Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6194
Gene name	Ribosomal protein S6
Gene symbol	RPS6
Synonyms (NCBI Gene)	S6eS6
Chromosome	9
Chromosome location	9p22.1
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic r

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Show/Hide all (246)

miRTarBase ID	miRNA	Experiments	Reference
MIRT003330	hsa-miR-15a-5p	Review	20026422
MIRT003326	hsa-miR-16-5p	Review	20026422
MIRT003326	hsa-miR-16-5p	Proteomics	18668040
MIRT051718	hsa-let-7d-5p	CLASH	23622248
MIRT048636	hsa-miR-99a-5p	CLASH	23622248
MIRT047174	hsa-miR-182-3p	CLASH	23622248
MIRT046422	hsa-miR-15b-5p	CLASH	23622248
MIRT039518	hsa-miR-652-3p	CLASH	23622248
MIRT037442	hsa-miR-744-5p	CLASH	23622248
MIRT052691	hsa-miR-1260b	CLASH	23622248
MIRT613798	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT613797	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT613796	hsa-miR-764	HITS-CLIP	23824327
MIRT613795	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT613794	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT613793	hsa-miR-4286	HITS-CLIP	23824327
MIRT613792	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT613791	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT613790	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT613789	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613788	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT613787	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT613786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613785	hsa-miR-4312	HITS-CLIP	23824327
MIRT613784	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT613783	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT613782	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT613781	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT613780	hsa-miR-640	HITS-CLIP	23824327
MIRT613779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT613778	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT613798	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT613794	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT613793	hsa-miR-4286	HITS-CLIP	23824327
MIRT613792	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT613791	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT613789	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613785	hsa-miR-4312	HITS-CLIP	23824327
MIRT613784	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT613783	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT613782	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT613779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT613778	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT613798	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT613797	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT613794	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT613793	hsa-miR-4286	HITS-CLIP	23824327
MIRT613792	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT613791	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT613789	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613785	hsa-miR-4312	HITS-CLIP	23824327
MIRT613784	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT613783	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT613782	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT613780	hsa-miR-640	HITS-CLIP	23824327
MIRT613779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT613778	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT613798	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT613794	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT613793	hsa-miR-4286	HITS-CLIP	23824327
MIRT613792	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT613791	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT613789	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613785	hsa-miR-4312	HITS-CLIP	23824327
MIRT613784	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT613783	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT613782	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT613779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT613778	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT613798	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT613797	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT613796	hsa-miR-764	HITS-CLIP	23824327
MIRT613795	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT613794	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT613793	hsa-miR-4286	HITS-CLIP	23824327
MIRT613792	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT613791	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT613789	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613785	hsa-miR-4312	HITS-CLIP	23824327
MIRT613784	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT613783	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT613782	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT613780	hsa-miR-640	HITS-CLIP	23824327
MIRT613779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT613778	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT613798	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT613797	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT613796	hsa-miR-764	HITS-CLIP	23824327
MIRT613795	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT613794	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT613793	hsa-miR-4286	HITS-CLIP	23824327
MIRT613792	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT613791	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT613789	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613785	hsa-miR-4312	HITS-CLIP	23824327
MIRT613784	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT613783	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT613782	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT613780	hsa-miR-640	HITS-CLIP	23824327
MIRT613779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT613778	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT613798	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT613797	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT613796	hsa-miR-764	HITS-CLIP	23824327
MIRT613795	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT613794	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT613793	hsa-miR-4286	HITS-CLIP	23824327
MIRT613792	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT613791	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT613790	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT613789	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613788	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT613787	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT613786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613785	hsa-miR-4312	HITS-CLIP	23824327
MIRT613784	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT613783	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT613782	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT613781	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT613780	hsa-miR-640	HITS-CLIP	23824327
MIRT613779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT613778	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT439727	hsa-miR-544a	HITS-CLIP	24374217
MIRT439727	hsa-miR-544a	HITS-CLIP	24374217
MIRT613798	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT613797	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT613796	hsa-miR-764	HITS-CLIP	23824327
MIRT613795	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT613794	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT613793	hsa-miR-4286	HITS-CLIP	23824327
MIRT613792	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT613791	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT613790	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT613789	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613788	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT613787	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT613786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613785	hsa-miR-4312	HITS-CLIP	23824327
MIRT613784	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT613783	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT613782	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT613781	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT613780	hsa-miR-640	HITS-CLIP	23824327
MIRT613779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT613778	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT613798	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT613794	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT613793	hsa-miR-4286	HITS-CLIP	23824327
MIRT613792	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT613791	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT613789	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613785	hsa-miR-4312	HITS-CLIP	23824327
MIRT613784	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT613783	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT613782	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT613779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT613778	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT613798	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT613797	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT613794	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT613793	hsa-miR-4286	HITS-CLIP	23824327
MIRT613792	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT613791	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT613789	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613785	hsa-miR-4312	HITS-CLIP	23824327
MIRT613784	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT613783	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT613782	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT613780	hsa-miR-640	HITS-CLIP	23824327
MIRT613779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT613778	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT613798	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT613794	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT613793	hsa-miR-4286	HITS-CLIP	23824327
MIRT613792	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT613791	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT613789	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613785	hsa-miR-4312	HITS-CLIP	23824327
MIRT613784	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT613783	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT613782	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT613779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT613778	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT613798	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT613797	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT613796	hsa-miR-764	HITS-CLIP	23824327
MIRT613795	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT613794	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT613793	hsa-miR-4286	HITS-CLIP	23824327
MIRT613792	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT613791	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT613789	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613785	hsa-miR-4312	HITS-CLIP	23824327
MIRT613784	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT613783	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT613782	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT613780	hsa-miR-640	HITS-CLIP	23824327
MIRT613779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT613778	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT613798	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT613797	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT613796	hsa-miR-764	HITS-CLIP	23824327
MIRT613795	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT613794	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT613793	hsa-miR-4286	HITS-CLIP	23824327
MIRT613792	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT613791	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT613789	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613785	hsa-miR-4312	HITS-CLIP	23824327
MIRT613784	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT613783	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT613782	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT613780	hsa-miR-640	HITS-CLIP	23824327
MIRT613779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT613778	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT613798	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT613797	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT613796	hsa-miR-764	HITS-CLIP	23824327
MIRT613795	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT613794	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT613793	hsa-miR-4286	HITS-CLIP	23824327
MIRT613792	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT613791	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT613790	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT613789	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613788	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT613787	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT613786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613785	hsa-miR-4312	HITS-CLIP	23824327
MIRT613784	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT613783	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT613782	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT613781	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT613780	hsa-miR-640	HITS-CLIP	23824327
MIRT613779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT613778	hsa-miR-6878-3p	HITS-CLIP	23824327

