Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6141
Gene name Gene Name - the full gene name approved by the HGNC.	Ribosomal protein L18
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RPL18
Synonyms (NCBI Gene) Gene synonyms aliases	DBA18, L18, eL18
Disease Acronyms (UniProt) Disease acronyms from UniProt database	DBA18
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19q13.33
Summary Summary of gene provided in NCBI Entrez Gene.	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the

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miRTarBase ID	miRNA	Experiments	Reference
MIRT051955	hsa-let-7b-5p	CLASH	23622248
MIRT045664	hsa-miR-149-5p	CLASH	23622248
MIRT044312	hsa-miR-106b-5p	CLASH	23622248
MIRT037632	hsa-miR-744-5p	CLASH	23622248
MIRT508316	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT514581	hsa-miR-548p	PAR-CLIP	20371350
MIRT508315	hsa-miR-6819-3p	PAR-CLIP	20371350
MIRT508314	hsa-miR-6877-3p	PAR-CLIP	20371350
MIRT508313	hsa-miR-4661-3p	PAR-CLIP	20371350
MIRT514579	hsa-miR-545-3p	PAR-CLIP	20371350
MIRT508312	hsa-miR-6823-5p	PAR-CLIP	20371350
MIRT508311	hsa-miR-7113-5p	PAR-CLIP	20371350
MIRT508310	hsa-miR-4685-5p	PAR-CLIP	20371350
MIRT508309	hsa-miR-6837-5p	PAR-CLIP	20371350
MIRT508308	hsa-miR-3674	PAR-CLIP	20371350
MIRT508315	hsa-miR-6819-3p	PAR-CLIP	20371350
MIRT508314	hsa-miR-6877-3p	PAR-CLIP	20371350
MIRT508312	hsa-miR-6823-5p	PAR-CLIP	20371350
MIRT508311	hsa-miR-7113-5p	PAR-CLIP	20371350
MIRT508310	hsa-miR-4685-5p	PAR-CLIP	20371350
MIRT508309	hsa-miR-6837-5p	PAR-CLIP	20371350
MIRT508308	hsa-miR-3674	PAR-CLIP	20371350
MIRT508316	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT514581	hsa-miR-548p	PAR-CLIP	23446348
MIRT508315	hsa-miR-6819-3p	PAR-CLIP	23446348
MIRT508314	hsa-miR-6877-3p	PAR-CLIP	23446348
MIRT508313	hsa-miR-4661-3p	PAR-CLIP	23446348
MIRT514580	hsa-miR-6760-3p	PAR-CLIP	23446348
MIRT514579	hsa-miR-545-3p	PAR-CLIP	23446348
MIRT508312	hsa-miR-6823-5p	PAR-CLIP	23446348
MIRT508311	hsa-miR-7113-5p	PAR-CLIP	23446348
MIRT508310	hsa-miR-4685-5p	PAR-CLIP	23446348
MIRT508309	hsa-miR-6837-5p	PAR-CLIP	23446348
MIRT508308	hsa-miR-3674	PAR-CLIP	23446348
MIRT508316	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT508315	hsa-miR-6819-3p	PAR-CLIP	23446348
MIRT508314	hsa-miR-6877-3p	PAR-CLIP	23446348
MIRT508313	hsa-miR-4661-3p	PAR-CLIP	23446348
MIRT508312	hsa-miR-6823-5p	PAR-CLIP	23446348
MIRT508311	hsa-miR-7113-5p	PAR-CLIP	23446348
MIRT508310	hsa-miR-4685-5p	PAR-CLIP	23446348
MIRT508309	hsa-miR-6837-5p	PAR-CLIP	23446348
MIRT508308	hsa-miR-3674	PAR-CLIP	23446348
MIRT508316	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT514581	hsa-miR-548p	PAR-CLIP	20371350
MIRT508315	hsa-miR-6819-3p	PAR-CLIP	20371350
MIRT508314	hsa-miR-6877-3p	PAR-CLIP	20371350
MIRT508313	hsa-miR-4661-3p	PAR-CLIP	20371350
MIRT514579	hsa-miR-545-3p	PAR-CLIP	20371350
MIRT508312	hsa-miR-6823-5p	PAR-CLIP	20371350
MIRT508311	hsa-miR-7113-5p	PAR-CLIP	20371350
MIRT508310	hsa-miR-4685-5p	PAR-CLIP	20371350
MIRT508309	hsa-miR-6837-5p	PAR-CLIP	20371350
MIRT508308	hsa-miR-3674	PAR-CLIP	20371350
MIRT508315	hsa-miR-6819-3p	PAR-CLIP	20371350
MIRT508314	hsa-miR-6877-3p	PAR-CLIP	20371350
MIRT508312	hsa-miR-6823-5p	PAR-CLIP	20371350
MIRT508311	hsa-miR-7113-5p	PAR-CLIP	20371350
MIRT508310	hsa-miR-4685-5p	PAR-CLIP	20371350
MIRT508309	hsa-miR-6837-5p	PAR-CLIP	20371350
MIRT508308	hsa-miR-3674	PAR-CLIP	20371350
MIRT508316	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT514581	hsa-miR-548p	PAR-CLIP	23446348
MIRT508315	hsa-miR-6819-3p	PAR-CLIP	23446348
MIRT508314	hsa-miR-6877-3p	PAR-CLIP	23446348
MIRT508313	hsa-miR-4661-3p	PAR-CLIP	23446348
MIRT514580	hsa-miR-6760-3p	PAR-CLIP	23446348
MIRT514579	hsa-miR-545-3p	PAR-CLIP	23446348
MIRT508312	hsa-miR-6823-5p	PAR-CLIP	23446348
MIRT508311	hsa-miR-7113-5p	PAR-CLIP	23446348
MIRT508310	hsa-miR-4685-5p	PAR-CLIP	23446348
MIRT508309	hsa-miR-6837-5p	PAR-CLIP	23446348
MIRT508308	hsa-miR-3674	PAR-CLIP	23446348
MIRT508316	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT508315	hsa-miR-6819-3p	PAR-CLIP	23446348
MIRT508314	hsa-miR-6877-3p	PAR-CLIP	23446348
MIRT508313	hsa-miR-4661-3p	PAR-CLIP	23446348
MIRT508312	hsa-miR-6823-5p	PAR-CLIP	23446348
MIRT508311	hsa-miR-7113-5p	PAR-CLIP	23446348
MIRT508310	hsa-miR-4685-5p	PAR-CLIP	23446348
MIRT508309	hsa-miR-6837-5p	PAR-CLIP	23446348
MIRT508308	hsa-miR-3674	PAR-CLIP	23446348
MIRT1316209	hsa-miR-545	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS
GO:0002181	Process	Cytoplasmic translation	IDA	25957688
GO:0003723	Function	RNA binding	IBA	21873635
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005730	Component	Nucleolus	IDA
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005791	Component	Rough endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	NAS	12962325
GO:0006413	Process	Translational initiation	TAS
GO:0006614	Process	SRP-dependent cotranslational protein targeting to membrane	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0019083	Process	Viral transcription	TAS
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA	21873635
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	25957688
GO:0042788	Component	Polysomal ribosome	IDA	25957688

