ERVK-8 (endogenous retrovirus group K member 8, envelope)

Gene

• Entrez ID: 619465
• Gene name: Endogenous retrovirus group K member 8, envelope
• Gene symbol: ERVK-8
• Synonyms (NCBI Gene): ERVK8, HERV-K115, PR, Protease, Proteinase, envK6
• Chromosome: 8
• Chromosome location: 8p23.1

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000731	Process	DNA synthesis involved in DNA repair	IEA
GO:0000768	Process	Syncytium formation by plasma membrane fusion	IDA	14557543
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0003964	Function	RNA-directed DNA polymerase activity	IEA
GO:0004190	Function	Aspartic-type endopeptidase activity	IEA
GO:0004518	Function	Nuclease activity	IEA
GO:0004519	Function	Endonuclease activity	IEA
GO:0004523	Function	RNA-DNA hybrid ribonuclease activity	IEA
GO:0005198	Function	Structural molecule activity	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0006261	Process	DNA-templated DNA replication	IEA
GO:0006278	Process	RNA-templated DNA biosynthetic process	IEA
GO:0006310	Process	DNA recombination	IEA
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0015074	Process	DNA integration	IEA
GO:0016020	Component	Membrane	IEA
GO:0016032	Process	Viral process	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0034061	Function	DNA polymerase activity	IEA
GO:0035613	Function	RNA stem-loop binding	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0075523	Process	Viral translational frameshifting	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: N/A

Protein

• UniProt ID: P63122
• Protein name: Endogenous retrovirus group K member 8 Pro protein (HERV-K115 Pro protein) (HERV-K_8p23.1 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)
• Protein function: Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00077	RVP	6 → 105		Domain
  PF01585	G-patch	111 → 155	G-patch domain	Family

• Sequence:

  WASQVSENRPVCKAIIQGKQFEGLVDTGADVSIIALNQWPKNWPKQKAVIGLVGIGTASE
  VYQSMEILHCLGPDNQESTVQPMITSIPLNLWGRDLLQQWGAEITMPAPLYSPTSQKIMT
  KRGYIPGKGLGKNEDGIKIPFEAKINQKREGIGYPF

• Sequence length: 156
• UniProt ID: P63133
• Protein name: Endogenous retrovirus group K member 8 Pol protein (HERV-K115 Pol protein) (HERV-K_8p23.1 provirus ancestral Pol protein) [Includes: Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN)]
• Protein function: Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA p
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00078	RVT_1	76 → 245	Reverse transcriptase (RNA-dependent DNA polymerase)	Family
  PF06817	RVT_thumb	252 → 317		Domain
  PF00075	RNase_H	461 → 590	RNase H	Domain
  PF02022	Integrase_Zn	592 → 629		Domain
  PF00665	rve	644 → 739		Domain
  PF00552	IN_DBD_C	813 → 857		Domain

• Sequence:

  NKSKKRRNRVSFLGVATIEPPKPIPLTWKTEKLVWVNQWPLPKQKLEALHLLANEQLEKG
  HIEPSFSPWNSPVFVIQKKSGKWRMLTDLRAVNAVIQPMGPLQPGLPSPAMIPKDWPLII
  IDLKDCFFTIPLAEQDCEKFAFTIPAINNKEPATRFQWKVLPQGMLNSPTICQTFVGRAL
  QPVRKKFSDCYIIHYIDDILCAAETKDKLIDCYTFLQAEVASAGLAIASDKIQTSTPFHY
  LGMQIENRKIKPQKIEIRKDTLKTLNDFQKLLGDINWIQPTLGIPTYAMSNLFSILRGDS
  DLNSKRILTPEATKEIKLVEEKIQSAQINRIDPLAPLQLLIFATAHSPTGIIIQNTDLVE
  WSFLPHSTVKTFTLYLDQIATLIGQTRLRIIKLCGNDPDKIVVPLTKEQVRQAFINSGAW
  QIGLANFVGIIDNHYPKTKIFQFLKLTTWILPKITRREPLENALTVFTDGSSNGKAAYTG
  PKERVIKTPYQSAQRAELVAVITVLQDFDQPINIISDSAYVVQATRVVETALIKYSMDDQ
  LNQLFNLLQQTVRKRNFPFYITHIRAHTNLPGPLTKANEQADLLVSSALIKAQELHALTH
  VNAAGLKNKFDVTWKQAKDIVQHCTQCQVLHLPTQEAGVNPRGLCPNALWQMDVTHVPSF
  GRLSYVHVTVDTYSHFIWATCQTGESTSHVKKHLLSCFAVMGVPEKIKTDNGPGYCSKAF
  QKFLSQWKISHTTGIPYNSQGQAIVERTNRTLKTQLVKQKEGGDSKECTTPQMQLNLALY
  TLNFLNIYRNQTTTSAEQHLTGKKNSPHEGKLIWWKDNKNKTWEIGKVITWGRGFACVSP
  GENQLPVWIPTRHLKFYNEPIRDAKKSTSAETETPQSSTVDSQDEQNGDVRRTDEVAIHQ
  EGRAADLGTTKEADAVSYKISREHKGDTNPREYAACSLDDCINGGKSPYACRSSCS

