anemia Diamond Blackfan Associate 19061985, 20116044, 22262766, 22431104, 25946618, 40029997
Bone Marrow Failure Disorders Associate 32054657
Carcinoma Hepatocellular Associate 32627011
COVID 19 Associate 35558576
Lupus Erythematosus Systemic Associate 35558576
Neoplasms Associate 23671674