Show/Hide all (53)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000028	Process	Ribosomal small subunit assembly	IEA
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	IDA	8706699, 34314702
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003729	Function	MRNA binding	IEA
GO:0003735	Function	Structural constituent of ribosome	HDA	15883184
GO:0003735	Function	Structural constituent of ribosome	IDA	8706699, 23636399, 34314702
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	IMP	18697920
GO:0005515	Function	Protein binding	IPI	16314389, 18423201, 19417104, 21418524, 24454821, 26496610, 29568061, 30021884, 34232536, 34901782, 36217030
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IDA	2334893
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA	8590812
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005840	Component	Ribosome	IEA
GO:0006364	Process	RRNA processing	IMP	18697920
GO:0006412	Process	Translation	IC	8706699, 15883184
GO:0006412	Process	Translation	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	17220279
GO:0015935	Component	Small ribosomal subunit	IDA	15590835
GO:0016020	Component	Membrane	HDA	19946888
GO:0019901	Function	Protein kinase binding	IPI	21418524
GO:0022626	Component	Cytosolic ribosome	IDA	8706699
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0022627	Component	Cytosolic small ribosomal subunit	HDA	15883184
GO:0022627	Component	Cytosolic small ribosomal subunit	IDA	8706699
GO:0022627	Component	Cytosolic small ribosomal subunit	IEA
GO:0022627	Component	Cytosolic small ribosomal subunit	NAS	1301164, 25901680
GO:0030425	Component	Dendrite	IDA	15121898
GO:0031929	Process	TOR signaling	IDA	16428328
GO:0032040	Component	Small-subunit processome	IDA	34516797
GO:0032868	Process	Response to insulin	IEA
GO:0036464	Component	Cytoplasmic ribonucleoprotein granule	IDA	15121898
GO:0042274	Process	Ribosomal small subunit biogenesis	IDA	34516797
GO:0042274	Process	Ribosomal small subunit biogenesis	IMP	18697920
GO:0042593	Process	Glucose homeostasis	ISS
GO:0043065	Process	Positive regulation of apoptotic process	IDA	18362888
GO:0044297	Component	Cell body	IDA	15121898
GO:0071361	Process	Cellular response to ethanol	IEA
GO:0098793	Component	Presynapse	IEA
GO:0098982	Component	GABA-ergic synapse	IEA
GO:1903347	Process	Negative regulation of bicellular tight junction assembly	IEA
GO:1990904	Component	Ribonucleoprotein complex	IDA	18809582
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
180460	10429	ENSG00000137154

P62753

Protein name

Small ribosomal subunit protein eS6 (40S ribosomal protein S6) (Phosphoprotein NP33)

Protein function

Component of the 40S small ribosomal subunit (PubMed:23636399, PubMed:8706699). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (PubMed:17220279). Part of the s

