Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6188
Gene name	Ribosomal protein S3
Gene symbol	RPS3
Synonyms (NCBI Gene)	S3uS3
Chromosome	11
Chromosome location	11q13.4
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

Show/Hide all (67)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051120	hsa-miR-16-5p	CLASH	23622248
MIRT047912	hsa-miR-30c-5p	CLASH	23622248
MIRT047193	hsa-miR-182-5p	CLASH	23622248
MIRT046540	hsa-miR-15b-5p	CLASH	23622248
MIRT046540	hsa-miR-15b-5p	CLASH	23622248
MIRT044122	hsa-miR-30e-3p	CLASH	23622248
MIRT043461	hsa-miR-331-3p	CLASH	23622248
MIRT042817	hsa-miR-324-3p	CLASH	23622248
MIRT041288	hsa-miR-193b-3p	CLASH	23622248
MIRT039732	hsa-miR-615-3p	CLASH	23622248
MIRT038586	hsa-miR-106b-3p	CLASH	23622248
MIRT035761	hsa-miR-196b-3p	CLASH	23622248
MIRT060732	hsa-miR-4282	PAR-CLIP	21572407
MIRT551855	hsa-miR-548m	PAR-CLIP	21572407
MIRT060729	hsa-miR-590-3p	PAR-CLIP	21572407
MIRT551854	hsa-miR-6758-5p	PAR-CLIP	21572407
MIRT551853	hsa-miR-6856-5p	PAR-CLIP	21572407
MIRT551852	hsa-miR-6830-3p	PAR-CLIP	21572407
MIRT551851	hsa-miR-4711-3p	PAR-CLIP	21572407
MIRT551850	hsa-miR-4477a	PAR-CLIP	21572407
MIRT551849	hsa-miR-6844	PAR-CLIP	21572407
MIRT060727	hsa-let-7c-3p	PAR-CLIP	21572407
MIRT551848	hsa-let-7a-2-3p	PAR-CLIP	21572407
MIRT551847	hsa-let-7g-3p	PAR-CLIP	21572407
MIRT551846	hsa-miR-493-5p	PAR-CLIP	21572407
MIRT551845	hsa-miR-511-5p	PAR-CLIP	21572407
MIRT551844	hsa-miR-592	PAR-CLIP	21572407
MIRT060730	hsa-miR-1303	PAR-CLIP	21572407
MIRT060732	hsa-miR-4282	PAR-CLIP	21572407
MIRT551855	hsa-miR-548m	PAR-CLIP	21572407
MIRT060729	hsa-miR-590-3p	PAR-CLIP	21572407
MIRT551854	hsa-miR-6758-5p	PAR-CLIP	21572407
MIRT551853	hsa-miR-6856-5p	PAR-CLIP	21572407
MIRT551852	hsa-miR-6830-3p	PAR-CLIP	21572407
MIRT551851	hsa-miR-4711-3p	PAR-CLIP	21572407
MIRT551850	hsa-miR-4477a	PAR-CLIP	21572407
MIRT551849	hsa-miR-6844	PAR-CLIP	21572407
MIRT060727	hsa-let-7c-3p	PAR-CLIP	21572407
MIRT551848	hsa-let-7a-2-3p	PAR-CLIP	21572407
MIRT551847	hsa-let-7g-3p	PAR-CLIP	21572407
MIRT551846	hsa-miR-493-5p	PAR-CLIP	21572407
MIRT551845	hsa-miR-511-5p	PAR-CLIP	21572407
MIRT551844	hsa-miR-592	PAR-CLIP	21572407
MIRT060730	hsa-miR-1303	PAR-CLIP	21572407
MIRT1317977	hsa-miR-22	CLIP-seq
MIRT1317978	hsa-miR-4428	CLIP-seq
MIRT1317979	hsa-miR-4480	CLIP-seq
MIRT1317980	hsa-miR-4725-5p	CLIP-seq
MIRT1317981	hsa-miR-504	CLIP-seq
MIRT1317982	hsa-miR-508-5p	CLIP-seq
MIRT1317983	hsa-miR-511	CLIP-seq
MIRT1317977	hsa-miR-22	CLIP-seq
MIRT1317978	hsa-miR-4428	CLIP-seq
MIRT1317979	hsa-miR-4480	CLIP-seq
MIRT1317980	hsa-miR-4725-5p	CLIP-seq
MIRT1317981	hsa-miR-504	CLIP-seq
MIRT1317982	hsa-miR-508-5p	CLIP-seq
MIRT1317977	hsa-miR-22	CLIP-seq
MIRT1317978	hsa-miR-4428	CLIP-seq
MIRT1317979	hsa-miR-4480	CLIP-seq
MIRT1317980	hsa-miR-4725-5p	CLIP-seq
MIRT1317981	hsa-miR-504	CLIP-seq
MIRT1317982	hsa-miR-508-5p	CLIP-seq
MIRT1317977	hsa-miR-22	CLIP-seq
MIRT1317978	hsa-miR-4428	CLIP-seq
MIRT1317979	hsa-miR-4480	CLIP-seq
MIRT1317982	hsa-miR-508-5p	CLIP-seq

