Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6185
Gene name	Ribophorin II
Gene symbol	RPN2
Synonyms (NCBI Gene)	RIBIIRRPN-IIRPNIISWP1
Chromosome	20
Chromosome location	20q11.23
Summary	This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-S

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miRTarBase ID	miRNA	Experiments	Reference
MIRT019733	hsa-miR-375	Microarray	20215506
MIRT051474	hsa-let-7e-5p	CLASH	23622248
MIRT049944	hsa-miR-30a-5p	CLASH	23622248
MIRT047806	hsa-miR-30d-5p	CLASH	23622248
MIRT046320	hsa-miR-23b-3p	CLASH	23622248
MIRT042274	hsa-miR-484	CLASH	23622248
MIRT042274	hsa-miR-484	CLASH	23622248
MIRT039690	hsa-miR-615-3p	CLASH	23622248
MIRT450694	hsa-miR-219a-2-3p	PAR-CLIP	22100165
MIRT450693	hsa-miR-4318	PAR-CLIP	22100165
MIRT450692	hsa-miR-892a	PAR-CLIP	22100165
MIRT450691	hsa-miR-1-5p	PAR-CLIP	22100165
MIRT450690	hsa-miR-219b-3p	PAR-CLIP	22100165
MIRT450689	hsa-miR-1257	PAR-CLIP	22100165
MIRT450688	hsa-miR-2116-5p	PAR-CLIP	22100165
MIRT450687	hsa-miR-22-5p	PAR-CLIP	22100165
MIRT450686	hsa-miR-4693-5p	PAR-CLIP	22100165
MIRT450685	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT450684	hsa-miR-4273	PAR-CLIP	22100165
MIRT450683	hsa-miR-7156-5p	PAR-CLIP	22100165
MIRT450682	hsa-miR-4677-5p	PAR-CLIP	22100165
MIRT450681	hsa-miR-6739-3p	PAR-CLIP	22100165
MIRT450694	hsa-miR-219a-2-3p	PAR-CLIP	22100165
MIRT450693	hsa-miR-4318	PAR-CLIP	22100165
MIRT450692	hsa-miR-892a	PAR-CLIP	22100165
MIRT450691	hsa-miR-1-5p	PAR-CLIP	22100165
MIRT450690	hsa-miR-219b-3p	PAR-CLIP	22100165
MIRT450689	hsa-miR-1257	PAR-CLIP	22100165
MIRT450688	hsa-miR-2116-5p	PAR-CLIP	22100165
MIRT450687	hsa-miR-22-5p	PAR-CLIP	22100165
MIRT450686	hsa-miR-4693-5p	PAR-CLIP	22100165
MIRT450685	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT450684	hsa-miR-4273	PAR-CLIP	22100165
MIRT450683	hsa-miR-7156-5p	PAR-CLIP	22100165
MIRT450682	hsa-miR-4677-5p	PAR-CLIP	22100165
MIRT450681	hsa-miR-6739-3p	PAR-CLIP	22100165
MIRT1317104	hsa-miR-1226	CLIP-seq
MIRT1317105	hsa-miR-128	CLIP-seq
MIRT1317106	hsa-miR-2110	CLIP-seq
MIRT1317107	hsa-miR-3200-5p	CLIP-seq
MIRT1317108	hsa-miR-3670	CLIP-seq
MIRT1317109	hsa-miR-3919	CLIP-seq
MIRT1317110	hsa-miR-3941	CLIP-seq
MIRT1317111	hsa-miR-4271	CLIP-seq
MIRT1317112	hsa-miR-4303	CLIP-seq
MIRT1317113	hsa-miR-4311	CLIP-seq
MIRT1317114	hsa-miR-466	CLIP-seq
