RPS6KA2 (ribosomal protein S6 kinase A2)

Gene

• Entrez ID: 6196
• Gene name: Ribosomal protein S6 kinase A2
• Gene symbol: RPS6KA2
• Synonyms (NCBI Gene): HU-2, MAPKAPK1C, RSK, RSK3, S6K-alpha, S6K-alpha2, p90-RSK3, p90RSK2, pp90RSK3
• Chromosome: 6
• Chromosome location: 6q27
• Summary: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK)

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018582	hsa-miR-335-5p	Microarray	18185580
MIRT496979	hsa-miR-370-5p	PAR-CLIP	22291592
MIRT496978	hsa-miR-5587-3p	PAR-CLIP	22291592
MIRT496977	hsa-miR-1247-3p	PAR-CLIP	22291592
MIRT496976	hsa-miR-1225-3p	PAR-CLIP	22291592
MIRT496975	hsa-miR-4755-3p	PAR-CLIP	22291592
MIRT496974	hsa-miR-6827-5p	PAR-CLIP	22291592
MIRT496973	hsa-miR-3175	PAR-CLIP	22291592
MIRT496972	hsa-miR-1343-5p	PAR-CLIP	22291592
MIRT496971	hsa-miR-939-5p	PAR-CLIP	22291592
MIRT496970	hsa-miR-6825-5p	PAR-CLIP	22291592
MIRT496969	hsa-miR-5006-5p	PAR-CLIP	22291592
MIRT496968	hsa-miR-3150a-3p	PAR-CLIP	22291592
MIRT496967	hsa-miR-6763-5p	PAR-CLIP	22291592
MIRT496979	hsa-miR-370-5p	PAR-CLIP	22291592
MIRT496978	hsa-miR-5587-3p	PAR-CLIP	22291592
MIRT496977	hsa-miR-1247-3p	PAR-CLIP	22291592
MIRT496976	hsa-miR-1225-3p	PAR-CLIP	22291592
MIRT496975	hsa-miR-4755-3p	PAR-CLIP	22291592
MIRT496974	hsa-miR-6827-5p	PAR-CLIP	22291592
MIRT496973	hsa-miR-3175	PAR-CLIP	22291592
MIRT496972	hsa-miR-1343-5p	PAR-CLIP	22291592
MIRT496971	hsa-miR-939-5p	PAR-CLIP	22291592
MIRT496970	hsa-miR-6825-5p	PAR-CLIP	22291592
MIRT496969	hsa-miR-5006-5p	PAR-CLIP	22291592
MIRT496968	hsa-miR-3150a-3p	PAR-CLIP	22291592
MIRT496967	hsa-miR-6763-5p	PAR-CLIP	22291592
MIRT1318043	hsa-miR-106a	CLIP-seq
MIRT1318044	hsa-miR-106b	CLIP-seq
MIRT1318045	hsa-miR-1294	CLIP-seq
MIRT1318046	hsa-miR-1298	CLIP-seq
MIRT1318047	hsa-miR-17	CLIP-seq
MIRT1318048	hsa-miR-1827	CLIP-seq
MIRT1318049	hsa-miR-19a	CLIP-seq
MIRT1318050	hsa-miR-19b	CLIP-seq
MIRT1318051	hsa-miR-20a	CLIP-seq
MIRT1318052	hsa-miR-20b	CLIP-seq
MIRT1318053	hsa-miR-2110	CLIP-seq
MIRT1318054	hsa-miR-2113	CLIP-seq
MIRT1318055	hsa-miR-302a	CLIP-seq
MIRT1318056	hsa-miR-302b	CLIP-seq
MIRT1318057	hsa-miR-302c	CLIP-seq
MIRT1318058	hsa-miR-302d	CLIP-seq
MIRT1318059	hsa-miR-302e	CLIP-seq
MIRT1318060	hsa-miR-3173-3p	CLIP-seq
MIRT1318061	hsa-miR-372	CLIP-seq
MIRT1318062	hsa-miR-373	CLIP-seq
MIRT1318063	hsa-miR-3919	CLIP-seq
MIRT1318064	hsa-miR-3942-3p	CLIP-seq
MIRT1318065	hsa-miR-4260	CLIP-seq
MIRT1318066	hsa-miR-4316	CLIP-seq
MIRT1318067	hsa-miR-4428	CLIP-seq
MIRT1318068	hsa-miR-4433	CLIP-seq
MIRT1318069	hsa-miR-4434	CLIP-seq
