Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6160
Gene name	Ribosomal protein L31
Gene symbol	RPL31
Synonyms (NCBI Gene)	L31eL31
Chromosome	2
Chromosome location	2q11.2
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

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miRTarBase ID	miRNA	Experiments	Reference
MIRT032013	hsa-miR-16-5p	Proteomics	18668040
MIRT051714	hsa-let-7d-5p	CLASH	23622248
MIRT050516	hsa-miR-20a-5p	CLASH	23622248
MIRT048580	hsa-miR-100-5p	CLASH	23622248
MIRT042935	hsa-miR-324-3p	CLASH	23622248
MIRT040775	hsa-miR-18a-3p	CLASH	23622248
MIRT040307	hsa-miR-615-3p	CLASH	23622248
MIRT1316644	hsa-miR-1264	CLIP-seq
MIRT1316645	hsa-miR-298	CLIP-seq
MIRT1316646	hsa-miR-3200-3p	CLIP-seq
MIRT1316647	hsa-miR-3617	CLIP-seq
MIRT1316648	hsa-miR-3913-3p	CLIP-seq
MIRT1316649	hsa-miR-4436b-3p	CLIP-seq
MIRT1316650	hsa-miR-4517	CLIP-seq
MIRT1316651	hsa-miR-4727-5p	CLIP-seq
MIRT1316652	hsa-miR-4755-3p	CLIP-seq
MIRT1316653	hsa-miR-4769-3p	CLIP-seq
MIRT1316654	hsa-miR-556-3p	CLIP-seq
MIRT1316655	hsa-miR-641	CLIP-seq
MIRT1316656	hsa-miR-653	CLIP-seq
MIRT1316657	hsa-miR-1245b-3p	CLIP-seq
MIRT1316658	hsa-miR-21	CLIP-seq
MIRT1316659	hsa-miR-23a	CLIP-seq
MIRT1316660	hsa-miR-23b	CLIP-seq
MIRT1316661	hsa-miR-23c	CLIP-seq
MIRT1316662	hsa-miR-3658	CLIP-seq
MIRT1316663	hsa-miR-4452	CLIP-seq
MIRT1316664	hsa-miR-4804-3p	CLIP-seq
MIRT1316665	hsa-miR-590-3p	CLIP-seq
MIRT1316666	hsa-miR-590-5p	CLIP-seq

Show/Hide all (33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IBA
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	IDA	25957688
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003723	Function	RNA binding	TAS	2780320
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399, 32669547
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0003735	Function	Structural constituent of ribosome	TAS	2780320
GO:0005515	Function	Protein binding	IPI	24725430, 24965446, 32814053, 33961781, 34232536, 34901782, 35271311, 36217030
GO:0005654	Component	Nucleoplasm	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	12962325
GO:0006412	Process	Translation	TAS	2780320
GO:0015934	Component	Large ribosomal subunit	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	25957688, 32669547
GO:0022625	Component	Cytosolic large ribosomal subunit	IEA
GO:0022625	Component	Cytosolic large ribosomal subunit	IPI	25901680
GO:0022625	Component	Cytosolic large ribosomal subunit	TAS	2780320
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0045202	Component	Synapse	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
617415	10334	ENSG00000071082

P62899

Protein name

Large ribosomal subunit protein eL31 (60S ribosomal protein L31)

Protein function

Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399

PDB

4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7BHP , 7F5S , 7OW7 , 7XNX , 7XNY , 8A3D , 8FKV , 8FKW , 8FKX , 8FKY , 8FKZ , 8FL2 , 8FL3 , 8FL4 , 8FL6 , 8FL7 , 8FL9 , 8FLA , 8FLB

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01198	Ribosomal_L31e	19 → 100	Ribosomal protein L31e	Family

Sequence

MAPAKKGGEKKKGRSAINEVVTREYTINIHKRIHGVGFKKRAPRALKEIRKFAMKEMGTP
DVRIDTRLNKAVWAKGIRNVPYRIRVRLSRKRNEDEDSPNKLYTLVTYVPVTTFKNLQTV
NVDEN

Sequence length

125

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
RPL31-related condition	Likely benign	rs148028338	RCV004758893

Show/Hide Text Mining Associations (14)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adrenocortical Carcinoma	Associate	34918636
Alzheimer Disease	Associate	35766008, 38176923
Alzheimer Disease	Inhibit	36195955
Anemia Diamond Blackfan	Associate	25042156
Bone Diseases	Associate	35248705
Breast Neoplasms	Associate	36077333
COVID 19	Associate	37019895
Hematologic Neoplasms	Associate	8387429
Nasopharyngeal Carcinoma	Associate	16549050
Neoplasms	Associate	25424858
Osteoporosis	Associate	28369098, 35248705
Prostatic Neoplasms	Associate	25285958
Prostatitis	Stimulate	25285958
Systemic Vasculitis	Associate	25410188

RPL31 (ribosomal protein L31)