Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6191
Gene name Gene Name - the full gene name approved by the HGNC.	Ribosomal protein S4 X-linked
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RPS4X
Synonyms (NCBI Gene) Gene synonyms aliases	CCG2, DXS306, RPS4, S4, SCAR, SCR10, eS4
Chromosome Chromosome number	X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	Xq13.1
Summary Summary of gene provided in NCBI Entrez Gene.	Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosom

Show/Hide all(145)

miRTarBase ID	miRNA	Experiments	Reference
MIRT052498	hsa-let-7a-5p	CLASH	23622248
MIRT052233	hsa-let-7b-5p	CLASH	23622248
MIRT050453	hsa-miR-22-3p	CLASH	23622248
MIRT050453	hsa-miR-22-3p	CLASH	23622248
MIRT050403	hsa-miR-23a-3p	CLASH	23622248
MIRT049977	hsa-miR-29a-3p	CLASH	23622248
MIRT048379	hsa-miR-29b-3p	CLASH	23622248
MIRT047191	hsa-miR-182-5p	CLASH	23622248
MIRT046132	hsa-miR-30b-5p	CLASH	23622248
MIRT045173	hsa-miR-186-5p	CLASH	23622248
MIRT044434	hsa-miR-320a	CLASH	23622248
MIRT043831	hsa-miR-330-3p	CLASH	23622248
MIRT040631	hsa-miR-92b-3p	CLASH	23622248
MIRT517856	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT517855	hsa-miR-338-5p	PAR-CLIP	20371350
MIRT517854	hsa-miR-4698	PAR-CLIP	20371350
MIRT517853	hsa-miR-16-2-3p	PAR-CLIP	20371350
MIRT517852	hsa-miR-195-3p	PAR-CLIP	20371350
MIRT517851	hsa-miR-4722-3p	PAR-CLIP	20371350
MIRT517850	hsa-miR-6727-3p	PAR-CLIP	20371350
MIRT517849	hsa-miR-6747-3p	PAR-CLIP	20371350
MIRT517842	hsa-miR-3064-3p	PAR-CLIP	20371350
MIRT517857	hsa-miR-3156-5p	PAR-CLIP	20371350
MIRT517856	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT517855	hsa-miR-338-5p	PAR-CLIP	20371350
MIRT517853	hsa-miR-16-2-3p	PAR-CLIP	20371350
MIRT517852	hsa-miR-195-3p	PAR-CLIP	20371350
MIRT517851	hsa-miR-4722-3p	PAR-CLIP	20371350
MIRT517850	hsa-miR-6727-3p	PAR-CLIP	20371350
MIRT517849	hsa-miR-6747-3p	PAR-CLIP	20371350
MIRT517848	hsa-miR-6730-3p	PAR-CLIP	20371350
MIRT517847	hsa-miR-3660	PAR-CLIP	20371350
MIRT517846	hsa-miR-4526	PAR-CLIP	20371350
MIRT517845	hsa-miR-6719-3p	PAR-CLIP	20371350
MIRT517844	hsa-miR-520d-5p	PAR-CLIP	20371350
MIRT517843	hsa-miR-524-5p	PAR-CLIP	20371350
MIRT517842	hsa-miR-3064-3p	PAR-CLIP	20371350
MIRT517857	hsa-miR-3156-5p	PAR-CLIP	20371350
MIRT517856	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT517855	hsa-miR-338-5p	PAR-CLIP	20371350
MIRT517853	hsa-miR-16-2-3p	PAR-CLIP	20371350
MIRT517852	hsa-miR-195-3p	PAR-CLIP	20371350
MIRT517851	hsa-miR-4722-3p	PAR-CLIP	20371350
MIRT517850	hsa-miR-6727-3p	PAR-CLIP	20371350
MIRT517849	hsa-miR-6747-3p	PAR-CLIP	20371350
MIRT517848	hsa-miR-6730-3p	PAR-CLIP	20371350
MIRT517847	hsa-miR-3660	PAR-CLIP	20371350
MIRT517846	hsa-miR-4526	PAR-CLIP	20371350
MIRT517845	hsa-miR-6719-3p	PAR-CLIP	20371350
MIRT517844	hsa-miR-520d-5p	PAR-CLIP	20371350
MIRT517843	hsa-miR-524-5p	PAR-CLIP	20371350
MIRT517842	hsa-miR-3064-3p	PAR-CLIP	20371350
MIRT517857	hsa-miR-3156-5p	PAR-CLIP	23446348
MIRT517856	hsa-miR-500a-5p	PAR-CLIP	23446348
MIRT517855	hsa-miR-338-5p	PAR-CLIP	23446348
MIRT517854	hsa-miR-4698	PAR-CLIP	23446348
MIRT517853	hsa-miR-16-2-3p	PAR-CLIP	23446348
MIRT517852	hsa-miR-195-3p	PAR-CLIP	23446348
MIRT517851	hsa-miR-4722-3p	PAR-CLIP	23446348
MIRT517850	hsa-miR-6727-3p	PAR-CLIP	23446348
MIRT517849	hsa-miR-6747-3p	PAR-CLIP	23446348
MIRT517848	hsa-miR-6730-3p	PAR-CLIP	23446348
MIRT517847	hsa-miR-3660	PAR-CLIP	23446348
MIRT517846	hsa-miR-4526	PAR-CLIP	23446348
MIRT517845	hsa-miR-6719-3p	PAR-CLIP	23446348
MIRT517844	hsa-miR-520d-5p	PAR-CLIP	23446348