• Sequence length: 956
• UniProt ID: Q902F8
• Protein name: Endogenous retrovirus group K member 8 Env polyprotein (EnvK6 protein) (Envelope polyprotein) (HERV-K115 envelope protein) (HERV-K_8p23.1 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]
• Protein function: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has los
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15695	HERV-K_REC	19 → 105		Family
  PF13804	HERV-K_env_2	115 → 283		Domain
  PF00517	GP41	486 → 682		Family

• Sequence:

  MNPSEMQRKAPPRRRRHRNRAPLTHKMNKMVTSEEQMKLPSTKKAEPPTWAQLKKLTQLA
  TKYLENTKVTQTPESMLLAALMIVSMVVSLPMPAGAAVANYTNWAYVPFPPLIRAVTWMD
  NPIEVYVNDSVWVPGPIDDRCPAKPEEEGMMINISIGYRYPPICLGRAPGCLMPAVQNWL
  VEVPTVSPISRFTYHMVSGMSLRPRVNYLQDFSYQRSLKFRPKGKPCPKEIPKESKNTEV
  LVWEECVANSAVILQNNEFGTIIDWAPRGQFYHNCSGQTQSCPSAQVSPAVDSDLTESLD
  KHKHKKLQSFYPWEWGEKRISTPRPKIVSPVSGPEHPELWRLTVASHHIRIWSGNQTLET
  RDRKPFYTVDLNSSLTLPLQSCVKPPYMLVVGNIVIKPDSQTITCENCRLLTCIDSTFNW
  QHRILLVRAREGVWIPVSMDRPWEASPSVHILTEVLKGVLNRSKRFIFTLIAVIMGLIAV
  TATAAVAGVALHSSVQSVNFVNDGQKNSTRLWNSQSSIDQKLANQINDLRQTVIWMGDRL
  MSLEHRFQLQCDWNTSDFCITPQIYNDSEHHWDMVRRHLQGREDNLTLDISKLKEQIFEA
  SKAHLNLVPGTEAIAGVADGLANLNPVTWVKTIGSTTIINLILILVCLFCLLLVCRCTQQ
  LRRDSDHRERAMMTMAVLSKRKGGNVGKSKRDQIVTVSV

• Sequence length: 699
• UniProt ID: P62685
• Protein name: Endogenous retrovirus group K member 8 Gag polyprotein (HERV-K115 Gag protein) (HERV-K_8p23.1 provirus ancestral Gag polyprotein) (Gag polyprotein)
• Protein function: The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form mem
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02337	Gag_p10	11 → 93		Family
  PF00607	Gag_p24	312 → 512		Family
  PF00098	zf-CCHC	544 → 561	Zinc knuckle	Domain
  PF14787	zf-CCHC_5	578 → 613		Domain

• Sequence:

  MGQTKSKIKSKYASYLSFIKILLKRGGVKVSTKNLIKLFQIIEQFCPWFPEQGTLDLKDW
  KRIGKELKQAGRKGNIIPLTVWNDWAIIKAALEPFQTEEDSISVSDAPGSCLIDCNENTR
  KKSQKETESLHCEYVAEPVMAQSTQNVDYNQLQEVIYPETLKLEGKGPELVGPSESKPRG
  TSPLPAGQVPVTLQPQKQVKENKTQPPVAYQYWPPAELQYRPPPESQYGYPGMPPAPQGR
  EPYPQPPTRRLNPTAPPSRQGSELHEIIDKSRKEGDTEAWQFPVTLEPMPPGEGAQEGEP
  PTVEARYKSFSIKMLKDMKEGVKQYGPNSPYMRTLLDSIAHGHRLIPYDWEILAKSSLSP
  SQFLQFKTWWIDGVQEQVRRNRAANPPVNIDADQLLGIGQNWSTISQQALMQNEAIEQVR
  AICLRAWEKIQDPGSTCPSFNTVRQGSKEPYPDFVARLQDVAQKSIADEKARKVIVELMA
  YENANPECQSAIKPLKGKVPAGSDVISEYVKACDGIGGAMHKAMLMAQAITGVVLGGQVR
  TFGGKCYNCGQIGHLKKNCPVLNKQNITIQATTTGREPPDLCPRCKKGKHWASQCRSKFD
  KNGQPLSGNEQRGQPQAPQQTGAFPIQPFVPQGFQDNNPHCPKCFRE

• Sequence length: 647
• UniProt ID: P61575
• Protein name: Endogenous retrovirus group K member 8 Rec protein (HERV-K115 Rec protein) (HERV-K_8p23.1 provirus Rec protein)
• Protein function: Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15695	HERV-K_REC	19 → 105		Family

• Sequence:

  MNPSEMQRKAPPRRRRHRNRAPLTHKMNKMVTSEEQMKLPSTKKAEPPTWAQLKKLTQLA
  TKYLENTKVTQTPESMLLAALMIVSMVSAGVLNSSEETATIENGP

• Sequence length: 105

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