MIM	HGNC	e!Ensembl
604179	10310	ENSG00000063177

Protein

UniProt ID

Q07020

Protein name

Large ribosomal subunit protein eL18 (60S ribosomal protein L18)

Protein function

Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962

PDB

4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6W6L , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZVK , 7A01 , 7BHP , 7F5S , 7OW7 , 7QVP , 7XNX , 7XNY , 8A3D , 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF17135	Ribosomal_L18	2 → 188	Ribosomal protein 60S L18 and 50S L18e	Family

Sequence

MGVDIRHNKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPP
LSLSRMIRKMKLPGRENKTAVVVGTITDDVRVQEVPKLKVCALRVTSRARSRILRAGGKI
LTFDQLALDSPKGCGTVLLSGPRKGREVYRHFGKAPGTPHSHTKPYVRSKGRKFERARGR
RASRGYKN

Sequence length

188

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Show/Hide Causal Diseases (5)

Disease term	Disease name	dbSNP ID	References
Causal
Anemia	Anemia, Macrocytic, Anemia, Diamond-Blackfan	rs118204044, rs118204045, rs118204046, rs121918330, rs869320719, rs869312029, rs121918332, rs869320724, rs767094129, rs786205058, rs786205059, rs137853119, rs137853120, rs137853121, rs1384933966 View all (89 more)	28280134
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802 View all (244 more)	21364753
Leukemia	Acute leukemia	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297
Migraine	Migraine Disorders	rs794727411
Neutropenia	Neutropenia	rs879253882

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Diamond-Blackfan anemia	Diamond-Blackfan anemia 18			GenCC

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References
Associations from Text Mining
Alzheimer Disease	Associate	35766008
Carcinoma Non Small Cell Lung	Associate	36067173
Intervertebral Disc Degeneration	Associate	31124977
Neoplasms	Associate	36067173
Sarcoma Kaposi	Associate	40016701

RPL18 (ribosomal protein L18)