MIRT517843	hsa-miR-524-5p	PAR-CLIP	23446348
MIRT517842	hsa-miR-3064-3p	PAR-CLIP	23446348
MIRT439733	hsa-miR-382-3p	HITS-CLIP	24374217
MIRT439732	hsa-miR-409-5p	HITS-CLIP	24374217
MIRT439731	hsa-miR-154-5p	HITS-CLIP	24374217
MIRT439729	hsa-miR-487a-3p	HITS-CLIP	24374217
MIRT439730	hsa-miR-485-3p	HITS-CLIP	24374217
MIRT439728	hsa-miR-539-5p	HITS-CLIP	24374217
MIRT439733	hsa-miR-382-3p	HITS-CLIP	24374217
MIRT439732	hsa-miR-409-5p	HITS-CLIP	24374217
MIRT439731	hsa-miR-154-5p	HITS-CLIP	24374217
MIRT439729	hsa-miR-487a-3p	HITS-CLIP	24374217
MIRT439730	hsa-miR-485-3p	HITS-CLIP	24374217
MIRT439728	hsa-miR-539-5p	HITS-CLIP	24374217
MIRT517856	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT517855	hsa-miR-338-5p	PAR-CLIP	20371350
MIRT517854	hsa-miR-4698	PAR-CLIP	20371350
MIRT517853	hsa-miR-16-2-3p	PAR-CLIP	20371350
MIRT517852	hsa-miR-195-3p	PAR-CLIP	20371350
MIRT517851	hsa-miR-4722-3p	PAR-CLIP	20371350
MIRT517850	hsa-miR-6727-3p	PAR-CLIP	20371350
MIRT517849	hsa-miR-6747-3p	PAR-CLIP	20371350
MIRT517842	hsa-miR-3064-3p	PAR-CLIP	20371350
MIRT517857	hsa-miR-3156-5p	PAR-CLIP	20371350
MIRT517856	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT517855	hsa-miR-338-5p	PAR-CLIP	20371350
MIRT517853	hsa-miR-16-2-3p	PAR-CLIP	20371350
MIRT517852	hsa-miR-195-3p	PAR-CLIP	20371350
MIRT517851	hsa-miR-4722-3p	PAR-CLIP	20371350
MIRT517850	hsa-miR-6727-3p	PAR-CLIP	20371350
MIRT517849	hsa-miR-6747-3p	PAR-CLIP	20371350
MIRT517848	hsa-miR-6730-3p	PAR-CLIP	20371350
MIRT517847	hsa-miR-3660	PAR-CLIP	20371350
MIRT517846	hsa-miR-4526	PAR-CLIP	20371350
MIRT517845	hsa-miR-6719-3p	PAR-CLIP	20371350
MIRT517844	hsa-miR-520d-5p	PAR-CLIP	20371350
MIRT517843	hsa-miR-524-5p	PAR-CLIP	20371350
MIRT517842	hsa-miR-3064-3p	PAR-CLIP	20371350
MIRT517857	hsa-miR-3156-5p	PAR-CLIP	20371350
MIRT517856	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT517855	hsa-miR-338-5p	PAR-CLIP	20371350
MIRT517853	hsa-miR-16-2-3p	PAR-CLIP	20371350
MIRT517852	hsa-miR-195-3p	PAR-CLIP	20371350
MIRT517851	hsa-miR-4722-3p	PAR-CLIP	20371350
MIRT517850	hsa-miR-6727-3p	PAR-CLIP	20371350
MIRT517849	hsa-miR-6747-3p	PAR-CLIP	20371350
MIRT517848	hsa-miR-6730-3p	PAR-CLIP	20371350
MIRT517847	hsa-miR-3660	PAR-CLIP	20371350
MIRT517846	hsa-miR-4526	PAR-CLIP	20371350
MIRT517845	hsa-miR-6719-3p	PAR-CLIP	20371350
MIRT517844	hsa-miR-520d-5p	PAR-CLIP	20371350
MIRT517843	hsa-miR-524-5p	PAR-CLIP	20371350
MIRT517842	hsa-miR-3064-3p	PAR-CLIP	20371350
MIRT517857	hsa-miR-3156-5p	PAR-CLIP	23446348
MIRT517856	hsa-miR-500a-5p	PAR-CLIP	23446348
MIRT517855	hsa-miR-338-5p	PAR-CLIP	23446348
MIRT517854	hsa-miR-4698	PAR-CLIP	23446348
MIRT517853	hsa-miR-16-2-3p	PAR-CLIP	23446348
MIRT517852	hsa-miR-195-3p	PAR-CLIP	23446348
MIRT517851	hsa-miR-4722-3p	PAR-CLIP	23446348
MIRT517850	hsa-miR-6727-3p	PAR-CLIP	23446348
MIRT517849	hsa-miR-6747-3p	PAR-CLIP	23446348
MIRT517848	hsa-miR-6730-3p	PAR-CLIP	23446348
MIRT517847	hsa-miR-3660	PAR-CLIP	23446348
MIRT517846	hsa-miR-4526	PAR-CLIP	23446348
MIRT517845	hsa-miR-6719-3p	PAR-CLIP	23446348
MIRT517844	hsa-miR-520d-5p	PAR-CLIP	23446348
MIRT517843	hsa-miR-524-5p	PAR-CLIP	23446348
MIRT517842	hsa-miR-3064-3p	PAR-CLIP	23446348
MIRT1317992	hsa-miR-1915	CLIP-seq
MIRT1317993	hsa-miR-500a	CLIP-seq
MIRT1317994	hsa-miR-660	CLIP-seq
MIRT1317995	hsa-miR-711	CLIP-seq
MIRT1317992	hsa-miR-1915	CLIP-seq
MIRT1317994	hsa-miR-660	CLIP-seq
MIRT1317995	hsa-miR-711	CLIP-seq
MIRT1317992	hsa-miR-1915	CLIP-seq
MIRT1317994	hsa-miR-660	CLIP-seq
MIRT1317995	hsa-miR-711	CLIP-seq