MIRT1318070	hsa-miR-4459	CLIP-seq
MIRT1318071	hsa-miR-4516	CLIP-seq
MIRT1318072	hsa-miR-4521	CLIP-seq
MIRT1318073	hsa-miR-4531	CLIP-seq
MIRT1318074	hsa-miR-4653-3p	CLIP-seq
MIRT1318075	hsa-miR-4663	CLIP-seq
MIRT1318076	hsa-miR-4676-5p	CLIP-seq
MIRT1318077	hsa-miR-4768-3p	CLIP-seq
MIRT1318078	hsa-miR-4802-5p	CLIP-seq
MIRT1318079	hsa-miR-487a	CLIP-seq
MIRT1318080	hsa-miR-512-3p	CLIP-seq
MIRT1318081	hsa-miR-518a-5p	CLIP-seq
MIRT1318082	hsa-miR-519d	CLIP-seq
MIRT1318083	hsa-miR-520a-3p	CLIP-seq
MIRT1318084	hsa-miR-520b	CLIP-seq
MIRT1318085	hsa-miR-520c-3p	CLIP-seq
MIRT1318086	hsa-miR-520d-3p	CLIP-seq
MIRT1318087	hsa-miR-520e	CLIP-seq
MIRT1318088	hsa-miR-520g	CLIP-seq
MIRT1318089	hsa-miR-520h	CLIP-seq
MIRT1318090	hsa-miR-527	CLIP-seq
MIRT1318091	hsa-miR-548c-3p	CLIP-seq
MIRT1318092	hsa-miR-570	CLIP-seq
MIRT1318093	hsa-miR-575	CLIP-seq
MIRT1318094	hsa-miR-579	CLIP-seq
MIRT1318095	hsa-miR-589	CLIP-seq
MIRT1318096	hsa-miR-616	CLIP-seq
MIRT1318097	hsa-miR-93	CLIP-seq
MIRT1318098	hsa-miR-939	CLIP-seq
MIRT1318099	hsa-miR-1184	CLIP-seq
MIRT1318100	hsa-miR-1206	CLIP-seq
MIRT1318048	hsa-miR-1827	CLIP-seq
MIRT1318101	hsa-miR-199a-3p	CLIP-seq
MIRT1318102	hsa-miR-199b-3p	CLIP-seq
MIRT1318103	hsa-miR-204	CLIP-seq
MIRT1318104	hsa-miR-211	CLIP-seq
MIRT1318105	hsa-miR-3129-5p	CLIP-seq
MIRT1318106	hsa-miR-361-3p	CLIP-seq
MIRT1318107	hsa-miR-3679-3p	CLIP-seq
MIRT1318108	hsa-miR-375	CLIP-seq
MIRT1318063	hsa-miR-3919	CLIP-seq
MIRT1318109	hsa-miR-4286	CLIP-seq
MIRT1318110	hsa-miR-4314	CLIP-seq
MIRT1318111	hsa-miR-4421	CLIP-seq
MIRT1318068	hsa-miR-4433	CLIP-seq
MIRT1318112	hsa-miR-4446-5p	CLIP-seq
MIRT1318070	hsa-miR-4459	CLIP-seq
MIRT1318113	hsa-miR-4695-3p	CLIP-seq
MIRT1318114	hsa-miR-4755-5p	CLIP-seq
MIRT1318077	hsa-miR-4768-3p	CLIP-seq
MIRT1318115	hsa-miR-4797-3p	CLIP-seq
MIRT1318094	hsa-miR-579	CLIP-seq
MIRT1318116	hsa-miR-623	CLIP-seq
MIRT1318117	hsa-miR-936	CLIP-seq
MIRT2094509	hsa-miR-1307	CLIP-seq
MIRT2094510	hsa-miR-199a-5p	CLIP-seq
MIRT2094511	hsa-miR-199b-5p	CLIP-seq
MIRT2094512	hsa-miR-296-3p	CLIP-seq
MIRT2094513	hsa-miR-3615	CLIP-seq
MIRT2094514	hsa-miR-3689a-3p	CLIP-seq
MIRT2094515	hsa-miR-3689c	CLIP-seq
MIRT2094516	hsa-miR-3918	CLIP-seq
MIRT2094517	hsa-miR-3926	CLIP-seq
MIRT2094518	hsa-miR-4252	CLIP-seq
MIRT2094519	hsa-miR-4255	CLIP-seq
MIRT2094520	hsa-miR-4293	CLIP-seq
MIRT1318066	hsa-miR-4316	CLIP-seq
MIRT2094521	hsa-miR-4324	CLIP-seq
MIRT2094522	hsa-miR-4435	CLIP-seq
MIRT2094523	hsa-miR-4638-5p	CLIP-seq
MIRT1318076	hsa-miR-4676-5p	CLIP-seq
