Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6141
Gene name Gene Name - the full gene name approved by the HGNC.	Ribosomal protein L18
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RPL18
Synonyms (NCBI Gene) Gene synonyms aliases	DBA18, L18, eL18
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19q13.33
Summary Summary of gene provided in NCBI Entrez Gene.	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the

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miRTarBase ID	miRNA	Experiments	Reference
MIRT051955	hsa-let-7b-5p	CLASH	23622248
MIRT045664	hsa-miR-149-5p	CLASH	23622248
MIRT044312	hsa-miR-106b-5p	CLASH	23622248
MIRT037632	hsa-miR-744-5p	CLASH	23622248
MIRT508316	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT514581	hsa-miR-548p	PAR-CLIP	20371350
MIRT508315	hsa-miR-6819-3p	PAR-CLIP	20371350
MIRT508314	hsa-miR-6877-3p	PAR-CLIP	20371350
MIRT508313	hsa-miR-4661-3p	PAR-CLIP	20371350
MIRT514579	hsa-miR-545-3p	PAR-CLIP	20371350
MIRT508312	hsa-miR-6823-5p	PAR-CLIP	20371350
MIRT508311	hsa-miR-7113-5p	PAR-CLIP	20371350
MIRT508310	hsa-miR-4685-5p	PAR-CLIP	20371350
MIRT508309	hsa-miR-6837-5p	PAR-CLIP	20371350
MIRT508308	hsa-miR-3674	PAR-CLIP	20371350
MIRT508315	hsa-miR-6819-3p	PAR-CLIP	20371350
MIRT508314	hsa-miR-6877-3p	PAR-CLIP	20371350
MIRT508312	hsa-miR-6823-5p	PAR-CLIP	20371350
MIRT508311	hsa-miR-7113-5p	PAR-CLIP	20371350
MIRT508310	hsa-miR-4685-5p	PAR-CLIP	20371350
MIRT508309	hsa-miR-6837-5p	PAR-CLIP	20371350
MIRT508308	hsa-miR-3674	PAR-CLIP	20371350
MIRT508316	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT514581	hsa-miR-548p	PAR-CLIP	23446348
MIRT508315	hsa-miR-6819-3p	PAR-CLIP	23446348
MIRT508314	hsa-miR-6877-3p	PAR-CLIP	23446348
MIRT508313	hsa-miR-4661-3p	PAR-CLIP	23446348
MIRT514580	hsa-miR-6760-3p	PAR-CLIP	23446348
MIRT514579	hsa-miR-545-3p	PAR-CLIP	23446348
MIRT508312	hsa-miR-6823-5p	PAR-CLIP	23446348
MIRT508311	hsa-miR-7113-5p	PAR-CLIP	23446348
MIRT508310	hsa-miR-4685-5p	PAR-CLIP	23446348
MIRT508309	hsa-miR-6837-5p	PAR-CLIP	23446348
MIRT508308	hsa-miR-3674	PAR-CLIP	23446348
MIRT508316	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT508315	hsa-miR-6819-3p	PAR-CLIP	23446348
MIRT508314	hsa-miR-6877-3p	PAR-CLIP	23446348
MIRT508313	hsa-miR-4661-3p	PAR-CLIP	23446348
MIRT508312	hsa-miR-6823-5p	PAR-CLIP	23446348
MIRT508311	hsa-miR-7113-5p	PAR-CLIP	23446348
MIRT508310	hsa-miR-4685-5p	PAR-CLIP	23446348
MIRT508309	hsa-miR-6837-5p	PAR-CLIP	23446348
MIRT508308	hsa-miR-3674	PAR-CLIP	23446348
MIRT508316	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT514581	hsa-miR-548p	PAR-CLIP	20371350
MIRT508315	hsa-miR-6819-3p	PAR-CLIP	20371350
MIRT508314	hsa-miR-6877-3p	PAR-CLIP	20371350
MIRT508313	hsa-miR-4661-3p	PAR-CLIP	20371350
MIRT514579	hsa-miR-545-3p	PAR-CLIP	20371350
MIRT508312	hsa-miR-6823-5p	PAR-CLIP	20371350
MIRT508311	hsa-miR-7113-5p	PAR-CLIP	20371350
MIRT508310	hsa-miR-4685-5p	PAR-CLIP	20371350
MIRT508309	hsa-miR-6837-5p	PAR-CLIP	20371350
MIRT508308	hsa-miR-3674	PAR-CLIP	20371350
MIRT508315	hsa-miR-6819-3p	PAR-CLIP	20371350
MIRT508314	hsa-miR-6877-3p	PAR-CLIP	20371350
MIRT508312	hsa-miR-6823-5p	PAR-CLIP	20371350
MIRT508311	hsa-miR-7113-5p	PAR-CLIP	20371350
MIRT508310	hsa-miR-4685-5p	PAR-CLIP	20371350