MIRT1317115	hsa-miR-4672	CLIP-seq
MIRT1317116	hsa-miR-4725-3p	CLIP-seq
MIRT1317117	hsa-miR-4733-3p	CLIP-seq
MIRT1317118	hsa-miR-4738-3p	CLIP-seq
MIRT1317119	hsa-miR-4756-3p	CLIP-seq
MIRT1317120	hsa-miR-548l	CLIP-seq
MIRT1317121	hsa-miR-548n	CLIP-seq
MIRT1317122	hsa-miR-548p	CLIP-seq
MIRT1317123	hsa-miR-606	CLIP-seq
MIRT1317124	hsa-miR-4659a-3p	CLIP-seq
MIRT1317125	hsa-miR-4659b-3p	CLIP-seq
MIRT1317126	hsa-miR-587	CLIP-seq
MIRT1317127	hsa-miR-942	CLIP-seq
MIRT2094127	hsa-miR-1305	CLIP-seq
MIRT1317104	hsa-miR-1226	CLIP-seq
MIRT1317105	hsa-miR-128	CLIP-seq
MIRT2439974	hsa-miR-3147	CLIP-seq
MIRT1317107	hsa-miR-3200-5p	CLIP-seq
MIRT1317108	hsa-miR-3670	CLIP-seq
MIRT1317109	hsa-miR-3919	CLIP-seq
MIRT1317110	hsa-miR-3941	CLIP-seq
MIRT1317112	hsa-miR-4303	CLIP-seq
MIRT1317113	hsa-miR-4311	CLIP-seq
MIRT2439975	hsa-miR-4425	CLIP-seq
MIRT1317114	hsa-miR-466	CLIP-seq
MIRT1317115	hsa-miR-4672	CLIP-seq
MIRT2439976	hsa-miR-4686	CLIP-seq
MIRT1317117	hsa-miR-4733-3p	CLIP-seq
MIRT1317119	hsa-miR-4756-3p	CLIP-seq
MIRT1317104	hsa-miR-1226	CLIP-seq
MIRT1317105	hsa-miR-128	CLIP-seq
MIRT2614391	hsa-miR-1299	CLIP-seq
MIRT2614392	hsa-miR-142-5p	CLIP-seq
MIRT2614393	hsa-miR-181a	CLIP-seq
MIRT2614394	hsa-miR-181b	CLIP-seq
MIRT2614395	hsa-miR-181c	CLIP-seq
MIRT2614396	hsa-miR-181d	CLIP-seq
MIRT1317106	hsa-miR-2110	CLIP-seq
MIRT2439974	hsa-miR-3147	CLIP-seq
MIRT2614397	hsa-miR-3150a-3p	CLIP-seq
MIRT2614398	hsa-miR-3182	CLIP-seq
MIRT1317107	hsa-miR-3200-5p	CLIP-seq
MIRT1317108	hsa-miR-3670	CLIP-seq
MIRT2614399	hsa-miR-378	CLIP-seq
MIRT2614400	hsa-miR-378b	CLIP-seq
MIRT2614401	hsa-miR-378c	CLIP-seq
MIRT2614402	hsa-miR-378d	CLIP-seq
MIRT2614403	hsa-miR-378e	CLIP-seq
MIRT2614404	hsa-miR-378f	CLIP-seq
MIRT2614405	hsa-miR-378h	CLIP-seq
MIRT2614406	hsa-miR-378i	CLIP-seq
MIRT1317109	hsa-miR-3919	CLIP-seq
MIRT1317110	hsa-miR-3941	CLIP-seq
MIRT2614407	hsa-miR-3942-3p	CLIP-seq
MIRT2614408	hsa-miR-422a	CLIP-seq
MIRT2614409	hsa-miR-4262	CLIP-seq
MIRT1317111	hsa-miR-4271	CLIP-seq
MIRT1317112	hsa-miR-4303	CLIP-seq
MIRT1317113	hsa-miR-4311	CLIP-seq
MIRT2614410	hsa-miR-4328	CLIP-seq
MIRT2439975	hsa-miR-4425	CLIP-seq
MIRT2614411	hsa-miR-4638-3p	CLIP-seq
MIRT1317124	hsa-miR-4659a-3p	CLIP-seq
MIRT1317125	hsa-miR-4659b-3p	CLIP-seq
MIRT1317114	hsa-miR-466	CLIP-seq
MIRT1317115	hsa-miR-4672	CLIP-seq