MIRT2094524	hsa-miR-4786-3p	CLIP-seq
MIRT1318081	hsa-miR-518a-5p	CLIP-seq
MIRT1318090	hsa-miR-527	CLIP-seq
MIRT1318092	hsa-miR-570	CLIP-seq
MIRT1318093	hsa-miR-575	CLIP-seq
MIRT2094525	hsa-miR-671-5p	CLIP-seq
MIRT2094526	hsa-miR-873	CLIP-seq
MIRT1318043	hsa-miR-106a	CLIP-seq
MIRT1318044	hsa-miR-106b	CLIP-seq
MIRT2319011	hsa-miR-1207-3p	CLIP-seq
MIRT2319012	hsa-miR-1253	CLIP-seq
MIRT2319013	hsa-miR-1269	CLIP-seq
MIRT2319014	hsa-miR-1269b	CLIP-seq
MIRT2319015	hsa-miR-1288	CLIP-seq
MIRT2094509	hsa-miR-1307	CLIP-seq
MIRT2319016	hsa-miR-150	CLIP-seq
MIRT1318047	hsa-miR-17	CLIP-seq
MIRT1318048	hsa-miR-1827	CLIP-seq
MIRT1318051	hsa-miR-20a	CLIP-seq
MIRT1318052	hsa-miR-20b	CLIP-seq
MIRT1318055	hsa-miR-302a	CLIP-seq
MIRT1318056	hsa-miR-302b	CLIP-seq
MIRT1318057	hsa-miR-302c	CLIP-seq
MIRT1318058	hsa-miR-302d	CLIP-seq
MIRT1318059	hsa-miR-302e	CLIP-seq
MIRT2319017	hsa-miR-30a	CLIP-seq
MIRT2319018	hsa-miR-30b	CLIP-seq
MIRT2319019	hsa-miR-30c	CLIP-seq
MIRT2319020	hsa-miR-30d	CLIP-seq
MIRT2319021	hsa-miR-30e	CLIP-seq
MIRT2319022	hsa-miR-3122	CLIP-seq
MIRT2319023	hsa-miR-3156-3p	CLIP-seq
MIRT2319024	hsa-miR-330-3p	CLIP-seq
MIRT2319025	hsa-miR-3612	CLIP-seq
MIRT2094513	hsa-miR-3615	CLIP-seq
MIRT2319026	hsa-miR-3662	CLIP-seq
MIRT1318061	hsa-miR-372	CLIP-seq
MIRT1318062	hsa-miR-373	CLIP-seq
MIRT2319027	hsa-miR-378	CLIP-seq
MIRT2319028	hsa-miR-378b	CLIP-seq
MIRT2319029	hsa-miR-378c	CLIP-seq
MIRT2319030	hsa-miR-378d	CLIP-seq
MIRT2319031	hsa-miR-378e	CLIP-seq
MIRT2319032	hsa-miR-378f	CLIP-seq
MIRT2319033	hsa-miR-378h	CLIP-seq
MIRT2319034	hsa-miR-378i	CLIP-seq
MIRT2319035	hsa-miR-3913-5p	CLIP-seq
MIRT2319036	hsa-miR-422a	CLIP-seq
MIRT2319037	hsa-miR-4251	CLIP-seq
MIRT2319038	hsa-miR-4266	CLIP-seq
MIRT2319039	hsa-miR-4267	CLIP-seq
MIRT2319040	hsa-miR-4291	CLIP-seq
MIRT2319041	hsa-miR-4301	CLIP-seq
MIRT2319042	hsa-miR-4418	CLIP-seq
MIRT2319043	hsa-miR-4464	CLIP-seq
MIRT2319044	hsa-miR-450b-3p	CLIP-seq
MIRT2319045	hsa-miR-4515	CLIP-seq
MIRT2094523	hsa-miR-4638-5p	CLIP-seq
MIRT1318075	hsa-miR-4663	CLIP-seq
MIRT1318076	hsa-miR-4676-5p	CLIP-seq
MIRT2319046	hsa-miR-4695-5p	CLIP-seq
MIRT2319047	hsa-miR-4713-5p	CLIP-seq
MIRT2319048	hsa-miR-4740-5p	CLIP-seq
MIRT2319049	hsa-miR-4747-5p	CLIP-seq
MIRT2319050	hsa-miR-4748	CLIP-seq
MIRT2319051	hsa-miR-4779	CLIP-seq
MIRT2319052	hsa-miR-4803	CLIP-seq
MIRT2319053	hsa-miR-509-3-5p	CLIP-seq
MIRT2319054	hsa-miR-509-5p	CLIP-seq
MIRT1318080	hsa-miR-512-3p	CLIP-seq
MIRT2319055	hsa-miR-518a-3p	CLIP-seq
MIRT2319056	hsa-miR-518b	CLIP-seq
MIRT2319057	hsa-miR-518c	CLIP-seq
