Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6184
Gene name Gene Name - the full gene name approved by the HGNC.	Ribophorin I
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RPN1
Synonyms (NCBI Gene) Gene synonyms aliases	OST1, RBPH1
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3q21.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-S

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miRTarBase ID	miRNA	Experiments	Reference
MIRT020068	hsa-miR-375	Microarray	20215506
MIRT030197	hsa-miR-26b-5p	Microarray	19088304
MIRT048357	hsa-miR-103a-3p	CLASH	23622248
MIRT020068	hsa-miR-375	Luciferase reporter assay, Western blotting, qRT-PCR, Immunoprecipitaion (IP)	37386831
MIRT1317077	hsa-miR-1236	CLIP-seq
MIRT1317078	hsa-miR-151-3p	CLIP-seq
MIRT1317079	hsa-miR-193a-3p	CLIP-seq
MIRT1317080	hsa-miR-193b	CLIP-seq
MIRT1317081	hsa-miR-2861	CLIP-seq
MIRT1317082	hsa-miR-3154	CLIP-seq
MIRT1317083	hsa-miR-3156-3p	CLIP-seq
MIRT1317084	hsa-miR-3176	CLIP-seq
MIRT1317085	hsa-miR-377	CLIP-seq
MIRT1317086	hsa-miR-3918	CLIP-seq
MIRT1317087	hsa-miR-3922-3p	CLIP-seq
MIRT1317088	hsa-miR-3929	CLIP-seq
MIRT1317089	hsa-miR-3945	CLIP-seq
MIRT1317090	hsa-miR-4301	CLIP-seq
MIRT1317091	hsa-miR-4419b	CLIP-seq
MIRT1317092	hsa-miR-4420	CLIP-seq
MIRT1317093	hsa-miR-4478	CLIP-seq
MIRT1317094	hsa-miR-4512	CLIP-seq
MIRT1317095	hsa-miR-4635	CLIP-seq
MIRT1317096	hsa-miR-4753-3p	CLIP-seq
MIRT1317097	hsa-miR-4757-5p	CLIP-seq
MIRT1317098	hsa-miR-4761-3p	CLIP-seq
MIRT1317099	hsa-miR-4768-5p	CLIP-seq
MIRT1317100	hsa-miR-4773	CLIP-seq
MIRT1317101	hsa-miR-502-5p	CLIP-seq
MIRT1317102	hsa-miR-532-3p	CLIP-seq
MIRT1317103	hsa-miR-587	CLIP-seq
MIRT1317088	hsa-miR-3929	CLIP-seq
MIRT1317089	hsa-miR-3945	CLIP-seq
MIRT1317091	hsa-miR-4419b	CLIP-seq
MIRT1317093	hsa-miR-4478	CLIP-seq
MIRT1317098	hsa-miR-4761-3p	CLIP-seq
MIRT1317079	hsa-miR-193a-3p	CLIP-seq
MIRT1317080	hsa-miR-193b	CLIP-seq
MIRT1317082	hsa-miR-3154	CLIP-seq
MIRT2094125	hsa-miR-342-3p	CLIP-seq
MIRT1317085	hsa-miR-377	CLIP-seq
MIRT1317089	hsa-miR-3945	CLIP-seq
MIRT1317092	hsa-miR-4420	CLIP-seq
MIRT2094126	hsa-miR-4643	CLIP-seq
MIRT1317098	hsa-miR-4761-3p	CLIP-seq
MIRT1317100	hsa-miR-4773	CLIP-seq
MIRT1317077	hsa-miR-1236	CLIP-seq
MIRT2318767	hsa-miR-1245b-5p	CLIP-seq
MIRT1317078	hsa-miR-151-3p	CLIP-seq
MIRT1317081	hsa-miR-2861	CLIP-seq
MIRT2318768	hsa-miR-3142	CLIP-seq
MIRT1317082	hsa-miR-3154	CLIP-seq
MIRT2094125	hsa-miR-342-3p	CLIP-seq
MIRT2318769	hsa-miR-3671	CLIP-seq
MIRT1317085	hsa-miR-377	CLIP-seq
MIRT1317086	hsa-miR-3918	CLIP-seq
MIRT1317088	hsa-miR-3929	CLIP-seq
MIRT1317089	hsa-miR-3945	CLIP-seq
MIRT1317091	hsa-miR-4419b	CLIP-seq
MIRT1317093	hsa-miR-4478	CLIP-seq
MIRT2318770	hsa-miR-4493	CLIP-seq
MIRT1317094	hsa-miR-4512	CLIP-seq
MIRT1317095	hsa-miR-4635	CLIP-seq
MIRT2094126	hsa-miR-4643	CLIP-seq
MIRT1317096	hsa-miR-4753-3p	CLIP-seq
MIRT1317098	hsa-miR-4761-3p	CLIP-seq
MIRT1317099	hsa-miR-4768-5p	CLIP-seq
MIRT1317100	hsa-miR-4773	CLIP-seq
MIRT1317101	hsa-miR-502-5p	CLIP-seq
