RPL35A (ribosomal protein L35a)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 6165
Gene name Ribosomal protein L35a
Gene symbol RPL35A
Synonyms (NCBI Gene)
DBA5L35AeL33
Chromosome 3
Chromosome location 3q29
Summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro
miRNA miRNA information provided by mirtarbase database.
90
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (90)
miRTarBase ID miRNA Experiments Reference
MIRT052577 hsa-let-7a-5p CLASH 23622248
MIRT050460 hsa-miR-22-3p CLASH 23622248
MIRT050460 hsa-miR-22-3p CLASH 23622248
MIRT046045 hsa-miR-125b-5p CLASH 23622248
MIRT045742 hsa-miR-125a-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
31
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (31)
GO ID Ontology Definition Evidence Reference
GO:0000049 Function TRNA binding IEA
GO:0002181 Process Cytoplasmic translation IBA
GO:0002181 Process Cytoplasmic translation IC 23636399
GO:0002181 Process Cytoplasmic translation NAS 25901680
GO:0003723 Function RNA binding HDA 22658674, 22681889
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
180468 10345 ENSG00000182899
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P18077
Protein name Large ribosomal subunit protein eL33 (60S ribosomal protein L35a) (Cell growth-inhibiting gene 33 protein)
Protein function Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). Required for the proliferati
PDB 4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6W6L , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7BHP , 7F5S , 7OW7 , 7QVP , 7XNX , 7XNY , 8A3D , 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY , 8FKZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01247 Ribosomal_L35Ae 5 → 104 Ribosomal protein L35Ae Domain
Sequence
Sequence length 110
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Ribosome
Coronavirus disease - COVID-19 		  L13a-mediated translational silencing of Ceruloplasmin expression
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
127
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (2)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Diamond-Blackfan anemia Likely pathogenic; Pathogenic rs2530430943, rs1560120302 RCV002403664
RCV002332516
Diamond-Blackfan anemia 5 Pathogenic; Likely pathogenic rs116840808, rs116840809, rs2530415161, rs1553811551, rs1560120302, rs1581106084, rs113752862, rs1720051488 RCV000013875
RCV000013877
RCV003514872
RCV000646032
RCV000707343
RCV000995859
RCV001045886
RCV001305334
Show/Hide Unknown Diseases (6)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Likely benign rs373782117 RCV005921112
Familial cancer of breast Uncertain significance rs766043927 RCV005897657
Familial pancreatic carcinoma Uncertain significance rs564722971 RCV005897654
Hepatocellular carcinoma Benign rs200335648 RCV005897656
Show/Hide Text Mining Associations (18)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Alzheimer Disease Associate 35766008, 38176923
Alzheimer Disease Inhibit 36195955
Anemia Associate 32241839
Anemia Diamond Blackfan Associate 18535205, 19061985, 19765279, 19773262, 20116044, 22262766, 22689679, 24675553, 25946618, 28432740, 31208452, 32241839
Anhedonia Associate 20378560
Carcinoma Hepatocellular Associate 12521301
Chromosome 5q Deletion Syndrome Associate 20378560
Congenital Hereditary and Neonatal Diseases and Abnormalities Associate 19773262
COVID 19 Associate 36509426
Craniofacial Abnormalities Associate 32241839