Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6143
Gene name	Ribosomal protein L19
Gene symbol	RPL19
Synonyms (NCBI Gene)	L19eL19
Chromosome	17
Chromosome location	17q12
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

Show/Hide all (48)

miRTarBase ID	miRNA	Experiments	Reference
MIRT050019	hsa-miR-27a-3p	CLASH	23622248
MIRT048491	hsa-miR-100-5p	CLASH	23622248
MIRT048491	hsa-miR-100-5p	CLASH	23622248
MIRT046258	hsa-miR-23b-3p	CLASH	23622248
MIRT046180	hsa-miR-27b-3p	CLASH	23622248
MIRT036951	hsa-miR-877-3p	CLASH	23622248
MIRT035950	hsa-miR-1180-3p	CLASH	23622248
MIRT116367	hsa-miR-5197-5p	PAR-CLIP	20371350
MIRT116363	hsa-miR-889-5p	PAR-CLIP	20371350
MIRT574291	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT574290	hsa-miR-506-3p	PAR-CLIP	20371350
MIRT116367	hsa-miR-5197-5p	PAR-CLIP	20371350
MIRT116363	hsa-miR-889-5p	PAR-CLIP	20371350
MIRT574291	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT574290	hsa-miR-506-3p	PAR-CLIP	20371350
MIRT1316212	hsa-miR-34b	CLIP-seq
MIRT1316213	hsa-miR-3689a-3p	CLIP-seq
MIRT1316214	hsa-miR-3689c	CLIP-seq
MIRT1316215	hsa-miR-380	CLIP-seq
MIRT1316216	hsa-miR-4495	CLIP-seq
MIRT1316217	hsa-miR-4728-5p	CLIP-seq
MIRT1316218	hsa-miR-4796-3p	CLIP-seq
MIRT1316219	hsa-miR-520g	CLIP-seq
MIRT1316220	hsa-miR-520h	CLIP-seq
MIRT1316212	hsa-miR-34b	CLIP-seq
MIRT1316213	hsa-miR-3689a-3p	CLIP-seq
MIRT1316214	hsa-miR-3689c	CLIP-seq
MIRT1316215	hsa-miR-380	CLIP-seq
MIRT1316216	hsa-miR-4495	CLIP-seq
MIRT1316217	hsa-miR-4728-5p	CLIP-seq
MIRT1316218	hsa-miR-4796-3p	CLIP-seq
MIRT1316219	hsa-miR-520g	CLIP-seq
MIRT1316220	hsa-miR-520h	CLIP-seq
MIRT1316212	hsa-miR-34b	CLIP-seq
MIRT1316213	hsa-miR-3689a-3p	CLIP-seq
MIRT1316214	hsa-miR-3689c	CLIP-seq
MIRT1316215	hsa-miR-380	CLIP-seq
MIRT1316216	hsa-miR-4495	CLIP-seq
MIRT1316217	hsa-miR-4728-5p	CLIP-seq
MIRT1316218	hsa-miR-4796-3p	CLIP-seq
MIRT1316219	hsa-miR-520g	CLIP-seq
MIRT1316220	hsa-miR-520h	CLIP-seq
MIRT1316212	hsa-miR-34b	CLIP-seq
MIRT1316215	hsa-miR-380	CLIP-seq
MIRT1316216	hsa-miR-4495	CLIP-seq
MIRT1316218	hsa-miR-4796-3p	CLIP-seq
MIRT1316219	hsa-miR-520g	CLIP-seq
MIRT1316220	hsa-miR-520h	CLIP-seq

Show/Hide all (33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	IDA	25957688
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	TAS	1577483
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399, 32669547
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0003735	Function	Structural constituent of ribosome	TAS	1577483
GO:0005515	Function	Protein binding	IPI	21044950, 24965446, 32814053, 33961781
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	12962325
GO:0006412	Process	Translation	TAS	1577483
GO:0016020	Component	Membrane	HDA	19946888
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	25957688, 32669547
GO:0022625	Component	Cytosolic large ribosomal subunit	IEA
GO:0022625	Component	Cytosolic large ribosomal subunit	IPI	25901680
GO:0022625	Component	Cytosolic large ribosomal subunit	TAS	1577483
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0045202	Component	Synapse	IEA
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
180466	10312	ENSG00000108298

P84098

Protein name

Large ribosomal subunit protein eL19 (60S ribosomal protein L19)

Protein function

Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399

PDB

4UG0 , 4V6X , 5A2Q , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6SXO , 6W6L , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7BHP , 7F5S , 7OW7 , 7XNX , 7XNY , 8A3D , 8FKY , 8FKZ , 8FL2 , 8FL3 , 8FL4 , 8FL6 , 8FL7 , 8FL9 , 8FLA , 8FLB

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01280	Ribosomal_L19e	3 → 146	Ribosomal protein L19e	Family

Sequence

MSMLRLQKRLASSVLRCGKKKVWLDPNETNEIANANSRQQIRKLIKDGLIIRKPVTVHSR
ARCRKNTLARRKGRHMGIGKRKGTANARMPEKVTWMRRMRILRRLLRRYRESKKIDRHMY
HSLYLKVKGNVFKNKRILMEHIHKLKADKARKKLLADQAEARRSKTKEARKRREERLQAK
KEEIIKTLSKEEETKK

Sequence length

196

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Diamond-Blackfan anemia	Likely benign; Benign	rs370663313, rs753150645, rs758902267, rs2228666, rs201777990, rs72823350, rs751845105, rs377198587, rs557578994, rs771955273, rs1421836231, rs538421498, rs2046297376	RCV002350747 RCV005722459 RCV002351000 RCV002414243 RCV002424960 RCV002343702 RCV002359142 RCV002373019 RCV004047118 RCV002347101 RCV002342117 RCV002376103 RCV002424362
RPL19-related disorder	Likely benign; Benign	rs758902267, rs72823350, rs113832291, rs149983979, rs751845105, rs781207977, rs779026156	RCV003965982 RCV003956162 RCV003956182 RCV003966088 RCV003956161 RCV003961810 RCV003959384

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	19799608
Carcinoma Non Small Cell Lung	Stimulate	19799608
Colorectal Neoplasms	Associate	18266979
Lung Neoplasms	Associate	19799608, 20682026
Lupus Erythematosus Systemic	Associate	35558576
Neoplasms	Associate	18266979, 19799608, 21799931
Prostatic Neoplasms	Associate	18266979, 21799931
Sarcoma Kaposi	Associate	40016701
Tuberculosis Spinal	Associate	35720320

RPL19 (ribosomal protein L19)