MIRT2614356	hsa-miR-106a	CLIP-seq
MIRT2614357	hsa-miR-106b	CLIP-seq
MIRT2614358	hsa-miR-1207-5p	CLIP-seq
MIRT1317077	hsa-miR-1236	CLIP-seq
MIRT2318767	hsa-miR-1245b-5p	CLIP-seq
MIRT2614359	hsa-miR-1323	CLIP-seq
MIRT1317078	hsa-miR-151-3p	CLIP-seq
MIRT2614360	hsa-miR-17	CLIP-seq
MIRT2614361	hsa-miR-1909	CLIP-seq
MIRT1317079	hsa-miR-193a-3p	CLIP-seq
MIRT1317080	hsa-miR-193b	CLIP-seq
MIRT2614362	hsa-miR-20a	CLIP-seq
MIRT2614363	hsa-miR-20b	CLIP-seq
MIRT1317081	hsa-miR-2861	CLIP-seq
MIRT2614364	hsa-miR-296-5p	CLIP-seq
MIRT2614365	hsa-miR-3064-3p	CLIP-seq
MIRT2614366	hsa-miR-3120-3p	CLIP-seq
MIRT2614367	hsa-miR-3121-5p	CLIP-seq
MIRT2318768	hsa-miR-3142	CLIP-seq
MIRT1317082	hsa-miR-3154	CLIP-seq
MIRT1317083	hsa-miR-3156-3p	CLIP-seq
MIRT1317084	hsa-miR-3176	CLIP-seq
MIRT2614368	hsa-miR-331-3p	CLIP-seq
MIRT2614369	hsa-miR-3605-5p	CLIP-seq
MIRT2614370	hsa-miR-3620	CLIP-seq
MIRT2614371	hsa-miR-3647-3p	CLIP-seq
MIRT2318769	hsa-miR-3671	CLIP-seq
MIRT1317085	hsa-miR-377	CLIP-seq
MIRT1317086	hsa-miR-3918	CLIP-seq
MIRT1317087	hsa-miR-3922-3p	CLIP-seq
MIRT1317088	hsa-miR-3929	CLIP-seq
MIRT1317089	hsa-miR-3945	CLIP-seq
MIRT2614372	hsa-miR-4254	CLIP-seq
MIRT2614373	hsa-miR-4269	CLIP-seq
MIRT2614374	hsa-miR-4292	CLIP-seq
MIRT1317090	hsa-miR-4301	CLIP-seq
MIRT2614375	hsa-miR-4308	CLIP-seq
MIRT2614376	hsa-miR-4313	CLIP-seq
MIRT1317091	hsa-miR-4419b	CLIP-seq
MIRT1317092	hsa-miR-4420	CLIP-seq
MIRT1317093	hsa-miR-4478	CLIP-seq
MIRT2318770	hsa-miR-4493	CLIP-seq
MIRT1317094	hsa-miR-4512	CLIP-seq
MIRT1317095	hsa-miR-4635	CLIP-seq
MIRT2614377	hsa-miR-4722-3p	CLIP-seq
MIRT1317096	hsa-miR-4753-3p	CLIP-seq
MIRT1317097	hsa-miR-4757-5p	CLIP-seq
MIRT1317098	hsa-miR-4761-3p	CLIP-seq
MIRT2614378	hsa-miR-4763-3p	CLIP-seq
MIRT2614379	hsa-miR-4763-5p	CLIP-seq
MIRT2614380	hsa-miR-4767	CLIP-seq
MIRT1317099	hsa-miR-4768-5p	CLIP-seq
MIRT1317100	hsa-miR-4773	CLIP-seq
MIRT1317101	hsa-miR-502-5p	CLIP-seq
MIRT2614381	hsa-miR-519a	CLIP-seq
MIRT2614382	hsa-miR-519b-3p	CLIP-seq
MIRT2614383	hsa-miR-519c-3p	CLIP-seq
MIRT2614384	hsa-miR-519d	CLIP-seq
MIRT2614385	hsa-miR-520g	CLIP-seq
MIRT2614386	hsa-miR-520h	CLIP-seq
MIRT1317102	hsa-miR-532-3p	CLIP-seq
MIRT2614387	hsa-miR-545	CLIP-seq
MIRT2614388	hsa-miR-548o	CLIP-seq
MIRT2614389	hsa-miR-765	CLIP-seq
MIRT2614390	hsa-miR-93	CLIP-seq
MIRT2614356	hsa-miR-106a	CLIP-seq
MIRT2614357	hsa-miR-106b	CLIP-seq
MIRT2614358	hsa-miR-1207-5p	CLIP-seq
MIRT1317077	hsa-miR-1236	CLIP-seq
MIRT2318767	hsa-miR-1245b-5p	CLIP-seq
MIRT2614359	hsa-miR-1323	CLIP-seq
MIRT1317078	hsa-miR-151-3p	CLIP-seq
MIRT2614360	hsa-miR-17	CLIP-seq
MIRT2614361	hsa-miR-1909	CLIP-seq
MIRT1317079	hsa-miR-193a-3p	CLIP-seq
MIRT1317080	hsa-miR-193b	CLIP-seq
MIRT2689950	hsa-miR-2052	CLIP-seq
MIRT2614362	hsa-miR-20a	CLIP-seq
MIRT2614363	hsa-miR-20b	CLIP-seq
MIRT1317081	hsa-miR-2861	CLIP-seq
MIRT2614364	hsa-miR-296-5p	CLIP-seq
MIRT2614365	hsa-miR-3064-3p	CLIP-seq
MIRT2614366	hsa-miR-3120-3p	CLIP-seq
MIRT2614367	hsa-miR-3121-5p	CLIP-seq
MIRT2318768	hsa-miR-3142	CLIP-seq
MIRT1317082	hsa-miR-3154	CLIP-seq
