RPLP2 (ribosomal protein lateral stalk subunit P2)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6181
Gene name Gene Name - the full gene name approved by the HGNC.
Ribosomal protein lateral stalk subunit P2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RPLP2
Synonyms (NCBI Gene) Gene synonyms aliases
D11S2243E, LP2, P2, RPP2
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11p15.5
Summary Summary of gene provided in NCBI Entrez Gene.
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pho
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(10)
miRTarBase ID miRNA Experiments Reference
MIRT051678 hsa-let-7e-5p CLASH 23622248
MIRT041698 hsa-miR-484 CLASH 23622248
MIRT039035 hsa-miR-766-3p CLASH 23622248
MIRT037947 hsa-miR-505-5p CLASH 23622248
MIRT1317075 hsa-miR-1909 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(19)
GO ID Ontology Definition Evidence Reference
GO:0002181 Process Cytoplasmic translation NAS 25901680
GO:0002182 Process Cytoplasmic translational elongation IEA
GO:0003735 Function Structural constituent of ribosome IDA 3323886
GO:0003735 Function Structural constituent of ribosome IEA
GO:0003735 Function Structural constituent of ribosome NAS 12962325
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
180530 10377 ENSG00000177600
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P05387
Protein name Large ribosomal subunit protein P2 (60S acidic ribosomal protein P2) (Renal carcinoma antigen NY-REN-44)
Protein function Plays an important role in the elongation step of protein synthesis.
PDB 1S4J , 2JDL , 2LBF , 2W1O , 4BEH , 4V6X , 5DDZ , 5GU4
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00428 Ribosomal_60s 17 → 114 Family
Sequence
Sequence length 115
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Ribosome
Coronavirus disease - COVID-19 		  L13a-mediated translational silencing of Ceruloplasmin expression
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Keratoconus Keratoconus N/A N/A GWAS
Show/Hide Text Mining Associations (10)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 29522283
Anemia Diamond Blackfan Associate 20116044
Breast Neoplasms Associate 1370760, 26176264, 36936167, 39512680
Colitis Ulcerative Associate 26419460
Colorectal Neoplasms Inhibit 9292708
Coronavirus Infections Associate 36632964
Diabetic Nephropathies Associate 32685558
Inflammatory Bowel Diseases Associate 26419460
Intervertebral disc disease Associate 33761671
Neoplasm Metastasis Associate 29522283