MIRT2319058	hsa-miR-518d-3p	CLIP-seq
MIRT2319059	hsa-miR-518f	CLIP-seq
MIRT1318082	hsa-miR-519d	CLIP-seq
MIRT1318083	hsa-miR-520a-3p	CLIP-seq
MIRT1318084	hsa-miR-520b	CLIP-seq
MIRT1318085	hsa-miR-520c-3p	CLIP-seq
MIRT1318086	hsa-miR-520d-3p	CLIP-seq
MIRT2319060	hsa-miR-520d-5p	CLIP-seq
MIRT1318087	hsa-miR-520e	CLIP-seq
MIRT1318088	hsa-miR-520g	CLIP-seq
MIRT1318089	hsa-miR-520h	CLIP-seq
MIRT2319061	hsa-miR-524-5p	CLIP-seq
MIRT2319062	hsa-miR-532-3p	CLIP-seq
MIRT2319063	hsa-miR-545	CLIP-seq
MIRT2319064	hsa-miR-548m	CLIP-seq
MIRT2319065	hsa-miR-548p	CLIP-seq
MIRT1318092	hsa-miR-570	CLIP-seq
MIRT1318093	hsa-miR-575	CLIP-seq
MIRT1318094	hsa-miR-579	CLIP-seq
MIRT2319066	hsa-miR-650	CLIP-seq
MIRT2094525	hsa-miR-671-5p	CLIP-seq
MIRT2319067	hsa-miR-766	CLIP-seq
MIRT2319068	hsa-miR-769-3p	CLIP-seq
MIRT2094526	hsa-miR-873	CLIP-seq
MIRT1318097	hsa-miR-93	CLIP-seq
MIRT2094509	hsa-miR-1307	CLIP-seq
MIRT2094513	hsa-miR-3615	CLIP-seq
MIRT2094523	hsa-miR-4638-5p	CLIP-seq
MIRT1318092	hsa-miR-570	CLIP-seq
MIRT2432833	hsa-miR-3609	CLIP-seq
MIRT2432834	hsa-miR-3610	CLIP-seq
MIRT2432835	hsa-miR-548ah	CLIP-seq
MIRT2432836	hsa-miR-548n	CLIP-seq
MIRT2432837	hsa-miR-548t	CLIP-seq
MIRT2094510	hsa-miR-199a-5p	CLIP-seq
MIRT2094511	hsa-miR-199b-5p	CLIP-seq
MIRT2439978	hsa-miR-2117	CLIP-seq
MIRT2094516	hsa-miR-3918	CLIP-seq
MIRT2094519	hsa-miR-4255	CLIP-seq
MIRT2439979	hsa-miR-4273	CLIP-seq
MIRT1318076	hsa-miR-4676-5p	CLIP-seq
MIRT2439980	hsa-miR-512-5p	CLIP-seq
MIRT1318093	hsa-miR-575	CLIP-seq
MIRT2458598	hsa-miR-1270	CLIP-seq
MIRT2458599	hsa-miR-2467-5p	CLIP-seq
MIRT2458600	hsa-miR-3188	CLIP-seq
MIRT1318106	hsa-miR-361-3p	CLIP-seq
MIRT2458601	hsa-miR-3943	CLIP-seq
MIRT2458602	hsa-miR-3975	CLIP-seq
MIRT1318066	hsa-miR-4316	CLIP-seq
MIRT2458603	hsa-miR-432	CLIP-seq
MIRT1318069	hsa-miR-4434	CLIP-seq
MIRT1318071	hsa-miR-4516	CLIP-seq
MIRT1318073	hsa-miR-4531	CLIP-seq
MIRT2458604	hsa-miR-4726-3p	CLIP-seq
MIRT2458605	hsa-miR-485-5p	CLIP-seq
MIRT2458606	hsa-miR-620	CLIP-seq
MIRT2458598	hsa-miR-1270	CLIP-seq
MIRT2458599	hsa-miR-2467-5p	CLIP-seq
MIRT2458600	hsa-miR-3188	CLIP-seq
MIRT1318106	hsa-miR-361-3p	CLIP-seq
MIRT2458601	hsa-miR-3943	CLIP-seq
MIRT2458602	hsa-miR-3975	CLIP-seq
MIRT1318066	hsa-miR-4316	CLIP-seq
MIRT2458603	hsa-miR-432	CLIP-seq
MIRT1318069	hsa-miR-4434	CLIP-seq
MIRT1318071	hsa-miR-4516	CLIP-seq
MIRT1318073	hsa-miR-4531	CLIP-seq
MIRT2458604	hsa-miR-4726-3p	CLIP-seq
MIRT2458605	hsa-miR-485-5p	CLIP-seq
MIRT2458606	hsa-miR-620	CLIP-seq
MIRT2614716	hsa-miR-1204	CLIP-seq
MIRT2614717	hsa-miR-138	CLIP-seq