MIRT1317083	hsa-miR-3156-3p	CLIP-seq
MIRT1317084	hsa-miR-3176	CLIP-seq
MIRT2614368	hsa-miR-331-3p	CLIP-seq
MIRT2614369	hsa-miR-3605-5p	CLIP-seq
MIRT2614370	hsa-miR-3620	CLIP-seq
MIRT2614371	hsa-miR-3647-3p	CLIP-seq
MIRT2318769	hsa-miR-3671	CLIP-seq
MIRT1317085	hsa-miR-377	CLIP-seq
MIRT1317086	hsa-miR-3918	CLIP-seq
MIRT1317087	hsa-miR-3922-3p	CLIP-seq
MIRT1317088	hsa-miR-3929	CLIP-seq
MIRT1317089	hsa-miR-3945	CLIP-seq
MIRT2614372	hsa-miR-4254	CLIP-seq
MIRT2614373	hsa-miR-4269	CLIP-seq
MIRT2614374	hsa-miR-4292	CLIP-seq
MIRT1317090	hsa-miR-4301	CLIP-seq
MIRT2689951	hsa-miR-4307	CLIP-seq
MIRT2614375	hsa-miR-4308	CLIP-seq
MIRT2614376	hsa-miR-4313	CLIP-seq
MIRT1317091	hsa-miR-4419b	CLIP-seq
MIRT1317092	hsa-miR-4420	CLIP-seq
MIRT1317093	hsa-miR-4478	CLIP-seq
MIRT2318770	hsa-miR-4493	CLIP-seq
MIRT1317094	hsa-miR-4512	CLIP-seq
MIRT1317095	hsa-miR-4635	CLIP-seq
MIRT2614377	hsa-miR-4722-3p	CLIP-seq
MIRT1317096	hsa-miR-4753-3p	CLIP-seq
MIRT1317097	hsa-miR-4757-5p	CLIP-seq
MIRT1317098	hsa-miR-4761-3p	CLIP-seq
MIRT2614378	hsa-miR-4763-3p	CLIP-seq
MIRT2614379	hsa-miR-4763-5p	CLIP-seq
MIRT2614380	hsa-miR-4767	CLIP-seq
MIRT1317099	hsa-miR-4768-5p	CLIP-seq
MIRT1317100	hsa-miR-4773	CLIP-seq
MIRT1317101	hsa-miR-502-5p	CLIP-seq
MIRT2614381	hsa-miR-519a	CLIP-seq
MIRT2614382	hsa-miR-519b-3p	CLIP-seq
MIRT2614383	hsa-miR-519c-3p	CLIP-seq
MIRT2614384	hsa-miR-519d	CLIP-seq
MIRT2614385	hsa-miR-520g	CLIP-seq
MIRT2614386	hsa-miR-520h	CLIP-seq
MIRT1317102	hsa-miR-532-3p	CLIP-seq
MIRT2614387	hsa-miR-545	CLIP-seq
MIRT2614388	hsa-miR-548o	CLIP-seq
MIRT2614389	hsa-miR-765	CLIP-seq
MIRT2614390	hsa-miR-93	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674
GO:0004579	Function	Dolichyl-diphosphooligosaccharide-protein glycotransferase activity	TAS	15835887
GO:0005515	Function	Protein binding	IPI	19167329, 22988243, 25416956, 30021884, 31515488, 31831667, 32296183, 32707033, 35271311
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	NAS	31831667
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005791	Component	Rough endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006486	Process	Protein glycosylation	IEA
GO:0006487	Process	Protein N-linked glycosylation	IDA	9642163
GO:0006487	Process	Protein N-linked glycosylation	NAS	31831667
GO:0008250	Component	Oligosaccharyltransferase complex	IBA
GO:0008250	Component	Oligosaccharyltransferase complex	IDA	9642163
GO:0008250	Component	Oligosaccharyltransferase complex	IEA
GO:0008250	Component	Oligosaccharyltransferase complex	IPI	31831667
GO:0008250	Component	Oligosaccharyltransferase complex	NAS	31831667
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0018279	Process	Protein N-linked glycosylation via asparagine	IBA
GO:0018279	Process	Protein N-linked glycosylation via asparagine	IMP	17264154
GO:0042470	Component	Melanosome	IEA
GO:0160226	Component	Oligosaccharyltransferase complex A	IDA	31831667, 36697828, 38670073
GO:0160227	Component	Oligosaccharyltransferase complex B	IDA	31831667

