RPL18 (ribosomal protein L18)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 6141
Gene name Ribosomal protein L18
Gene symbol RPL18
Synonyms (NCBI Gene)
DBA18L18eL18
Chromosome 19
Chromosome location 19q13.33
Summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the
miRNA miRNA information provided by mirtarbase database.
83
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (83)
miRTarBase ID miRNA Experiments Reference
MIRT051955 hsa-let-7b-5p CLASH 23622248
MIRT045664 hsa-miR-149-5p CLASH 23622248
MIRT044312 hsa-miR-106b-5p CLASH 23622248
MIRT037632 hsa-miR-744-5p CLASH 23622248
MIRT508316 hsa-miR-548c-3p PAR-CLIP 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
34
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0002181 Process Cytoplasmic translation IC 23636399
GO:0002181 Process Cytoplasmic translation IDA 25957688
GO:0002181 Process Cytoplasmic translation NAS 25901680
GO:0003723 Function RNA binding IBA
GO:0003723 Function RNA binding TAS 8218404
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
604179 10310 ENSG00000063177
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q07020
Protein name Large ribosomal subunit protein eL18 (60S ribosomal protein L18)
Protein function Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962
PDB 4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6W6L , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZVK , 7A01 , 7BHP , 7F5S , 7OW7 , 7QVP , 7XNX , 7XNY , 8A3D , 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF17135 Ribosomal_L18 2 → 188 Ribosomal protein 60S L18 and 50S L18e Family
Sequence
Sequence length 188
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Ribosome
Coronavirus disease - COVID-19 		  L13a-mediated translational silencing of Ceruloplasmin expression
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Diamond-Blackfan anemia 18 Pathogenic rs1568425218 RCV000754828
Show/Hide Unknown Diseases (3)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Familial cancer of breast Likely benign rs200188369 RCV005903062
Ovarian serous cystadenocarcinoma Likely benign rs200188369 RCV005903063
RPL18-related disorder Uncertain significance; Likely benign; Benign rs11554936, rs201393157, rs143728553, rs138053229, rs199791473, rs2513857906, rs200523276, rs568080288 RCV003936391
RCV003926594
RCV003943658
RCV004757601
RCV003907202
RCV003901614
RCV003940420
RCV003942925
Show/Hide Text Mining Associations (5)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Alzheimer Disease Associate 35766008
Carcinoma Non Small Cell Lung Associate 36067173
Intervertebral Disc Degeneration Associate 31124977
Neoplasms Associate 36067173
Sarcoma Kaposi Associate 40016701