MIRT2614718	hsa-miR-1537	CLIP-seq
MIRT2094510	hsa-miR-199a-5p	CLIP-seq
MIRT2094511	hsa-miR-199b-5p	CLIP-seq
MIRT2439978	hsa-miR-2117	CLIP-seq
MIRT2614719	hsa-miR-3127-3p	CLIP-seq
MIRT2614720	hsa-miR-3160-3p	CLIP-seq
MIRT1318060	hsa-miR-3173-3p	CLIP-seq
MIRT2614721	hsa-miR-3183	CLIP-seq
MIRT2614722	hsa-miR-3189-5p	CLIP-seq
MIRT2614723	hsa-miR-3667-3p	CLIP-seq
MIRT2614724	hsa-miR-3671	CLIP-seq
MIRT2094516	hsa-miR-3918	CLIP-seq
MIRT2094519	hsa-miR-4255	CLIP-seq
MIRT2439979	hsa-miR-4273	CLIP-seq
MIRT2614725	hsa-miR-4279	CLIP-seq
MIRT2614726	hsa-miR-4294	CLIP-seq
MIRT2614727	hsa-miR-4297	CLIP-seq
MIRT2614728	hsa-miR-4457	CLIP-seq
MIRT2614729	hsa-miR-4487	CLIP-seq
MIRT2614730	hsa-miR-4640-3p	CLIP-seq
MIRT2614731	hsa-miR-4666-5p	CLIP-seq
MIRT2614732	hsa-miR-4668-5p	CLIP-seq
MIRT1318076	hsa-miR-4676-5p	CLIP-seq
MIRT2614733	hsa-miR-4679	CLIP-seq
MIRT2614734	hsa-miR-4723-3p	CLIP-seq
MIRT2614735	hsa-miR-4731-3p	CLIP-seq
MIRT2614736	hsa-miR-4758-3p	CLIP-seq
MIRT2614737	hsa-miR-4763-5p	CLIP-seq
MIRT2319051	hsa-miR-4779	CLIP-seq
MIRT2614738	hsa-miR-4801	CLIP-seq
MIRT2439980	hsa-miR-512-5p	CLIP-seq
MIRT2614739	hsa-miR-548q	CLIP-seq
MIRT2614740	hsa-miR-556-5p	CLIP-seq
MIRT2614741	hsa-miR-558	CLIP-seq
MIRT1318092	hsa-miR-570	CLIP-seq
MIRT1318093	hsa-miR-575	CLIP-seq
MIRT2614742	hsa-miR-591	CLIP-seq
MIRT2614743	hsa-miR-596	CLIP-seq
MIRT2614744	hsa-miR-720	CLIP-seq
MIRT1318098	hsa-miR-939	CLIP-seq
MIRT2690024	hsa-miR-1229	CLIP-seq
MIRT2690025	hsa-miR-1271	CLIP-seq
MIRT2614717	hsa-miR-138	CLIP-seq
MIRT2690026	hsa-miR-182	CLIP-seq
MIRT2094510	hsa-miR-199a-5p	CLIP-seq
MIRT2094511	hsa-miR-199b-5p	CLIP-seq
MIRT1318103	hsa-miR-204	CLIP-seq
MIRT1318104	hsa-miR-211	CLIP-seq
MIRT2439978	hsa-miR-2117	CLIP-seq
MIRT2614719	hsa-miR-3127-3p	CLIP-seq
MIRT2614720	hsa-miR-3160-3p	CLIP-seq
MIRT1318060	hsa-miR-3173-3p	CLIP-seq
MIRT2614721	hsa-miR-3183	CLIP-seq
MIRT2614722	hsa-miR-3189-5p	CLIP-seq
MIRT1318106	hsa-miR-361-3p	CLIP-seq
MIRT2614723	hsa-miR-3667-3p	CLIP-seq
MIRT2614724	hsa-miR-3671	CLIP-seq
MIRT1318107	hsa-miR-3679-3p	CLIP-seq
MIRT2094516	hsa-miR-3918	CLIP-seq
MIRT2094519	hsa-miR-4255	CLIP-seq
MIRT2439979	hsa-miR-4273	CLIP-seq
MIRT2614725	hsa-miR-4279	CLIP-seq
MIRT1318109	hsa-miR-4286	CLIP-seq
MIRT2614726	hsa-miR-4294	CLIP-seq
MIRT2614727	hsa-miR-4297	CLIP-seq
MIRT2614728	hsa-miR-4457	CLIP-seq
MIRT2614729	hsa-miR-4487	CLIP-seq
MIRT2614730	hsa-miR-4640-3p	CLIP-seq
MIRT2614731	hsa-miR-4666-5p	CLIP-seq
MIRT1318076	hsa-miR-4676-5p	CLIP-seq
MIRT2614733	hsa-miR-4679	CLIP-seq