MIM	HGNC	e!Ensembl
180470	10381	ENSG00000163902

Protein

UniProt ID

P04843

Protein name

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1)

Protein function

Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr

PDB

6S7O , 6S7T , 8B6L , 8PN9

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04597	Ribophorin_I	31 → 457	Ribophorin I	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in all tissues tested. {ECO:0000269|PubMed:12887896}.

Sequence

MEAPAAGLFLLLLLGTWAPAPGSASSEAPPLINEDVKRTVDLSSHLAKVTAEVVLAHLGG
GSTSRATSFLLALEPELEARLAHLGVQVKGEDEEENNLEVRETKIKGKSGRFFTVKLPVA
LDPGAKISVIVETVYTHVLHPYPTQITQSEKQFVVFEGNHYFYSPYPTKTQTMRVKLASR
NVESYTKLGNPTRSEDLLDYGPFRDVPAYSQDTFKVHYENNSPFLTITSMTRVIEVSHWG
NIAVEENVDLKHTGAVLKGPFSRYDYQRQPDSGISSIRSFKTILPAAAQDVYYRDEIGNV
STSHLLILDDSVEMEIRPRFPLFGGWKTHYIVGYNLPSYEYLYNLGDQYALKMRFVDHVF
DEQVIDSLTVKIILPEGAKNIEIDSPYEISRAPDELHYTYLDTFGRPVIVAYKKNLVEQH
IQDIVVHYTFNKVLMLQEPLLVVAAFYILFFTVIIYVRLDFSITKDPAAEARMKVACITE
QVLTLVNKRIGLYRHFDETVNRYKQSRDISTLNSGKKSLETEHKALTSEIALLQSRLKTE
GSDLCDRVSEMQKLDAQVKELVLKSAVEAERLVAGKLKKDTYIENEKLISGKRQELVTKI
DHILDAL

Sequence length

607

Interactions

View interactions

	KEGG		Reactome
	N-Glycan biosynthesis Various types of N-glycan biosynthesis Metabolic pathways Protein processing in endoplasmic reticulum		Asparagine N-linked glycosylation

RPN1 (ribophorin I)