Show/Hide all(32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA	21873635
GO:0003735	Function	Structural constituent of ribosome	HDA	15883184
GO:0003735	Function	Structural constituent of ribosome	IBA	21873635
GO:0003735	Function	Structural constituent of ribosome	IMP	8358435
GO:0005515	Function	Protein binding	IPI	24965446, 32814053
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	HDA	15883184
GO:0005844	Component	Polysome	IDA	8139551
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	IBA	21873635
GO:0006412	Process	Translation	IC	8706699, 15883184
GO:0006412	Process	Translation	IMP	8358435
GO:0006413	Process	Translational initiation	TAS
GO:0006614	Process	SRP-dependent cotranslational protein targeting to membrane	TAS
GO:0007275	Process	Multicellular organism development	IMP	8358435
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	1795030
GO:0015935	Component	Small ribosomal subunit	IDA	8139551
GO:0016020	Component	Membrane	HDA	19946888
GO:0019083	Process	Viral transcription	TAS
GO:0019843	Function	RRNA binding	IEA
GO:0022627	Component	Cytosolic small ribosomal subunit	IBA	21873635
GO:0022627	Component	Cytosolic small ribosomal subunit	IDA	8706699
GO:0022627	Component	Cytosolic small ribosomal subunit	NAS	2124517, 8358435
GO:0036464	Component	Cytoplasmic ribonucleoprotein granule	IDA	15121898
GO:0045202	Component	Synapse	IEA
GO:0045471	Process	Response to ethanol	IEA
GO:0045727	Process	Positive regulation of translation	IMP	1795030
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:1990904	Component	Ribonucleoprotein complex	IDA	17289661