MIRT2439976	hsa-miR-4686	CLIP-seq
MIRT1317116	hsa-miR-4725-3p	CLIP-seq
MIRT1317117	hsa-miR-4733-3p	CLIP-seq
MIRT1317118	hsa-miR-4738-3p	CLIP-seq
MIRT1317119	hsa-miR-4756-3p	CLIP-seq
MIRT2614412	hsa-miR-4782-5p	CLIP-seq
MIRT2614413	hsa-miR-516b	CLIP-seq
MIRT1317120	hsa-miR-548l	CLIP-seq
MIRT1317121	hsa-miR-548n	CLIP-seq
MIRT1317122	hsa-miR-548p	CLIP-seq
MIRT2614414	hsa-miR-561	CLIP-seq
MIRT1317126	hsa-miR-587	CLIP-seq
MIRT1317123	hsa-miR-606	CLIP-seq
MIRT2614415	hsa-miR-875-3p	CLIP-seq
MIRT1317104	hsa-miR-1226	CLIP-seq
MIRT1317105	hsa-miR-128	CLIP-seq
MIRT2614391	hsa-miR-1299	CLIP-seq
MIRT2614392	hsa-miR-142-5p	CLIP-seq
MIRT2614393	hsa-miR-181a	CLIP-seq
MIRT2614394	hsa-miR-181b	CLIP-seq
MIRT2614395	hsa-miR-181c	CLIP-seq
MIRT2614396	hsa-miR-181d	CLIP-seq
MIRT1317106	hsa-miR-2110	CLIP-seq
MIRT2439974	hsa-miR-3147	CLIP-seq
MIRT2614397	hsa-miR-3150a-3p	CLIP-seq
MIRT2614398	hsa-miR-3182	CLIP-seq
MIRT1317107	hsa-miR-3200-5p	CLIP-seq
MIRT1317108	hsa-miR-3670	CLIP-seq
MIRT2614399	hsa-miR-378	CLIP-seq
MIRT2614400	hsa-miR-378b	CLIP-seq
MIRT2614401	hsa-miR-378c	CLIP-seq
MIRT2614402	hsa-miR-378d	CLIP-seq
MIRT2614403	hsa-miR-378e	CLIP-seq
MIRT2614404	hsa-miR-378f	CLIP-seq
MIRT2614405	hsa-miR-378h	CLIP-seq
MIRT2614406	hsa-miR-378i	CLIP-seq
MIRT1317109	hsa-miR-3919	CLIP-seq
MIRT1317110	hsa-miR-3941	CLIP-seq
MIRT2614407	hsa-miR-3942-3p	CLIP-seq
MIRT2614408	hsa-miR-422a	CLIP-seq
MIRT2614409	hsa-miR-4262	CLIP-seq
MIRT1317111	hsa-miR-4271	CLIP-seq
MIRT1317112	hsa-miR-4303	CLIP-seq
MIRT1317113	hsa-miR-4311	CLIP-seq
MIRT2614410	hsa-miR-4328	CLIP-seq
MIRT2439975	hsa-miR-4425	CLIP-seq
MIRT2614411	hsa-miR-4638-3p	CLIP-seq
MIRT1317124	hsa-miR-4659a-3p	CLIP-seq
MIRT1317125	hsa-miR-4659b-3p	CLIP-seq
MIRT1317114	hsa-miR-466	CLIP-seq
MIRT1317115	hsa-miR-4672	CLIP-seq
MIRT2439976	hsa-miR-4686	CLIP-seq
MIRT1317116	hsa-miR-4725-3p	CLIP-seq
MIRT1317117	hsa-miR-4733-3p	CLIP-seq
MIRT1317118	hsa-miR-4738-3p	CLIP-seq
MIRT1317119	hsa-miR-4756-3p	CLIP-seq
MIRT2614412	hsa-miR-4782-5p	CLIP-seq
MIRT2614413	hsa-miR-516b	CLIP-seq
MIRT1317120	hsa-miR-548l	CLIP-seq
MIRT1317121	hsa-miR-548n	CLIP-seq
MIRT1317122	hsa-miR-548p	CLIP-seq
MIRT2614414	hsa-miR-561	CLIP-seq
MIRT1317126	hsa-miR-587	CLIP-seq
MIRT1317123	hsa-miR-606	CLIP-seq
MIRT2614415	hsa-miR-875-3p	CLIP-seq
MIRT1317127	hsa-miR-942	CLIP-seq

Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004579	Function	Dolichyl-diphosphooligosaccharide-protein glycotransferase activity	NAS	15835887
GO:0005515	Function	Protein binding	IPI	24965446, 28169274, 29290612, 32707033
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	NAS	31831667
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006486	Process	Protein glycosylation	IEA
GO:0006487	Process	Protein N-linked glycosylation	IBA
GO:0006487	Process	Protein N-linked glycosylation	IDA	9642163
GO:0006487	Process	Protein N-linked glycosylation	IEA
GO:0006487	Process	Protein N-linked glycosylation	NAS	31831667
GO:0008250	Component	Oligosaccharyltransferase complex	IBA
GO:0008250	Component	Oligosaccharyltransferase complex	IDA	9642163
GO:0008250	Component	Oligosaccharyltransferase complex	IEA
GO:0008250	Component	Oligosaccharyltransferase complex	IPI	31831667
GO:0008250	Component	Oligosaccharyltransferase complex	NAS	31831667
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0036211	Process	Protein modification process	TAS	10660554
GO:0160226	Component	Oligosaccharyltransferase complex A	IDA	31831667, 36697828, 38670073
GO:0160227	Component	Oligosaccharyltransferase complex B	IDA	31831667

MIM	HGNC	e!Ensembl
180490	10382	ENSG00000118705

P04844

Protein name

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit) (RIBIIR) (Ribophorin II) (RPN-II) (Ribophorin-2)

Protein function

Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr

PDB

6S7O , 6S7T , 8B6L , 8PN9

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05817	Ribophorin_II	9 → 627	Oligosaccharyltransferase subunit Ribophorin II	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in all tissues tested.

Sequence

MAPPGSSTVFLLALTIIASTWALTPTHYLTKHDVERLKASLDRPFTNLESAFYSIVGLSS
LGAQVPDAKKACTYIRSNLDPSNVDSLFYAAQASQALSGCEISISNETKDLLLAAVSEDS
SVTQIYHAVAALSGFGLPLASQEALSALTARLSKEETVLATVQALQTASHLSQQADLRSI
VEEIEDLVARLDELGGVYLQFEEGLETTALFVAATYKLMDHVGTEPSIKEDQVIQLMNAI
FSKKNFESLSEAFSVASAAAVLSHNRYHVPVVVVPEGSASDTHEQAILRLQVTNVLSQPL
TQATVKLEHAKSVASRATVLQKTSFTPVGDVFELNFMNVKFSSGYYDFLVEVEGDNRYIA
NTVELRVKISTEVGITNVDLSTVDKDQSIAPKTTRVTYPAKAKGTFIADSHQNFALFFQL
VDVNTGAELTPHQTFVRLHNQKTGQEVVFVAEPDNKNVYKFELDTSERKIEFDSASGTYT
LYLIIGDATLKNPILWNVADVVIKFPEEEAPSTVLSQNLFTPKQEIQHLFREPEKRPPTV
VSNTFTALILSPLLLLFALWIRIGANVSNFTFAPSTIIFHLGHAAMLGLMYVYWTQLNMF
QTLKYLAILGSVTFLAGNRMLAQQAVKRTAH

Sequence length

631

Interactions

View interactions

	KEGG		Reactome
	N-Glycan biosynthesis Various types of N-glycan biosynthesis Metabolic pathways Protein processing in endoplasmic reticulum		Asparagine N-linked glycosylation

