RPL19 (ribosomal protein L19)

Gene

• Entrez ID: 6143
• Gene name: Ribosomal protein L19
• Gene symbol: RPL19
• Synonyms (NCBI Gene): L19, eL19
• Chromosome: 17
• Chromosome location: 17q12
• Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT050019	hsa-miR-27a-3p	CLASH	23622248
MIRT048491	hsa-miR-100-5p	CLASH	23622248
MIRT048491	hsa-miR-100-5p	CLASH	23622248
MIRT046258	hsa-miR-23b-3p	CLASH	23622248
MIRT046180	hsa-miR-27b-3p	CLASH	23622248
MIRT036951	hsa-miR-877-3p	CLASH	23622248
MIRT035950	hsa-miR-1180-3p	CLASH	23622248
MIRT116367	hsa-miR-5197-5p	PAR-CLIP	20371350
MIRT116363	hsa-miR-889-5p	PAR-CLIP	20371350
MIRT574291	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT574290	hsa-miR-506-3p	PAR-CLIP	20371350
MIRT116367	hsa-miR-5197-5p	PAR-CLIP	20371350
MIRT116363	hsa-miR-889-5p	PAR-CLIP	20371350
MIRT574291	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT574290	hsa-miR-506-3p	PAR-CLIP	20371350
MIRT1316212	hsa-miR-34b	CLIP-seq
MIRT1316213	hsa-miR-3689a-3p	CLIP-seq
MIRT1316214	hsa-miR-3689c	CLIP-seq
MIRT1316215	hsa-miR-380	CLIP-seq
MIRT1316216	hsa-miR-4495	CLIP-seq
MIRT1316217	hsa-miR-4728-5p	CLIP-seq
MIRT1316218	hsa-miR-4796-3p	CLIP-seq
MIRT1316219	hsa-miR-520g	CLIP-seq
MIRT1316220	hsa-miR-520h	CLIP-seq
MIRT1316212	hsa-miR-34b	CLIP-seq
MIRT1316213	hsa-miR-3689a-3p	CLIP-seq
MIRT1316214	hsa-miR-3689c	CLIP-seq
MIRT1316215	hsa-miR-380	CLIP-seq
MIRT1316216	hsa-miR-4495	CLIP-seq
MIRT1316217	hsa-miR-4728-5p	CLIP-seq
MIRT1316218	hsa-miR-4796-3p	CLIP-seq
MIRT1316219	hsa-miR-520g	CLIP-seq
MIRT1316220	hsa-miR-520h	CLIP-seq
MIRT1316212	hsa-miR-34b	CLIP-seq
MIRT1316213	hsa-miR-3689a-3p	CLIP-seq
MIRT1316214	hsa-miR-3689c	CLIP-seq
MIRT1316215	hsa-miR-380	CLIP-seq
MIRT1316216	hsa-miR-4495	CLIP-seq
MIRT1316217	hsa-miR-4728-5p	CLIP-seq
MIRT1316218	hsa-miR-4796-3p	CLIP-seq
MIRT1316219	hsa-miR-520g	CLIP-seq
MIRT1316220	hsa-miR-520h	CLIP-seq
MIRT1316212	hsa-miR-34b	CLIP-seq
MIRT1316215	hsa-miR-380	CLIP-seq
MIRT1316216	hsa-miR-4495	CLIP-seq
MIRT1316218	hsa-miR-4796-3p	CLIP-seq
MIRT1316219	hsa-miR-520g	CLIP-seq
MIRT1316220	hsa-miR-520h	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS
GO:0002181	Process	Cytoplasmic translation	IDA	25957688
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003723	Function	RNA binding	IBA	21873635
GO:0003723	Function	RNA binding	TAS	1577483
GO:0003735	Function	Structural constituent of ribosome	IBA	21873635
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0003735	Function	Structural constituent of ribosome	TAS	1577483
GO:0005515	Function	Protein binding	IPI	21044950, 24965446, 32814053
GO:0005730	Component	Nucleolus	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	NAS	12962325
GO:0006412	Process	Translation	TAS	1577483
GO:0006413	Process	Translational initiation	TAS
GO:0006614	Process	SRP-dependent cotranslational protein targeting to membrane	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0019083	Process	Viral transcription	TAS
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA	21873635
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	25957688
GO:0022625	Component	Cytosolic large ribosomal subunit	TAS	1577483
GO:0042788	Component	Polysomal ribosome	IDA	25957688

