Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6159
Gene name	Ribosomal protein L29
Gene symbol	RPL29
Synonyms (NCBI Gene)	HIPHUMRPL29L29RPL29P10RPL29_3_370eL29
Chromosome	3
Chromosome location	3p21.2
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic r

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miRTarBase ID	miRNA	Experiments	Reference
MIRT005011	hsa-miR-125b-5p	Microarray	17891175
MIRT045203	hsa-miR-186-5p	CLASH	23622248
MIRT043525	hsa-miR-331-3p	CLASH	23622248
MIRT040029	hsa-miR-615-3p	CLASH	23622248
MIRT039506	hsa-miR-652-3p	CLASH	23622248
MIRT038917	hsa-miR-92a-1-5p	CLASH	23622248
MIRT036750	hsa-miR-760	CLASH	23622248
MIRT035785	hsa-miR-1914-5p	CLASH	23622248
MIRT1316621	hsa-miR-1237	CLIP-seq
MIRT1316622	hsa-miR-1248	CLIP-seq
MIRT1316623	hsa-miR-1908	CLIP-seq
MIRT1316624	hsa-miR-1910	CLIP-seq
MIRT1316625	hsa-miR-1915	CLIP-seq
MIRT1316626	hsa-miR-3180	CLIP-seq
MIRT1316627	hsa-miR-3180-3p	CLIP-seq
MIRT1316628	hsa-miR-3182	CLIP-seq
MIRT1316629	hsa-miR-3189-5p	CLIP-seq
MIRT1316630	hsa-miR-3196	CLIP-seq
MIRT1316631	hsa-miR-3909	CLIP-seq
MIRT1316632	hsa-miR-4323	CLIP-seq
MIRT1316633	hsa-miR-4447	CLIP-seq
MIRT1316634	hsa-miR-4459	CLIP-seq
MIRT1316635	hsa-miR-4472	CLIP-seq
MIRT1316636	hsa-miR-4651	CLIP-seq
MIRT1316637	hsa-miR-4722-3p	CLIP-seq
MIRT1316638	hsa-miR-4751	CLIP-seq
MIRT1316639	hsa-miR-4756-3p	CLIP-seq
MIRT1316640	hsa-miR-4781-3p	CLIP-seq
MIRT1316641	hsa-miR-4787-5p	CLIP-seq
MIRT1316642	hsa-miR-608	CLIP-seq
MIRT1316643	hsa-miR-663	CLIP-seq
MIRT1316621	hsa-miR-1237	CLIP-seq
MIRT1316622	hsa-miR-1248	CLIP-seq
MIRT1316623	hsa-miR-1908	CLIP-seq
MIRT1316624	hsa-miR-1910	CLIP-seq
MIRT1316626	hsa-miR-3180	CLIP-seq
MIRT1316627	hsa-miR-3180-3p	CLIP-seq
MIRT1316628	hsa-miR-3182	CLIP-seq
MIRT1316629	hsa-miR-3189-5p	CLIP-seq
MIRT1316630	hsa-miR-3196	CLIP-seq
MIRT1316631	hsa-miR-3909	CLIP-seq
MIRT1316632	hsa-miR-4323	CLIP-seq
MIRT1316633	hsa-miR-4447	CLIP-seq
MIRT1316634	hsa-miR-4459	CLIP-seq
MIRT1316635	hsa-miR-4472	CLIP-seq
MIRT1316636	hsa-miR-4651	CLIP-seq
MIRT1316637	hsa-miR-4722-3p	CLIP-seq
MIRT1316638	hsa-miR-4751	CLIP-seq
MIRT1316639	hsa-miR-4756-3p	CLIP-seq
MIRT1316640	hsa-miR-4781-3p	CLIP-seq
MIRT1316641	hsa-miR-4787-5p	CLIP-seq
MIRT1316642	hsa-miR-608	CLIP-seq
MIRT1316643	hsa-miR-663	CLIP-seq
MIRT1316621	hsa-miR-1237	CLIP-seq
MIRT1316622	hsa-miR-1248	CLIP-seq
MIRT1316624	hsa-miR-1910	CLIP-seq
MIRT1316628	hsa-miR-3182	CLIP-seq
MIRT1316631	hsa-miR-3909	CLIP-seq
MIRT1316639	hsa-miR-4756-3p	CLIP-seq
MIRT1316640	hsa-miR-4781-3p	CLIP-seq
MIRT1316621	hsa-miR-1237	CLIP-seq
MIRT1316622	hsa-miR-1248	CLIP-seq
MIRT1316624	hsa-miR-1910	CLIP-seq
MIRT1316628	hsa-miR-3182	CLIP-seq
MIRT1316631	hsa-miR-3909	CLIP-seq
MIRT1316639	hsa-miR-4756-3p	CLIP-seq
MIRT1316640	hsa-miR-4781-3p	CLIP-seq
MIRT1316623	hsa-miR-1908	CLIP-seq
MIRT1316625	hsa-miR-1915	CLIP-seq
MIRT1316626	hsa-miR-3180	CLIP-seq
MIRT1316627	hsa-miR-3180-3p	CLIP-seq
MIRT1316629	hsa-miR-3189-5p	CLIP-seq
MIRT1316630	hsa-miR-3196	CLIP-seq
MIRT1316632	hsa-miR-4323	CLIP-seq
MIRT1316633	hsa-miR-4447	CLIP-seq
MIRT1316634	hsa-miR-4459	CLIP-seq
MIRT1316635	hsa-miR-4472	CLIP-seq
MIRT1316636	hsa-miR-4651	CLIP-seq
MIRT1316638	hsa-miR-4751	CLIP-seq
MIRT1316641	hsa-miR-4787-5p	CLIP-seq
MIRT1316642	hsa-miR-608	CLIP-seq
MIRT1316643	hsa-miR-663	CLIP-seq
MIRT1316625	hsa-miR-1915	CLIP-seq
MIRT1316629	hsa-miR-3189-5p	CLIP-seq
MIRT1316632	hsa-miR-4323	CLIP-seq
MIRT1316634	hsa-miR-4459	CLIP-seq
MIRT1316638	hsa-miR-4751	CLIP-seq