MIRT2614734	hsa-miR-4723-3p	CLIP-seq
MIRT2614735	hsa-miR-4731-3p	CLIP-seq
MIRT2690027	hsa-miR-4746-5p	CLIP-seq
MIRT2614736	hsa-miR-4758-3p	CLIP-seq
MIRT2614737	hsa-miR-4763-5p	CLIP-seq
MIRT2319051	hsa-miR-4779	CLIP-seq
MIRT2614738	hsa-miR-4801	CLIP-seq
MIRT2690028	hsa-miR-483-3p	CLIP-seq
MIRT2439980	hsa-miR-512-5p	CLIP-seq
MIRT2614739	hsa-miR-548q	CLIP-seq
MIRT2614740	hsa-miR-556-5p	CLIP-seq
MIRT2614741	hsa-miR-558	CLIP-seq
MIRT1318093	hsa-miR-575	CLIP-seq
MIRT2614742	hsa-miR-591	CLIP-seq
MIRT2614743	hsa-miR-596	CLIP-seq
MIRT2614744	hsa-miR-720	CLIP-seq
MIRT1318098	hsa-miR-939	CLIP-seq
MIRT2690029	hsa-miR-96	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	IEA
GO:0001556	Process	Oocyte maturation	IEA
GO:0002035	Process	Brain renin-angiotensin system	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	TAS	7623830
GO:0004711	Function	Ribosomal protein S6 kinase activity	IBA
GO:0004711	Function	Ribosomal protein S6 kinase activity	IEA
GO:0004712	Function	Protein serine/threonine/tyrosine kinase activity	IDA	22797923
GO:0005515	Function	Protein binding	IPI	16810323, 21988832, 23602568, 25852190, 29144123, 30126976, 32296183, 32707033, 32814053, 33961781, 34591642, 35271311, 36931259
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IDA	16878154
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	7623830
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	16878154
GO:0005737	Component	Cytoplasm	IEA
GO:0005819	Component	Spindle	IEA
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	NAS	7623830
GO:0007268	Process	Chemical synaptic transmission	TAS
GO:0007507	Process	Heart development	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IDA	16878154
GO:0010628	Process	Positive regulation of gene expression	IEA
GO:0010659	Process	Cardiac muscle cell apoptotic process	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0035556	Process	Intracellular signal transduction	TAS	7623830, 8141249
GO:0038202	Process	TORC1 signaling	IBA
GO:0043065	Process	Positive regulation of apoptotic process	IDA	16878154
GO:0045202	Component	Synapse	IEA
GO:0045786	Process	Negative regulation of cell cycle	IDA	16878154
GO:0045835	Process	Negative regulation of meiotic nuclear division	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0060047	Process	Heart contraction	IEA
GO:0070613	Process	Regulation of protein processing	IEA
GO:0071322	Process	Cellular response to carbohydrate stimulus	IEA
GO:0072687	Component	Meiotic spindle	IEA
GO:0106310	Function	Protein serine kinase activity	IEA

