Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6157
Gene name Gene Name - the full gene name approved by the HGNC.
Ribosomal protein L27a
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RPL27A
Synonyms (NCBI Gene) Gene synonyms aliases
L27A, uL15
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11p15.4
Summary Summary of gene provided in NCBI Entrez Gene.
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT031412 hsa-miR-16-5p Proteomics 18668040
MIRT051684 hsa-let-7e-5p CLASH 23622248
MIRT049914 hsa-miR-30a-3p CLASH 23622248
MIRT047910 hsa-miR-30c-5p CLASH 23622248
MIRT046409 hsa-miR-15b-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000184 Process Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
GO:0003723 Function RNA binding HDA 22681889
GO:0003735 Function Structural constituent of ribosome IBA 21873635
GO:0003735 Function Structural constituent of ribosome NAS 12962325
GO:0005515 Function Protein binding IPI 20195357, 21145461, 30021884
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603637 10329 ENSG00000166441
Protein
UniProt ID P46776
Protein name Large ribosomal subunit protein uL15 (60S ribosomal protein L27a)
Protein function Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399
PDB 4BXF , 4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6W6L , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7BHP , 7F5S , 7OW7 , 7QVP , 7XNY , 8A3D , 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY , 8FKZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00828 Ribosomal_L27A 26 146 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Family
Sequence
Sequence length 148
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Ribosome
Coronavirus disease - COVID-19
  L13a-mediated translational silencing of Ceruloplasmin expression
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Lung adenocarcinoma Adenocarcinoma of lung (disorder) rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370
View all (5 more)
27602772
Pancytopenia Pancytopenia rs869312883, rs770551610, rs1131690788, rs530073586, rs374333820 21674502
Associations from Text Mining
Disease Name Relationship Type References
Allanson Pantzar McLeod syndrome Associate 27374104
Alzheimer Disease Associate 35766008
Anemia Diamond Blackfan Associate 20116044
Breast Neoplasms Associate 35030975, 36984424
Carcinoma Hepatocellular Stimulate 37474947
Carcinoma Hepatocellular Associate 37956648
Carcinoma Renal Cell Associate 34002666
Colorectal Neoplasms Associate 29505855
Diabetes Mellitus Associate 27322064
Microsatellite Instability Associate 30664178