Show/Hide all (29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IBA
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	TAS	8597591
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399, 32669547
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0003735	Function	Structural constituent of ribosome	TAS	8597591
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	12962325
GO:0006412	Process	Translation	TAS	8597591
GO:0007566	Process	Embryo implantation	TAS	8662616
GO:0008201	Function	Heparin binding	IEA
GO:0008201	Function	Heparin binding	TAS	8662616
GO:0016020	Component	Membrane	HDA	19946888
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	32669547
GO:0022625	Component	Cytosolic large ribosomal subunit	IPI	25901680
GO:0022625	Component	Cytosolic large ribosomal subunit	TAS	8597591
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
601832	10331	ENSG00000162244

P47914

Protein name

Large ribosomal subunit protein eL29 (60S ribosomal protein L29) (Cell surface heparin-binding protein HIP)

Protein function

Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669

PDB

4UG0 , 4V6X , 5AJ0 , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6W6L , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7BHP , 7F5S , 7OW7 , 7QVP , 7XNX , 7XNY , 8A3D , 8FL6 , 8FL7 , 8FL9 , 8FLA , 8FLB , 8FLC , 8FLD , 8FLE , 8FLF , 8G5Y , 8G60 , 8G61

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01779	Ribosomal_L29e	3 → 42	Ribosomal L29e protein family	Family

Sequence

MAKSKNHTTHNQSRKWHRNGIKKPRSQRYESLKGVDPKFLRNMRFAKKHNKKGLKKMQAN
NAKAMSARAEAIKALVKPKEVKPKIPKGVSRKLDRLAYIAHPKLGKRARARIAKGLRLCR
PKAKAKAKAKDQTKAQAAAPASVPAQAPKRTQAPTKASE

Sequence length

159

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CROHN'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ULCERATIVE COLITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Anemia Diamond Blackfan	Associate	20116044	★★★★★ ★☆☆☆☆ Found in Text Mining only
Down Syndrome	Associate	16100769	★★★★★ ★☆☆☆☆ Found in Text Mining only
Head and Neck Neoplasms	Associate	36010616	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mesothelioma Malignant	Associate	23830731	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	23830731	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Associate	20507635	★★★★★ ★☆☆☆☆ Found in Text Mining only

RPL29 (ribosomal protein L29)