MIRT508309	hsa-miR-6837-5p	PAR-CLIP	20371350
MIRT508308	hsa-miR-3674	PAR-CLIP	20371350
MIRT508316	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT514581	hsa-miR-548p	PAR-CLIP	23446348
MIRT508315	hsa-miR-6819-3p	PAR-CLIP	23446348
MIRT508314	hsa-miR-6877-3p	PAR-CLIP	23446348
MIRT508313	hsa-miR-4661-3p	PAR-CLIP	23446348
MIRT514580	hsa-miR-6760-3p	PAR-CLIP	23446348
MIRT514579	hsa-miR-545-3p	PAR-CLIP	23446348
MIRT508312	hsa-miR-6823-5p	PAR-CLIP	23446348
MIRT508311	hsa-miR-7113-5p	PAR-CLIP	23446348
MIRT508310	hsa-miR-4685-5p	PAR-CLIP	23446348
MIRT508309	hsa-miR-6837-5p	PAR-CLIP	23446348
MIRT508308	hsa-miR-3674	PAR-CLIP	23446348
MIRT508316	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT508315	hsa-miR-6819-3p	PAR-CLIP	23446348
MIRT508314	hsa-miR-6877-3p	PAR-CLIP	23446348
MIRT508313	hsa-miR-4661-3p	PAR-CLIP	23446348
MIRT508312	hsa-miR-6823-5p	PAR-CLIP	23446348
MIRT508311	hsa-miR-7113-5p	PAR-CLIP	23446348
MIRT508310	hsa-miR-4685-5p	PAR-CLIP	23446348
MIRT508309	hsa-miR-6837-5p	PAR-CLIP	23446348
MIRT508308	hsa-miR-3674	PAR-CLIP	23446348
MIRT1316209	hsa-miR-545	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	IDA	25957688
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	TAS	8218404
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399, 32669547
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0003735	Function	Structural constituent of ribosome	TAS	8218404
GO:0005515	Function	Protein binding	IPI	30021884, 32814053, 33961781, 35271311
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005791	Component	Rough endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	12962325
GO:0006412	Process	Translation	TAS	8218404
GO:0016020	Component	Membrane	HDA	19946888
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	25957688, 32669547
GO:0022625	Component	Cytosolic large ribosomal subunit	IPI	25901680
GO:0022625	Component	Cytosolic large ribosomal subunit	TAS	8218404
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
604179	10310	ENSG00000063177

Protein

UniProt ID

Q07020

Protein name

Large ribosomal subunit protein eL18 (60S ribosomal protein L18)

Protein function

Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962

PDB

4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6W6L , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZVK , 7A01 , 7BHP , 7F5S , 7OW7 , 7QVP , 7XNX , 7XNY , 8A3D , 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF17135	Ribosomal_L18	2 → 188	Ribosomal protein 60S L18 and 50S L18e	Family

Sequence

MGVDIRHNKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPP
LSLSRMIRKMKLPGRENKTAVVVGTITDDVRVQEVPKLKVCALRVTSRARSRILRAGGKI
LTFDQLALDSPKGCGTVLLSGPRKGREVYRHFGKAPGTPHSHTKPYVRSKGRKFERARGR
RASRGYKN

Sequence length

188

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Show/Hide Causal Diseases (1)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Diamond-Blackfan anemia	Diamond-Blackfan anemia 18	rs1568425218	N/A

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Alzheimer Disease	Associate	35766008
Carcinoma Non Small Cell Lung	Associate	36067173
Intervertebral Disc Degeneration	Associate	31124977
Neoplasms	Associate	36067173
Sarcoma Kaposi	Associate	40016701

RPL18 (ribosomal protein L18)