Other IDs

• MIM: 601685
• HGNC: 10431
• e!Ensembl: ENSG00000071242

Protein

• UniProt ID: Q15349
• Protein name: Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3
• Protein function: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	59 → 318	Protein kinase domain	Domain
  PF00433	Pkinase_C	340 → 378	Protein kinase C terminal domain	Family
  PF00069	Pkinase	415 → 672	Protein kinase domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}.
• Sequence:

  MDLSMKKFAVRRFFSVYLRRKSRSKSSSLSRLEEEGVVKEIDISHHVKEGFEKADPSQFE
  LLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPF
  IVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGI
  IYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSA
  DWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCN
  RLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDS
  PGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKED
  IGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGK
  FVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILY
  RDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGIL
  LYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQR
  LTAMQVLKHPWVVNREYLSPNQLSRQDVHLVKGAMAATYFALNRTPQAPRLEPVLSSNLA
  QRRGMKRLTSTRL

• Sequence length: 733

Pathways

KEGG:

MAPK signaling pathway
Oocyte meiosis
mTOR signaling pathway
Thermogenesis
Long-term potentiation
Neurotrophin signaling pathway
Progesterone-mediated oocyte maturation
Insulin resistance
Yersinia infection
Chemical carcinogenesis - receptor activation

Reactome:

ERK/MAPK targets
CREB phosphorylation
Senescence-Associated Secretory Phenotype (SASP)
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
RSK activation
Gastrin-CREB signalling pathway via PKC and MAPK

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Autism spectrum disorder	association	rs1254821821	RCV001291500
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	rs1450913451	RCV004557926

Associations from Text Mining
Disease Name	Relationship Type	References
Breast Neoplasms	Associate	19287968, 19514121, 22562547
Cafe au Lait Spots	Associate	32869517
Carcinoma Lobular	Associate	32661241
Carcinoma Squamous Cell	Associate	24205356
Colorectal Neoplasms	Stimulate	21035469
Colorectal Neoplasms	Associate	25197367, 35635239, 37382881
Crohn Disease	Associate	37331566
Dental Caries	Associate	24556642
Diabetes Mellitus Type 2	Associate	33430853
Diabetic Neuropathies	Associate	33430853
Dyskinesias	Associate	24205356
Glioma	Inhibit	31701625
Inflammation	Associate	21035469
Inflammatory Bowel Diseases	Associate	27886173, 36029471
Leukemia	Associate	21368869
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	21368869
Leukemia Myeloid Acute	Associate	34602526, 35364561
Melanoma	Associate	24627490, 25002506, 31678930, 34411141
Neoplasms	Inhibit	19287968
Neoplasms	Associate	21035469, 24879340, 25002506, 28675785, 28837395, 31959052
Neuroblastoma	Associate	31959052
Neurofibromatosis 1	Associate	32869517
Obesity	Associate	30397228
Ovarian Neoplasms	Associate	24879340
Pancreatic Neoplasms	Associate	28679769
Precancerous Conditions	Associate	21035469
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	28009354
Prostatic Neoplasms	Associate	25472581
Rectal Neoplasms	Associate	21035469
Smoke Inhalation Injury	Associate	25424692
Squamous Cell Carcinoma of Head and Neck	Associate	33660438