Other IDs

• MIM: 180466
• HGNC: 10312
• e!Ensembl: ENSG00000108298

Protein

• UniProt ID: P84098
• Protein name: Large ribosomal subunit protein eL19 (60S ribosomal protein L19)
• Protein function: Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399
• PDB: 4UG0, 4V6X, 5A2Q, 5AJ0, 5LKS, 5T2C, 6IP5, 6IP6, 6IP8, 6LQM, 6LSR, 6LSS, 6LU8, 6OLE, 6OLF, 6OLG, 6OLI, 6OLZ, 6OM0, 6OM7, 6QZP, 6SXO, 6W6L, 6XA1, 6Y0G, 6Y2L, 6Y57, 6Y6X, 6Z6L, 6Z6M, 6Z6N, 6ZM7, 6ZME, 6ZMI, 6ZMO, 7BHP, 7F5S, 7OW7, 7XNX, 7XNY, 8A3D, 8FKY, 8FKZ, 8FL2, 8FL3, 8FL4, 8FL6, 8FL7, 8FL9, 8FLA, 8FLB
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01280	Ribosomal_L19e	3 → 146	Ribosomal protein L19e	Family

• Sequence:

  MSMLRLQKRLASSVLRCGKKKVWLDPNETNEIANANSRQQIRKLIKDGLIIRKPVTVHSR
  ARCRKNTLARRKGRHMGIGKRKGTANARMPEKVTWMRRMRILRRLLRRYRESKKIDRHMY
  HSLYLKVKGNVFKNKRILMEHIHKLKADKARKKLLADQAEARRSKTKEARKRREERLQAK
  KEEIIKTLSKEEETKK

• Sequence length: 196

Pathways

KEGG:

Ribosome
Coronavirus disease - COVID-19

Reactome:

L13a-mediated translational silencing of Ceruloplasmin expression
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Anemia	Anemia, Diamond-Blackfan	rs118204044, rs118204045, rs118204046, rs121918330, rs869320719, rs869312029, rs121918332, rs869320724, rs767094129, rs786205058, rs786205059, rs137853119, rs137853120, rs137853121, rs1384933966, rs137853122, rs137853123, rs786205060, rs267607121, rs121908584, rs80338697, rs80338699, rs120074166, rs120074167, rs1050828, rs74575103, rs137852314, rs5030868, rs137852316, rs137852317, rs137852318, rs137852319, rs137852320, rs137852321, rs137852322, rs137852323, rs137852324, rs72554665, rs387906468, rs5030872, rs137852326, rs137852333, rs137852327, rs137852328, rs137852329, rs137852330, rs137852331, rs137852332, rs137852334, rs137852335, rs137852336, rs137852339, rs76645461, rs137852340, rs137852341, rs78478128, rs137852343, rs137852344, rs137852345, rs587776730, rs137852346, rs137852347, rs137852349, rs2070404412, rs2070350038, rs2070350009, rs137852303, rs137852304, rs33946267, rs34378160, rs33933298, rs11549407, rs35724775, rs34598529, rs41469945, rs267607201, rs80338694, rs80338696, rs387907018, rs398123546, rs78365220, rs587777100, rs587777101, rs483352840, rs869312752, rs765487627, rs1557229599, rs1557230040, rs1555524842, rs782090947, rs1358275550, rs1557229736, rs1557230573, rs1556323334, rs1233124208, rs1293528130, rs146864395, rs1595503440, rs1603411214, rs137852325, rs1575247302, rs1603411177, rs1336651679, rs782322505	23718193

Unknown
Disease term	Disease name	Evidence	References	Source
Moyamoya Disease	Moyamoya Disease			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma of Lung	Associate	19799608
Carcinoma Non Small Cell Lung	Stimulate	19799608
Colorectal Neoplasms	Associate	18266979
Lung Neoplasms	Associate	19799608, 20682026
Lupus Erythematosus Systemic	Associate	35558576
Neoplasms	Associate	18266979, 19799608, 21799931
Prostatic Neoplasms	Associate	18266979, 21799931
Sarcoma Kaposi	Associate	40016701
Tuberculosis Spinal	Associate	35720320