PDB

4UG0 , 4V6X , 5A2Q , 5AJ0 , 5FLX , 5LKS , 5OA3 , 5T2C , 5VYC , 6F4P , 6F4Q , 6FEC , 6G18 , 6G4S , 6G4W , 6G51 , 6G53 , 6G5H , 6G5I , 6IP5 , 6IP6 , 6IP8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6YBW , 6Z6L , 6Z6M , 6Z6N , 6ZLW , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZMT , 6ZMW , 6ZN5 , 6ZOJ , 6ZOK , 6ZON , 6ZP4 , 6ZUO

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01092	Ribosomal_S6e	1 → 126	Ribosomal protein S6e	Family

Sequence

MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQG
FPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKD
IPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLV
TPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRAS
TSKSESSQK

Sequence length

249

Interactions

View interactions

	KEGG		Reactome
	EGFR tyrosine kinase inhibitor resistance Ribosome HIF-1 signaling pathway mTOR signaling pathway PI3K-Akt signaling pathway Apelin signaling pathway Thermogenesis Insulin signaling pathway Coronavirus disease - COVID-19 Proteoglycans in cancer		L13a-mediated translational silencing of Ceruloplasmin expression mTORC1-mediated signalling SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Gastric cancer	Benign	rs117840373	RCV005907310
Hemimegalencephaly	Uncertain significance	rs748611445	RCV000855715
Hepatocellular carcinoma	Benign	rs117840373	RCV005907308
Malignant lymphoma, large B-cell, diffuse	Benign	rs117840373	RCV005907309
Ovarian serous cystadenocarcinoma	Benign	rs117840373	RCV005907311

Show/Hide Text Mining Associations (51)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenoma	Associate	32862831
Anemia Diamond Blackfan	Associate	20116044
Angiomyolipoma	Associate	16575396
Autism Spectrum Disorder	Associate	30705255
Breast Neoplasms	Associate	28247844, 29258115
Carcinoma Hepatocellular	Associate	24643969
Carcinoma Non Small Cell Lung	Associate	24908424, 26490682
Carcinoma Ovarian Epithelial	Associate	32862831
Carcinoma Renal Cell	Associate	26506236, 28713889
Chondrosarcoma	Associate	16779802
Chordoma	Associate	19401700
Colorectal Neoplasms	Associate	25379021, 37475862
Diabetes Mellitus	Associate	26549531
Diarrhea 5 With Tufting Enteropathy Congenital	Associate	23015458
Drug Related Side Effects and Adverse Reactions	Associate	36409827
Esophageal Neoplasms	Associate	22996377
Esophageal Squamous Cell Carcinoma	Associate	22996377
Fetal Growth Retardation	Associate	33371356
Focal cortical dysplasia of Taylor	Associate	20613634
Glioblastoma	Associate	29328863, 32246865, 34831193
Glioma	Associate	32246865, 34831193, 35287169
Hyperlipoproteinemia Type II	Associate	20613634
Hypoxia	Inhibit	19147540, 34200497
Hypoxia Brain	Inhibit	19147540
Leukemia Lymphocytic Chronic B Cell	Associate	26919095, 27189785
Leukemia Myeloid Acute	Associate	21067588, 29723246
Leukemia T Cell	Associate	26985829
Lymphangioleiomyomatosis	Associate	12045200, 16575396
Lymphoma Large B Cell Diffuse	Associate	21102526
Lymphoma Large Cell Anaplastic	Associate	16818631
Lymphoma Mantle Cell	Associate	17148679
Lymphoma Non Hodgkin	Associate	21102526
Lymphoma Primary Effusion	Associate	21734034
Melanoma	Associate	25749517, 29777202
Melanoma Cutaneous Malignant	Associate	33082316
Mesothelioma	Associate	36115922
Mouth Neoplasms	Associate	23015458
Mucormycosis	Associate	34861346
Multiple Sclerosis	Associate	23077530
Neoplasm Metastasis	Associate	25953157
Neoplasms	Associate	16779802, 16818631, 18538015, 19147540, 23015458, 27119232, 30129426, 35287169, 35596155, 36619896, 37638009
Ovarian Neoplasms	Associate	32862831
Post Acute COVID 19 Syndrome	Associate	34861346
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	26985829
Prostatic Neoplasms	Associate	24885093, 26124442
Sarcoma	Associate	33564073
Squamous Cell Carcinoma of Head and Neck	Associate	18538015, 23015458
Teratozoospermia	Associate	29901159
Triple Negative Breast Neoplasms	Associate	25955731
Urinary Bladder Neoplasms	Associate	35896848
Uterine Cervical Neoplasms	Associate	27581326

RPS6 (ribosomal protein S6)