MIM	HGNC	e!Ensembl
312760	10424	ENSG00000198034

Protein

UniProt ID

P62701

Protein name

Small ribosomal subunit protein eS4, X isoform (40S ribosomal protein S4) (SCR10) (Single copy abundant mRNA protein)

Protein function

Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryo

PDB

4UG0 , 4V6X , 5A2Q , 5LKS , 5OA3 , 5T2C , 5VYC , 6FEC , 6G18 , 6G4S , 6G4W , 6G51 , 6G53 , 6G5H , 6G5I , 6IP5 , 6IP6 , 6IP8 , 6OLE , 6OLF , 6OLI , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6YBW , 6Z6L , 6Z6M , 6Z6N , 6ZLW , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZMT , 6ZMW , 6ZN5 , 6ZOJ , 6ZOK , 6ZON , 6ZP4 , 6ZUO , 6ZV6 , 6ZVH , 6ZVJ , 6ZXD , 6ZXE , 6ZXF

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08071	RS4NT	3 → 39	RS4NT (NUC023) domain	Domain
PF01479	S4	42 → 90	S4 domain	Domain
PF00900	Ribosomal_S4e	95 → 169	Ribosomal family S4e	Family
PF00467	KOW	177 → 211	KOW motif	Family
PF16121	40S_S4_C	212 → 259	40S ribosomal protein S4 C-terminus	Family

Sequence

MARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIIFLRNRLKYALTGDE
VKKICMQRFIKIDGKVRTDITYPAGFMDVISIDKTGENFRLIYDTKGRFAVHRITPEEAK
YKLCKVRKIFVGTKGIPHLVTHDARTIRYPDPLIKVNDTIQIDLETGKITDFIKFDTGNL
CMVTGGANLGRIGVITNRERHPGSFDVVHVKDANGNSFATRLSNIFVIGKGNKPWISLPR
GKGIRLTIAEERDKRLAAKQSSG

Sequence length

263

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Show/Hide Causal Diseases (3)

Disease term	Disease name	dbSNP ID	References
Causal
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)	21466612
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451 View all (71 more)	21466612
Marfan syndrome	Mammary Carcinoma, Human	rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465 View all (942 more)	21466612

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma Mucinous	Associate	36690709
Alzheimer Disease	Associate	35766008
Atypical Hemolytic Uremic Syndrome	Associate	37373158
Azoospermia	Associate	34738918
Breast Neoplasms	Associate	21466612
Carcinoma Ovarian Epithelial	Associate	23800275
Death	Inhibit	23800275
Osteoarthritis	Associate	29344651
Ovarian Neoplasms	Associate	23800275
Sarcoma Kaposi	Associate	40016701
Wiskott Aldrich Syndrome	Associate	24980502

RPS4X (ribosomal protein S4 X-linked)