141

Show/Hide Unknown Diseases (12)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cervical cancer	Likely benign	rs202178300	RCV005931532
Cholangiocarcinoma	Benign	rs77501105	RCV005923419
Colon adenocarcinoma	Uncertain significance	rs760804350	RCV005932668
Congenital disorder of glycosylation	Uncertain significance; Likely benign; Benign; Conflicting classifications of pathogenicity	rs773226770, rs745748573, rs2067322572, rs372064976, rs111986827, rs2146608181, rs114917981, rs200360517, rs11467214, rs117475222, rs2067319229, rs144151309, rs535586576, rs62206558, rs138894622 View all (103 more)	RCV001322349 RCV001325721 RCV001314568 RCV001326748 RCV001364207 RCV001411119 RCV001405055 RCV001419319 RCV001443516 RCV001423790 RCV001470731 RCV001476001 RCV001468054 RCV001488404 RCV001488007 RCV001482794 RCV001499284 RCV001488593 RCV001523658 RCV001522355 RCV001522485 RCV001510513 RCV001512571 RCV001511414 RCV001522942 RCV002021835 RCV001911711 RCV001982618 RCV002002861 RCV001995348 RCV001896843 RCV001908530 RCV002146935 RCV002094210 RCV002087605 RCV002161181 RCV002196799 RCV002129432 RCV002215959 RCV002085453 RCV002148910 RCV002182539 RCV002185259 RCV002194930 RCV002206318 RCV002299769 RCV003050923 RCV003085919 RCV003091934 RCV003092670 RCV002516687 RCV002647287 RCV002650884 RCV002629864 RCV001519481 RCV002596749 RCV002584553 RCV002596868 RCV002609714 RCV002653844 RCV002676643 RCV002715250 RCV002712098 RCV002785975 RCV002780074 RCV002806993 RCV002852338 RCV002890912 RCV002909090 RCV002918606 RCV002927304 RCV002942378 RCV002922243 RCV002932497 RCV002948397 RCV002982644 RCV002996131 RCV002976614 RCV002985725 RCV003059309 RCV003054117 RCV003643034 RCV003528465 RCV003528863 RCV003529081 RCV003529120 RCV003529176 RCV003529374 RCV003529690 RCV003527947 RCV003527850 RCV003527804 RCV003527956 RCV003643099 RCV003643269 RCV003643586 RCV003644232 RCV003644216 RCV003644407 RCV003642688 RCV003642786 RCV003642661 RCV003643443 RCV003643369 RCV003642826 RCV003850400 RCV003874764 RCV001491408 RCV000552409 RCV000695907 RCV000694248 RCV000706984 RCV000824152 RCV001513232 RCV000966328 RCV001500973 RCV001421214 RCV000960496 RCV001433730 RCV001046532 RCV001035090 RCV001070401 RCV001035984 RCV001041726 RCV001225525 RCV001309762
Lung cancer	Benign	rs11086969	RCV005916570
Malignant tumor of esophagus	Likely benign	rs376939930	RCV005901353
Malignant tumor of urinary bladder	Uncertain significance	rs372064976	RCV005911055
Ovarian serous cystadenocarcinoma	Likely benign	rs202178300	RCV005931533
Sarcoma	Benign	rs11086969	RCV005916569
Thymoma	Uncertain significance; Benign; Likely benign	rs372064976, rs77501105, rs376939930	RCV005911056 RCV005923418 RCV005901354
Uterine carcinosarcoma	Benign	rs77838287	RCV005929832
Uterine corpus endometrial carcinoma	Benign	rs11086969	RCV005916571

Show/Hide Text Mining Associations (25)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Abortion Habitual	Associate	36439123
Alzheimer Disease	Associate	35766008
Breast Neoplasms	Associate	23959174, 24237343, 24884960
Carcinoma Hepatocellular	Associate	31481647
Colonic Neoplasms	Associate	29749494
Colorectal Neoplasms	Associate	10601642, 23341073, 29749494
Congenital Disorders of Glycosylation	Associate	24243557
Esophageal Neoplasms	Associate	22955852
Esophageal Squamous Cell Carcinoma	Associate	22955852
Glaucoma Open Angle	Associate	23536807
Glioblastoma	Associate	32404045, 33000268, 36168628
Glioma	Associate	32404045, 33000268
Glioma	Stimulate	36227125
Lymphatic Metastasis	Associate	24386425
Macular Degeneration	Stimulate	24286321
Myelodysplastic Syndromes	Associate	32447991
Neoplasm Invasiveness	Associate	16371738
Neoplasm Metastasis	Associate	23959174, 31481647
Neoplasms	Associate	10601642, 23341073, 24884960, 29749494, 31481647, 32404045
Neoplasms	Stimulate	36227125
Osteoporosis	Associate	31743606
Pancreatic Neoplasms	Associate	22335271
Squamous Cell Carcinoma of Head and Neck	Associate	24386425
Stomach Neoplasms	Associate	16371738
Urinary Bladder Neoplasms	Associate	37108067

RPN2 (ribophorin II)