120

Show/Hide all (120)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP	18045535
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003677	Function	DNA binding	IDA	18610840
GO:0003677	Function	DNA binding	IEA
GO:0003684	Function	Damaged DNA binding	IDA	14706345, 15518571, 16737853, 17560175, 18610840
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IDA	20217897
GO:0003723	Function	RNA binding	IEA
GO:0003729	Function	MRNA binding	IDA	18464793
GO:0003735	Function	Structural constituent of ribosome	HDA	15883184
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	1712897
GO:0003906	Function	DNA-(apurinic or apyrimidinic site) endonuclease activity	IDA	7775413, 15707971, 16737853, 18610840, 19059439
GO:0003906	Function	DNA-(apurinic or apyrimidinic site) endonuclease activity	IEA
GO:0004520	Function	DNA endonuclease activity	IDA	15707971, 20605787
GO:0005515	Function	Protein binding	IPI	15161933, 18045535, 18274552, 19059439, 19656744, 20041225, 20618440, 21145461, 21146485, 21399639, 22113938, 22244329, 22510408, 23911537, 24423872, 24457201, 24725412, 24965446, 25609649, 26526615, 28065601, 28132843, 30021884, 31046837, 32296183, 32814053, 33961781, 35271311, 392
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	14988002, 16814409, 17560175, 18045535, 19059439, 19460357, 20041225
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	IMP	21399639, 21871177
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA	19460357
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IDA	14988002, 19059439, 20217897
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	IMP	21871177
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IDA	23911537
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005759	Component	Mitochondrial matrix	IDA	23911537
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005819	Component	Spindle	IEA
GO:0005829	Component	Cytosol	IDA	16814409, 17560175, 18045535
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IDA	19059439, 19460357, 20217897
GO:0005840	Component	Ribosome	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IDA	22510408
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006281	Process	DNA repair	IEA
GO:0006281	Process	DNA repair	IMP	19059439
GO:0006284	Process	Base-excision repair	IDA	15518571
GO:0006412	Process	Translation	IC	8706699
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	1712897
GO:0006413	Process	Translational initiation	NAS	15883184
GO:0006417	Process	Regulation of translation	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0006974	Process	DNA damage response	IEP	17560175
GO:0007059	Process	Chromosome segregation	IMP	23131551
GO:0008017	Function	Microtubule binding	IDA	23131551
GO:0010628	Process	Positive regulation of gene expression	IMP	20605787
GO:0014069	Component	Postsynaptic density	EXP	21170055
GO:0014069	Component	Postsynaptic density	IDA	21170055
GO:0015631	Function	Tubulin binding	IDA	23131551
GO:0015935	Component	Small ribosomal subunit	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016829	Function	Lyase activity	IEA
GO:0017148	Process	Negative regulation of translation	IDA	20217897
GO:0019104	Function	DNA N-glycosylase activity	IDA	18610840
GO:0019104	Function	DNA N-glycosylase activity	TAS	15707971
GO:0019899	Function	Enzyme binding	IPI	15518571, 18973764, 19460357
GO:0019900	Function	Kinase binding	IPI	20605787
GO:0019901	Function	Protein kinase binding	IPI	15950189, 21871177
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0022626	Component	Cytosolic ribosome	IEA
GO:0022627	Component	Cytosolic small ribosomal subunit	HDA	15883184
GO:0022627	Component	Cytosolic small ribosomal subunit	IBA
GO:0022627	Component	Cytosolic small ribosomal subunit	IDA	8706699
GO:0022627	Component	Cytosolic small ribosomal subunit	IEA
GO:0022627	Component	Cytosolic small ribosomal subunit	NAS	25901680
GO:0030544	Function	Hsp70 protein binding	IDA	23911537
GO:0031116	Process	Positive regulation of microtubule polymerization	IMP	23131551
GO:0031334	Process	Positive regulation of protein-containing complex assembly	IEA
GO:0031334	Process	Positive regulation of protein-containing complex assembly	IMP	18045535
GO:0031397	Process	Negative regulation of protein ubiquitination	IDA	19656744
GO:0032079	Process	Positive regulation of endodeoxyribonuclease activity	IDA	18973764
GO:0032357	Function	Oxidized purine DNA binding	IDA	14706345
GO:0032358	Function	Oxidized pyrimidine DNA binding	IDA	19656744
GO:0032587	Component	Ruffle membrane	IDA	16814409
GO:0032743	Process	Positive regulation of interleukin-2 production	IMP	18045535
GO:0034614	Process	Cellular response to reactive oxygen species	IDA	23911537
GO:0042104	Process	Positive regulation of activated T cell proliferation	IMP	18045535
GO:0042981	Process	Regulation of apoptotic process	IMP	20605787
GO:0044390	Function	Ubiquitin-like protein conjugating enzyme binding	IPI	21968017
GO:0044877	Function	Protein-containing complex binding	IMP	18045535
GO:0045202	Component	Synapse	IEA
GO:0045738	Process	Negative regulation of DNA repair	IMP	17049931
GO:0045739	Process	Positive regulation of DNA repair	IDA	23911537
GO:0050862	Process	Positive regulation of T cell receptor signaling pathway	IMP	18045535
GO:0051018	Function	Protein kinase A binding	IPI	16814409
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	IGI	18045535
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	IMP	18045535
GO:0051225	Process	Spindle assembly	IMP	23131551
GO:0051301	Process	Cell division	IEA
GO:0051536	Function	Iron-sulfur cluster binding	NAS	11911468
GO:0051879	Function	Hsp90 protein binding	IDA	23911537
GO:0061481	Process	Response to TNF agonist	IDA	20041225
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0070181	Function	Small ribosomal subunit rRNA binding	IDA	18610840
GO:0070301	Process	Cellular response to hydrogen peroxide	IDA	23911537
GO:0071159	Component	NF-kappaB complex	IDA	18045535
GO:0071356	Process	Cellular response to tumor necrosis factor	IMP	18045535
GO:0072686	Component	Mitotic spindle	IDA	23131551
GO:0097100	Function	Supercoiled DNA binding	IDA	15707971
GO:0140078	Function	Class I DNA-(apurinic or apyrimidinic site) endonuclease activity	IEA
GO:0140297	Function	DNA-binding transcription factor binding	IPI	20605787
GO:1901224	Process	Positive regulation of non-canonical NF-kappaB signal transduction	IDA	20041225
GO:1902231	Process	Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IMP	22510408
GO:1905053	Process	Positive regulation of base-excision repair	IDA	18973764
GO:1990904	Component	Ribonucleoprotein complex	IDA	17289661
GO:1990904	Component	Ribonucleoprotein complex	IEA
GO:2001235	Process	Positive regulation of apoptotic signaling pathway	IBA
GO:2001235	Process	Positive regulation of apoptotic signaling pathway	IDA	14988002

MIM	HGNC	e!Ensembl
600454	10420	ENSG00000149273

P23396

Protein name

Small ribosomal subunit protein uS3 (40S ribosomal protein S3) (EC 4.2.99.18)

Protein function

Component of the small ribosomal subunit (PubMed:23636399, PubMed:8706699). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:8706699). Has endonuclease activity and

PDB

1WH9 , 4UG0 , 4V6X , 5A2Q , 5AJ0 , 5FLX , 5LKS , 5OA3 , 5T2C , 5VYC , 6FEC , 6G51 , 6G53 , 6G5H , 6G5I , 6IP5 , 6IP6 , 6IP8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6YBS , 6Z6L , 6Z6M , 6Z6N , 6ZLW , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZMT , 6ZMW , 6ZN5 , 6ZOJ , 6ZOL , 6ZON , 6ZP4 , 6ZUO , 6ZV6 , 6ZVH , 6ZVJ , 6ZXD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07650	KH_2	20 → 96	KH domain	Domain
PF00189	Ribosomal_S3_C	105 → 188	Ribosomal protein S3, C-terminal domain	Domain

Sequence

MAVQISKKRKFVADGIFKAELNEFLTRELAEDGYSGVEVRVTPTRTEIIILATRTQNVLG
EKGRRIRELTAVVQKRFGFPEGSVELYAEKVATRGLCAIAQAESLRYKLLGGLAVRRACY
GVLRFIMESGAKGCEVVVSGKLRGQRAKSMKFVDGLMIHSGDPVNYYVDTAVRHVLLRQG
VLGIKVKIMLPWDPTGKIGPKKPLPDHVSIVEPKDEILPTTPISEQKGGKPEPPAMPQPV
PTA

Sequence length

243

Interactions

View interactions

	KEGG		Reactome
	Ribosome Pathogenic Escherichia coli infection Salmonella infection Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Show/Hide Unknown Diseases (16)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign	rs11236421	RCV005905142
Cervical cancer	Benign	rs11236421	RCV005905145
Clear cell carcinoma of kidney	Benign	rs11236421	RCV005905146
Colon adenocarcinoma	Benign	rs11236421	RCV005905141
Colorectal cancer	Benign	rs11236421	RCV005905148
Familial cancer of breast	Benign	rs11236421	RCV005905140
Gastric cancer	Benign	rs11236421	RCV005905150
Lung cancer	Benign	rs11236421	RCV005905154
Malignant tumor of esophagus	Benign	rs11236421	RCV005905143
Melanoma	Benign	rs11236421	RCV005905153
Nonpapillary renal cell carcinoma	Benign	rs11236421	RCV005905144
Ovarian serous cystadenocarcinoma	Benign	rs11236421	RCV005905151
Sarcoma	Benign	rs11236421	RCV005905149
Uterine carcinosarcoma	Benign	rs11236421	RCV005905152
Uterine corpus endometrial carcinoma	Benign	rs11236421	RCV005905155
Uveal melanoma	Benign	rs11236421	RCV005905147

Show/Hide Text Mining Associations (22)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	36257285
Alzheimer Disease	Associate	35766008, 37925455
Anemia Diamond Blackfan	Associate	20116044
Carcinoma Hepatocellular	Associate	40264052
Carcinoma Non Small Cell Lung	Associate	23188828
Carcinoma Ovarian Epithelial	Associate	35951361
Cerebral Infarction	Associate	40696650
Colorectal Neoplasms	Associate	36567344
Coronary Artery Disease	Associate	38267845
Diabetes Mellitus Type 1	Associate	12950147
Diabetes Mellitus Type 2	Associate	12950147
Fibrosarcoma	Associate	16814409
Gastroschisis	Associate	31075877
Hepatomegaly	Associate	37603533
Kidney Diseases	Associate	37603533
Liver Failure	Associate	37603533
Necrosis	Associate	37603533
Neoplasms	Associate	35951361, 37603533, 37784026
Osteoarthritis	Associate	30298554, 39796139
Teratozoospermia	Associate	29901159
Triple Negative Breast Neoplasms	Associate	35313339, 35616135
Xeroderma Pigmentosum	Associate	33464383

RPS3 (ribosomal protein S3)