SCART1 (scavenger receptor family member expressed on T cells 1)

Gene Gene information from NCBI Gene database.
Gene Gene ontology Other IDs Protein Associated diseases
Entrez ID 619207
Gene name Scavenger receptor family member expressed on T cells 1
Gene symbol SCART1
Synonyms (NCBI Gene)
-
Chromosome 10
Chromosome location 10q26.3
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
7
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide all (7)
GO ID Ontology Definition Evidence Reference
GO:0002376 Process Immune system process IEA
GO:0002456 Process T cell mediated immunity NAS 22795646
GO:0005737 Component Cytoplasm IDA 22795646
GO:0005737 Component Cytoplasm IEA
GO:0005886 Component Plasma membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
Gene Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q4G0T1
Protein name Scavenger receptor cysteine-rich domain-containing protein SCART1 (Scavenger receptor family member expressed on T cells 1)
Protein function May play a role in the immune system, perhaps as a co-receptor on alphabeta and gammadelta T-cells.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00530 SRCR 32 → 128 Scavenger receptor cysteine-rich domain Domain
PF00530 SRCR 138 → 227 Scavenger receptor cysteine-rich domain Domain
PF00530 SRCR 235 → 326 Scavenger receptor cysteine-rich domain Domain
PF00530 SRCR 331 → 428 Scavenger receptor cysteine-rich domain Domain
PF00530 SRCR 437 → 534 Scavenger receptor cysteine-rich domain Domain
PF00530 SRCR 564 → 656 Scavenger receptor cysteine-rich domain Domain
PF00530 SRCR 664 → 720 Scavenger receptor cysteine-rich domain Domain
PF00530 SRCR 789 → 886 Scavenger receptor cysteine-rich domain Domain
Tissue specificity TISSUE SPECIFICITY: Mainly expressed by CD4(+) and CD8(+) T lymphocytes. Also highly expressed in small intestine and colon. Expressed (at protein level) in small intestine, stomach, gall bladder, and placental villi. {ECO:0000269|PubMed:22795646}.
Sequence 
MRAALWTLGLGPLLLNLWAVPIGGPGALRLAYRHSTCDGVVLVRHHGAWGYVCNQEWTLA
EASVVCRQLGCGPAVGAPKYVPLPGEMAQPWLHNVSCRGNESSLWECSLGSWCQSPCPHA
WVVVALCSNGTFRELRLVKGRSPCAGLPEIRNVNGVDRLCVLHVEEAMVFCRELGCGPVL
QAPRRDVGVVRKYLACRGTEPTIRSCRLDNNFRSGCDLRLDAEVVCSGHTEARLVGGEHP
CAGRLEVTWGTVCDAALDLATAHVVCRELQCGAVVSTPEGARFGRGSGPVWTEAFRCAGN
ESLLFHCPRGRGSQCGHGHDAGLRCSEFRMVNGSSSCEGRVEFQVQGSWAPLCATHWDIA
DATVLCHQLNCGNAVAAPGGGHFGDGDAAIWPDAFHCEGTESYLWNCPVSTLGAPACAPG
NTASAVCSGLAHALRLREGQSRCDGRVEVSLDGVWGRVLDDAWDLRGAGVVCRQLGCRGA
QQAYDAPAPSRGSVQVALSRVRCLGTETRLTQCNVSATLQEPAGTSRDAGVVCSGEVGTA
SPMARRHGIPGALTLSLHREPQGAAGRGAGALHGGAWGTVCDDAWDLRDAHVVCRQLGCG
RALSALGAAHFGAGAGRIWLDELGCQGHESALWQCPSAGWGRHDWRHKEDAGVFCSESVA
LRLRGGTCCCAGWLDVFYNGTWGAMCSNALKDLSLSIICKQLGCGVWGVGLAGEQALPLC
GHRDRLGGQHRVPQAAQLHSVAMPFPPMAPALLRPSRAGLSEDRPQAAGEPLNCSSWLGC
PEEGALRVRGGEDRCSGRVELWHAGSWGTVCDDGWDLADAEVVCRQLGCGRAVAALGAAA
FGPGSGPVWLDEVGCRGSEASLWGCPAERWGRGDRAHEEDAGVRCWEPGPGPPLPAAPFR
TFWVVSVVLGSLLGLLLLGLMAFLILPRVTQAMQRGLGRSEVSPGEAIYDVIGEMPPAGL
YEEIMEAEAVLQDEEDGSVVKVDTEAAVSGEVSNLLEGQSIRAEGGHSRPVSQGYDEAAF
PLEEMTL
Sequence length 1027
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Gene Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (1)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
HEARING LOSS — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations